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Protein

Zinc finger X-chromosomal protein

Gene

Zfx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional activator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri419 – 444C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri450 – 472C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 536C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri542 – 564C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 593C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri599 – 621C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 650C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri656 – 678C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri684 – 707C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri713 – 735C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 764C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri770 – 792C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • fertilization Source: MGI
  • germ cell development Source: MGI
  • homeostasis of number of cells Source: MGI
  • multicellular organism growth Source: MGI
  • oocyte development Source: MGI
  • ovarian follicle development Source: MGI
  • parental behavior Source: MGI
  • post-embryonic development Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • spermatogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger X-chromosomal protein
Gene namesi
Name:Zfx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:99211 Zfx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472591 – 799Zinc finger X-chromosomal proteinAdd BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP17012
MaxQBiP17012
PaxDbiP17012
PRIDEiP17012

PTM databases

iPTMnetiP17012
PhosphoSitePlusiP17012

Expressioni

Gene expression databases

BgeeiENSMUSG00000079509
CleanExiMM_ZFX
ExpressionAtlasiP17012 baseline and differential
GenevisibleiP17012 MM

Interactioni

Protein-protein interaction databases

IntActiP17012, 1 interactor
STRINGi10090.ENSMUSP00000085423

Structurei

3D structure databases

ProteinModelPortaliP17012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri419 – 444C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri450 – 472C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 536C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri542 – 564C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 593C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri599 – 621C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 650C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri656 – 678C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri684 – 707C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri713 – 735C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 764C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri770 – 792C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP17012
OMAiHVVHDNV
OrthoDBiEOG091G02CA
PhylomeDBiP17012
TreeFamiTF335557

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

P17012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDGLELQQ QAPNSFFDAT GAGATHMDGN QIVVEVQETV YVSDVVDSDI
60 70 80 90 100
TVHNYVPDDP DSVVIQDVIE DVVIEDVQCT DIMDEADVSE TVIIPEQVLD
110 120 130 140 150
SDVTEEVSLT HCTVPDDVLA SDITSASISM PEHVLTSESI HVSDVGHVEH
160 170 180 190 200
VVHDSVVEAE IVTDPLAADV VSEEVLVADC ASEAVIDANG IPVNQQDEEK
210 220 230 240 250
NNCEDYLMIS LDDAGKIEHD GSSGLTMDNE TEIDPCKVDG TCPEVIKVYI
260 270 280 290 300
FKADPGEDDL GGTVDIVESE PENEHGVELL DPNNSIRVPR EKMVYMAVND
310 320 330 340 350
SQQEEEELNV AEIADEVYME VIVGEEDAAA AAAAAVHEQQ VEDNEMKTFM
360 370 380 390 400
PIAWAAAYGN NSDGIENRNG TASALLHIDE SAGLGRLAKQ KPKKRRRPDS
410 420 430 440 450
RQYQTAIIIG PDGHPLTVYP CMICGKKFKS RGFLKRHMKN HPEHLAKKKY
460 470 480 490 500
RCTDCDYTTN KKISLHNHLE SHKLTSKAEK AIECDECGKH FSHAGALFTH
510 520 530 540 550
KMVHKEKGAN KMHKCKFCEY ETAEQGLLNR HLLAVHSKNF PHICVECGKG
560 570 580 590 600
FRHPSELKKH MRIHTGEKPY ECQYCEYRSA DSSNLKTHVK TKHSKEMPFK
610 620 630 640 650
CDICLLTFSD TKEVQQHALV HQESKTHQCL HCDHKSSNSS DLKRHIISVH
660 670 680 690 700
TKDYPHKCDM CDKGFHRPSE LKKHVAAHKG KKMHQCRHCD FKIADPFVLS
710 720 730 740 750
RHILSVHTKD LPFRCKRCRK GFRQQSELKK HMKTHSGRKV YQCEYCEYST
760 770 780 790
TDASGFKRHV ISIHTKDYPH RCEYCKKGFR RPSEKNQHIM RHHKEVGLP
Length:799
Mass (Da):90,026
Last modified:July 25, 2006 - v2
Checksum:i3FB6B4D2159EADFD
GO

Sequence cautioni

The sequence AAA40585 differs from that shown. The sequence differs from that shown due to a duplication of 120 bp after position 480.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32308 mRNA Translation: AAA40584.1
M32309 mRNA Translation: AAA40585.1 Sequence problems.
L19714 mRNA Translation: AAA75393.1
CCDSiCCDS30276.1
PIRiA34729
RefSeqiNP_001037851.1, NM_001044386.1
NP_035898.2, NM_011768.2
XP_006528029.1, XM_006527966.3
XP_011245879.1, XM_011247577.2
XP_011245880.1, XM_011247578.2
UniGeneiMm.919

Genome annotation databases

EnsembliENSMUST00000088102; ENSMUSP00000085423; ENSMUSG00000079509
ENSMUST00000113926; ENSMUSP00000109559; ENSMUSG00000079509
ENSMUST00000113927; ENSMUSP00000109560; ENSMUSG00000079509
GeneIDi22764
KEGGimmu:22764
UCSCiuc009tsz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZFX_MOUSE
AccessioniPrimary (citable) accession number: P17012
Secondary accession number(s): P17011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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