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Entry version 150 (05 Jun 2019)
Sequence version 4 (06 Dec 2005)
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Protein

Neurofilament heavy polypeptide

Gene

Nefh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurofilament heavy polypeptide
Short name:
NF-H
Alternative name(s):
200 kDa neurofilament protein
Neurofilament triplet H protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nefh
Synonyms:Nfh
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3159 Nefh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000638031 – 1072Neurofilament heavy polypeptideAdd BLAST1072

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei74PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Modified residuei618PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei642PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei654PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei678PhosphoserineBy similarity1
Modified residuei684PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei696PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei732PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1
Modified residuei776PhosphoserineBy similarity1
Modified residuei782PhosphoserineCombined sources1
Modified residuei788PhosphoserineBy similarity1
Modified residuei802PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Modified residuei832PhosphothreonineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei880PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16884

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16884

PRoteomics IDEntifications database

More...
PRIDEi
P16884

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16884

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16884

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-105N

Protein interaction database and analysis system

More...
IntActi
P16884, 3 interactors

Molecular INTeraction database

More...
MINTi
P16884

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000011604

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16884

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 409IF rodPROSITE-ProRule annotationAdd BLAST316
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati507 – 51216
Repeati515 – 52026
Repeati521 – 52636
Repeati527 – 53246
Repeati533 – 53856
Repeati539 – 54466
Repeati545 – 55076
Repeati551 – 55686
Repeati557 – 56296
Repeati563 – 568106
Repeati569 – 574116
Repeati575 – 580126
Repeati581 – 586136
Repeati587 – 592146
Repeati593 – 598156
Repeati599 – 604166
Repeati605 – 610176
Repeati611 – 616186
Repeati617 – 622196
Repeati623 – 628206
Repeati629 – 634216
Repeati635 – 640226
Repeati641 – 646236
Repeati647 – 652246
Repeati653 – 658256
Repeati659 – 664266
Repeati665 – 670276
Repeati671 – 676286
Repeati677 – 682296
Repeati683 – 688306
Repeati689 – 694316
Repeati695 – 700326
Repeati701 – 706336
Repeati707 – 712346
Repeati713 – 718356
Repeati719 – 724366
Repeati725 – 73037; approximate6
Repeati731 – 736386
Repeati737 – 742396
Repeati743 – 748406
Repeati749 – 754416
Repeati755 – 760426
Repeati761 – 766436
Repeati767 – 772446
Repeati775 – 78045; approximate6
Repeati781 – 786466
Repeati787 – 792476
Repeati795 – 80048; approximate6
Repeati801 – 806496
Repeati807 – 812506
Repeati815 – 820516
Repeati826 – 831526
Repeati851 – 856536
Repeati859 – 864546
Repeati879 – 884556

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni278 – 64355 X 6 AA approximate tandem repeats of K-S-P-[VAGSE]-[KEVTSGA]-[EAVK]Add BLAST366

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili98 – 132Sequence analysisAdd BLAST35
Coiled coili174 – 222Sequence analysisAdd BLAST49
Coiled coili293 – 380Sequence analysisAdd BLAST88

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGME Eukaryota
ENOG410XPTM LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230977

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16884

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16884

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010790 DUF1388
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR033183 NF-H

The PANTHER Classification System

More...
PANTHERi
PTHR23214 PTHR23214, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07142 DUF1388, 19 hits
PF00038 Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P16884-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFGSADAL LGAPFAPLHG GGSLHYALSR KAGAGGTRSA AGSSSGFHSW
60 70 80 90 100
ARTSVSSVSA SPSRFRGAAS STDSLDTLSN GPEGCVAAVA ARSEKEQLQA
110 120 130 140 150
LNDRFAGYID KVRQLEAHNR TLEGEAAALR QQKGRAAMGE LYEREVREMR
160 170 180 190 200
GAVLRLGAAR GHVRLEQEHL LEDIAHVRQR LDEEARQREE AEAAARALAR
210 220 230 240 250
FAQEAEAARV ELQKKAQALQ EECGYLRRHH QEEVGELLGQ IQGCGAAQAQ
260 270 280 290 300
AQAEARDALK CDVTSALREI RAQLEGHTVQ STLQSEEWFR VRLDRLSEAA
310 320 330 340 350
KVNTDAMRSA QEEITEYRRQ LQARTTELEA LKSTKESLER QRSELEDRHQ
360 370 380 390 400
VDMASYQDAI QQLDNELRNT KWEMAAQLRE YQDLLNVKMA LDIEIAAYRK
410 420 430 440 450
LLEGEECRIG FGPSPFSLTE GLPKIPSMST HIKVKSEEKI KVVEKSEKET
460 470 480 490 500
VIVEEQTEEI QVTEEVTEEE DKEAQGEEEE EAEEGGEEAA TTSPPAEEAA
510 520 530 540 550
SPEKETKSPV KEEAKSPAEA KSPAEAKSPA EAKSPAEVKS PAEVKSPAEA
560 570 580 590 600
KSPAEAKSPA EVKSPAEVKS PAEAKSPAEA KSPAEVKSPA TVKSPGEAKS
610 620 630 640 650
PAEAKSPAEV KSPVEAKSPA EAKSPASVKS PGEAKSPAEA KSPAEVKSPA
660 670 680 690 700
TVKSPVEAKS PAEVKSPVTV KSPAEAKSPV EVKSPASVKS PSEAKSPAGA
710 720 730 740 750
KSPAEAKSPV VAKSPAEAKS PAEAKPPAEA KSPAEAKSPA EAKSPAEAKS
760 770 780 790 800
PAEAKSPVEV KSPEKAKSPV KEGAKSLAEA KSPEKAKSPV KEEIKPPAEV
810 820 830 840 850
KSPEKAKSPM KEEAKSPEKA KTLDVKSPEA KTPAKEEAKR PADIRSPEQV
860 870 880 890 900
KSPAKEEAKS PEKEETRTEK VAPKKEEVKS PVEEVKAKEP PKKVEEEKTP
910 920 930 940 950
ATPKTEVKES KKDEAPKEAQ KPKAEEKEPL TEKPKDSPGE AKKEEAKEKK
960 970 980 990 1000
AAAPEEETPA KLGVKEEAKP KEKAEDAKAK EPSKPSEKEK PKKEEVPAAP
1010 1020 1030 1040 1050
EKKDTKEEKT TESKKPEEKP KMEAKAKEED KGLPQEPSKP KTEKAEKSSS
1060 1070
TDQKDSQPSE KAPEDKAAKG DK
Length:1,072
Mass (Da):115,378
Last modified:December 6, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89BDFD7E2164D78B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LRZ7F1LRZ7_RAT
Neurofilament heavy polypeptide
Nefh
1,064Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA32038 differs from that shown. Reason: Frameshift at position 1024.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti393I → L in AAA41693 (PubMed:3143606).Curated1
Sequence conflicti393I → L in CAA32038 (PubMed:3143606).Curated1
Sequence conflicti414S → I in AAA41693 (PubMed:3143606).Curated1
Sequence conflicti414S → I in CAA32038 (PubMed:3143606).Curated1
Sequence conflicti422L → T in AAA41695 (PubMed:2457365).Curated1
Sequence conflicti428M → T in AAA41695 (PubMed:2457365).Curated1
Sequence conflicti555E → V (PubMed:3143606).Curated1
Sequence conflicti555E → V (PubMed:2457365).Curated1
Sequence conflicti567E → T in AAB87068 (PubMed:2230956).Curated1
Sequence conflicti587K → N in AAA41693 (PubMed:3143606).Curated1
Sequence conflicti587K → N in CAA32038 (PubMed:3143606).Curated1
Sequence conflicti614V → A (PubMed:2457365).Curated1
Sequence conflicti614V → A (Ref. 7) Curated1
Sequence conflicti723E → G in AAA41693 (PubMed:3143606).Curated1
Sequence conflicti723E → G in CAA32038 (PubMed:3143606).Curated1
Sequence conflicti726P → S (PubMed:2457365).Curated1
Sequence conflicti726P → S (Ref. 7) Curated1
Sequence conflicti811 – 812KE → RK in AAA41693 (PubMed:3143606).Curated2
Sequence conflicti811 – 812KE → RK in CAA32038 (PubMed:3143606).Curated2
Sequence conflicti832T → P in AAA41693 (PubMed:3143606).Curated1
Sequence conflicti832T → P in CAA32038 (PubMed:3143606).Curated1
Sequence conflicti968A → V in AAA41692 (PubMed:2928342).Curated1
Sequence conflicti998 – 1000AAP → GST in AAA41692 (PubMed:2928342).Curated3
Sequence conflicti1010T → L (PubMed:2457365).Curated1
Sequence conflicti1010T → L (Ref. 7) Curated1
Sequence conflicti1016P → R in AAA41693 (PubMed:3143606).Curated1
Sequence conflicti1016P → R in CAA32038 (PubMed:3143606).Curated1
Sequence conflicti1023E → Q in AAB87068 (PubMed:2230956).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The number of repeats in the tandem repeat domain is shown to vary between 53 and 55.

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37227 mRNA Translation: AAA41693.1 Frameshift.
X13804 mRNA Translation: CAA32038.1 Frameshift.
AF031879 mRNA Translation: AAB87068.1
M21964 mRNA Translation: AAA41695.1
J04517 mRNA Translation: AAA41692.1
AY112897 mRNA Translation: AAM49796.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37221
S02003

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:3159 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37227 mRNA Translation: AAA41693.1 Frameshift.
X13804 mRNA Translation: CAA32038.1 Frameshift.
AF031879 mRNA Translation: AAB87068.1
M21964 mRNA Translation: AAA41695.1
J04517 mRNA Translation: AAA41692.1
AY112897 mRNA Translation: AAM49796.1
PIRiA37221
S02003

3D structure databases

SMRiP16884
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-105N
IntActiP16884, 3 interactors
MINTiP16884
STRINGi10116.ENSRNOP00000011604

PTM databases

iPTMnetiP16884
PhosphoSitePlusiP16884

Proteomic databases

jPOSTiP16884
PaxDbiP16884
PRIDEiP16884

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3159 rat

Organism-specific databases

RGDi3159 Nefh

Phylogenomic databases

eggNOGiENOG410IGME Eukaryota
ENOG410XPTM LUCA
HOGENOMiHOG000230977
InParanoidiP16884
PhylomeDBiP16884

Miscellaneous databases

Protein Ontology

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PROi
PR:P16884

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR010790 DUF1388
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR033183 NF-H
PANTHERiPTHR23214 PTHR23214, 2 hits
PfamiView protein in Pfam
PF07142 DUF1388, 19 hits
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFH_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16884
Secondary accession number(s): O35482, Q540Z7, Q63368
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 6, 2005
Last modified: June 5, 2019
This is version 150 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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