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UniProtKB - P16869 (FHUE_ECOLI)

Protein

FhuE receptor

Gene

fhuE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the uptake of Fe3+ via coprogen, ferrioxamine B, and rhodotorulic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • iron ion binding Source: InterPro
  • siderophore uptake transmembrane transporter activity Source: GO_Central
  • signaling receptor activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG10306-MONOMER
MetaCyc:EG10306-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		1.B.14.1.1 the outer membrane receptor (omr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FhuE receptor
Alternative name(s):
Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fhuE
Ordered Locus Names:b1102, JW1088
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...EcoGenei		EG10306 fhuE

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi44V → P: Abolishes transport activity. 1 Publication1
Mutagenesisi46V → P: Abolishes transport activity. 1 Publication1
Mutagenesisi163G → A, V, N, D or H: Impaired transport and growth. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 361 PublicationAdd BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003474937 – 729FhuE receptorAdd BLAST693

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P16869

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16869

PRoteomics IDEntifications database

More...PRIDEi		P16869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

For induction, the TonB and the ExbB proteins have to be active. Induced by hydroxyurea (PubMed:20005847).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4260942, 181 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3579 Ferric-coprogen outer membrane transporter complex

STRING: functional protein association networks

More...STRINGi		316385.ECDH10B_1174

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P16869

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16869

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi42 – 49TonB box8
Motifi712 – 729TonB C-terminal boxAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105CNM Bacteria
COG4773 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000217242

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16869

KEGG Orthology (KO)

More...KOi		K16088

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16869

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.170.130.10, 1 hit
2.40.170.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR039423 TonB-dep_rcpt
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR036942 TonB_rcpt_b-brl_sf
IPR010917 TonB_rcpt_CS
IPR010105 TonB_sidphr_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR32552 PTHR32552, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01783 TonB-siderophor, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit
PS01156 TONB_DEPENDENT_REC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P16869-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSTQFNRDN QYQAITKPSL LAGCIALALL PSAAFAAPAT EETVIVEGSA 
        60         70         80         90        100
TAPDDGENDY SVTSTSAGTK MQMTQRDIPQ SVTIVSQQRM EDQQLQTLGE 
       110        120        130        140        150
VMENTLGISK SQADSDRALY YSRGFQIDNY MVDGIPTYFE SRWNLGDALS 
       160        170        180        190        200
DMALFERVEV VRGATGLMTG TGNPSAAINM VRKHATSREF KGDVSAEYGS 
       210        220        230        240        250
WNKERYVADL QSPLTEDGKI RARIVGGYQN NDSWLDRYNS EKTFFSGIVD 
       260        270        280        290        300
ADLGDLTTLS AGYEYQRIDV NSPTWGGLPR WNTDGSSNSY DRARSTAPDW 
       310        320        330        340        350
AYNDKEINKV FMTLKQQFAD TWQATLNATH SEVEFDSKMM YVDAYVNKAD 
       360        370        380        390        400
GMLVGPYSNY GPGFDYVGGT GWNSGKRKVD ALDLFADGSY ELFGRQHNLM 
       410        420        430        440        450
FGGSYSKQNN RYFSSWANIF PDEIGSFYNF NGNFPQTDWS PQSLAQDDTT 
       460        470        480        490        500
HMKSLYAATR VTLADPLHLI LGARYTNWRV DTLTYSMEKN HTTPYAGLVF 
       510        520        530        540        550
DINDNWSTYA SYTSIFQPQN DRDSSGKYLA PITGNNYELG LKSDWMNSRL 
       560        570        580        590        600
TTTLAIFRIE QDNVAQSTGT PIPGSNGETA YKAVDGTVSK GVEFELNGAI 
       610        620        630        640        650
TDNWQLTFGA TRYIAEDNEG NAVNPNLPRT TVKMFTSYRL PVMPELTVGG 
       660        670        680        690        700
GVNWQNRVYT DTVTPYGTFR AEQGSYALVD LFTRYQVTKN FSLQGNVNNL 
       710        720 
FDKTYDTNVE GSIVYGTPRN FSITGTYQF
Length:729
Mass (Da):81,233
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68ACEE7D110F76CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti363G → C in CAA35616 (PubMed:2162465).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X17615 Genomic DNA Translation: CAA35616.1
U00096 Genomic DNA Translation: AAC74186.1
AP009048 Genomic DNA Translation: BAA35909.1

Protein sequence database of the Protein Information Resource

More...PIRi		C64854

NCBI Reference Sequences

More...RefSeqi		NP_415620.1, NC_000913.3
WP_000953441.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74186; AAC74186; b1102
BAA35909; BAA35909; BAA35909

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1088
eco:b1102

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1166

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17615 Genomic DNA Translation: CAA35616.1
U00096 Genomic DNA Translation: AAC74186.1
AP009048 Genomic DNA Translation: BAA35909.1
PIRiC64854
RefSeqiNP_415620.1, NC_000913.3
WP_000953441.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP16869
SMRiP16869
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260942, 181 interactors
ComplexPortaliCPX-3579 Ferric-coprogen outer membrane transporter complex
STRINGi316385.ECDH10B_1174

Protein family/group databases

TCDBi1.B.14.1.1 the outer membrane receptor (omr) family

Proteomic databases

EPDiP16869
PaxDbiP16869
PRIDEiP16869

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74186; AAC74186; b1102
BAA35909; BAA35909; BAA35909
GeneIDi945649
KEGGiecj:JW1088
eco:b1102
PATRICifig|1411691.4.peg.1166

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0302
EcoGeneiEG10306 fhuE

Phylogenomic databases

eggNOGiENOG4105CNM Bacteria
COG4773 LUCA
HOGENOMiHOG000217242
InParanoidiP16869
KOiK16088
PhylomeDBiP16869

Enzyme and pathway databases

BioCyciEcoCyc:EG10306-MONOMER
MetaCyc:EG10306-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P16869

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR039423 TonB-dep_rcpt
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR036942 TonB_rcpt_b-brl_sf
IPR010917 TonB_rcpt_CS
IPR010105 TonB_sidphr_rcpt
PANTHERiPTHR32552 PTHR32552, 1 hit
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01783 TonB-siderophor, 1 hit
PROSITEiView protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit
PS01156 TONB_DEPENDENT_REC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHUE_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16869
Secondary accession number(s): P77292
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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