UniProtKB - P16871 (IL7RA_HUMAN)
Protein
Interleukin-7 receptor subunit alpha
Gene
IL7R
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
GO - Molecular functioni
- antigen binding Source: ProtInc
- cytokine receptor activity Source: UniProtKB
- interleukin-7 receptor activity Source: ProtInc
GO - Biological processi
- B cell proliferation Source: Ensembl
- cell morphogenesis Source: Ensembl
- cell surface receptor signaling pathway Source: ProtInc
- defense response to Gram-positive bacterium Source: Ensembl
- homeostasis of number of cells Source: Ensembl
- immune response Source: ProtInc
- immunoglobulin production Source: Ensembl
- interleukin-7-mediated signaling pathway Source: Reactome
- lymph node development Source: Ensembl
- membrane organization Source: Reactome
- negative regulation of T cell apoptotic process Source: Ensembl
- negative regulation of T cell mediated cytotoxicity Source: Ensembl
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: Ensembl
- positive regulation of receptor signaling pathway via STAT Source: UniProtKB
- positive regulation of T cell differentiation in thymus Source: Ensembl
- regulation of cell size Source: Ensembl
- regulation of DNA recombination Source: ProtInc
- signal transduction Source: ProtInc
- T cell differentiation Source: Ensembl
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P16871 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P16871 |
SIGNORi | P16871 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-7 receptor subunit alphaShort name: IL-7 receptor subunit alpha Short name: IL-7R subunit alpha Short name: IL-7R-alpha Short name: IL-7RA Alternative name(s): CDw127 CD_antigen: CD127 |
Gene namesi | Name:IL7R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6024, IL7R |
MIMi | 146661, gene |
neXtProti | NX_P16871 |
VEuPathDBi | HostDB:ENSG00000168685.14 |
Subcellular locationi
Plasma membrane
Plasma membrane
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- clathrin-coated vesicle membrane Source: Reactome
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 239 | ExtracellularSequence analysisAdd BLAST | 219 | |
Transmembranei | 240 – 264 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 265 – 459 | CytoplasmicSequence analysisAdd BLAST | 195 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034870 | 132 | P → S in T(-)B(+)NK(+) SCID. 1 PublicationCorresponds to variant dbSNP:rs104893894EnsemblClinVar. | 1 |
Multiple sclerosis 3 (MS3)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.
Disease descriptionA multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Related information in OMIMKeywords - Diseasei
Disease variant, SCIDOrganism-specific databases
DisGeNETi | 3575 |
MalaCardsi | IL7R |
MIMi | 608971, phenotype 612595, phenotype |
OpenTargetsi | ENSG00000168685 |
Orphaneti | 39041, Omenn syndrome 169154, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency |
PharmGKBi | PA29840 |
Miscellaneous databases
Pharosi | P16871, Tbio |
Chemistry databases
GuidetoPHARMACOLOGYi | 1698 |
Genetic variation databases
BioMutai | IL7R |
DMDMi | 215274000 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000010909 | 21 – 459 | Interleukin-7 receptor subunit alphaAdd BLAST | 439 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 57 | 1 Publication | ||
Glycosylationi | 49 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 65 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 74 ↔ 82 | 1 Publication | ||
Disulfide bondi | 108 ↔ 118 | 1 Publication | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 233 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 282 | Phosphothreonine; by PKCSequence analysis | 1 |
Post-translational modificationi
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P16871 |
PaxDbi | P16871 |
PeptideAtlasi | P16871 |
PRIDEi | P16871 |
ProteomicsDBi | 53396 [P16871-1] 53397 [P16871-2] 53398 [P16871-3] 53399 [P16871-4] |
PTM databases
GlyGeni | P16871, 6 sites |
iPTMneti | P16871 |
PhosphoSitePlusi | P16871 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168685, Expressed in blood and 174 other tissues |
ExpressionAtlasi | P16871, baseline and differential |
Genevisiblei | P16871, HS |
Organism-specific databases
HPAi | ENSG00000168685, Group enriched (blood, intestine, lung, lymphoid tissue) |
Interactioni
Subunit structurei
The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.
1 PublicationBinary interactionsi
Hide detailsP16871
Protein-protein interaction databases
BioGRIDi | 109789, 130 interactors |
DIPi | DIP-3045N |
ELMi | P16871 |
IntActi | P16871, 18 interactors |
STRINGi | 9606.ENSP00000306157 |
Miscellaneous databases
RNActi | P16871, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | P16871 |
SMRi | P16871 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16871 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 131 – 231 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 101 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 217 – 221 | WSXWS motif | 5 | |
Motifi | 272 – 280 | Box 1 motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 184 – 189 | Ser/Thr-rich | 6 |
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4WE, Eukaryota |
GeneTreei | ENSGT00510000048500 |
HOGENOMi | CLU_045398_0_0_1 |
InParanoidi | P16871 |
OMAi | KPIVWPS |
OrthoDBi | 617812at2759 |
PhylomeDBi | P16871 |
TreeFami | TF336573 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR040997, FN3_7 IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF18447, FN3_7, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P16871-1) [UniParc]FASTAAdd to basket
Also known as: H20
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG
60 70 80 90 100
SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL
110 120 130 140 150
LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF
160 170 180 190 200
NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM
210 220 230 240 250
YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP ILLTISILSF
260 270 280 290 300
FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP
310 320 330 340 350
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP
360 370 380 390 400
SEDVVITPES FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV
410 420 430 440 450
YQDLLLSLGT TNSTLPPPFS LQSGILTLNP VAQGQPILTS LGSNQEEAYV
TMSSFYQNQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RDM4 | D6RDM4_HUMAN | Interleukin-7 receptor subunit alph... | IL7R | 150 | Annotation score: | ||
B8YG18 | B8YG18_HUMAN | Interleukin 7 receptor isoform H5-6 | IL7R | 180 | Annotation score: | ||
D6RG28 | D6RG28_HUMAN | Interleukin-7 receptor subunit alph... | IL7R | 59 | Annotation score: | ||
D6RCR9 | D6RCR9_HUMAN | Interleukin-7 receptor subunit alph... | IL7R | 52 | Annotation score: | ||
H0YA41 | H0YA41_HUMAN | Interleukin-7 receptor subunit alph... | IL7R | 65 | Annotation score: |
Sequence cautioni
The sequence AAH20717 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | S → T in AAH67539 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 52 | Q → R in AAH67538 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 384 | S → P in AAH67537 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 386 | R → G in AAH67539 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021286 | 66 | I → T5 PublicationsCorresponds to variant dbSNP:rs1494558EnsemblClinVar. | 1 | |
Natural variantiVAR_021287 | 113 | E → D1 PublicationCorresponds to variant dbSNP:rs11567735EnsemblClinVar. | 1 | |
Natural variantiVAR_034870 | 132 | P → S in T(-)B(+)NK(+) SCID. 1 PublicationCorresponds to variant dbSNP:rs104893894EnsemblClinVar. | 1 | |
Natural variantiVAR_021288 | 138 | V → I5 PublicationsCorresponds to variant dbSNP:rs1494555EnsemblClinVar. | 1 | |
Natural variantiVAR_021289 | 244 | T → I3 PublicationsCorresponds to variant dbSNP:rs6897932EnsemblClinVar. | 1 | |
Natural variantiVAR_021290 | 356 | I → V4 PublicationsCorresponds to variant dbSNP:rs3194051EnsemblClinVar. | 1 | |
Natural variantiVAR_047742 | 414 | T → M. Corresponds to variant dbSNP:rs2229232EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001713 | 237 – 459 | EMDPI…FYQNQ → LSLSYGPVSPIIRRLWNIFV RNQEK in isoform 4. 1 PublicationAdd BLAST | 223 | |
Alternative sequenceiVSP_012618 | 237 – 252 | EMDPI…LSFFS → LSLSYGPVSPIIRQEL in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_012619 | 253 – 459 | Missing in isoform 2. 1 PublicationAdd BLAST | 207 | |
Alternative sequenceiVSP_001714 | 293 – 459 | NLNVS…FYQNQ → VSVFGA in isoform 3. CuratedAdd BLAST | 167 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29696 mRNA Translation: AAA59157.1 AF043129 , AF043123, AF043124, AF043125, AF043126, AF043127, AF043128 Genomic DNA Translation: AAC83204.1 AK301220 mRNA Translation: BAG62793.1 AK315251 mRNA Translation: BAG37673.1 AY449709 Genomic DNA Translation: AAR08908.1 AC112204 Genomic DNA No translation available. BC020717 mRNA Translation: AAH20717.1 Sequence problems. BC067537 mRNA Translation: AAH67537.1 BC067538 mRNA Translation: AAH67538.1 BC067539 mRNA Translation: AAH67539.1 BC067540 mRNA Translation: AAH67540.1 BC069999 mRNA Translation: AAH69999.1 |
CCDSi | CCDS3911.1 [P16871-1] |
PIRi | A34791 B34791 C34791 |
RefSeqi | NP_002176.2, NM_002185.3 [P16871-1] |
Genome annotation databases
Ensembli | ENST00000303115; ENSP00000306157; ENSG00000168685 [P16871-1] ENST00000506850; ENSP00000421207; ENSG00000168685 [P16871-3] |
GeneIDi | 3575 |
KEGGi | hsa:3575 |
UCSCi | uc003jjs.5, human [P16871-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
IL7Rbase IL7R mutation db |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29696 mRNA Translation: AAA59157.1 AF043129 , AF043123, AF043124, AF043125, AF043126, AF043127, AF043128 Genomic DNA Translation: AAC83204.1 AK301220 mRNA Translation: BAG62793.1 AK315251 mRNA Translation: BAG37673.1 AY449709 Genomic DNA Translation: AAR08908.1 AC112204 Genomic DNA No translation available. BC020717 mRNA Translation: AAH20717.1 Sequence problems. BC067537 mRNA Translation: AAH67537.1 BC067538 mRNA Translation: AAH67538.1 BC067539 mRNA Translation: AAH67539.1 BC067540 mRNA Translation: AAH67540.1 BC069999 mRNA Translation: AAH69999.1 |
CCDSi | CCDS3911.1 [P16871-1] |
PIRi | A34791 B34791 C34791 |
RefSeqi | NP_002176.2, NM_002185.3 [P16871-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DI2 | X-ray | 2.70 | B/D | 21-239 | [»] | |
3DI3 | X-ray | 2.90 | B | 21-239 | [»] | |
3UP1 | X-ray | 2.15 | A/B | 21-239 | [»] | |
5J11 | X-ray | 2.56 | B | 21-236 | [»] | |
6P50 | X-ray | 2.90 | C | 21-239 | [»] | |
6P67 | X-ray | 2.90 | G/I/J/K | 21-239 | [»] | |
SASBDBi | P16871 | |||||
SMRi | P16871 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109789, 130 interactors |
DIPi | DIP-3045N |
ELMi | P16871 |
IntActi | P16871, 18 interactors |
STRINGi | 9606.ENSP00000306157 |
Chemistry databases
GuidetoPHARMACOLOGYi | 1698 |
PTM databases
GlyGeni | P16871, 6 sites |
iPTMneti | P16871 |
PhosphoSitePlusi | P16871 |
Genetic variation databases
BioMutai | IL7R |
DMDMi | 215274000 |
Proteomic databases
MassIVEi | P16871 |
PaxDbi | P16871 |
PeptideAtlasi | P16871 |
PRIDEi | P16871 |
ProteomicsDBi | 53396 [P16871-1] 53397 [P16871-2] 53398 [P16871-3] 53399 [P16871-4] |
Protocols and materials databases
ABCDi | P16871, 4 sequenced antibodies |
Antibodypediai | 4129, 1282 antibodies |
DNASUi | 3575 |
Genome annotation databases
Ensembli | ENST00000303115; ENSP00000306157; ENSG00000168685 [P16871-1] ENST00000506850; ENSP00000421207; ENSG00000168685 [P16871-3] |
GeneIDi | 3575 |
KEGGi | hsa:3575 |
UCSCi | uc003jjs.5, human [P16871-1] |
Organism-specific databases
CTDi | 3575 |
DisGeNETi | 3575 |
GeneCardsi | IL7R |
HGNCi | HGNC:6024, IL7R |
HPAi | ENSG00000168685, Group enriched (blood, intestine, lung, lymphoid tissue) |
MalaCardsi | IL7R |
MIMi | 146661, gene 608971, phenotype 612595, phenotype |
neXtProti | NX_P16871 |
OpenTargetsi | ENSG00000168685 |
Orphaneti | 39041, Omenn syndrome 169154, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency |
PharmGKBi | PA29840 |
VEuPathDBi | HostDB:ENSG00000168685.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4WE, Eukaryota |
GeneTreei | ENSGT00510000048500 |
HOGENOMi | CLU_045398_0_0_1 |
InParanoidi | P16871 |
OMAi | KPIVWPS |
OrthoDBi | 617812at2759 |
PhylomeDBi | P16871 |
TreeFami | TF336573 |
Enzyme and pathway databases
PathwayCommonsi | P16871 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P16871 |
SIGNORi | P16871 |
Miscellaneous databases
BioGRID-ORCSi | 3575, 1 hit in 874 CRISPR screens |
ChiTaRSi | IL7R, human |
EvolutionaryTracei | P16871 |
GeneWikii | Interleukin-7_receptor-%CE%B1 |
GenomeRNAii | 3575 |
Pharosi | P16871, Tbio |
PROi | PR:P16871 |
RNActi | P16871, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168685, Expressed in blood and 174 other tissues |
ExpressionAtlasi | P16871, baseline and differential |
Genevisiblei | P16871, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR040997, FN3_7 IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF18447, FN3_7, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL7RA_HUMAN | |
Accessioni | P16871Primary (citable) accession number: P16871 Secondary accession number(s): B2RCS6 Q9UPC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 10, 2021 | |
This is version 208 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families