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Protein

Beta-lactamase PSE-4

Gene

pse4

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes both carbenicillin and oxacillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Acyl-ester intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Enzyme and pathway databases

BRENDAi3.5.2.6 5087
SABIO-RKiP16897

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase PSE-4 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase CARB-1
Carbenicillinase 1
Gene namesi
Name:pse4
Synonyms:carB1
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1744489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001704718 – 288Beta-lactamase PSE-4Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 118By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP16897

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 35Combined sources13
Beta strandi39 – 46Combined sources8
Turni47 – 50Combined sources4
Beta strandi51 – 56Combined sources6
Helixi64 – 66Combined sources3
Helixi68 – 80Combined sources13
Beta strandi89 – 91Combined sources3
Helixi94 – 96Combined sources3
Helixi104 – 106Combined sources3
Beta strandi110 – 113Combined sources4
Helixi114 – 124Combined sources11
Helixi127 – 136Combined sources10
Helixi145 – 149Combined sources5
Helixi163 – 165Combined sources3
Helixi178 – 185Combined sources8
Beta strandi191 – 194Combined sources4
Helixi196 – 207Combined sources12
Turni213 – 215Combined sources3
Helixi216 – 219Combined sources4
Beta strandi225 – 232Combined sources8
Helixi234 – 236Combined sources3
Beta strandi238 – 246Combined sources9
Beta strandi249 – 260Combined sources12
Helixi265 – 284Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G68X-ray1.95A18-288[»]
1G6AX-ray1.75A18-288[»]
4ID4X-ray1.05A145-185[»]
4R4RX-ray1.20A145-185[»]
ProteinModelPortaliP16897
SMRiP16897
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16897

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 231Substrate binding3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLLAFSLL IPSVVFASSS KFQQVEQDVK AIEVSLSARI GVSVLDTQNG
60 70 80 90 100
EYWDYNGNQR FPLTSTFKTI ACAKLLYDAE QGKVNPNSTV EIKKADLVTY
110 120 130 140 150
SPVIEKQVGQ AITLDDACFA TMTTSDNTAA NIILSAVGGP KGVTDFLRQI
160 170 180 190 200
GDKETRLDRI EPDLNEGKLG DLRDTTTPKA IASTLNKFLF GSALSEMNQK
210 220 230 240 250
KLESWMVNNQ VTGNLLRSVL PAGWNIADRS GAGGFGARSI TAVVWSEHQA
260 270 280
PIIVSIYLAQ TQASMEERND AIVKIGHSIF DVYTSQSR
Length:288
Mass (Da):31,406
Last modified:August 1, 1990 - v1
Checksum:i0E618F058720F3A5
GO

Sequence cautioni

The sequence AAA25979 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05162 Genomic DNA Translation: AAA25979.1 Different initiation.
PIRiA35001
RefSeqiWP_063857835.1, NZ_LLOM01000076.1

Similar proteinsi

Entry informationi

Entry nameiBLP4_PSEAI
AccessioniPrimary (citable) accession number: P16897
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Transposable element

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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