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Entry version 57 (03 Jul 2019)
Sequence version 2 (15 Feb 2005)
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Protein

Glycoprotein UL22A

Gene

UL22A

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycoprotein UL22A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UL22A
Synonyms:UL20A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10360 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008992 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008991 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003745421 – 103Glycoprotein UL22AAdd BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P16845

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HHV-5 UL22A protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K22784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009245 Cytomegalo_UL22A

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05984 Cytomega_UL20A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P16845-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRLWILSL LAVTLTVALA APSQKSKRSV TVEQPSTSAD GSNTTPSKNV
60 70 80 90 100
TLSQGGSTTD GDEDYSGEYD VLITDGDGSE HQQPQKTDEH KENQAKENEK

KIQ
Length:103
Mass (Da):11,147
Last modified:February 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86941819BD83ECCD
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA35421 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti5L → V in strain: Isolate clinical 48A. 1
Natural varianti10Missing in strain: Isolate clinical 17A, Isolate clinical 27A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 47A, Isolate clinical 48A and Isolate clinical 79A. 1
Natural varianti33E → K in strain: Isolate clinical 5A, Isolate clinical 44A and Isolate clinical 49A. 1
Natural varianti39 – 42ADGS → TNSDG in strain: Isolate clinical 3A, Isolate clinical 5A, Isolate clinical 17A, Isolate clinical 19A, Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 27A, Isolate clinical 29A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 38A, Isolate clinical 44A, Isolate clinical 47A, Isolate clinical 48A, Isolate clinical 49A, Isolate clinical 56A and Isolate clinical 79A. 4
Natural varianti43N → NN in strain: Isolate clinical 29A and Isolate clinical 38A. 1
Natural varianti46 – 49PSKN → RNKD in strain: Isolate clinical 29A, Isolate clinical 38A and Isolate clinical 56A. 4
Natural varianti62D → N in strain: Isolate clinical 5A, Isolate clinical 17A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 44A, Isolate clinical 47A, Isolate clinical 48A, Isolate clinical 49A and Isolate clinical 79A. 1
Natural varianti68E → EE in strain: Isolate clinical 5A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 44A, Isolate clinical 47A, Isolate clinical 48A, Isolate clinical 49A and Isolate clinical 79A. 1
Natural varianti68E → GD in strain: Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 38A and Isolate clinical 56A. 1
Natural varianti76G → T in strain: Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 38A and Isolate clinical 56A. 1
Natural varianti79S → G in strain: Isolate clinical 5A, Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 38A, Isolate clinical 44A, Isolate clinical 49A and Isolate clinical 56A. 1
Natural varianti80E → N in strain: Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 38A and Isolate clinical 56A. 1
Natural varianti85Q → QE in strain: Isolate clinical 5A, Isolate clinical 17A, Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 38A, Isolate clinical 44A, Isolate clinical 47A, Isolate clinical 48A, clinical Isolate 49A, Isolate clinical 56A and Isolate clinical 79A. 1
Natural varianti88D → N in strain: Isolate clinical 29A and Isolate clinical 38A. 1
Natural varianti92E → G in strain: Isolate clinical 17A, Isolate clinical 21A and Isolate clinical 22A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 47A, Isolate clinical 48A and Isolate clinical 79A. 1
Natural varianti92E → K in strain: Isolate clinical 56A. 1
Natural varianti93 – 95NQA → EHT in strain: Isolate clinical 5A, Isolate clinical 17A, Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 38A, Isolate clinical 44A, Isolate clinical 47A, Isolate clinical 48A, Isolate clinical 49A, Isolate clinical 56A and Isolate clinical 79A. 3
Natural varianti93N → D in strain: Isolate clinical 8A. 1
Natural varianti98 – 100NEK → DDE in strain: Isolate clinical 27A. 3
Natural varianti99Missing in strain: Isolate clinical 49A. 1
Natural varianti101 – 102KI → T in strain: Isolate clinical 5A, Isolate clinical 17A, Isolate clinical 21A, Isolate clinical 22A, Isolate clinical 29A, Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 38A, Isolate clinical 44A, Isolate clinical 47A, Isolate clinical 48A, Isolate clinical 49A, Isolate clinical 56A and Isolate clinical 79A. 2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35421.1 Sequence problems.
AF413626 Genomic DNA Translation: AAL08513.1
AF413627 Genomic DNA Translation: AAL08514.1
AF413628 Genomic DNA Translation: AAL08515.1
AF413629 Genomic DNA Translation: AAL08516.1
AF413630 Genomic DNA Translation: AAL08517.1
AF413631 Genomic DNA Translation: AAL08518.1
AF413632 Genomic DNA Translation: AAL08519.1
AF413633 Genomic DNA Translation: AAL08520.1
AF413634 Genomic DNA Translation: AAL08521.1
AF413635 Genomic DNA Translation: AAL08522.1
AF413636 Genomic DNA Translation: AAL08523.1
AF413637 Genomic DNA Translation: AAL08524.1
AF413638 Genomic DNA Translation: AAL08525.1
AF413639 Genomic DNA Translation: AAL08526.1
AF413640 Genomic DNA Translation: AAL08527.1
AF413641 Genomic DNA Translation: AAL08528.1
AF413642 Genomic DNA Translation: AAL08529.1
AF413643 Genomic DNA Translation: AAL08530.1
AF413644 Genomic DNA Translation: AAL08531.1
AF413645 Genomic DNA Translation: AAL08532.1
BK000394 Genomic DNA Translation: DAA00126.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S09785

NCBI Reference Sequences

More...
RefSeqi
YP_081481.1, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3077571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077571

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35421.1 Sequence problems.
AF413626 Genomic DNA Translation: AAL08513.1
AF413627 Genomic DNA Translation: AAL08514.1
AF413628 Genomic DNA Translation: AAL08515.1
AF413629 Genomic DNA Translation: AAL08516.1
AF413630 Genomic DNA Translation: AAL08517.1
AF413631 Genomic DNA Translation: AAL08518.1
AF413632 Genomic DNA Translation: AAL08519.1
AF413633 Genomic DNA Translation: AAL08520.1
AF413634 Genomic DNA Translation: AAL08521.1
AF413635 Genomic DNA Translation: AAL08522.1
AF413636 Genomic DNA Translation: AAL08523.1
AF413637 Genomic DNA Translation: AAL08524.1
AF413638 Genomic DNA Translation: AAL08525.1
AF413639 Genomic DNA Translation: AAL08526.1
AF413640 Genomic DNA Translation: AAL08527.1
AF413641 Genomic DNA Translation: AAL08528.1
AF413642 Genomic DNA Translation: AAL08529.1
AF413643 Genomic DNA Translation: AAL08530.1
AF413644 Genomic DNA Translation: AAL08531.1
AF413645 Genomic DNA Translation: AAL08532.1
BK000394 Genomic DNA Translation: DAA00126.1
PIRiS09785
RefSeqiYP_081481.1, NC_006273.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP16845

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077571
KEGGivg:3077571

Phylogenomic databases

KOiK22784

Family and domain databases

InterProiView protein in InterPro
IPR009245 Cytomegalo_UL22A
PfamiView protein in Pfam
PF05984 Cytomega_UL20A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUL22A_HCMVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16845
Secondary accession number(s): Q910H5
, Q910K8, Q910L5, Q910N2, Q910S8, Q910U1, Q918F6, Q918F7, Q918F8, Q918F9, Q918G0, Q918G1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 15, 2005
Last modified: July 3, 2019
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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