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UniProtKB - P16860 (ANFB_HUMAN)

Entry version 202 (23 Feb 2022)
Sequence version 1 (01 Aug 1990)
Previous versions | rss
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Protein

Natriuretic peptides B

Gene

NPPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:9458824, PubMed:1672777, PubMed:1914098, PubMed:17372040).

May also function as a paracrine antifibrotic factor in the heart (By similarity).

Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:9458824, PubMed:1672777, PubMed:17372040, PubMed:21098034, PubMed:17349887, PubMed:25339504).

Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:9458824, PubMed:1914098).

Binds the clearance receptor NPR3 (PubMed:16870210).

By similarity8 Publications

May affect cardio-renal homeostasis (PubMed:17372040).

Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040).

1 Publication

May have a role in cardio-renal homeostasis (PubMed:17372040).

Able to promote the production of cGMP (PubMed:17372040).

1 Publication

Miscellaneous

Plasma levels of natriuretic peptides B, brain natriuretic peptide 32 and NT-proBNP are widely used for screening and diagnosis of heart failure (HF), as these markers are typically higher in patients with severe HF.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • diuretic hormone activity Source: UniProtKB
  • hormone activity Source: GO_Central
  • hormone receptor binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Vasoactive, Vasodilator

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16860

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P16860

SIGNOR Signaling Network Open Resource

More...SIGNORi		P16860

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Natriuretic peptides B
Alternative name(s):
Brain natriuretic factor prohormone1 Publication
Short name:
preproBNPBy similarity
Short name:
proBNP1 Publication
Gamma-brain natriuretic peptideBy similarity
Iso-ANPBy similarity
Cleaved into the following 18 chains:
NT-proBNP1 Publication
Alternative name(s):
NT-pro-BNP1 Publication
NT-proBNP(1-76)1 Publication
proBNP(3-108)1 Publication
Brain natriuretic peptide 32Curated
Short name:
BNP(1-32)Curated
Short name:
BNP-32Curated
Alternative name(s):
Brain natriuretic peptide1 Publication
Short name:
BNP1 Publication
BNP(1-30)
BNP(1-29)
BNP(1-28)
BNP(2-31)
BNP(3-32)1 Publication
Alternative name(s):
des-SerPro-BNP1 Publication
proBNP(79-108)1 Publication
BNP(3-30)
BNP(3-29)
Brain natriuretic peptide 29By similarity
Short name:
BNP(4-32)1 Publication
BNP(4-31)
BNP(4-30)
BNP(4-29)
BNP(4-27)
BNP(5-32)
BNP(5-31)
BNP(5-29)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPPB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7940, NPPB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600295, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16860

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120937

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the name Nesiritide (Scios). Used for the treatment of heart failure.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi97T → A: Prevents O-glycosylation at this residue. Decreased extracellular levels of NPPB due to decreased stability after secretion whereas extracellular levels of brain natriuretic peptide 32 is increased. In HEK293 cells, proteolytic processing by CORIN or FURIN is reduced but in HL1 cells proteolytic processing is not affected. 2 Publications1
Mutagenesisi99R → A: Loss of FURIN-mediated proteolytic processing in HEK293 cells, however processing in HL1 cells, likely mediated by CORIN, is only slightly reduced. Loss of CORIN-mediated processing in HL1 cells; when associated with A-102 and A-105. 1 Publication1
Mutagenesisi102R → A: Loss of FURIN-mediated proteolytic processing in HEK293 cells, however processing in HL1 cells, likely mediated by CORIN, is only slightly reduced. Loss of CORIN-mediated processing in HL1 cells; when associated with A-99 and A-105. 1 Publication1
Mutagenesisi105K → A: No effect on proteolytic processing in HEK293 or HL1 cells. Loss of CORIN-mediated processing in HL1 cells; when associated with A-99 and A-102. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4879

Open Targets

More...OpenTargetsi		ENSG00000120937

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31734

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16860, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01136, Carvedilol
DB06412, Oxymetholone

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NPPB

Domain mapping of disease mutations (DMDM)

More...DMDMi		113836

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000153127 – 134Natriuretic peptides BAdd BLAST108
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000045193927 – 102NT-proBNP1 PublicationAdd BLAST76
PeptideiPRO_000045194029 – 134proBNP(3-108)1 PublicationAdd BLAST106
PeptideiPRO_0000001532103 – 134Brain natriuretic peptide 322 PublicationsAdd BLAST32
PeptideiPRO_0000364993103 – 132BNP(1-30)Add BLAST30
PeptideiPRO_0000364994103 – 131BNP(1-29)Add BLAST29
PeptideiPRO_0000364995103 – 130BNP(1-28)Add BLAST28
PeptideiPRO_0000364996104 – 133BNP(2-31)Add BLAST30
PeptideiPRO_0000364997105 – 134BNP(3-32)1 PublicationAdd BLAST30
PeptideiPRO_0000364998105 – 132BNP(3-30)Add BLAST28
PeptideiPRO_0000364999105 – 131BNP(3-29)Add BLAST27
PeptideiPRO_0000365000106 – 134Brain natriuretic peptide 29Add BLAST29
PeptideiPRO_0000365001106 – 133BNP(4-31)Add BLAST28
PeptideiPRO_0000365002106 – 132BNP(4-30)Add BLAST27
PeptideiPRO_0000365003106 – 131BNP(4-29)Add BLAST26
PeptideiPRO_0000365004106 – 129BNP(4-27)Add BLAST24
PeptideiPRO_0000365005107 – 134BNP(5-32)Add BLAST28
PeptideiPRO_0000365006107 – 133BNP(5-31)Add BLAST27
PeptideiPRO_0000365007107 – 131BNP(5-29)Add BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi62O-linked (HexNAc...) threonine; Partial1 Publication1
Glycosylationi63O-linked (HexNAc...) serine1 Publication1
Glycosylationi70O-linked (HexNAc...) serine1 Publication1
Glycosylationi74O-linked (HexNAc...) threonine1 Publication1
Glycosylationi79O-linked (HexNAc...) serine1 Publication1
Glycosylationi84O-linked (HexNAc...) threonine; Partial1 Publication1
Glycosylationi97O-linked (HexNAc...) threonine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi112 ↔ 1281 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-102 to produce brain natriuretic peptide 32 and NT-proBNP (PubMed:21314817, PubMed:10880574, PubMed:21763278, PubMed:20489134, PubMed:21482747). This likely occurs after it has been secreted into the blood, either during circulation or in the target cells (PubMed:21482747). CORIN also cleaves the precursor molecule at additional residues including Arg-99 and possibly Lys-105 (PubMed:20489134, PubMed:21763278). In patients with heart failure, processing and degradation of natriuretic peptides B occurs but is delayed, possibly due to a decrease in enzyme level or activity of CORIN and DPP4 (PubMed:25339504).6 Publications
Undergoes further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (PubMed:16254193, PubMed:19808300, PubMed:21314817, PubMed:21098034). Cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817). Degraded by IDE (PubMed:21098034). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (PubMed:21098034).4 Publications
O-glycosylated on at least seven residues (PubMed:20489134, PubMed:21763278, PubMed:16750161, PubMed:17349887, PubMed:21482747). In cardiomyocytes, glycosylation at Thr-97 is essential for the stability and processing of the extracellular natriuretic peptides B (PubMed:21482747). Glycosylation, especially at Thr-97, may also be important for brain natriuretic peptide 32 stability and/or extracellular distribution (PubMed:21763278). Glycosylation at Thr-97 appears to inhibit FURIN- or CORIN-mediated proteolytic processing, at least in HEK293 cells (PubMed:20489134, PubMed:21763278).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei99 – 100Cleavage; by CORIN1 Publication2
Sitei102 – 103Cleavage; by FURIN or CORIN2 Publications2
Sitei104 – 105Cleavage; by FAP1 Publication2
Sitei105 – 106Cleavage; by CORIN2 Publications2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16860

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16860

PeptideAtlas

More...PeptideAtlasi		P16860

PRoteomics IDEntifications database

More...PRIDEi		P16860

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53393

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16860, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16860

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16860

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the cardiac atria (at protein level) (PubMed:2138890, PubMed:2136732). Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120937, Expressed in right atrium auricular region and 106 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16860, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120937, Tissue enriched (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110939, 26 interactors

Protein interaction database and analysis system

More...IntActi		P16860, 10 interactors

Molecular INTeraction database

More...MINTi		P16860

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365651

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16860, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16860

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16860

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SD0X, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_158067_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16860

Identification of Orthologs from Complete Genome Data

More...OMAi		PTGVWKA

Database of Orthologous Groups

More...OrthoDBi		1493586at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16860

TreeFam database of animal gene trees

More...TreeFami		TF106304

Family and domain databases

Database of protein disorder

More...DisProti		DP00551

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000663, Natr_peptide
IPR030480, Natr_peptide_CS
IPR002408, Natriuretic_peptide_brain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00212, ANP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00712, BNATPEPTIDE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00183, NAT_PEP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00263, NATRIURETIC_PEPTIDE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P16860-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL 
        60         70         80         90        100
QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA 
       110        120        130 
PRSPKMVQGS GCFGRKMDRI SSSSGLGCKV LRRH
Length:134
Mass (Da):14,726
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC884D9408462146
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90441 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01458025R → L. Corresponds to variant dbSNP:rs5227EnsemblClinVar.1
Natural variantiVAR_01458147R → H. Corresponds to variant dbSNP:rs5229Ensembl.1
Natural variantiVAR_01458293M → L. Corresponds to variant dbSNP:rs5230Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M31776 Genomic DNA Translation: AAA35603.1
M25296 mRNA Translation: AAA36355.1
AB037521 Genomic DNA Translation: BAA90441.1 Frameshift.
CR541976 mRNA Translation: CAG46774.1
CR542003 mRNA Translation: CAG46800.1
EU326309 Genomic DNA Translation: ACA05917.1
AL021155 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71718.1
BC025785 mRNA Translation: AAH25785.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS140.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36736, AWHUB

NCBI Reference Sequences

More...RefSeqi		NP_002512.1, NM_002521.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376468; ENSP00000365651; ENSG00000120937

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4879

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4879

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376468.4; ENSP00000365651.3; NM_002521.3; NP_002512.1

UCSC genome browser

More...UCSCi		uc001atj.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Brain natriuretic peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31776 Genomic DNA Translation: AAA35603.1
M25296 mRNA Translation: AAA36355.1
AB037521 Genomic DNA Translation: BAA90441.1 Frameshift.
CR541976 mRNA Translation: CAG46774.1
CR542003 mRNA Translation: CAG46800.1
EU326309 Genomic DNA Translation: ACA05917.1
AL021155 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71718.1
BC025785 mRNA Translation: AAH25785.1
CCDSiCCDS140.1
PIRiA36736, AWHUB
RefSeqiNP_002512.1, NM_002521.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YK1X-ray2.90E111-131[»]
3N56X-ray3.10C/D103-134[»]
SMRiP16860
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110939, 26 interactors
IntActiP16860, 10 interactors
MINTiP16860
STRINGi9606.ENSP00000365651

Chemistry databases

DrugBankiDB01136, Carvedilol
DB06412, Oxymetholone

PTM databases

GlyGeniP16860, 7 sites
iPTMnetiP16860
PhosphoSitePlusiP16860

Genetic variation databases

BioMutaiNPPB
DMDMi113836

Proteomic databases

MassIVEiP16860
PaxDbiP16860
PeptideAtlasiP16860
PRIDEiP16860
ProteomicsDBi53393

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P16860, 9 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13918, 1539 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		4879

Genome annotation databases

EnsembliENST00000376468; ENSP00000365651; ENSG00000120937
GeneIDi4879
KEGGihsa:4879
MANE-SelectiENST00000376468.4; ENSP00000365651.3; NM_002521.3; NP_002512.1
UCSCiuc001atj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4879
DisGeNETi4879

GeneCards: human genes, protein and diseases

More...GeneCardsi		NPPB
HGNCiHGNC:7940, NPPB
HPAiENSG00000120937, Tissue enriched (heart)
MIMi600295, gene
neXtProtiNX_P16860
OpenTargetsiENSG00000120937
PharmGKBiPA31734
VEuPathDBiHostDB:ENSG00000120937

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SD0X, Eukaryota
GeneTreeiENSGT00940000154513
HOGENOMiCLU_158067_0_0_1
InParanoidiP16860
OMAiPTGVWKA
OrthoDBi1493586at2759
PhylomeDBiP16860
TreeFamiTF106304

Enzyme and pathway databases

PathwayCommonsiP16860
SignaLinkiP16860
SIGNORiP16860

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4879, 10 hits in 1039 CRISPR screens
EvolutionaryTraceiP16860

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Brain_natriuretic_peptide

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4879
PharosiP16860, Tbio

Protein Ontology

More...PROi		PR:P16860
RNActiP16860, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120937, Expressed in right atrium auricular region and 106 other tissues
GenevisibleiP16860, HS

Family and domain databases

DisProtiDP00551
InterProiView protein in InterPro
IPR000663, Natr_peptide
IPR030480, Natr_peptide_CS
IPR002408, Natriuretic_peptide_brain
PfamiView protein in Pfam
PF00212, ANP, 1 hit
PRINTSiPR00712, BNATPEPTIDE
SMARTiView protein in SMART
SM00183, NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263, NATRIURETIC_PEPTIDE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANFB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16860
Secondary accession number(s): B0ZBE9, Q6FGY0, Q9P2Q7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 23, 2022
This is version 202 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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