UniProtKB - P16686 (PHNH_ECOLI)
Protein
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH
Gene
phnH
Organism
Escherichia coli (strain K12)
Status
Functioni
Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.1 Publication
Miscellaneous
The sequence shown is that of strains K12 and B.
Catalytic activityi
- EC:2.7.8.371 Publication
GO - Molecular functioni
- alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity Source: UniProtKB-EC
- identical protein binding Source: IntAct
GO - Biological processi
- organic phosphonate catabolic process Source: EcoCyc
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10717-MONOMER MetaCyc:EG10717-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH (EC:2.7.8.37)Short name: RPnTP synthase subunit PhnH |
Gene namesi | Name:phnH Ordered Locus Names:b4100, JW4061 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex Source: EcoCyc
- carbon phosphorus lyase complex Source: EcoCyc
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058393 | 1 – 194 | Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnHAdd BLAST | 194 |
Proteomic databases
PaxDbi | P16686 |
PRIDEi | P16686 |
Interactioni
Subunit structurei
Homodimer.
Forms a complex with PhnG, PhnI, PhnJ and PhnK with the suggested composition PhnG4H2I2J2K.
2 PublicationsBinary interactionsi
P16686
With | #Exp. | IntAct |
---|---|---|
itself | 5 | EBI-6401276,EBI-6401276 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 4262694, 8 interactors |
ComplexPortali | CPX-1929, PhnGHIJKL complex |
DIPi | DIP-10487N |
IntActi | P16686, 2 interactors |
STRINGi | 511145.b4100 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P16686 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16686 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PhnH family.Curated
Phylogenomic databases
eggNOGi | COG3625, Bacteria |
HOGENOMi | CLU_115317_1_0_6 |
InParanoidi | P16686 |
PhylomeDBi | P16686 |
Family and domain databases
Gene3Di | 3.40.50.11310, 1 hit |
InterProi | View protein in InterPro IPR038058, PhnH-like_sp IPR008772, Phosphonate_metab_PhnH |
Pfami | View protein in Pfam PF05845, PhnH, 1 hit |
PIRSFi | PIRSF020680, PhnH, 1 hit |
SUPFAMi | SSF159709, SSF159709, 1 hit |
TIGRFAMsi | TIGR03292, PhnH_redo, 1 hit |
i Sequence
Sequence statusi: Complete.
P16686-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLETAFMLP VQDAQHSFRR LLKAMSEPGV IVALHQLKRG WQPLNIATTS
60 70 80 90 100
VLLTLADNDT PVWLSTPLNN DIVNQSLRFH TNAPLVSQPE QATFAVTDEA
110 120 130 140 150
ISSEQLNALS TGTAVAPEAG ATLILQVASL SGGRMLRLTG AGIAEERMIA
160 170 180 190
PQLPECILHE LTERPHPFPL GIDLILTCGE RLLAIPRTTH VEVC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05260 Genomic DNA Translation: AAA24345.1 D90227 Genomic DNA Translation: BAA14268.1 U14003 Genomic DNA Translation: AAA96999.1 U00096 Genomic DNA Translation: AAC77061.1 AP009048 Genomic DNA Translation: BAE78103.1 |
PIRi | I35718 |
RefSeqi | NP_418524.1, NC_000913.3 WP_000171628.1, NZ_SSZK01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC77061; AAC77061; b4100 BAE78103; BAE78103; BAE78103 |
GeneIDi | 948619 |
KEGGi | ecj:JW4061 eco:b4100 |
PATRICi | fig|1411691.4.peg.2600 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05260 Genomic DNA Translation: AAA24345.1 D90227 Genomic DNA Translation: BAA14268.1 U14003 Genomic DNA Translation: AAA96999.1 U00096 Genomic DNA Translation: AAC77061.1 AP009048 Genomic DNA Translation: BAE78103.1 |
PIRi | I35718 |
RefSeqi | NP_418524.1, NC_000913.3 WP_000171628.1, NZ_SSZK01000016.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FSU | X-ray | 1.70 | A | 1-194 | [»] | |
4XB6 | X-ray | 1.70 | B/F | 1-194 | [»] | |
SMRi | P16686 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262694, 8 interactors |
ComplexPortali | CPX-1929, PhnGHIJKL complex |
DIPi | DIP-10487N |
IntActi | P16686, 2 interactors |
STRINGi | 511145.b4100 |
Proteomic databases
PaxDbi | P16686 |
PRIDEi | P16686 |
Genome annotation databases
EnsemblBacteriai | AAC77061; AAC77061; b4100 BAE78103; BAE78103; BAE78103 |
GeneIDi | 948619 |
KEGGi | ecj:JW4061 eco:b4100 |
PATRICi | fig|1411691.4.peg.2600 |
Organism-specific databases
EchoBASEi | EB0711 |
Phylogenomic databases
eggNOGi | COG3625, Bacteria |
HOGENOMi | CLU_115317_1_0_6 |
InParanoidi | P16686 |
PhylomeDBi | P16686 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10717-MONOMER MetaCyc:EG10717-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P16686 |
PROi | PR:P16686 |
Family and domain databases
Gene3Di | 3.40.50.11310, 1 hit |
InterProi | View protein in InterPro IPR038058, PhnH-like_sp IPR008772, Phosphonate_metab_PhnH |
Pfami | View protein in Pfam PF05845, PhnH, 1 hit |
PIRSFi | PIRSF020680, PhnH, 1 hit |
SUPFAMi | SSF159709, SSF159709, 1 hit |
TIGRFAMsi | TIGR03292, PhnH_redo, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHNH_ECOLI | |
Accessioni | P16686Primary (citable) accession number: P16686 Secondary accession number(s): Q2M6K3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families