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Entry version 149 (07 Oct 2020)
Sequence version 1 (01 Aug 1990)
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Protein

Protein RhsA

Gene

rhsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell.

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10846-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein RhsA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rhsA
Ordered Locus Names:b3593, JW3566
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000222251 – 1377Protein RhsAAdd BLAST1377

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16916

PRoteomics IDEntifications database

More...
PRIDEi
P16916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4262562, 134 interactors

Database of interacting proteins

More...
DIPi
DIP-10699N

Protein interaction database and analysis system

More...
IntActi
P16916, 27 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3593

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati330 – 35211 PublicationAdd BLAST23
Repeati353 – 37421 PublicationAdd BLAST22
Repeati375 – 41731 PublicationAdd BLAST43
Repeati418 – 43841 PublicationAdd BLAST21
Repeati439 – 46051 PublicationAdd BLAST22
Repeati461 – 48161 PublicationAdd BLAST21
Repeati482 – 50271 PublicationAdd BLAST21
Repeati503 – 52581 PublicationAdd BLAST23
Repeati526 – 54691 PublicationAdd BLAST21
Repeati547 – 567101 PublicationAdd BLAST21
Repeati568 – 588111 PublicationAdd BLAST21
Repeati589 – 609121 PublicationAdd BLAST21
Repeati610 – 629131 PublicationAdd BLAST20
Repeati630 – 650141 PublicationAdd BLAST21
Repeati651 – 671151 PublicationAdd BLAST21
Repeati672 – 691161 PublicationAdd BLAST20
Repeati692 – 711171 PublicationAdd BLAST20
Repeati712 – 734181 PublicationAdd BLAST23
Repeati735 – 758191 PublicationAdd BLAST24
Repeati808 – 828201 PublicationAdd BLAST21
Repeati829 – 850211 PublicationAdd BLAST22
Repeati851 – 871221 PublicationAdd BLAST21
Repeati872 – 894231 PublicationAdd BLAST23
Repeati895 – 930241 PublicationAdd BLAST36
Repeati931 – 959251 PublicationAdd BLAST29
Repeati960 – 984261 PublicationAdd BLAST25
Repeati985 – 1019271 PublicationAdd BLAST35
Repeati1162 – 1186281 PublicationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni330 – 118628 X approximate tandem repeats1 PublicationAdd BLAST857

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each rhs appears to consist of a highly conserved 141 kDa amino fragment followed by a highly divergent C-terminus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RHS family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3209, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001218_0_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16916

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16916

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028947, Ntox34
IPR001826, RHS
IPR022385, Rhs_assc_core
IPR031325, RHS_repeat
IPR006530, YD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15606, Ntox34, 1 hit
PF03527, RHS, 1 hit
PF05593, RHS_repeat, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00394, RHSPROTEIN

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P16916-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGKPAARQG DMTQYGGSIV QGSAGVRIGA PTGVACSVCP GGVTSGHPVN
60 70 80 90 100
PLLGAKVLPG ETDIALPGPL PFILSRTYSS YRTKTPAPVG SLGPGWKMPA
110 120 130 140 150
DIRLQLRDNT LILSDNGGRS LYFEHLFPGE DGYSRSESLW LVRGGVAKLD
160 170 180 190 200
EGHRLAALWQ ALPEELRLSP HRYLATNSPQ GPWWLLGWCE RVPEADEVLP
210 220 230 240 250
APLPPYRVLT GLVDRFGRTQ TFHREAAGEF SGEITGVTDG AWRHFRLVLT
260 270 280 290 300
TQAQRAEEAR QQAISGGTEP SAFPDTLPGY TEYGRDNGIR LSAVWLTHDP
310 320 330 340 350
EYPENLPAAP LVRYGWTPRG ELAVVYDRSG KQVRSFTYDD KYRGRMVAHR
360 370 380 390 400
HTGRPEIRYR YDSDGRVTEQ LNPAGLSYTY QYEKDRITIT DSLDRREVLH
410 420 430 440 450
TQGEAGLKRV VKKEHADGSV TQSQFDAVGR LRAQTDAAGR TTEYSPDVVT
460 470 480 490 500
GLITRITTPD GRASAFYYNH HNQLTSATGP DGLELRREYD ELGRLIQETA
510 520 530 540 550
PDGDITRYRY DNPHSDLPCA TEDATGSRKT MTWSRYGQLL SFTDCSGYVT
560 570 580 590 600
RYDHDRFGQM TAVHREEGLS QYRAYDSRGQ LIAVKDTQGH ETRYEYNIAG
610 620 630 640 650
DLTAVIAPDG SRNGTQYDAW GKAVRTTQGG LTRSMEYDAA GRVIRLTSEN
660 670 680 690 700
GSHTTFRYDV LDRLIQETGF DGRTQRYHHD LTGKLIRSED EGLVTHWHYD
710 720 730 740 750
EADRLTHRTV KGETAERWQY DERGWLTDIS HISEGHRVAV HYRYDEKGRL
760 770 780 790 800
TGERQTVHHP QTEALLWQHE TRHAYNAQGL ANRCIPDSLP AVEWLTYGSG
810 820 830 840 850
YLAGMKLGDT PLVEYTRDRL HRETLRSFGR YELTTAYTPA GQLQSQHLNS
860 870 880 890 900
LLSDRDYTWN DNGELIRISS PRQTRSYSYS TTGRLTGVHT TAANLDIRIP
910 920 930 940 950
YATDPAGNRL PDPELHPDST LSMWPDNRIA RDAHYLYRYD RHGRLTEKTD
960 970 980 990 1000
LIPEGVIRTD DERTHRYHYD SQHRLVHYTR TQYEEPLVES RYLYDPLGRR
1010 1020 1030 1040 1050
VAKRVWRRER DLTGWMSLSR KPQVTWYGWD GDRLTTIQND RTRIQTIYQP
1060 1070 1080 1090 1100
GSFTPLIRVE TATGELAKTQ RRSLADALQQ SGGEDGGSVV FPPVLVQMLD
1110 1120 1130 1140 1150
RLESEILADR VSEESRRWLA SCGLTVEQMQ NQMDPVYTPA RKIHLYHCDH
1160 1170 1180 1190 1200
RGLPLALISK EGTTEWCAEY DEWGNLLNEE NPHQLQQLIR LPGQQYDEES
1210 1220 1230 1240 1250
GLYYNRHRYY DPLQGRYITQ DPIGLKGGWN FYQYPLNPVT NTDPLGLEVF
1260 1270 1280 1290 1300
PRPFPLPIPW PKSPAQQQAD DNAAKALTKW WNDTASQRIF DSLILNNPGL
1310 1320 1330 1340 1350
ALDITMIASR GNVADTGITD RVNDIINDRF WSDGKKPDRC DVLQELIDCG
1360 1370
DISAKDAKST QKAWNCRHSR QSNDKKR
Length:1,377
Mass (Da):156,321
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21ACA989E74200FE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L19044 Genomic DNA Translation: AAC95065.1
U00039 Genomic DNA Translation: AAB18570.1
U00096 Genomic DNA Translation: AAC76617.1
AP009048 Genomic DNA Translation: BAE77700.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C65159

NCBI Reference Sequences

More...
RefSeqi
NP_418050.1, NC_000913.3
WP_000015300.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76617; AAC76617; b3593
BAE77700; BAE77700; BAE77700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948120

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3566
eco:b3593

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3710

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19044 Genomic DNA Translation: AAC95065.1
U00039 Genomic DNA Translation: AAB18570.1
U00096 Genomic DNA Translation: AAC76617.1
AP009048 Genomic DNA Translation: BAE77700.1
PIRiC65159
RefSeqiNP_418050.1, NC_000913.3
WP_000015300.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262562, 134 interactors
DIPiDIP-10699N
IntActiP16916, 27 interactors
STRINGi511145.b3593

Proteomic databases

PaxDbiP16916
PRIDEiP16916

Genome annotation databases

EnsemblBacteriaiAAC76617; AAC76617; b3593
BAE77700; BAE77700; BAE77700
GeneIDi948120
KEGGiecj:JW3566
eco:b3593
PATRICifig|511145.12.peg.3710

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0839

Phylogenomic databases

eggNOGiCOG3209, Bacteria
HOGENOMiCLU_001218_0_1_6
InParanoidiP16916
PhylomeDBiP16916

Enzyme and pathway databases

BioCyciEcoCyc:EG10846-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P16916

Family and domain databases

InterProiView protein in InterPro
IPR028947, Ntox34
IPR001826, RHS
IPR022385, Rhs_assc_core
IPR031325, RHS_repeat
IPR006530, YD
PfamiView protein in Pfam
PF15606, Ntox34, 1 hit
PF03527, RHS, 1 hit
PF05593, RHS_repeat, 7 hits
PRINTSiPR00394, RHSPROTEIN
TIGRFAMsiTIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHSA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16916
Secondary accession number(s): Q2M7Q6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 7, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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