UniProtKB - P16863 (CXA1_XENLA)
Protein
Gap junction alpha-1 protein
Gene
gja1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles.By similarity
GO - Molecular functioni
- gap junction hemi-channel activity Source: UniProtKB
GO - Biological processi
- cell-cell signaling Source: InterPro
- heart development Source: InterPro
- microtubule-based transport Source: UniProtKB
- neural crest cell migration Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction alpha-1 proteinAlternative name(s): Connexin-43 Short name: Cx43 |
Gene namesi | Name:gja1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-876609, gja1.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- gap junction By similarity
Note: Localizes at the intercalated disk (ICD) in cardiomyocytes and proper localization at ICD is dependent on TMEM65.By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- connexin complex Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- intercalated disc Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 23 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 24 – 44 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 76 | ExtracellularBy similarityAdd BLAST | 32 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 163 | CytoplasmicBy similarityAdd BLAST | 66 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 207 | ExtracellularBy similarityAdd BLAST | 23 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 379 | CytoplasmicBy similarityAdd BLAST | 151 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000057806 | 2 – 379 | Gap junction alpha-1 proteinAdd BLAST | 378 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 192 | By similarity | ||
Disulfide bondi | 187 ↔ 198 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed in most tissues. Highest levels found in eye and brain.
Developmental stagei
Appears during organogenesis.
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Interacts with TMEM65.
By similarityFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | LVIQWYM |
OrthoDBi | 823525at2759 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit 1.20.5.1130, 1 hit |
InterProi | View protein in InterPro IPR035091, Alpha_helix_dom_sf IPR000500, Connexin IPR002261, Connexin43 IPR013124, Connexin43_C IPR034634, Connexin_C IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF33, PTHR11984:SF33, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit PF03508, Connexin43, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01132, CONNEXINA1 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
SUPFAMi | SSF118220, SSF118220, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P16863-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDWSALGRL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS
60 70 80 90 100
AFVCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSTPTL LYLAHVFYLM
110 120 130 140 150
RKEEKLNRKE EELKMVQNEG GNVDMHLKQI EIKKFKYGLE EHGKVKMRGG
160 170 180 190 200
LLRTYIISIL FKSVFEVGFI IIQWYMYGFS LSAIYTCKRD PCPHQVDCFL
210 220 230 240 250
SRPTEKTIFI WFMLIVSIVS LALNIIELFY VTYKSIKDGI KGKKDPFSAT
260 270 280 290 300
NDAVISGKEC GSPKYAYFNG CSSPTAPMSP PGYKLVTGER NPSSCRNYNK
310 320 330 340 350
QASEQNWANY SAEQNRMGQA GSTISNTHAQ PFDFSDEHQN TKKMAPGHEM
360 370
QPLTILDQRP SSRASSHASS RPRPDDLEI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17243 mRNA Translation: CAA35108.1 BC073407 mRNA Translation: AAH73407.1 |
PIRi | A34575 |
RefSeqi | NP_001079129.1, NM_001085660.1 XP_018117108.1, XM_018261619.1 |
Genome annotation databases
GeneIDi | 373664 |
KEGGi | xla:373664 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17243 mRNA Translation: CAA35108.1 BC073407 mRNA Translation: AAH73407.1 |
PIRi | A34575 |
RefSeqi | NP_001079129.1, NM_001085660.1 XP_018117108.1, XM_018261619.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 373664 |
KEGGi | xla:373664 |
Organism-specific databases
CTDi | 373664 |
Xenbasei | XB-GENE-876609, gja1.L |
Phylogenomic databases
OMAi | LVIQWYM |
OrthoDBi | 823525at2759 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit 1.20.5.1130, 1 hit |
InterProi | View protein in InterPro IPR035091, Alpha_helix_dom_sf IPR000500, Connexin IPR002261, Connexin43 IPR013124, Connexin43_C IPR034634, Connexin_C IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF33, PTHR11984:SF33, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit PF03508, Connexin43, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01132, CONNEXINA1 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
SUPFAMi | SSF118220, SSF118220, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXA1_XENLA | |
Accessioni | P16863Primary (citable) accession number: P16863 Secondary accession number(s): Q6GNU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |