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Protein

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG

Gene

phnG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.1 Publication

Miscellaneous

The sequence shown is that of strain K12.

Catalytic activityi

ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine.1 Publication

GO - Molecular functioni

GO - Biological processi

  • organic phosphonate catabolic process Source: EcoCyc
  • organic phosphonate transport Source: InterPro

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciEcoCyc:EG10716-MONOMER
MetaCyc:EG10716-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG (EC:2.7.8.37)
Short name:
RPnTP synthase subunit PhnG
Gene namesi
Name:phnG
Ordered Locus Names:b4101, JW4062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10716 phnG

Subcellular locationi

GO - Cellular componenti

  • alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex Source: EcoCyc
  • carbon phosphorus lyase complex Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000583911 – 150Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnGAdd BLAST150

Proteomic databases

PaxDbiP16685
PRIDEiP16685

Interactioni

Subunit structurei

Forms a complex with PhnH, PhnI, PhnJ and PhnK with the suggested composition PhnG4H2I2J2K.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4263094, 3 interactors
ComplexPortaliCPX-1929 PhnGHIJKL complex
DIPiDIP-10486N
IntActiP16685, 6 interactors
STRINGi316385.ECDH10B_4292

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Helixi20 – 30Combined sources11
Beta strandi36 – 52Combined sources17
Helixi53 – 55Combined sources3
Beta strandi57 – 74Combined sources18
Beta strandi79 – 87Combined sources9
Helixi89 – 102Combined sources14
Helixi105 – 114Combined sources10
Helixi116 – 134Combined sources19
Helixi135 – 137Combined sources3

3D structure databases

ProteinModelPortaliP16685
SMRiP16685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PhnG family.Curated

Phylogenomic databases

eggNOGiENOG4105KQZ Bacteria
COG3624 LUCA
HOGENOMiHOG000127029
InParanoidiP16685
KOiK06166
OMAiRQRWMSV
PhylomeDBiP16685

Family and domain databases

InterProiView protein in InterPro
IPR009609 Phosphonate_metab_PhnG
PfamiView protein in Pfam
PF06754 PhnG, 1 hit
TIGRFAMsiTIGR03293 PhnG_redo, 1 hit

Sequencei

Sequence statusi: Complete.

P16685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHADTATRQH WMSVLAHSQP AELAARLNAL NITADYEVIR AAETGLVQIQ
60 70 80 90 100
ARMGGTGERF FAGDATLTRA AVRLTDGTLG YSWVQGRDKQ HAERCALIDA
110 120 130 140 150
LMQQSRHFQN LSETLIAPLD ADRMARIAAR QAEVNASRVD FFTMVRGDNA
Length:150
Mass (Da):16,540
Last modified:November 1, 1991 - v2
Checksum:i818A95526FAD0817
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti85Q → L in strain: B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA Translation: AAA24344.1
D90227 Genomic DNA Translation: BAA14267.1
U14003 Genomic DNA Translation: AAA97000.1
U00096 Genomic DNA Translation: AAC77062.1
AP009048 Genomic DNA Translation: BAE78104.1
PIRiD65219
RefSeqiNP_418525.1, NC_000913.3
WP_000542790.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77062; AAC77062; b4101
BAE78104; BAE78104; BAE78104
GeneIDi948618
KEGGiecj:JW4062
eco:b4101
PATRICifig|1411691.4.peg.2599

Similar proteinsi

Entry informationi

Entry nameiPHNG_ECOLI
AccessioniPrimary (citable) accession number: P16685
Secondary accession number(s): Q2M6K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: July 18, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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