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Entry version 186 (13 Feb 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Zinc finger protein 12

Gene

ZNF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri269 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 12
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 3
Short name:
GIOT-3
Zinc finger protein 325
Zinc finger protein KOX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF12
Synonyms:GIOT3, KOX3, ZNF325
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164631.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12902 ZNF12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
194536 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17014

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000164631

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134931984
PA37491

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373491

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473351 – 697Zinc finger protein 12Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki365Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki547Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P17014

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17014

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17014

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17014

PeptideAtlas

More...
PeptideAtlasi
P17014

PRoteomics IDEntifications database

More...
PRIDEi
P17014

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53409
53410 [P17014-2]
53411 [P17014-3]
53412 [P17014-4]
53413 [P17014-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17014

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17014

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in various adult tissues and embryonic developmental stages (isoform 3).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Shows a relatively higher expression level in the fetal brain and a lower level in adult. The expression level in liver is highest at 16 weeks of development and declines from 16 to 24 weeks and is lower in adult. Expressed strongly in fetal heart on 18 and 24 weeks, but relatively weakly on the other development stage of embryo, and then reaches a higher level in adult (isoform 3).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164631 Expressed in 232 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P17014 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P17014 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063402

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113391, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P17014, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385939

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P17014

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17014

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri269 – 291C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154303

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17014

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYKWNES

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17014

TreeFam database of animal gene trees

More...
TreeFami
TF350803

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P17014-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKSLGPVSF KDVAVDFTQE EWQQLDPEQK ITYRDVMLEN YSNLVSVGYH
60 70 80 90 100
IIKPDVISKL EQGEEPWIVE GEFLLQSYPD EVWQTDDLIE RIQEEENKPS
110 120 130 140 150
RQTVFIETLI EERGNVPGKT FDVETNPVPS RKIAYKNSLC DSCEKCLTSV
160 170 180 190 200
SEYISSDGSY ARMKADECSG CGKSLLHIKL EKTHPGDQAY EFNQNGEPYT
210 220 230 240 250
LNEESLYQKI RILEKPFEYI ECQKAFQKDT VFVNHMEEKP YKWNGSEIAF
260 270 280 290 300
LQMSDLTVHQ TSHMEMKPYE CSECGKSFCK KSKFIIHQRT HTGEKPYECN
310 320 330 340 350
QCGKSFCQKG TLTVHQRTHT GEKPYECNEC GKNFYQKLHL IQHQRTHSGE
360 370 380 390 400
KPYECSYCGK SFCQKTHLTQ HQRTHSGERP YVCHDCGKTF SQKSALNDHQ
410 420 430 440 450
KIHTGVKLYK CSECGKCFCR KSTLTTHLRT HTGEKPYECN ECGKFFSRLS
460 470 480 490 500
YLTVHYRTHS GEKPYECNEC GKTFYLNSAL MRHQRVHTGE KPYECNECGK
510 520 530 540 550
LFSQLSYLTI HHRTHSGVKP YECSECGKTF YQNSALCRHR RIHKGEKPYE
560 570 580 590 600
CYICGKFFSQ MSYLTIHHRI HSGEKPYECS ECGKTFCQNS ALNRHQRTHT
610 620 630 640 650
GEKAYECYEC GKCFSQMSYL TIHHRIHSGE KPFECNECGK AFSRMSYLTV
660 670 680 690
HYRTHSGEKP YECTECGKKF YHKSAFNSHQ RIHRRGNMNV IDVGRLL
Length:697
Mass (Da):81,202
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D12F61C265D6BE3
GO
Isoform 2 (identifier: P17014-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-653: Missing.

Show »
Length:501
Mass (Da):58,223
Checksum:iADF25EBC8378EA8C
GO
Isoform 3 (identifier: P17014-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-235: Missing.

Show »
Length:462
Mass (Da):54,051
Checksum:iED006CB45373F75A
GO
Isoform 4 (identifier: P17014-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     114-151: Missing.

Show »
Length:623
Mass (Da):72,906
Checksum:iBDC0B647761EB17F
GO
Isoform 5 (identifier: P17014-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-151: Missing.

Show »
Length:659
Mass (Da):77,131
Checksum:i4EF63A8987DA48D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV98H9KV98_HUMAN
Zinc finger protein 12
ZNF12
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14183 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG57306 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86D → E in AAI54415 (PubMed:15489334).Curated1
Sequence conflicti508L → P in CAE45857 (PubMed:17974005).Curated1
Sequence conflicti525E → G in BAB14183 (PubMed:14702039).Curated1
Sequence conflicti551C → Y in CAE45857 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0403341 – 235Missing in isoform 3. 1 PublicationAdd BLAST235
Alternative sequenceiVSP_0407381 – 36Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_040739114 – 151Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_040335458 – 653Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF505656 mRNA Translation: AAM28195.1
AB021643 mRNA Translation: BAA86989.1
AK022691 mRNA Translation: BAB14183.1 Different initiation.
AK293925 mRNA Translation: BAG57306.1 Different initiation.
BX640749 mRNA Translation: CAE45857.1
AC073343 Genomic DNA No translation available.
CH878731 Genomic DNA Translation: EAW55016.1
BC051892 mRNA No translation available.
BC137068 mRNA Translation: AAI37069.1
BC137069 mRNA Translation: AAI37070.1
BC154414 mRNA Translation: AAI54415.1
X52334 mRNA Translation: CAA36560.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47538.1 [P17014-1]
CCDS47539.1 [P17014-5]

Protein sequence database of the Protein Information Resource

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PIRi
I37970

NCBI Reference Sequences

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RefSeqi
NP_008887.2, NM_006956.2 [P17014-5]
NP_057349.2, NM_016265.3 [P17014-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.431471

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000342651; ENSP00000344745; ENSG00000164631 [P17014-5]
ENST00000404360; ENSP00000384405; ENSG00000164631 [P17014-4]
ENST00000405858; ENSP00000385939; ENSG00000164631 [P17014-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7559

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7559

UCSC genome browser

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UCSCi
uc003sqs.3 human [P17014-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505656 mRNA Translation: AAM28195.1
AB021643 mRNA Translation: BAA86989.1
AK022691 mRNA Translation: BAB14183.1 Different initiation.
AK293925 mRNA Translation: BAG57306.1 Different initiation.
BX640749 mRNA Translation: CAE45857.1
AC073343 Genomic DNA No translation available.
CH878731 Genomic DNA Translation: EAW55016.1
BC051892 mRNA No translation available.
BC137068 mRNA Translation: AAI37069.1
BC137069 mRNA Translation: AAI37070.1
BC154414 mRNA Translation: AAI54415.1
X52334 mRNA Translation: CAA36560.1
CCDSiCCDS47538.1 [P17014-1]
CCDS47539.1 [P17014-5]
PIRiI37970
RefSeqiNP_008887.2, NM_006956.2 [P17014-5]
NP_057349.2, NM_016265.3 [P17014-1]
UniGeneiHs.431471

3D structure databases

ProteinModelPortaliP17014
SMRiP17014
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113391, 3 interactors
IntActiP17014, 8 interactors
STRINGi9606.ENSP00000385939

PTM databases

iPTMnetiP17014
PhosphoSitePlusiP17014

Polymorphism and mutation databases

BioMutaiZNF12
DMDMi317373491

Proteomic databases

EPDiP17014
jPOSTiP17014
MaxQBiP17014
PaxDbiP17014
PeptideAtlasiP17014
PRIDEiP17014
ProteomicsDBi53409
53410 [P17014-2]
53411 [P17014-3]
53412 [P17014-4]
53413 [P17014-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342651; ENSP00000344745; ENSG00000164631 [P17014-5]
ENST00000404360; ENSP00000384405; ENSG00000164631 [P17014-4]
ENST00000405858; ENSP00000385939; ENSG00000164631 [P17014-1]
GeneIDi7559
KEGGihsa:7559
UCSCiuc003sqs.3 human [P17014-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7559
EuPathDBiHostDB:ENSG00000164631.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF12
HGNCiHGNC:12902 ZNF12
HPAiHPA063402
MIMi194536 gene
neXtProtiNX_P17014
OpenTargetsiENSG00000164631
PharmGKBiPA134931984
PA37491

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000154303
HOVERGENiHBG018163
InParanoidiP17014
KOiK09228
OMAiPYKWNES
OrthoDBi1318335at2759
PhylomeDBiP17014
TreeFamiTF350803

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7559

Protein Ontology

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PROi
PR:P17014

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164631 Expressed in 232 organ(s), highest expression level in prostate gland
ExpressionAtlasiP17014 baseline and differential
GenevisibleiP17014 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17014
Secondary accession number(s): A8MYC4
, A8WFQ8, B2RNQ7, B4DF45, Q6N016, Q8NHZ0, Q9H9P0, Q9ULZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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