UniProtKB - P17022 (ZNF18_HUMAN)
Protein
Zinc finger protein 18
Gene
ZNF18
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 408 – 430 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P17022 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 18Alternative name(s): Heart development-specific gene 1 protein Zinc finger protein 535 Zinc finger protein KOX11 Zinc finger protein with KRAB and SCAN domains 6 |
Gene namesi | Name:ZNF18 Synonyms:HDSG1, KOX11, ZKSCAN6, ZNF535 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000154957.13 |
HGNCi | HGNC:12969, ZNF18 |
MIMi | 194524, gene |
neXtProti | NX_P17022 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7566 |
OpenTargetsi | ENSG00000154957 |
PharmGKBi | PA37551 |
Miscellaneous databases
Pharosi | P17022, Tbio |
Polymorphism and mutation databases
BioMutai | ZNF18 |
DMDMi | 85681864 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047340 | 1 – 549 | Zinc finger protein 18Add BLAST | 549 |
Proteomic databases
EPDi | P17022 |
jPOSTi | P17022 |
MassIVEi | P17022 |
PaxDbi | P17022 |
PeptideAtlasi | P17022 |
PRIDEi | P17022 |
ProteomicsDBi | 53420 [P17022-1] 53421 [P17022-2] |
PTM databases
iPTMneti | P17022 |
PhosphoSitePlusi | P17022 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154957, Expressed in body of pancreas and 114 other tissues |
ExpressionAtlasi | P17022, baseline and differential |
Genevisiblei | P17022, HS |
Organism-specific databases
HPAi | ENSG00000154957, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP17022
With | #Exp. | IntAct |
---|---|---|
CCNC [P24863] | 4 | EBI-8648067,EBI-395261 |
CPNE7 - isoform 2 [Q9UBL6-2] | 3 | EBI-8648067,EBI-12012272 |
TTC32 [Q5I0X7] | 3 | EBI-8648067,EBI-8636434 |
ZNF446 - isoform 2 [Q9NWS9-2] | 3 | EBI-8648067,EBI-740232 |
Protein-protein interaction databases
BioGRIDi | 113397, 11 interactors |
IntActi | P17022, 10 interactors |
MINTi | P17022 |
STRINGi | 9606.ENSP00000315664 |
Miscellaneous databases
RNActi | P17022, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 123 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 211 – 283 | KRABPROSITE-ProRule annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 408 – 430 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161617 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | P17022 |
OMAi | DEPGCFE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17022 |
TreeFami | TF337489 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR027764, Zfp18 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF190, PTHR23226:SF190, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P17022-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ
60 70 80 90 100
VMSGPHETLK QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW
110 120 130 140 150
VRKQCPGSGE EAVTLVESLK GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ
160 170 180 190 200
VGEVEPHLEV VPQELGLENS SSGPGELLSH IVKEESDTEA ELALAASQPA
210 220 230 240 250
RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM LETYGKMVSG
260 270 280 290 300
AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL
310 320 330 340 350
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI
360 370 380 390 400
QDEGTGEQLS PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR
410 420 430 440 450
APMAQKLPTC RECGKTFYRN SQLIFHQRTH TGETYFQCTI CKKAFLRSSD
460 470 480 490 500
FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR HHEKIHTGEK PYKCPICEKS
510 520 530 540
FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR SHLGKKPFQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KTA0 | J3KTA0_HUMAN | Zinc finger protein 18 | ZNF18 | 243 | Annotation score: | ||
J3KSA1 | J3KSA1_HUMAN | Zinc finger protein 18 | ZNF18 | 232 | Annotation score: | ||
J3KSC1 | J3KSC1_HUMAN | Zinc finger protein 18 | ZNF18 | 96 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024835 | 210 | Q → R1 PublicationCorresponds to variant dbSNP:rs17857095Ensembl. | 1 | |
Natural variantiVAR_024836 | 240 | M → I1 PublicationCorresponds to variant dbSNP:rs17853545Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016947 | 251 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY491053 mRNA Translation: AAS67595.1 AK092656 mRNA Translation: BAC03939.1 BC036096 mRNA Translation: AAH36096.1 X52342 mRNA Translation: CAA36568.1 |
CCDSi | CCDS32568.1 [P17022-1] CCDS76957.1 [P17022-2] |
PIRi | I37950, S10399 |
RefSeqi | NP_001290210.1, NM_001303281.1 [P17022-1] NP_001290211.1, NM_001303282.1 [P17022-2] NP_653281.2, NM_144680.3 [P17022-1] XP_011522304.1, XM_011524002.2 [P17022-1] XP_016880495.1, XM_017025006.1 [P17022-1] XP_016880496.1, XM_017025007.1 [P17022-1] XP_016880497.1, XM_017025008.1 [P17022-2] XP_016880498.1, XM_017025009.1 XP_016880499.1, XM_017025010.1 [P17022-2] XP_016880500.1, XM_017025011.1 [P17022-2] |
Genome annotation databases
Ensembli | ENST00000322748; ENSP00000315664; ENSG00000154957 [P17022-1] ENST00000454073; ENSP00000391376; ENSG00000154957 [P17022-2] ENST00000580306; ENSP00000463471; ENSG00000154957 [P17022-1] ENST00000580613; ENSP00000462296; ENSG00000154957 [P17022-1] |
GeneIDi | 7566 |
KEGGi | hsa:7566 |
UCSCi | uc002gng.1, human [P17022-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY491053 mRNA Translation: AAS67595.1 AK092656 mRNA Translation: BAC03939.1 BC036096 mRNA Translation: AAH36096.1 X52342 mRNA Translation: CAA36568.1 |
CCDSi | CCDS32568.1 [P17022-1] CCDS76957.1 [P17022-2] |
PIRi | I37950, S10399 |
RefSeqi | NP_001290210.1, NM_001303281.1 [P17022-1] NP_001290211.1, NM_001303282.1 [P17022-2] NP_653281.2, NM_144680.3 [P17022-1] XP_011522304.1, XM_011524002.2 [P17022-1] XP_016880495.1, XM_017025006.1 [P17022-1] XP_016880496.1, XM_017025007.1 [P17022-1] XP_016880497.1, XM_017025008.1 [P17022-2] XP_016880498.1, XM_017025009.1 XP_016880499.1, XM_017025010.1 [P17022-2] XP_016880500.1, XM_017025011.1 [P17022-2] |
3D structure databases
SMRi | P17022 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113397, 11 interactors |
IntActi | P17022, 10 interactors |
MINTi | P17022 |
STRINGi | 9606.ENSP00000315664 |
PTM databases
iPTMneti | P17022 |
PhosphoSitePlusi | P17022 |
Polymorphism and mutation databases
BioMutai | ZNF18 |
DMDMi | 85681864 |
Proteomic databases
EPDi | P17022 |
jPOSTi | P17022 |
MassIVEi | P17022 |
PaxDbi | P17022 |
PeptideAtlasi | P17022 |
PRIDEi | P17022 |
ProteomicsDBi | 53420 [P17022-1] 53421 [P17022-2] |
Protocols and materials databases
ABCDi | P17022, 1 sequenced antibody |
Antibodypediai | 1806, 145 antibodies |
DNASUi | 7566 |
Genome annotation databases
Ensembli | ENST00000322748; ENSP00000315664; ENSG00000154957 [P17022-1] ENST00000454073; ENSP00000391376; ENSG00000154957 [P17022-2] ENST00000580306; ENSP00000463471; ENSG00000154957 [P17022-1] ENST00000580613; ENSP00000462296; ENSG00000154957 [P17022-1] |
GeneIDi | 7566 |
KEGGi | hsa:7566 |
UCSCi | uc002gng.1, human [P17022-1] |
Organism-specific databases
CTDi | 7566 |
DisGeNETi | 7566 |
EuPathDBi | HostDB:ENSG00000154957.13 |
GeneCardsi | ZNF18 |
HGNCi | HGNC:12969, ZNF18 |
HPAi | ENSG00000154957, Low tissue specificity |
MIMi | 194524, gene |
neXtProti | NX_P17022 |
OpenTargetsi | ENSG00000154957 |
PharmGKBi | PA37551 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161617 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | P17022 |
OMAi | DEPGCFE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17022 |
TreeFami | TF337489 |
Enzyme and pathway databases
PathwayCommonsi | P17022 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7566, 1 hit in 863 CRISPR screens |
ChiTaRSi | ZNF18, human |
GenomeRNAii | 7566 |
Pharosi | P17022, Tbio |
PROi | PR:P17022 |
RNActi | P17022, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154957, Expressed in body of pancreas and 114 other tissues |
ExpressionAtlasi | P17022, baseline and differential |
Genevisiblei | P17022, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR027764, Zfp18 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF190, PTHR23226:SF190, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF18_HUMAN | |
Accessioni | P17022Primary (citable) accession number: P17022 Secondary accession number(s): Q5QHQ3, Q8IYC4, Q8NAH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 10, 2006 | |
Last modified: | December 2, 2020 | |
This is version 193 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations