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Entry version 104 (05 Jun 2019)
Sequence version 1 (01 Aug 1990)
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Protein

Serine/threonine protein kinase UL97

Gene

UL97

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase that plays important roles in several processes including nuclear viral egress, viral replication or regulation of host cell cycle progression. Participates in the acquisition of tegument during virion morphogenesis in the nucleus. Redistributes the host nuclear lamina by phosphorylating cellular Lamins-A/C. Plays a role in viral DNA synthesis by phosphorylating the DNA polymerase processivity factor UL44. Stimulates host cell cycle to support viral DNA synthesis by phosphorylating host retinoblastoma/RB1 protein. Additional substrates have been identified including host EF1D or H2B.9 Publications

Miscellaneous

Monophosphorylates and thereby activates the antiviral nucleoside analog ganciclovir (GCV) used to treat CMV infections. Subsequent di- and triphosphorylation are carried out by cellular enzymes. The viral DNA polymerase incorporates GCV triphosphate into the viral genome, leading to marked attenuation of viral DNA replication and successful suppression of the infection, while the uninfected cell does not have this ability because it lacks the viral kinase. Mutations in phosphotransferase may induce CMV resistance to antiviral therapies in immunocompromised patients.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei359ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei456Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi337 – 345ATPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processHost-virus interaction, Modulation of host cell cycle by virus
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine protein kinase UL97 (EC:2.7.1.-)
Alternative name(s):
Ganciclovir kinase
HSRF3 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UL97
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10360 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008992 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008991 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1287608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881921 – 707Serine/threonine protein kinase UL97Add BLAST707

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylates on serine and threonine residues.1 Publication

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P16788

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UL83.

1 Publication

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P16788

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 63Ala-richAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010615 Herpes_UL97
IPR011009 Kinase-like_dom_sf
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06734 UL97, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P16788-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSALRSRAR SASLGTTTQG WDPPPLRRPS RARRRQWMRE AAQAAAQAAV
60 70 80 90 100
QAAQAAAAQV AQAHVDENEV VDLMADEAGG GVTTLTTLSS VSTTTVLGHA
110 120 130 140 150
TFSACVRSDV MRDGEKEDAA SDKENLRRPV VPSTSSRGSA ASGDGYHGLR
160 170 180 190 200
CRETSAMWSF EYDRDGDVTS VRRALFTGGS DPSDSVSGVR GGRKRPLRPP
210 220 230 240 250
LVSLARTPLC RRRVGGVDAV LEENDVELRA ESQDSAVASG PGRIPQPLSG
260 270 280 290 300
SSGEESATAV EADSTSHDDV HCTCSNDQII TTSIRGLTCD PRMFLRLTHP
310 320 330 340 350
ELCELSISYL LVYVPKEDDF CHKICYAVDM SDESYRLGQG SFGEVWPLDR
360 370 380 390 400
YRVVKVARKH SETVLTVWMS GLIRTRAAGE QQQPPSLVGT GVHRGLLTAT
410 420 430 440 450
GCCLLHNVTV HRRFHTDMFH HDQWKLACID SYRRAFCTLA DAIKFLNHQC
460 470 480 490 500
RVCHFDITPM NVLIDVNPHN PSEIVRAALC DYSLSEPYPD YNERCVAVFQ
510 520 530 540 550
ETGTARRIPN CSHRLRECYH PAFRPMPLQK LLICDPHARF PVAGLRRYCM
560 570 580 590 600
SELSALGNVL GFCLMRLLDR RGLDEVRMGT EALLFKHAGA ACRALENGKL
610 620 630 640 650
THCSDACLLI LAAQMSYGAC LLGEHGAALV SHTLRFVEAK MSSCRVRAFR
660 670 680 690 700
RFYHECSQTM LHEYVRKNVE RLLATSDGLY LYNAFRRTTS IICEEDLDGD

CRQLFPE
Length:707
Mass (Da):78,233
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74914183E5A5E03A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti19Q → E in strain: Isolate clinical E460, Isolate clinical E763 and Isolate clinical TH-7A. 1
Natural varianti68N → D in strain: Isolate clinical C005, Isolate clinical C076, Isolate clinical C128, Isolate clinical C325, Isolate clinical C327, Isolate clinical C336, Isolate clinical CL-1A, Isolate clinical E428, Isolate clinical E460, Isolate clinical E540, Isolate clinical E759, Isolate clinical E760, Isolate clinical E761, Isolate clinical E763, Isolate clinical FK-2A, Isolate clinical GR-3A, Isolate clinical HD-4A, Isolate clinical HR-7, Isolate clinical MG-8, Isolate clinical SN-11, Isolate clinical SW-12, Isolate clinical TH-7A and Isolate clinical TL-8A. 1
Natural varianti95T → S in strain: Isolate clinical C128. 1
Natural varianti108S → N in strain: Isolate clinical E460, Isolate clinical E763, Isolate clinical TH-7A and Isolate clinical TL-8A. 1
Natural varianti112R → C in strain: Isolate clinical C128. 1
Natural varianti126L → Q in strain: Isolate clinical C128, Isolate clinical C076, Isolate clinical CL-1A, Isolate clinical E428, Isolate clinical E760, Isolate clinical FK-2A, Isolate clinical HR-7, Isolate clinical MG-8, Isolate clinical SN-11 and Isolate clinical SW-12. 1
Natural varianti137R → C in strain: Isolate clinical HD-4A. 1
Natural varianti227E → D in strain: Isolate clinical TH-7A. 1
Natural varianti244I → V in strain: Isolate clinical C005, Isolate clinical C076, Isolate clinical C128, Isolate clinical C325, Isolate clinical C327, Isolate clinical C336, Isolate clinical CL-1A, Isolate clinical E428, Isolate clinical E460, Isolate clinical E540, Isolate clinical E759, Isolate clinical E760, Isolate clinical E761, Isolate clinical E763, Isolate clinical FK-2A, Isolate clinical GR-3A, Isolate clinical HD-4A, Isolate clinical HR-7, Isolate clinical MG-8, Isolate clinical SN-11, Isolate clinical SW-12, Isolate clinical TH-7A and Isolate clinical TL-8A. 1
Natural varianti449Q → K in strain: Isolate clinical C076. 1
Natural varianti460M → I in GCV resistant isolate. 1 Publication1
Natural varianti460M → V in GCV resistant isolate. 1 Publication1
Natural varianti469H → Y in strain: Isolate clinical C327 and Isolate clinical E761 and Isolate clinical FK-2A. 1
Natural varianti510N → S in strain: Isolate clinical HG-5A. 1
Natural varianti520H → Q in GCV resistant isolate. 1 Publication1
Natural varianti582A → T in strain: Isolate clinical PB-9. 1
Natural varianti592C → G in GCV resistant isolate. 1 Publication1
Natural varianti594A → P in GCV resistant isolate. 1 Publication1
Natural varianti594A → V in GCV resistant isolate. 1 Publication1
Natural varianti595L → S in GCV resistant isolate. 1 Publication1
Natural varianti595L → W in GCV resistant isolate. 1 Publication1
Natural varianti603C → W in GCV resistant isolate. 1
Natural varianti605D → E in strain: Isolate clinical C325. 1
Natural varianti607C → Y in GCV resistant isolate. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35333.1
AF345348 Genomic DNA Translation: AAL10763.1
AF345349 Genomic DNA Translation: AAL10764.1
AF345350 Genomic DNA Translation: AAL10765.1
AF345351 Genomic DNA Translation: AAL10766.1
AF345352 Genomic DNA Translation: AAL10767.1
AF345353 Genomic DNA Translation: AAL10768.1
AF345354 Genomic DNA Translation: AAL10769.1
AF345355 Genomic DNA Translation: AAL10770.1
AF345356 Genomic DNA Translation: AAL10771.1
AF345357 Genomic DNA Translation: AAL10772.1
AF345358 Genomic DNA Translation: AAL10773.1
AF345359 Genomic DNA Translation: AAL10774.1
AF345360 Genomic DNA Translation: AAL10775.1
AF345361 Genomic DNA Translation: AAL10776.1
AF345362 Genomic DNA Translation: AAL10777.1
AF345363 Genomic DNA Translation: AAL10778.1
AF345364 Genomic DNA Translation: AAL10779.1
AF345365 Genomic DNA Translation: AAL10780.1
AF345366 Genomic DNA Translation: AAL10781.1
AF345367 Genomic DNA Translation: AAL10782.1
AF345368 Genomic DNA Translation: AAL10783.1
AF345369 Genomic DNA Translation: AAL10784.1
AF345370 Genomic DNA Translation: AAL10785.1
AF345371 Genomic DNA Translation: AAL10786.1
AF345372 Genomic DNA Translation: AAL10787.1
AF345373 Genomic DNA Translation: AAL10788.1
AF425081 Genomic DNA Translation: AAL10789.1
AF425082 Genomic DNA Translation: AAL10790.1
BK000394 Genomic DNA Translation: DAA00194.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S09862 QQBEJ5

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35333.1
AF345348 Genomic DNA Translation: AAL10763.1
AF345349 Genomic DNA Translation: AAL10764.1
AF345350 Genomic DNA Translation: AAL10765.1
AF345351 Genomic DNA Translation: AAL10766.1
AF345352 Genomic DNA Translation: AAL10767.1
AF345353 Genomic DNA Translation: AAL10768.1
AF345354 Genomic DNA Translation: AAL10769.1
AF345355 Genomic DNA Translation: AAL10770.1
AF345356 Genomic DNA Translation: AAL10771.1
AF345357 Genomic DNA Translation: AAL10772.1
AF345358 Genomic DNA Translation: AAL10773.1
AF345359 Genomic DNA Translation: AAL10774.1
AF345360 Genomic DNA Translation: AAL10775.1
AF345361 Genomic DNA Translation: AAL10776.1
AF345362 Genomic DNA Translation: AAL10777.1
AF345363 Genomic DNA Translation: AAL10778.1
AF345364 Genomic DNA Translation: AAL10779.1
AF345365 Genomic DNA Translation: AAL10780.1
AF345366 Genomic DNA Translation: AAL10781.1
AF345367 Genomic DNA Translation: AAL10782.1
AF345368 Genomic DNA Translation: AAL10783.1
AF345369 Genomic DNA Translation: AAL10784.1
AF345370 Genomic DNA Translation: AAL10785.1
AF345371 Genomic DNA Translation: AAL10786.1
AF345372 Genomic DNA Translation: AAL10787.1
AF345373 Genomic DNA Translation: AAL10788.1
AF425081 Genomic DNA Translation: AAL10789.1
AF425082 Genomic DNA Translation: AAL10790.1
BK000394 Genomic DNA Translation: DAA00194.1
PIRiS09862 QQBEJ5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ELMiP16788

Chemistry databases

ChEMBLiCHEMBL1287608

Proteomic databases

PRIDEiP16788

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR010615 Herpes_UL97
IPR011009 Kinase-like_dom_sf
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF06734 UL97, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUL97_HCMVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16788
Secondary accession number(s): Q7M6J4
, Q910D5, Q910F8, Q910W3, Q91B46, Q91B47, Q91B48, Q91B49, Q91B50, Q91B51, Q91B52, Q91B53, Q91B54, Q91B55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 5, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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