UniProtKB - P16729 (MCP_HCMVA)
Protein
Major capsid protein
Gene
MCP
Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Functioni
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation
GO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: Major capsid proteinUniRule annotationShort name: MCPUniRule annotation |
Gene namesi | Name:MCPUniRule annotation Synonyms:UL86 |
Organismi | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Taxonomic identifieri | 10360 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
- T=16 icosahedral viral capsid Source: UniProtKB-UniRule
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=16 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115711 | 1 – 1370 | Major capsid proteinAdd BLAST | 1370 |
Proteomic databases
PRIDEi | P16729 |
Interactioni
Subunit structurei
Homomultimer. Makes the hexons and eleven out of twelve pentons.
Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.
Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.
Interacts with capsid vertex component 2/CVC2.
Interacts with the small capsomere-interacting protein/SCP.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the herpesviridae major capsid protein family.UniRule annotation
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
i Sequence
Sequence statusi: Complete.
P16729-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENWSALELL PKVGIPTDFL THVKTSAGEE MFEALRIYYG DDPERYNIHF
60 70 80 90 100
EAIFGTFCNR LEWVYFLTSG LAAAAHAIKF HDLNKLTTGK MLFHVQVPRV
110 120 130 140 150
ASGAGLPTSR QTTIMVTKYS EKSPITIPFE LSAACLTYLR ETFEGTILDK
160 170 180 190 200
ILNVEAMHTV LRALKNTADA MERGLIHSFL QTLLRKAPPY FVVQTLVENA
210 220 230 240 250
TLARQALNRI QRSNILQSFK AKMLATLFLL NRTRDRDYVL KFLTRLAEAA
260 270 280 290 300
TDSILDNPTT YTTSSGAKIS GVMVSTANVM QIIMSLLSSH ITKETVSAPA
310 320 330 340 350
TYGNFVLSPE NAVTAISYHS ILADFNSYKA HLTSGQPHLP NDSLSQAGAH
360 370 380 390 400
SLTPLSMDVI RLGEKTVIME NLRRVYKNTD TKDPLERNVD LTFFFPVGLY
410 420 430 440 450
LPEDRGYTTV ESKVKLNDTV RNALPTTAYL LNRDRAVQKI DFVDALKTLC
460 470 480 490 500
HPVLHEPAPC LQTFTERGPP SEPAMQRLLE CRFQQEPMGG AARRIPHFYR
510 520 530 540 550
VRREVPRTVN EMKQDFVVTD FYKVGNITLY TELHPFFDFT HCQENSETVA
560 570 580 590 600
LCTPRIVIGN LPDGLAPGPF HELRTWEIME HMRLRPPPDY EETLRLFKTT
610 620 630 640 650
VTSPNYPELC YLVDVLVHGN VDAFLLIRTF VARCIVNMFH TRQLLVFAHS
660 670 680 690 700
YALVTLIAEH LADGALPPQL LFHYRNLVAV LRLVTRISAL PGLNNGQLAE
710 720 730 740 750
EPLSAYVNAL HDHRLWPPFV THLPRNMEGV QVVADRQPLN PANIEARHHG
760 770 780 790 800
VSDVPRLGAM DADEPLFVDD YRATDDEWTL QKVFYLCLMP AMTNNRACGL
810 820 830 840 850
GLNLKTLLVD LFYRPAFLLM PAATAVSTSG TTSKESTSGV TPEDSIAAQR
860 870 880 890 900
QAVGEMLTEL VEDVATDAHT PLLQACRELF LAVQFVGEHV KVLEVRAPLD
910 920 930 940 950
HAQRQGLPDF ISRQHVLYNG CCVVTAPKTL IEYSLPVPFH RFYSNPTICA
960 970 980 990 1000
ALSDDIKRYV TEFPHYHRHD GGFPLPTAFA HEYHNWLRSP FSRYSATCPN
1010 1020 1030 1040 1050
VLHSVMTLAA MLYKISPVSL VLQTKAHIHP GFALTAVRTD TFEVDMLLYS
1060 1070 1080 1090 1100
GKSCTSVIIN NPIVTKEERD ISTTYHVTQN INTVDMGLGY TSNTCVAYVN
1110 1120 1130 1140 1150
RVRTDMGVRV QDLFRVFPMN VYRHDEVDRW IRHAAGVERP QLLDTETISM
1160 1170 1180 1190 1200
LTFGSMSERN AAATVHGQKA ACELILTPVT MDVNYFKIPN NPRGRASCML
1210 1220 1230 1240 1250
AVDPYDTEAA TKAIYDHREA DAQTFAATHN PWASQAGCLS DVLYNTRHRE
1260 1270 1280 1290 1300
RLGYNSKFYS PCAQYFNTEE IIAANKTLFK TIDEYLLRAK DCIRGDTDTQ
1310 1320 1330 1340 1350
YVCVEGTEQL IENPCRLTQE ALPILSTTTL ALMETKLKGG AGAFATSETH
1360 1370
FGNYVVGEII PLQQSMLFNS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17403 Genomic DNA Translation: CAA35360.1 M25411 Genomic DNA Translation: AAA51532.1 BK000394 Genomic DNA Translation: DAA00183.1 |
PIRi | A31882, VCBECA |
RefSeqi | YP_081534.1, NC_006273.2 |
Genome annotation databases
GeneIDi | 3077538 |
KEGGi | vg:3077538 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17403 Genomic DNA Translation: CAA35360.1 M25411 Genomic DNA Translation: AAA51532.1 BK000394 Genomic DNA Translation: DAA00183.1 |
PIRi | A31882, VCBECA |
RefSeqi | YP_081534.1, NC_006273.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5VKU | electron microscopy | 3.90 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P | 1-1370 | [»] | |
SMRi | P16729 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P16729 |
Genome annotation databases
GeneIDi | 3077538 |
KEGGi | vg:3077538 |
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCP_HCMVA | |
Accessioni | P16729Primary (citable) accession number: P16729 Secondary accession number(s): Q7M6K5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families