Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P16692 (PHNP_ECOLI)

Entry version 138 (02 Dec 2020)
Sequence version 1 (01 Aug 1990)
Previous versions | rss
Add a publicationFeedback
Protein

Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase

Gene

phnP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate.2 Publications

Miscellaneous

The sequence shown is that of strains K12 and B.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi21Zinc2 Publications1
Metal bindingi23Zinc2 Publications1
Metal bindingi26Zinc2 Publications1
Metal bindingi76Manganese 1; via tele nitrogen2 Publications1
Metal bindingi78Manganese 1; via pros nitrogen2 Publications1
Metal bindingi80Manganese 22 Publications1
Metal bindingi81Manganese 2; via tele nitrogen2 Publications1
Metal bindingi143Manganese 1; via tele nitrogen2 Publications1
Metal bindingi164Manganese 12 Publications1
Metal bindingi164Manganese 22 Publications1
Metal bindingi222Manganese 2; via tele nitrogen2 Publications1
Metal bindingi225Zinc; via pros nitrogen2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • organic phosphonate catabolic process Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG10725-MONOMER
MetaCyc:EG10725-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.4.55, 2026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase (EC:3.1.4.55)
Alternative name(s):
Phosphoribosyl cyclic phosphodiesterase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:phnP
Ordered Locus Names:b4092, JW4053
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54D → A: Has a 1000-fold lower activity. 1 Publication1
Mutagenesisi75T → A: Has 40-fold lower activity. 1 Publication1
Mutagenesisi78H → A: Has 250-fold lower activity. 1 Publication1
Mutagenesisi80D → A: Has 1000-fold lower activity, and has 100-fold lower affinity for manganese. 1 Publication1
Mutagenesisi164D → A: Has a 1000-fold lower activity. 1 Publication1
Mutagenesisi187D → A: No effect. 1 Publication1
Mutagenesisi200H → A: Has 10-fold lower activity. 1 Publication1
Mutagenesisi222H → A: Has 9-fold lower activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584021 – 252Phosphoribosyl 1,2-cyclic phosphate phosphodiesteraseAdd BLAST252

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16692

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16692

PRoteomics IDEntifications database

More...PRIDEi		P16692

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261542, 14 interactors

Protein interaction database and analysis system

More...IntActi		P16692, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b4092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16692

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16692

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1235, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044538_3_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16692

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16692

Family and domain databases

Conserved Domains Database

More...CDDi		cd07736, PhnP-like_MBL-fold, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001279, Metallo-B-lactamas
IPR035682, PhnP_MBL
IPR017693, Phosphonate_metab_PhnP
IPR036866, RibonucZ/Hydroxyglut_hydro

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12706, Lactamase_B_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56281, SSF56281, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03307, PhnP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P16692-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTLTLTGT GGAQGVPAWG CECAACARAR RSPQYRRQPC SGVVKFNDAI 
        60         70         80         90        100
TLIDAGLHDL ADRWSPGSFQ QFLLTHYHMD HVQGLFPLRW GVGDPIPVYG 
       110        120        130        140        150
PPDEQGCDDL FKHPGLLDFS HTVEPFVVFD LQGLQVTPLP LNHSKLTFGY 
       160        170        180        190        200
LLETAHSRVA WLSDTAGLPE KTLKFLRNNQ PQVMVMDCSH PPRADAPRNH 
       210        220        230        240        250
CDLNTVLALN QVIRSPRVIL THISHQFDAW LMENALPSGF EVGFDGMEIG 

VA
Length:252
Mass (Da):27,848
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE23922C46A8386F5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J05260 Genomic DNA Translation: AAA24356.1
D90227 Genomic DNA Translation: BAA14276.1
U14003 Genomic DNA Translation: AAA96991.1
U00096 Genomic DNA Translation: AAC77053.1
AP009048 Genomic DNA Translation: BAE78095.1

Protein sequence database of the Protein Information Resource

More...PIRi		H35719

NCBI Reference Sequences

More...RefSeqi		NP_418516.1, NC_000913.3
WP_000059908.1, NZ_SSUW01000018.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77053; AAC77053; b4092
BAE78095; BAE78095; BAE78095

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4053
eco:b4092

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2608

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA Translation: AAA24356.1
D90227 Genomic DNA Translation: BAA14276.1
U14003 Genomic DNA Translation: AAA96991.1
U00096 Genomic DNA Translation: AAC77053.1
AP009048 Genomic DNA Translation: BAE78095.1
PIRiH35719
RefSeqiNP_418516.1, NC_000913.3
WP_000059908.1, NZ_SSUW01000018.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G1PX-ray1.40A/B1-252[»]
3P2UX-ray1.48A/B1-252[»]
SMRiP16692
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4261542, 14 interactors
IntActiP16692, 1 interactor
STRINGi511145.b4092

Proteomic databases

jPOSTiP16692
PaxDbiP16692
PRIDEiP16692

Genome annotation databases

EnsemblBacteriaiAAC77053; AAC77053; b4092
BAE78095; BAE78095; BAE78095
GeneIDi948600
KEGGiecj:JW4053
eco:b4092
PATRICifig|1411691.4.peg.2608

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0719

Phylogenomic databases

eggNOGiCOG1235, Bacteria
HOGENOMiCLU_044538_3_0_6
InParanoidiP16692
PhylomeDBiP16692

Enzyme and pathway databases

BioCyciEcoCyc:EG10725-MONOMER
MetaCyc:EG10725-MONOMER
BRENDAi3.1.4.55, 2026

Miscellaneous databases

EvolutionaryTraceiP16692

Protein Ontology

More...PROi		PR:P16692

Family and domain databases

CDDicd07736, PhnP-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR001279, Metallo-B-lactamas
IPR035682, PhnP_MBL
IPR017693, Phosphonate_metab_PhnP
IPR036866, RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF12706, Lactamase_B_2, 1 hit
SUPFAMiSSF56281, SSF56281, 1 hit
TIGRFAMsiTIGR03307, PhnP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHNP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16692
Secondary accession number(s): Q2M6L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: December 2, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again