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UniProtKB - P16869 (FHUE_ECOLI)
Protein
FhuE receptor
Gene
fhuE
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the uptake of Fe3+ via coprogen, ferrioxamine B, and rhodotorulic acid.
GO - Molecular functioni
- siderophore uptake transmembrane transporter activity Source: GO_Central
- signaling receptor activity Source: InterPro
GO - Biological processi
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10306-MONOMER |
Protein family/group databases
TCDBi | 1.B.14.1.1, the outer membrane receptor (omr) family |
Names & Taxonomyi
Protein namesi | Recommended name: FhuE receptorAlternative name(s): Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid |
Gene namesi | Name:fhuE Ordered Locus Names:b1102, JW1088 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- cell outer membrane Source: EcoCyc
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Cell outer membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 44 | V → P: Abolishes transport activity. 1 Publication | 1 | |
Mutagenesisi | 46 | V → P: Abolishes transport activity. 1 Publication | 1 | |
Mutagenesisi | 163 | G → A, V, N, D or H: Impaired transport and growth. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | 1 PublicationAdd BLAST | 36 | |
ChainiPRO_0000034749 | 37 – 729 | FhuE receptorAdd BLAST | 693 |
Proteomic databases
PaxDbi | P16869 |
PRIDEi | P16869 |
Expressioni
Inductioni
For induction, the TonB and the ExbB proteins have to be active. Induced by hydroxyurea (PubMed:20005847).1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260942, 181 interactors |
ComplexPortali | CPX-3579, Ferric-coprogen outer membrane transporter complex |
STRINGi | 511145.b1102 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P16869 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 72 | DisorderedSequence analysisAdd BLAST | 25 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 42 – 49 | TonB box | 8 | |
Motifi | 712 – 729 | TonB C-terminal boxAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 72 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the TonB-dependent receptor family.Curated
Keywords - Domaini
Signal, TonB box, Transmembrane, Transmembrane beta strandPhylogenomic databases
eggNOGi | COG4773, Bacteria |
HOGENOMi | CLU_008287_9_3_6 |
InParanoidi | P16869 |
PhylomeDBi | P16869 |
Family and domain databases
Gene3Di | 2.170.130.10, 1 hit 2.40.170.20, 1 hit |
InterProi | View protein in InterPro IPR012910, Plug_dom IPR037066, Plug_dom_sf IPR039423, TonB-dep_rcpt IPR000531, TonB-dep_rcpt_b-brl IPR010916, TonB_box_CS IPR036942, TonB_rcpt_b-brl_sf IPR010917, TonB_rcpt_CS IPR010105, TonB_sidphr_rcpt |
PANTHERi | PTHR32552, PTHR32552, 1 hit |
Pfami | View protein in Pfam PF07715, Plug, 1 hit PF00593, TonB_dep_Rec, 1 hit |
TIGRFAMsi | TIGR01783, TonB-siderophor, 1 hit |
PROSITEi | View protein in PROSITE PS00430, TONB_DEPENDENT_REC_1, 1 hit PS01156, TONB_DEPENDENT_REC_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P16869-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSTQFNRDN QYQAITKPSL LAGCIALALL PSAAFAAPAT EETVIVEGSA
60 70 80 90 100
TAPDDGENDY SVTSTSAGTK MQMTQRDIPQ SVTIVSQQRM EDQQLQTLGE
110 120 130 140 150
VMENTLGISK SQADSDRALY YSRGFQIDNY MVDGIPTYFE SRWNLGDALS
160 170 180 190 200
DMALFERVEV VRGATGLMTG TGNPSAAINM VRKHATSREF KGDVSAEYGS
210 220 230 240 250
WNKERYVADL QSPLTEDGKI RARIVGGYQN NDSWLDRYNS EKTFFSGIVD
260 270 280 290 300
ADLGDLTTLS AGYEYQRIDV NSPTWGGLPR WNTDGSSNSY DRARSTAPDW
310 320 330 340 350
AYNDKEINKV FMTLKQQFAD TWQATLNATH SEVEFDSKMM YVDAYVNKAD
360 370 380 390 400
GMLVGPYSNY GPGFDYVGGT GWNSGKRKVD ALDLFADGSY ELFGRQHNLM
410 420 430 440 450
FGGSYSKQNN RYFSSWANIF PDEIGSFYNF NGNFPQTDWS PQSLAQDDTT
460 470 480 490 500
HMKSLYAATR VTLADPLHLI LGARYTNWRV DTLTYSMEKN HTTPYAGLVF
510 520 530 540 550
DINDNWSTYA SYTSIFQPQN DRDSSGKYLA PITGNNYELG LKSDWMNSRL
560 570 580 590 600
TTTLAIFRIE QDNVAQSTGT PIPGSNGETA YKAVDGTVSK GVEFELNGAI
610 620 630 640 650
TDNWQLTFGA TRYIAEDNEG NAVNPNLPRT TVKMFTSYRL PVMPELTVGG
660 670 680 690 700
GVNWQNRVYT DTVTPYGTFR AEQGSYALVD LFTRYQVTKN FSLQGNVNNL
710 720
FDKTYDTNVE GSIVYGTPRN FSITGTYQF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 363 | G → C in CAA35616 (PubMed:2162465).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17615 Genomic DNA Translation: CAA35616.1 U00096 Genomic DNA Translation: AAC74186.1 AP009048 Genomic DNA Translation: BAA35909.1 |
PIRi | C64854 |
RefSeqi | NP_415620.1, NC_000913.3 WP_000953441.1, NZ_SSZK01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC74186; AAC74186; b1102 BAA35909; BAA35909; BAA35909 |
GeneIDi | 945649 |
KEGGi | ecj:JW1088 eco:b1102 |
PATRICi | fig|1411691.4.peg.1166 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17615 Genomic DNA Translation: CAA35616.1 U00096 Genomic DNA Translation: AAC74186.1 AP009048 Genomic DNA Translation: BAA35909.1 |
PIRi | C64854 |
RefSeqi | NP_415620.1, NC_000913.3 WP_000953441.1, NZ_SSZK01000019.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6E4V | X-ray | 2.00 | A | 37-729 | [»] | |
SMRi | P16869 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260942, 181 interactors |
ComplexPortali | CPX-3579, Ferric-coprogen outer membrane transporter complex |
STRINGi | 511145.b1102 |
Protein family/group databases
TCDBi | 1.B.14.1.1, the outer membrane receptor (omr) family |
Proteomic databases
PaxDbi | P16869 |
PRIDEi | P16869 |
Genome annotation databases
EnsemblBacteriai | AAC74186; AAC74186; b1102 BAA35909; BAA35909; BAA35909 |
GeneIDi | 945649 |
KEGGi | ecj:JW1088 eco:b1102 |
PATRICi | fig|1411691.4.peg.1166 |
Organism-specific databases
EchoBASEi | EB0302 |
Phylogenomic databases
eggNOGi | COG4773, Bacteria |
HOGENOMi | CLU_008287_9_3_6 |
InParanoidi | P16869 |
PhylomeDBi | P16869 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10306-MONOMER |
Miscellaneous databases
PROi | PR:P16869 |
Family and domain databases
Gene3Di | 2.170.130.10, 1 hit 2.40.170.20, 1 hit |
InterProi | View protein in InterPro IPR012910, Plug_dom IPR037066, Plug_dom_sf IPR039423, TonB-dep_rcpt IPR000531, TonB-dep_rcpt_b-brl IPR010916, TonB_box_CS IPR036942, TonB_rcpt_b-brl_sf IPR010917, TonB_rcpt_CS IPR010105, TonB_sidphr_rcpt |
PANTHERi | PTHR32552, PTHR32552, 1 hit |
Pfami | View protein in Pfam PF07715, Plug, 1 hit PF00593, TonB_dep_Rec, 1 hit |
TIGRFAMsi | TIGR01783, TonB-siderophor, 1 hit |
PROSITEi | View protein in PROSITE PS00430, TONB_DEPENDENT_REC_1, 1 hit PS01156, TONB_DEPENDENT_REC_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FHUE_ECOLI | |
Accessioni | P16869Primary (citable) accession number: P16869 Secondary accession number(s): P77292 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families