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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (DUT)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00610;UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:UL72
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829651 – 388Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST388

Structurei

3D structure databases

ProteinModelPortaliP16824
SMRiP16824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000AY

Family and domain databases

HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR036157 dUTPase-like_sf
IPR006882 Herpes_Orf11
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF04797 Herpes_ORF11, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

P16824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTMLTDRID SQLVLSRLPR SRFQRFWETP TLIMKEESAS SSGSIILAEK
60 70 80 90 100
SVNMRYCVRF ASDSDFQTTF TLPQSTEEKY DKEQHPGEDE ASSPLPSPLK
110 120 130 140 150
VPYKWMPSSF IVKQCHTQLA FYNKHIIWLS RERKVPTSLG VSLYIPEGFF
160 170 180 190 200
GITFYKCLDA QFVCMPELLE SRLQVPQLDV VNLNDTFQSI FPGTIEGDIG
210 220 230 240 250
VFPCFVPEPW QLMNLPPPNE HRFFSLRTRQ TLVIGPGHTQ TVYFDAAYVH
260 270 280 290 300
APGICALIVG VRQFSQSDLI IRPTIWLPGT AAGVTVVNTS HTTVCISPHT
310 320 330 340 350
TVAKAVFTTH RFTYLPVGSH PLGQMIVPPT PDIGFTHTPE HALLQRTPSP
360 370 380
VDDDVDETEE DEKSSDAESP VNTNDVIFDV GPKPPRHP
Length:388
Mass (Da):43,575
Last modified:August 1, 1990 - v1
Checksum:iA747D7D4C1E80DA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35387.1
BK000394 Genomic DNA Translation: DAA00168.1
PIRiS09835

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35387.1
BK000394 Genomic DNA Translation: DAA00168.1
PIRiS09835

3D structure databases

ProteinModelPortaliP16824
SMRiP16824
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000AY

Enzyme and pathway databases

UniPathwayi
UPA00610;UER00666

Family and domain databases

HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR036157 dUTPase-like_sf
IPR006882 Herpes_Orf11
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF04797 Herpes_ORF11, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_HCMVA
AccessioniPrimary (citable) accession number: P16824
Secondary accession number(s): Q7M6M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 10, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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