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Protein

Uncharacterized protein UL128

Gene

UL128

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection. Additionally, monomeric UL128 may interfere with certain inflammatory cytokines to increase infection and dissemination by blocking monocytes migration.By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Viral attachment to host entry receptor, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein UL128
Gene namesi
Name:UL128
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001153631 – 171Uncharacterized protein UL128Add BLAST171

Proteomic databases

PRIDEiP16837

Interactioni

Subunit structurei

Forms the envelope pentamer complex (PC) composed of gH, gL, UL128, UL130, and UL131A (PubMed:28783665). The pentamer interacts with host NRP2 (By similarity).By similarity1 Publication

Structurei

Secondary structure

1171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP16837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HHV-5 UL128 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090002FC

Sequencei

Sequence statusi: Complete.

P16837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPKDLTPFL TTLWLLLGHS RVPRVRAEEC CEFINVNHPP ERCYDFKMCN
60 70 80 90 100
RFTVALRCPD GEVCYSPEKT AEIRGIVTTM THSLTRQVVH NKLTSCNYNP
110 120 130 140 150
LYLEADGRIR CGKVNDKAQY LLGAAGSVPY RWINLEYDKI TRIVGLDQYL
160 170
ESVKKHKRLD VCRAKMGYML Q
Length:171
Mass (Da):19,747
Last modified:February 15, 2005 - v2
Checksum:i1E2A70A913F49098
GO

Sequence cautioni

The sequence CAA35330 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35330.1 Sequence problems.
BK000394 Genomic DNA Translation: DAA00114.1
PIRiS09894

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35330.1 Sequence problems.
BK000394 Genomic DNA Translation: DAA00114.1
PIRiS09894

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VOBX-ray3.02C1-171[»]
5VOCX-ray3.99C1-171[»]
5VODX-ray5.90C1-171[»]
SMRiP16837
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP16837

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090002FC

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiUL128_HCMVA
AccessioniPrimary (citable) accession number: P16837
Secondary accession number(s): Q7M6S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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