Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P17022 (ZNF18_HUMAN)

Entry version 193 (02 Dec 2020)
Sequence version 2 (10 Jan 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger protein 18

Gene

ZNF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri408 – 430C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P17022

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 18
Alternative name(s):
Heart development-specific gene 1 protein
Zinc finger protein 535
Zinc finger protein KOX11
Zinc finger protein with KRAB and SCAN domains 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF18
Synonyms:HDSG1, KOX11, ZKSCAN6, ZNF535
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000154957.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:12969, ZNF18

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		194524, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P17022

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7566

Open Targets

More...OpenTargetsi		ENSG00000154957

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37551

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P17022, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF18

Domain mapping of disease mutations (DMDM)

More...DMDMi		85681864

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473401 – 549Zinc finger protein 18Add BLAST549

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P17022

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P17022

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P17022

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P17022

PeptideAtlas

More...PeptideAtlasi		P17022

PRoteomics IDEntifications database

More...PRIDEi		P17022

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53420 [P17022-1]
53421 [P17022-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P17022

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P17022

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154957, Expressed in body of pancreas and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P17022, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P17022, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154957, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113397, 11 interactors

Protein interaction database and analysis system

More...IntActi		P17022, 10 interactors

Molecular INTeraction database

More...MINTi		P17022

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315664

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P17022, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P17022

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini211 – 283KRABPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri408 – 430C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P17022

Identification of Orthologs from Complete Genome Data

More...OMAi		DEPGCFE

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P17022

TreeFam database of animal gene trees

More...TreeFami		TF337489

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR027764, Zfp18
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR23226:SF190, PTHR23226:SF190, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17022-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ 
        60         70         80         90        100
VMSGPHETLK QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW 
       110        120        130        140        150
VRKQCPGSGE EAVTLVESLK GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ 
       160        170        180        190        200
VGEVEPHLEV VPQELGLENS SSGPGELLSH IVKEESDTEA ELALAASQPA 
       210        220        230        240        250
RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM LETYGKMVSG 
       260        270        280        290        300
AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL 
       310        320        330        340        350
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI 
       360        370        380        390        400
QDEGTGEQLS PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR 
       410        420        430        440        450
APMAQKLPTC RECGKTFYRN SQLIFHQRTH TGETYFQCTI CKKAFLRSSD 
       460        470        480        490        500
FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR HHEKIHTGEK PYKCPICEKS 
       510        520        530        540 
FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR SHLGKKPFQ
Length:549
Mass (Da):62,288
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5468BA67A459174D
GO
Isoform 2 (identifier: P17022-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: Missing.

Show »
Length:548
Mass (Da):62,217
Checksum:i16D51E59E7C7EEA2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTA0J3KTA0_HUMAN
Zinc finger protein 18
ZNF18
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSA1J3KSA1_HUMAN
Zinc finger protein 18
ZNF18
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSC1J3KSC1_HUMAN
Zinc finger protein 18
ZNF18
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024835210Q → R1 PublicationCorresponds to variant dbSNP:rs17857095Ensembl.1
Natural variantiVAR_024836240M → I1 PublicationCorresponds to variant dbSNP:rs17853545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016947251Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY491053 mRNA Translation: AAS67595.1
AK092656 mRNA Translation: BAC03939.1
BC036096 mRNA Translation: AAH36096.1
X52342 mRNA Translation: CAA36568.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32568.1 [P17022-1]
CCDS76957.1 [P17022-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I37950, S10399

NCBI Reference Sequences

More...RefSeqi		NP_001290210.1, NM_001303281.1 [P17022-1]
NP_001290211.1, NM_001303282.1 [P17022-2]
NP_653281.2, NM_144680.3 [P17022-1]
XP_011522304.1, XM_011524002.2 [P17022-1]
XP_016880495.1, XM_017025006.1 [P17022-1]
XP_016880496.1, XM_017025007.1 [P17022-1]
XP_016880497.1, XM_017025008.1 [P17022-2]
XP_016880498.1, XM_017025009.1
XP_016880499.1, XM_017025010.1 [P17022-2]
XP_016880500.1, XM_017025011.1 [P17022-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000322748; ENSP00000315664; ENSG00000154957 [P17022-1]
ENST00000454073; ENSP00000391376; ENSG00000154957 [P17022-2]
ENST00000580306; ENSP00000463471; ENSG00000154957 [P17022-1]
ENST00000580613; ENSP00000462296; ENSG00000154957 [P17022-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7566

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7566

UCSC genome browser

More...UCSCi		uc002gng.1, human [P17022-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491053 mRNA Translation: AAS67595.1
AK092656 mRNA Translation: BAC03939.1
BC036096 mRNA Translation: AAH36096.1
X52342 mRNA Translation: CAA36568.1
CCDSiCCDS32568.1 [P17022-1]
CCDS76957.1 [P17022-2]
PIRiI37950, S10399
RefSeqiNP_001290210.1, NM_001303281.1 [P17022-1]
NP_001290211.1, NM_001303282.1 [P17022-2]
NP_653281.2, NM_144680.3 [P17022-1]
XP_011522304.1, XM_011524002.2 [P17022-1]
XP_016880495.1, XM_017025006.1 [P17022-1]
XP_016880496.1, XM_017025007.1 [P17022-1]
XP_016880497.1, XM_017025008.1 [P17022-2]
XP_016880498.1, XM_017025009.1
XP_016880499.1, XM_017025010.1 [P17022-2]
XP_016880500.1, XM_017025011.1 [P17022-2]

3D structure databases

SMRiP17022
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113397, 11 interactors
IntActiP17022, 10 interactors
MINTiP17022
STRINGi9606.ENSP00000315664

PTM databases

iPTMnetiP17022
PhosphoSitePlusiP17022

Polymorphism and mutation databases

BioMutaiZNF18
DMDMi85681864

Proteomic databases

EPDiP17022
jPOSTiP17022
MassIVEiP17022
PaxDbiP17022
PeptideAtlasiP17022
PRIDEiP17022
ProteomicsDBi53420 [P17022-1]
53421 [P17022-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P17022, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1806, 145 antibodies

The DNASU plasmid repository

More...DNASUi		7566

Genome annotation databases

EnsembliENST00000322748; ENSP00000315664; ENSG00000154957 [P17022-1]
ENST00000454073; ENSP00000391376; ENSG00000154957 [P17022-2]
ENST00000580306; ENSP00000463471; ENSG00000154957 [P17022-1]
ENST00000580613; ENSP00000462296; ENSG00000154957 [P17022-1]
GeneIDi7566
KEGGihsa:7566
UCSCiuc002gng.1, human [P17022-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7566
DisGeNETi7566
EuPathDBiHostDB:ENSG00000154957.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF18
HGNCiHGNC:12969, ZNF18
HPAiENSG00000154957, Low tissue specificity
MIMi194524, gene
neXtProtiNX_P17022
OpenTargetsiENSG00000154957
PharmGKBiPA37551

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161617
HOGENOMiCLU_002678_49_8_1
InParanoidiP17022
OMAiDEPGCFE
OrthoDBi1318335at2759
PhylomeDBiP17022
TreeFamiTF337489

Enzyme and pathway databases

PathwayCommonsiP17022
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7566, 1 hit in 863 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF18, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7566
PharosiP17022, Tbio

Protein Ontology

More...PROi		PR:P17022
RNActiP17022, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154957, Expressed in body of pancreas and 114 other tissues
ExpressionAtlasiP17022, baseline and differential
GenevisibleiP17022, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR027764, Zfp18
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR23226:SF190, PTHR23226:SF190, 1 hit
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17022
Secondary accession number(s): Q5QHQ3, Q8IYC4, Q8NAH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: December 2, 2020
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again