UniProtKB - P16949 (STMN1_HUMAN)
Protein
Stathmin
Gene
STMN1
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).By similarity
GO - Molecular functioni
- tubulin binding Source: MGI
GO - Biological processi
- axonogenesis Source: Ensembl
- brain development Source: Ensembl
- establishment of skin barrier Source: CAFA
- hepatocyte growth factor receptor signaling pathway Source: CAFA
- intracellular signal transduction Source: ProtInc
- microtubule depolymerization Source: MGI
- mitotic cytokinesis Source: GO_Central
- mitotic spindle organization Source: MGI
- negative regulation of guanyl-nucleotide exchange factor activity Source: CAFA
- negative regulation of microtubule polymerization Source: CAFA
- negative regulation of Rho protein signal transduction Source: CAFA
- negative regulation of stress fiber assembly Source: CAFA
- negative regulation of thrombin-activated receptor signaling pathway Source: CAFA
- neuron projection development Source: GO_Central
- positive regulation of cellular component movement Source: Ensembl
- regulation of microtubule polymerization or depolymerization Source: CAFA
- response to virus Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | P16949 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 |
SignaLinki | P16949 |
SIGNORi | P16949 |
Names & Taxonomyi
Protein namesi | Recommended name: StathminAlternative name(s): Leukemia-associated phosphoprotein p18 Metablastin Oncoprotein 18 Short name: Op18 Phosphoprotein p19 Short name: pp19 Prosolin Protein Pr22 pp17 |
Gene namesi | Name:STMN1 Synonyms:C1orf215, LAP18, OP18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6510, STMN1 |
MIMi | 151442, gene |
neXtProti | NX_P16949 |
VEuPathDBi | HostDB:ENSG00000117632.20 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- microtubule Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- membrane Source: Ensembl
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 3925 |
OpenTargetsi | ENSG00000117632 |
PharmGKBi | PA35491 |
Miscellaneous databases
Pharosi | P16949, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3879843 |
Genetic variation databases
BioMutai | STMN1 |
DMDMi | 134973 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000182389 | 2 – 149 | StathminAdd BLAST | 148 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 4 | PhosphoserineCombined sources | 1 | |
Modified residuei | 9 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources2 Publications | 1 | |
Modified residuei | 25 | Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources4 Publications | 1 | |
Modified residuei | 29 | N6-methyllysineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 38 | Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources4 Publications | 1 | |
Modified residuei | 63 | Phosphoserine; by PKACombined sources | 1 | |
Modified residuei | 100 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 119 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.By similarity4 Publications
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1009 CPTAC-1010 CPTAC-1368 |
EPDi | P16949 |
jPOSTi | P16949 |
MassIVEi | P16949 |
MaxQBi | P16949 |
PaxDbi | P16949 |
PeptideAtlasi | P16949 |
PRIDEi | P16949 |
ProteomicsDBi | 53402 [P16949-1] 53403 [P16949-2] |
TopDownProteomicsi | P16949-1 [P16949-1] P16949-2 [P16949-2] |
2D gel databases
DOSAC-COBS-2DPAGEi | P16949 |
REPRODUCTION-2DPAGEi | IPI00479997 |
SWISS-2DPAGEi | P16949 |
UCD-2DPAGEi | P16949 |
PTM databases
iPTMneti | P16949 |
PhosphoSitePlusi | P16949 |
SwissPalmi | P16949 |
Expressioni
Tissue specificityi
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.2 Publications
Inductioni
Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000117632, Expressed in cortical plate and 229 other tissues |
ExpressionAtlasi | P16949, baseline and differential |
Genevisiblei | P16949, HS |
Organism-specific databases
HPAi | ENSG00000117632, Tissue enhanced (brain, lymphoid tissue) |
Interactioni
Subunit structurei
Binds to two alpha/beta-tubulin heterodimers.
Interacts with KIST.
2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- tubulin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 110119, 84 interactors |
IntActi | P16949, 28 interactors |
MINTi | P16949 |
STRINGi | 9606.ENSP00000410452 |
Miscellaneous databases
RNActi | P16949, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 145 | SLDPROSITE-ProRule annotationAdd BLAST | 142 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 41 – 140 | Sequence analysisAdd BLAST | 100 |
Sequence similaritiesi
Belongs to the stathmin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1280, Eukaryota |
GeneTreei | ENSGT01020000230457 |
HOGENOMi | CLU_1562320_0_0_1 |
InParanoidi | P16949 |
OMAi | RESHIND |
OrthoDBi | 1381987at2759 |
PhylomeDBi | P16949 |
TreeFami | TF326935 |
Family and domain databases
DisProti | DP00174 |
InterProi | View protein in InterPro IPR030514, Stathmin_CS IPR000956, Stathmin_fam IPR036002, Stathmin_sf |
PANTHERi | PTHR10104, PTHR10104, 1 hit |
Pfami | View protein in Pfam PF00836, Stathmin, 1 hit |
PIRSFi | PIRSF002285, Stathmin, 1 hit |
PRINTSi | PR00345, STATHMIN |
SUPFAMi | SSF101494, SSF101494, 1 hit |
PROSITEi | View protein in PROSITE PS00563, STATHMIN_1, 1 hit PS01041, STATHMIN_2, 1 hit PS51663, STATHMIN_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P16949-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2A2D0 | A2A2D0_HUMAN | Stathmin | STMN1 | 85 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041377 | 127 – 149 | DKHIE…ETEAD → MYFWTHGPGAHPAQISAEQS CLHSVPALCPALGLQSALIT WSDLSHHH in isoform 2. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04991 mRNA Translation: AAA59980.1 M31303 Genomic DNA Translation: AAA59971.1 X53305 mRNA Translation: CAA37391.1 Z11566 mRNA Translation: CAA77660.1 X94912 Genomic DNA Translation: CAA64398.1 AK303692 mRNA Translation: BAH14020.1 AK311801 mRNA Translation: BAG34744.1 AL033528 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07854.1 CH471059 Genomic DNA Translation: EAX07855.1 CH471059 Genomic DNA Translation: EAX07856.1 CH471059 Genomic DNA Translation: EAX07857.1 CH471059 Genomic DNA Translation: EAX07858.1 CH471059 Genomic DNA Translation: EAX07859.1 CH471059 Genomic DNA Translation: EAX07860.1 BC082228 mRNA Translation: AAH82228.1 |
CCDSi | CCDS269.1 [P16949-1] CCDS44090.1 [P16949-2] |
PIRi | A40936 |
RefSeqi | NP_001138926.1, NM_001145454.2 [P16949-2] NP_005554.1, NM_005563.3 [P16949-1] NP_981944.1, NM_203399.1 [P16949-1] NP_981946.1, NM_203401.1 [P16949-1] |
Genome annotation databases
Ensembli | ENST00000357865; ENSP00000350531; ENSG00000117632 [P16949-1] ENST00000374291; ENSP00000363409; ENSG00000117632 [P16949-1] ENST00000399728; ENSP00000382633; ENSG00000117632 [P16949-1] ENST00000426559; ENSP00000410452; ENSG00000117632 [P16949-2] ENST00000455785; ENSP00000387858; ENSG00000117632 [P16949-1] |
GeneIDi | 3925 |
KEGGi | hsa:3925 |
UCSCi | uc001bkz.4, human [P16949-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04991 mRNA Translation: AAA59980.1 M31303 Genomic DNA Translation: AAA59971.1 X53305 mRNA Translation: CAA37391.1 Z11566 mRNA Translation: CAA77660.1 X94912 Genomic DNA Translation: CAA64398.1 AK303692 mRNA Translation: BAH14020.1 AK311801 mRNA Translation: BAG34744.1 AL033528 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07854.1 CH471059 Genomic DNA Translation: EAX07855.1 CH471059 Genomic DNA Translation: EAX07856.1 CH471059 Genomic DNA Translation: EAX07857.1 CH471059 Genomic DNA Translation: EAX07858.1 CH471059 Genomic DNA Translation: EAX07859.1 CH471059 Genomic DNA Translation: EAX07860.1 BC082228 mRNA Translation: AAH82228.1 |
CCDSi | CCDS269.1 [P16949-1] CCDS44090.1 [P16949-2] |
PIRi | A40936 |
RefSeqi | NP_001138926.1, NM_001145454.2 [P16949-2] NP_005554.1, NM_005563.3 [P16949-1] NP_981944.1, NM_203399.1 [P16949-1] NP_981946.1, NM_203401.1 [P16949-1] |
3D structure databases
SMRi | P16949 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110119, 84 interactors |
IntActi | P16949, 28 interactors |
MINTi | P16949 |
STRINGi | 9606.ENSP00000410452 |
Chemistry databases
ChEMBLi | CHEMBL3879843 |
PTM databases
iPTMneti | P16949 |
PhosphoSitePlusi | P16949 |
SwissPalmi | P16949 |
Genetic variation databases
BioMutai | STMN1 |
DMDMi | 134973 |
2D gel databases
DOSAC-COBS-2DPAGEi | P16949 |
REPRODUCTION-2DPAGEi | IPI00479997 |
SWISS-2DPAGEi | P16949 |
UCD-2DPAGEi | P16949 |
Proteomic databases
CPTACi | CPTAC-1009 CPTAC-1010 CPTAC-1368 |
EPDi | P16949 |
jPOSTi | P16949 |
MassIVEi | P16949 |
MaxQBi | P16949 |
PaxDbi | P16949 |
PeptideAtlasi | P16949 |
PRIDEi | P16949 |
ProteomicsDBi | 53402 [P16949-1] 53403 [P16949-2] |
TopDownProteomicsi | P16949-1 [P16949-1] P16949-2 [P16949-2] |
Protocols and materials databases
Antibodypediai | 4112, 1436 antibodies |
DNASUi | 3925 |
Genome annotation databases
Ensembli | ENST00000357865; ENSP00000350531; ENSG00000117632 [P16949-1] ENST00000374291; ENSP00000363409; ENSG00000117632 [P16949-1] ENST00000399728; ENSP00000382633; ENSG00000117632 [P16949-1] ENST00000426559; ENSP00000410452; ENSG00000117632 [P16949-2] ENST00000455785; ENSP00000387858; ENSG00000117632 [P16949-1] |
GeneIDi | 3925 |
KEGGi | hsa:3925 |
UCSCi | uc001bkz.4, human [P16949-1] |
Organism-specific databases
CTDi | 3925 |
DisGeNETi | 3925 |
GeneCardsi | STMN1 |
HGNCi | HGNC:6510, STMN1 |
HPAi | ENSG00000117632, Tissue enhanced (brain, lymphoid tissue) |
MIMi | 151442, gene |
neXtProti | NX_P16949 |
OpenTargetsi | ENSG00000117632 |
PharmGKBi | PA35491 |
VEuPathDBi | HostDB:ENSG00000117632.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1280, Eukaryota |
GeneTreei | ENSGT01020000230457 |
HOGENOMi | CLU_1562320_0_0_1 |
InParanoidi | P16949 |
OMAi | RESHIND |
OrthoDBi | 1381987at2759 |
PhylomeDBi | P16949 |
TreeFami | TF326935 |
Enzyme and pathway databases
PathwayCommonsi | P16949 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 |
SignaLinki | P16949 |
SIGNORi | P16949 |
Miscellaneous databases
BioGRID-ORCSi | 3925, 15 hits in 1000 CRISPR screens |
ChiTaRSi | STMN1, human |
GeneWikii | Stathmin |
GenomeRNAii | 3925 |
Pharosi | P16949, Tbio |
PROi | PR:P16949 |
RNActi | P16949, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117632, Expressed in cortical plate and 229 other tissues |
ExpressionAtlasi | P16949, baseline and differential |
Genevisiblei | P16949, HS |
Family and domain databases
DisProti | DP00174 |
InterProi | View protein in InterPro IPR030514, Stathmin_CS IPR000956, Stathmin_fam IPR036002, Stathmin_sf |
PANTHERi | PTHR10104, PTHR10104, 1 hit |
Pfami | View protein in Pfam PF00836, Stathmin, 1 hit |
PIRSFi | PIRSF002285, Stathmin, 1 hit |
PRINTSi | PR00345, STATHMIN |
SUPFAMi | SSF101494, SSF101494, 1 hit |
PROSITEi | View protein in PROSITE PS00563, STATHMIN_1, 1 hit PS01041, STATHMIN_2, 1 hit PS51663, STATHMIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STMN1_HUMAN | |
Accessioni | P16949Primary (citable) accession number: P16949 Secondary accession number(s): A2A2D1 D3DPJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 216 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families