UniProtKB - P17019 (ZN708_HUMAN)
Protein
Zinc finger protein 708
Gene
ZNF708
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 76 – 98 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 104 – 126 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 132 – 154 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 160 – 182 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 244 – 266 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 272 – 294 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 300 – 322 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 328 – 350 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 490 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P17019 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 708Alternative name(s): Zinc finger protein 15 Zinc finger protein 15-like 1 Zinc finger protein KOX8 |
Gene namesi | Name:ZNF708 Synonyms:KOX8, ZNF15, ZNF15L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182141.9 |
HGNCi | HGNC:12945, ZNF708 |
neXtProti | NX_P17019 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Miscellaneous databases
Pharosi | P17019, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF708 |
DMDMi | 527504092 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047706 | 1 – 499 | Zinc finger protein 708Add BLAST | 499 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 480 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P17019 |
jPOSTi | P17019 |
MassIVEi | P17019 |
MaxQBi | P17019 |
PaxDbi | P17019 |
PeptideAtlasi | P17019 |
PRIDEi | P17019 |
ProteomicsDBi | 53415 |
PTM databases
iPTMneti | P17019 |
PhosphoSitePlusi | P17019 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182141, Expressed in corpus callosum and 171 other tissues |
ExpressionAtlasi | P17019, baseline and differential |
Genevisiblei | P17019, HS |
Organism-specific databases
HPAi | ENSG00000182141, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113394, 4 interactors |
IntActi | P17019, 2 interactors |
STRINGi | 9606.ENSP00000349401 |
Miscellaneous databases
RNActi | P17019, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 76 – 98 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 104 – 126 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 132 – 154 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 160 – 182 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 188 – 210 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 216 – 238 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 244 – 266 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 272 – 294 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 300 – 322 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 328 – 350 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 490 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | P17019 |
OrthoDBi | 1318335at2759 |
TreeFami | TF342117 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P17019-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRHEMAAKP PAMCSHFAKD LRPEQYIKNS FQQVILRRYG KCGYQKGCKS
60 70 80 90 100
VDEHKLHKGG HKGLNRCVTT TQSKIVQCDK YVKVFHKYSN AKRHKIRHTG
110 120 130 140 150
KNPFKCKECG KSFCMLSQLT QHEIIHTGEK PYKCEECGKA FKKSSNLTNH
160 170 180 190 200
KIIHTGEKPY KCEECGKAFN QSSTLTRHKI IHTGEKLYKC EECGKAFNRS
210 220 230 240 250
SNLTKHKIVH TGEKPYKCEE CGKAFKQSSN LTNHKKIHTG EKPYKCGECG
260 270 280 290 300
KAFTLSSHLT THKRIHTGEK PYKCEECGKA FSVFSTLTKH KIIHTEEKPY
310 320 330 340 350
KCEECGKAFN RSSHLTNHKV IHTGEKPYKC EECGKAFTKS STLTYHKVIH
360 370 380 390 400
TGKKPYKCEE CGKAFSIFSI LTKHKVIHTE DKPYKCEECG KTFNYSSNFT
410 420 430 440 450
NHKKIHTGEK PYKCEECGKS FILSSHLTTH KIIHTGEKPY KCKECGKAFN
460 470 480 490
QSSTLMKHKI IHTGEKPYKC EECGKAFNQS PNLTKHKRIH TKEKPYKCK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R2V2 | M0R2V2_HUMAN | Zinc finger protein 708 | ZNF708 | 38 | Annotation score: | ||
M0QYN4 | M0QYN4_HUMAN | Zinc finger protein 708 | ZNF708 | 126 | Annotation score: | ||
M0R1G3 | M0R1G3_HUMAN | Zinc finger protein 708 | ZNF708 | 65 | Annotation score: |
Sequence cautioni
The sequence BAD18665 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054795 | 7 | A → V1 PublicationCorresponds to variant dbSNP:rs547516Ensembl. | 1 | |
Natural variantiVAR_054796 | 49 | K → E1 PublicationCorresponds to variant dbSNP:rs1781873Ensembl. | 1 | |
Natural variantiVAR_054797 | 58 | K → T. Corresponds to variant dbSNP:rs1781872Ensembl. | 1 | |
Natural variantiVAR_054798 | 66 | R → Q1 PublicationCorresponds to variant dbSNP:rs504280Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131527 mRNA Translation: BAD18665.1 Different initiation. AK095062 mRNA No translation available. AC022432 Genomic DNA No translation available. X52339 mRNA Translation: CAA36565.1 |
PIRi | I37976 |
RefSeqi | NP_001284489.1, NM_001297560.1 NP_001284490.1, NM_001297561.1 |
Genome annotation databases
Ensembli | ENST00000356929; ENSP00000349401; ENSG00000182141 |
GeneIDi | 7562 |
KEGGi | hsa:7562 |
UCSCi | uc002npq.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131527 mRNA Translation: BAD18665.1 Different initiation. AK095062 mRNA No translation available. AC022432 Genomic DNA No translation available. X52339 mRNA Translation: CAA36565.1 |
PIRi | I37976 |
RefSeqi | NP_001284489.1, NM_001297560.1 NP_001284490.1, NM_001297561.1 |
3D structure databases
SMRi | P17019 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113394, 4 interactors |
IntActi | P17019, 2 interactors |
STRINGi | 9606.ENSP00000349401 |
PTM databases
iPTMneti | P17019 |
PhosphoSitePlusi | P17019 |
Polymorphism and mutation databases
BioMutai | ZNF708 |
DMDMi | 527504092 |
Proteomic databases
EPDi | P17019 |
jPOSTi | P17019 |
MassIVEi | P17019 |
MaxQBi | P17019 |
PaxDbi | P17019 |
PeptideAtlasi | P17019 |
PRIDEi | P17019 |
ProteomicsDBi | 53415 |
Protocols and materials databases
Antibodypediai | 28681, 93 antibodies |
DNASUi | 7562 |
Genome annotation databases
Ensembli | ENST00000356929; ENSP00000349401; ENSG00000182141 |
GeneIDi | 7562 |
KEGGi | hsa:7562 |
UCSCi | uc002npq.2, human |
Organism-specific databases
CTDi | 7562 |
EuPathDBi | HostDB:ENSG00000182141.9 |
GeneCardsi | ZNF708 |
HGNCi | HGNC:12945, ZNF708 |
HPAi | ENSG00000182141, Tissue enhanced (brain) |
neXtProti | NX_P17019 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | P17019 |
OrthoDBi | 1318335at2759 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | P17019 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7562, 4 hits in 845 CRISPR screens |
ChiTaRSi | ZNF708, human |
GenomeRNAii | 7562 |
Pharosi | P17019, Tdark |
PROi | PR:P17019 |
RNActi | P17019, protein |
Gene expression databases
Bgeei | ENSG00000182141, Expressed in corpus callosum and 171 other tissues |
ExpressionAtlasi | P17019, baseline and differential |
Genevisiblei | P17019, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN708_HUMAN | |
Accessioni | P17019Primary (citable) accession number: P17019 Secondary accession number(s): Q6ZMR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | July 24, 2013 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations