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Entry version 124 (10 Feb 2021)
Sequence version 2 (07 Jun 2005)
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Protein

Acetyl-coenzyme A synthetase

Gene

acu-5

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei327Coenzyme ABy similarity1
Binding sitei517ATPBy similarity1
Binding sitei532ATPBy similarity1
Binding sitei540Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei543ATPBy similarity1
Binding sitei601Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi402 – 404ATPBy similarity3
Nucleotide bindingi426 – 431ATPBy similarity6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acu-5
ORF Names:B23D6.070, NCU06836
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Linkage Group II, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU06836

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002084161 – 667Acetyl-coenzyme A synthetaseAdd BLAST667

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P16929

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By acetate.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16929

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 212Coenzyme A bindingBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_3_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16929

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHWWHDL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011904, Ac_CoA_lig
IPR032387, ACAS_N
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16177, ACAS_N, 1 hit
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02188, Ac_CoA_lig_AcsA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P16929-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSTVPAGA VVPEAHTIET FQPPREMLQN HPSKPHLANF EEYQKLYKQS
60 70 80 90 100
ITEPNVFWAE RARELLSWSK DFQTVHSGSL ANGDNAWFVE GELNASYNCV
110 120 130 140 150
DRHAHKDPNR VAIIYEADEP GQGRNVTYGE LLREVSKLAH VLTNLGVRKG
160 170 180 190 200
DTVAIYLPMI PEAIVAMLAC TRIGAIHSVV FAGFSSDSLR DRVVDAQSKV
210 220 230 240 250
VITTDEGKRG GKLIGTKKIV DEALQQCPDV RNVLVYKRTG ADISMTPGRD
260 270 280 290 300
LWWHEEVEKY PAYYTPVAMA SEDPLFLLYT SGSTGKPKGV AHSTGGYLLG
310 320 330 340 350
AAMTGKYVFD IHDGDRYFCG GDVGWITGHT YVLYAPLLLG VSTVVFEGTP
360 370 380 390 400
AYPNFSRYWD IIEEHKVTQF YVAPTALRLL KRAGDHHVRN EMKHLRVLGS
410 420 430 440 450
VGEPIAAEVW KWYYDVVGKG RAQICDTYWQ TETGSNVITP LAGVTPTKPG
460 470 480 490 500
SASFPFFGIE PALVDPVTGE EIHGNDVEGV LAFKQPWPSM ARTVWGAHKR
510 520 530 540 550
YMETYLHVYK GYYFTGDGAA RDHEGFYWIR GRVDDVVNVS GHRLSTAEIE
560 570 580 590 600
AALIEHHSIA EAAVVGVADE LTGQAVNAFV AVKEGTQIND ALRKEFVLQV
610 620 630 640 650
RRSIGPFAAP KAIYIVPDLP KTRSGKIMRR ILRKIVAGEE DQLGDITTLS
660
DPSVVAKIID VVHAQRQ
Length:667
Mass (Da):73,766
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88E360BB2F135495
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA34857 differs from that shown. Reason: Frameshift.Curated
The sequence CAA34857 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102 – 104RHA → KR in CAA34857 (PubMed:1972535).Curated3
Sequence conflicti121 – 123GQG → VR in CAA34857 (PubMed:1972535).Curated3
Sequence conflicti140 – 147HVLTNLGV → MSSPTWVI in CAA34857 (PubMed:1972535).Curated8
Sequence conflicti241 – 242AD → PI in CAA34857 (PubMed:1972535).Curated2
Sequence conflicti300 – 301GA → R in CAA34857 (PubMed:1972535).Curated2
Sequence conflicti329 – 330HT → PH in CAA34857 (PubMed:1972535).Curated2
Sequence conflicti334Y → S in CAA34857 (PubMed:1972535).Curated1
Sequence conflicti351 – 357AYPNFSR → PTNSP in CAA34857 (PubMed:1972535).Curated7
Sequence conflicti371Y → S in CAA34857 (PubMed:1972535).Curated1
Sequence conflicti405I → S in CAA34857 (PubMed:1972535).Curated1
Sequence conflicti420 – 421GR → AA in CAA34857 (PubMed:1972535).Curated2
Sequence conflicti473H → R in CAA34857 (PubMed:1972535).Curated1
Sequence conflicti535 – 536DV → R in CAA34857 (PubMed:1972535).Curated2
Sequence conflicti596 – 597FV → SPS in CAA34857 (PubMed:1972535).Curated2
Sequence conflicti623R → L in CAA34857 (PubMed:1972535).Curated1
Sequence conflicti665 – 667QRQ → HQ in CAA34857 (PubMed:1972535).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL669993 Genomic DNA Translation: CAD21159.1
CM002237 Genomic DNA Translation: EAA34441.2
X16989 Genomic DNA Translation: CAA34857.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
S09244, SYNCAA

NCBI Reference Sequences

More...
RefSeqi
XP_963677.2, XM_958584.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA34441; EAA34441; NCU06836

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3879801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU06836

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669993 Genomic DNA Translation: CAD21159.1
CM002237 Genomic DNA Translation: EAA34441.2
X16989 Genomic DNA Translation: CAA34857.1 Sequence problems.
PIRiS09244, SYNCAA
RefSeqiXP_963677.2, XM_958584.3

3D structure databases

SMRiP16929
ModBaseiSearch...

Proteomic databases

PRIDEiP16929

Genome annotation databases

EnsemblFungiiEAA34441; EAA34441; NCU06836
GeneIDi3879801
KEGGincr:NCU06836

Organism-specific databases

VEuPathDBiFungiDB:NCU06836

Phylogenomic databases

HOGENOMiCLU_000022_3_6_1
InParanoidiP16929
OMAiDHWWHDL

Family and domain databases

Gene3Di3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR011904, Ac_CoA_lig
IPR032387, ACAS_N
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
PfamiView protein in Pfam
PF16177, ACAS_N, 1 hit
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
TIGRFAMsiTIGR02188, Ac_CoA_lig_AcsA, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSA_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16929
Secondary accession number(s): Q7RVJ2, Q8X016
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 7, 2005
Last modified: February 10, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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