IL7R

Functionⁱ

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

GO - Molecular functionⁱ

antigen binding
Source: ProtInc
Traceable author statementⁱ
- 9495344
cytokine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11418668
interleukin-7 receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8266077

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell proliferation Source: Ensembl
cell morphogenesis Source: Ensembl
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9843216
homeostasis of number of cells Source: Ensembl
immune response
Source: ProtInc
Traceable author statementⁱ
- 9843216
immunoglobulin production Source: Ensembl
interleukin-7-mediated signaling pathway Source: Reactome
lymph node development Source: Ensembl
membrane organization Source: Reactome
negative regulation of T cell apoptotic process Source: Ensembl
negative regulation of T cell mediated cytotoxicity Source: Ensembl
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 11418668
positive regulation of gene expression Source: Ensembl
positive regulation of STAT cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 11418668
positive regulation of T cell differentiation in thymus Source: Ensembl
regulation of cell size Source: Ensembl
regulation of DNA recombination
Source: ProtInc
Traceable author statementⁱ
- 9495344
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2317865
T cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1266695 Interleukin-7 signaling R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	P16871
SIGNORⁱ	P16871

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-7 receptor subunit alpha Short name: IL-7 receptor subunit alpha Short name: IL-7R subunit alpha Short name: IL-7R-alpha Short name: IL-7RA Alternative name(s): CDw127 CD_antigen: CD127
Gene namesⁱ	Name:IL7R
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168685.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6024 IL7R
MIMⁱ	146661 gene
neXtProtⁱ	NX_P16871

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 239	ExtracellularSequence analysisAdd BLAST	219
Transmembraneⁱ	240 – 264	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	265 – 459	CytoplasmicSequence analysisAdd BLAST	195

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034870	132	P → S in T(-)B(+)NK(+) SCID. 1 Publication		1

Multiple sclerosis 3 (MS3)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.

Disease descriptionA multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

Keywords - Diseaseⁱ

Disease mutation, SCID

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3575
MalaCards human disease database More...MalaCardsⁱ	IL7R
MIMⁱ	608971 phenotype 612595 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000168685
Orphanetⁱ	39041 Omenn syndrome 169154 T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency
PharmGKBⁱ	PA29840

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1698

GuidetoPHARMACOLOGYⁱ

1698

Polymorphism and mutation databases

BioMutaⁱ	IL7R
DMDMⁱ	215274000

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Add BLAST		20
ChainⁱPRO_0000010909	21 – 459	Interleukin-7 receptor subunit alphaAdd BLAST		439

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	42 ↔ 57	1 Publication
Glycosylationⁱ	49	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	65	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	74 ↔ 82	1 Publication
Disulfide bondⁱ	108 ↔ 118	1 Publication
Glycosylationⁱ	151	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	182	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	232	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	233	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	282	Phosphothreonine; by PKCSequence analysis	1

Post-translational modificationⁱ

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16871
PaxDbⁱ	P16871
PeptideAtlas More...PeptideAtlasⁱ	P16871
PRIDEⁱ	P16871
ProteomicsDBⁱ	53396 53397 [P16871-2] 53398 [P16871-3] 53399 [P16871-4]

PTM databases

iPTMnetⁱ	P16871
PhosphoSitePlusⁱ	P16871

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168685 Expressed in 157 organ(s), highest expression level in blood
CleanExⁱ	HS_IL7R
ExpressionAtlasⁱ	P16871 baseline and differential
Genevisibleⁱ	P16871 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010215

HPAⁱ

CAB010215

Interactionⁱ

Subunit structureⁱ

The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL7	P13232	7	EBI-15750828,EBI-80516

With

Entry

#Exp.

IntAct

Notes

IL7

P13232

7

EBI-15750828,EBI-80516

Protein-protein interaction databases

BioGridⁱ	109789, 122 interactors
Database of interacting proteins More...DIPⁱ	DIP-3045N
ELMⁱ	P16871
IntActⁱ	P16871, 9 interactors
STRINGⁱ	9606.ENSP00000306157

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 38	Combined sources	4
Beta strandⁱ	40 – 49	Combined sources	10
Beta strandⁱ	52 – 61	Combined sources	10
Beta strandⁱ	69 – 79	Combined sources	11
Beta strandⁱ	81 – 84	Combined sources	4
Beta strandⁱ	86 – 88	Combined sources	3
Beta strandⁱ	91 – 97	Combined sources	7
Beta strandⁱ	102 – 111	Combined sources	10
Beta strandⁱ	114 – 122	Combined sources	9
Helixⁱ	123 – 125	Combined sources	3
Beta strandⁱ	133 – 140	Combined sources	8
Turnⁱ	141 – 144	Combined sources	4
Beta strandⁱ	145 – 151	Combined sources	7
Helixⁱ	153 – 156	Combined sources	4
Beta strandⁱ	158 – 160	Combined sources	3
Beta strandⁱ	163 – 173	Combined sources	11
Beta strandⁱ	179 – 191	Combined sources	13
Helixⁱ	192 – 194	Combined sources	3
Beta strandⁱ	200 – 209	Combined sources	10
Beta strandⁱ	211 – 213	Combined sources	3
Beta strandⁱ	224 – 227	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P16871
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P16871

EvolutionaryTraceⁱ

P16871

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	131 – 231	Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST		101

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	217 – 221	WSXWS motif		5
Motifⁱ	272 – 280	Box 1 motif		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	184 – 189	Ser/Thr-rich		6

Domainⁱ

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesⁱ

Belongs to the type I cytokine receptor family. Type 4 subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGXR Eukaryota ENOG410YWZG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048500
HOVERGENⁱ	HBG055773
InParanoidⁱ	P16871
KEGG Orthology (KO) More...KOⁱ	K05072
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N4J
PhylomeDBⁱ	P16871
TreeFamⁱ	TF336573

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003531 Hempt_rcpt_S_F1_CS IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P16871-1) [UniParc]FASTA Add to basket

Also known as: H20

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG 
        60         70         80         90        100
SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL 
       110        120        130        140        150
LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF 
       160        170        180        190        200
NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM 
       210        220        230        240        250
YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP ILLTISILSF 
       260        270        280        290        300
FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP 
       310        320        330        340        350
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP 
       360        370        380        390        400
SEDVVITPES FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV 
       410        420        430        440        450
YQDLLLSLGT TNSTLPPPFS LQSGILTLNP VAQGQPILTS LGSNQEEAYV 

TMSSFYQNQ

Length:459

Mass (Da):51,579

Last modified:September 12, 2018 - v3

Checksum:ⁱEF50BF2615EEF50C

GO

Isoform 3 (identifier: P16871-2) [UniParc]FASTA Add to basket

Also known as: H1

The sequence of this isoform differs from the canonical sequence as follows:
293-459: NLNVSFNPES...VTMSSFYQNQ → VSVFGA

« Hide

        10         20         30         40         50
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG 
        60         70         80         90        100
SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL 
       110        120        130        140        150
LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF 
       160        170        180        190        200
NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM 
       210        220        230        240        250
YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP ILLTISILSF 
       260        270        280        290 
FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKVSVFGA

Show »

Length:298

Mass (Da):34,018

Checksum:ⁱ92DBD635C263E400

GO

Isoform 4 (identifier: P16871-3) [UniParc]FASTA Add to basket

Also known as: H6, Secreted

The sequence of this isoform differs from the canonical sequence as follows:
237-459: EMDPILLTIS...VTMSSFYQNQ → LSLSYGPVSPIIRRLWNIFVRNQEK

« Hide

        10         20         30         40         50
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG 
        60         70         80         90        100
SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL 
       110        120        130        140        150
LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF 
       160        170        180        190        200
NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM 
       210        220        230        240        250
YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS YGPVSPIIRR 
       260 
LWNIFVRNQE K

Show »

Length:261

Mass (Da):29,936

Checksum:ⁱ7E74A79A067977AF

GO

Isoform 2 (identifier: P16871-4) [UniParc]FASTA Add to basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
237-252: EMDPILLTISILSFFS → LSLSYGPVSPIIRQEL
253-459: Missing.

« Hide

        10         20         30         40         50
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG 
        60         70         80         90        100
SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL 
       110        120        130        140        150
LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF 
       160        170        180        190        200
NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM 
       210        220        230        240        250
YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS YGPVSPIIRQ 

EL

Show »

Length:252

Mass (Da):28,722

Checksum:ⁱ6C656D418284D071

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RGV2	D6RGV2_HUMAN	Interleukin-7 receptor subunit alph... Interleukin-7 receptor subunit alpha	IL7R	261	Annotation score:
B8YG18	B8YG18_HUMAN	Interleukin 7 receptor isoform H5-6 Interleukin 7 receptor isoform H5-6 (Interleukin-7 receptor subunit alpha)	IL7R	180	Annotation score:
D6RDM4	D6RDM4_HUMAN	Interleukin-7 receptor subunit alph... Interleukin-7 receptor subunit alpha	IL7R	150	Annotation score:
D6RCR9	D6RCR9_HUMAN	Interleukin-7 receptor subunit alph... Interleukin-7 receptor subunit alpha	IL7R	52	Annotation score:
D6RG28	D6RG28_HUMAN	Interleukin-7 receptor subunit alph... Interleukin-7 receptor subunit alpha	IL7R	59	Annotation score:
H0YA41	H0YA41_HUMAN	Interleukin-7 receptor subunit alph... Interleukin-7 receptor subunit alpha	IL7R	65	Annotation score:

Sequence cautionⁱ

The sequence AAH20717 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	39	S → T in AAH67539 (PubMed:15489334).Curated	1
Sequence conflictⁱ	52	Q → R in AAH67538 (PubMed:15489334).Curated	1
Sequence conflictⁱ	384	S → P in AAH67537 (PubMed:15489334).Curated	1
Sequence conflictⁱ	386	R → G in AAH67539 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021286	66	I → T5 PublicationsCorresponds to variant dbSNP:rs1494558EnsemblClinVar.	1
Natural variantⁱVAR_021287	113	E → D1 PublicationCorresponds to variant dbSNP:rs11567735EnsemblClinVar.	1
Natural variantⁱVAR_034870	132	P → S in T(-)B(+)NK(+) SCID. 1 Publication	1
Natural variantⁱVAR_021288	138	V → I5 PublicationsCorresponds to variant dbSNP:rs1494555EnsemblClinVar.	1
Natural variantⁱVAR_021289	244	T → I3 PublicationsCorresponds to variant dbSNP:rs6897932EnsemblClinVar.	1
Natural variantⁱVAR_021290	356	I → V4 PublicationsCorresponds to variant dbSNP:rs3194051EnsemblClinVar.	1
Natural variantⁱVAR_047742	414	T → M. Corresponds to variant dbSNP:rs2229232EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_001713	237 – 459	EMDPI…FYQNQ → LSLSYGPVSPIIRRLWNIFV RNQEK in isoform 4. 1 PublicationAdd BLAST	223
Alternative sequenceⁱVSP_012618	237 – 252	EMDPI…LSFFS → LSLSYGPVSPIIRQEL in isoform 2. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_012619	253 – 459	Missing in isoform 2. 1 PublicationAdd BLAST	207
Alternative sequenceⁱVSP_001714	293 – 459	NLNVS…FYQNQ → VSVFGA in isoform 3. CuratedAdd BLAST	167

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29696 mRNA Translation: AAA59157.1 AF043129 AF043128 Genomic DNA Translation: AAC83204.1 AK301220 mRNA Translation: BAG62793.1 AK315251 mRNA Translation: BAG37673.1 AY449709 Genomic DNA Translation: AAR08908.1 AC112204 Genomic DNA No translation available. BC020717 mRNA Translation: AAH20717.1 Sequence problems. BC067537 mRNA Translation: AAH67537.1 BC067538 mRNA Translation: AAH67538.1 BC067539 mRNA Translation: AAH67539.1 BC067540 mRNA Translation: AAH67540.1 BC069999 mRNA Translation: AAH69999.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3911.1 [P16871-1]
PIRⁱ	A34791 B34791 C34791
NCBI Reference Sequences More...RefSeqⁱ	NP_002176.2, NM_002185.3 [P16871-1]
UniGeneⁱ	Hs.591742

Genome annotation databases

Ensemblⁱ	ENST00000303115; ENSP00000306157; ENSG00000168685 [P16871-1] ENST00000506850; ENSP00000421207; ENSG00000168685 [P16871-3]
GeneIDⁱ	3575
KEGGⁱ	hsa:3575
UCSC genome browser More...UCSCⁱ	uc003jjs.5 human [P16871-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16871	Interleukin-7 receptor subunit alpha (Fragment)		HUMAN		52	UniRef100_P16871
IL7R isoform 3 (Fragment)		PONAB		52
Interleukin-7 receptor subunit alpha (Fragment)		HUMAN		59
P16871-3	Interleukin-7 receptor subunit alpha		HUMAN		261	UniRef100_D6RGV2
IL7R isoform 4 (Fragment)		PANTR		65
Interleukin-7 receptor subunit alpha (Fragment)		HUMAN		65
UPI000048C8AB		HUMAN		262

Protein	Similar proteins		Species	Score	Length	Source
P16871	Interleukin-7 receptor subunit alpha		MACFA		459	UniRef90_P16871
Interleukin-7 receptor subunit alpha (Fragment)		HUMAN		52
IL7R isoform 3 (Fragment)		PONAB		52
Interleukin-7 receptor subunit alpha		MACMU		459
IL7R isoform 1		PANTR		459
+20
P16871-2	Uncharacterized protein		PANPA		261	UniRef90_P16871-2
Uncharacterized protein		NOMLE		261
IL7R isoform 6		PONAB		261
IL7R isoform 7		PANTR		261
Interleukin-7 receptor subunit alpha		HUMAN		261
+7
P16871-3	Isoform 3 of Interleukin-7 receptor subunit alpha		HUMAN		298	UniRef90_P16871-2
Uncharacterized protein		PANPA		261
Uncharacterized protein		NOMLE		261
IL7R isoform 6		PONAB		261
IL7R isoform 7		PANTR		261
+7
P16871-4	Isoform 3 of Interleukin-7 receptor subunit alpha		HUMAN		298	UniRef90_P16871-2
Uncharacterized protein		PANPA		261
Uncharacterized protein		NOMLE		261
IL7R isoform 6		PONAB		261
IL7R isoform 7		PANTR		261
+7

Protein	Similar proteins		Species	Score	Length	Source
P16871	Interleukin-7 receptor subunit alpha		MACFA		459	UniRef50_P16871
Interleukin-7 receptor subunit alpha	)	MOUSE		459
Interleukin-7 receptor subunit alpha		HORSE		458
Interleukin-7 receptor subunit alpha		CALJA		459
Interleukin-7 receptor subunit alpha (Fragment)		HUMAN		52
+163
P16871-2	IL7R isoform 7		PANTR		261	UniRef50_P16871-2
Interleukin-7 receptor subunit alpha		HUMAN		261
IL7R isoform 6		PONAB		261
Uncharacterized protein		NOMLE		261
Uncharacterized protein		PANPA		261
+29
P16871-3	Isoform 3 of Interleukin-7 receptor subunit alpha		HUMAN		298	UniRef50_P16871-2
IL7R isoform 7		PANTR		261
IL7R isoform 6		PONAB		261
Uncharacterized protein		NOMLE		261
Uncharacterized protein		PANPA		261
+29
P16871-4	Isoform 3 of Interleukin-7 receptor subunit alpha		HUMAN		298	UniRef50_P16871-2
IL7R isoform 7		PANTR		261
IL7R isoform 6		PONAB		261
Uncharacterized protein		NOMLE		261
Uncharacterized protein		PANPA		261
+29

Cross-referencesⁱ

Web resourcesⁱ

IL7Rbase

IL7R mutation db

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29696 mRNA Translation: AAA59157.1 AF043129 AF043128 Genomic DNA Translation: AAC83204.1 AK301220 mRNA Translation: BAG62793.1 AK315251 mRNA Translation: BAG37673.1 AY449709 Genomic DNA Translation: AAR08908.1 AC112204 Genomic DNA No translation available. BC020717 mRNA Translation: AAH20717.1 Sequence problems. BC067537 mRNA Translation: AAH67537.1 BC067538 mRNA Translation: AAH67538.1 BC067539 mRNA Translation: AAH67539.1 BC067540 mRNA Translation: AAH67540.1 BC069999 mRNA Translation: AAH69999.1
CCDSⁱ	CCDS3911.1 [P16871-1]
PIRⁱ	A34791 B34791 C34791
RefSeqⁱ	NP_002176.2, NM_002185.3 [P16871-1]
UniGeneⁱ	Hs.591742

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3DI2	X-ray	2.70	B/D	21-239	[»]
	3DI3	X-ray	2.90	B	21-239	[»]
	3UP1	X-ray	2.15	A/B	21-239	[»]
	5J11	X-ray	2.56	B	21-236	[»]
ProteinModelPortalⁱ	P16871
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109789, 122 interactors
DIPⁱ	DIP-3045N
ELMⁱ	P16871
IntActⁱ	P16871, 9 interactors
STRINGⁱ	9606.ENSP00000306157

Chemistry databases

GuidetoPHARMACOLOGYⁱ	1698

GuidetoPHARMACOLOGYⁱ

1698

PTM databases

iPTMnetⁱ	P16871
PhosphoSitePlusⁱ	P16871

Polymorphism and mutation databases

BioMutaⁱ	IL7R
DMDMⁱ	215274000

Proteomic databases

MaxQBⁱ	P16871
PaxDbⁱ	P16871
PeptideAtlasⁱ	P16871
PRIDEⁱ	P16871
ProteomicsDBⁱ	53396 53397 [P16871-2] 53398 [P16871-3] 53399 [P16871-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3575
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303115; ENSP00000306157; ENSG00000168685 [P16871-1] ENST00000506850; ENSP00000421207; ENSG00000168685 [P16871-3]
GeneIDⁱ	3575
KEGGⁱ	hsa:3575
UCSCⁱ	uc003jjs.5 human [P16871-1]

Organism-specific databases

CTDⁱ	3575
DisGeNETⁱ	3575
EuPathDBⁱ	HostDB:ENSG00000168685.14
GeneCardsⁱ	IL7R
H-InvDBⁱ	HIX0024815
HGNCⁱ	HGNC:6024 IL7R
HPAⁱ	CAB010215
MalaCardsⁱ	IL7R
MIMⁱ	146661 gene 608971 phenotype 612595 phenotype
neXtProtⁱ	NX_P16871
OpenTargetsⁱ	ENSG00000168685
Orphanetⁱ	39041 Omenn syndrome 169154 T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency
PharmGKBⁱ	PA29840
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGXR Eukaryota ENOG410YWZG LUCA
GeneTreeⁱ	ENSGT00510000048500
HOVERGENⁱ	HBG055773
InParanoidⁱ	P16871
KOⁱ	K05072
OrthoDBⁱ	EOG091G0N4J
PhylomeDBⁱ	P16871
TreeFamⁱ	TF336573

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1266695 Interleukin-7 signaling R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	P16871
SIGNORⁱ	P16871

Miscellaneous databases

ChiTaRSⁱ	IL7R human
EvolutionaryTraceⁱ	P16871
GeneWikiⁱ	Interleukin-7_receptor-%CE%B1
GenomeRNAiⁱ	3575
Protein Ontology More...PROⁱ	PR:P16871
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168685 Expressed in 157 organ(s), highest expression level in blood
CleanExⁱ	HS_IL7R
ExpressionAtlasⁱ	P16871 baseline and differential
Genevisibleⁱ	P16871 HS

Family and domain databases

CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003531 Hempt_rcpt_S_F1_CS IPR013783 Ig-like_fold
Pfamⁱ	View protein in Pfam PF00041 fn3, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit PS01355 HEMATOPO_REC_S_F1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL7RA_HUMAN
Accessionⁱ	P16871Primary (citable) accession number: P16871 Secondary accession number(s): B2RCS6 Q9UPC1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	September 12, 2018
	Last modified:	November 7, 2018
	This is version 192 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P16871 (IL7RA_HUMAN)

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Interleukin-7 receptor subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ