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Protein

G-protein coupled receptor homolog UL33

Gene

UL33

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein-coupled receptor (vGPCR) that constitutively activates multiple signaling pathways in a ligand independent manner. For example, promotes phospholipase C and cAMP-responsive element (CRE) pathway activation. Therefore, greatly contributes to viral pathogenesis. Inhibits US28-mediated NF-kappa-B activation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processHost-virus interaction, Inhibition of host chemokines by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor homolog UL33
Short name:
vGPCR UL33
Gene namesi
Name:UL33
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29Virion surfaceSequence analysisAdd BLAST29
Transmembranei30 – 54Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini55 – 70IntravirionSequence analysisAdd BLAST16
Transmembranei71 – 95Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini96 – 102Virion surfaceSequence analysis7
Transmembranei103 – 129Helical; Name=3Sequence analysisAdd BLAST27
Topological domaini130 – 138IntravirionSequence analysis9
Transmembranei139 – 160Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini161 – 203Virion surfaceSequence analysisAdd BLAST43
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 240IntravirionSequence analysisAdd BLAST16
Transmembranei241 – 267Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini268 – 281Virion surfaceSequence analysisAdd BLAST14
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 412IntravirionSequence analysisAdd BLAST107

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702401 – 412G-protein coupled receptor homolog UL33Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Disulfide bondi104 ↔ 188PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP16849

Interactioni

Subunit structurei

Heterodimerizes with US28.

Structurei

3D structure databases

ProteinModelPortaliP16849
SMRiP16849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NY

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P16849-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTIIHNSTR NNTPPHINDT CNMTGPLFAI RTTEAVLNTF IIFVGGPLNA
60 70 80 90 100
IVLITQLLTN RVLGYSTPTI YMTNLYSTNF LTLTVLPFIV LSNQWLLPAG
110 120 130 140 150
VASCKFLSVI YYSSCTVGFA TVALIAADRY RVLHKRTYAR QSYRSTYMIL
160 170 180 190 200
LLTWLAGLIF SVPAAVYTTV VMHHDANDTN NTNGHATCVL YFVAEEVHTV
210 220 230 240 250
LLSWKVLLTM VWGAAPVIMM TWFYAFFYST VQRTSQKQRS RTLTFVSVLL
260 270 280 290 300
ISFVALQTPY VSLMIFNSYA TTAWPMQCEH LTLRRTIGTL ARVVPHLHCL
310 320 330 340 350
INPILYALLG HDFLQRMRQC FRGQLLDRRA FLRSQQNQRA TAETNLAAGN
360 370 380 390 400
NSQSVATSLD TNSKNYNQHA KRSVSFNFPS GTWKGGQKTA SNDTSTKIPH
410
RLSQSHHNLS GV
Length:412
Mass (Da):46,295
Last modified:February 15, 2005 - v2
Checksum:i19C1B2344717DECD
GO

Sequence cautioni

The sequence CAA35432 differs from that shown. Reason: Frameshift at position 9.Curated
The sequence CAA37385 differs from that shown. Reason: Frameshift at position 9.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35432.1 Frameshift.
X53293 Genomic DNA Translation: CAA37385.1 Frameshift.
BK000394 Genomic DNA Translation: DAA00138.1
PIRiS09796 QQBET9

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35432.1 Frameshift.
X53293 Genomic DNA Translation: CAA37385.1 Frameshift.
BK000394 Genomic DNA Translation: DAA00138.1
PIRiS09796 QQBET9

3D structure databases

ProteinModelPortaliP16849
SMRiP16849
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP16849

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000NY

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUL33_HCMVA
AccessioniPrimary (citable) accession number: P16849
Secondary accession number(s): Q7M6Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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