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UniProtKB - P16684 (PHNF_ECOLI)
Protein
Probable transcriptional regulator PhnF
Gene
phnF
Organism
Escherichia coli (strain K12)
Status
Functioni
Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator.
Miscellaneous
The sequence shown is that of strains K12 and B.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 38 – 57 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- organic phosphonate transport Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Alkylphosphonate uptake, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10715-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable transcriptional regulator PhnF |
Gene namesi | Name:phnF Ordered Locus Names:b4102, JW4063 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050667 | 1 – 241 | Probable transcriptional regulator PhnFAdd BLAST | 241 |
Proteomic databases
PaxDbi | P16684 |
PRIDEi | P16684 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263093, 10 interactors |
IntActi | P16684, 2 interactors |
STRINGi | 511145.b4102 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P16684 |
SMRi | P16684 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16684 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 78 | HTH gntR-typePROSITE-ProRule annotationAdd BLAST | 68 |
Phylogenomic databases
eggNOGi | COG2188, Bacteria |
HOGENOMi | CLU_063236_2_2_6 |
InParanoidi | P16684 |
OMAi | HRPDKFR |
PhylomeDBi | P16684 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.40.1410.10, 1 hit |
InterProi | View protein in InterPro IPR028978, Chorismate_lyase_/UTRA_dom_sf IPR012702, CP_lyase_PhnF IPR000524, Tscrpt_reg_HTH_GntR IPR011663, UTRA IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00392, GntR, 1 hit PF07702, UTRA, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00345, HTH_GNTR, 1 hit SM00866, UTRA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF64288, SSF64288, 1 hit |
TIGRFAMsi | TIGR02325, C_P_lyase_phnF, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
i Sequence
Sequence statusi: Complete.
P16684-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHLSTHPTSY PTRYQEIAAK LEQELRQHYR CGDYLPAEQQ LAARFEVNRH
60 70 80 90 100
TLRRAIDQLV EKGWVQRRQG VGVLVLMRPF DYPLNAQARF SQNLLDQGSH
110 120 130 140 150
PTSEKLLSVL RPASGHVADA LGITEGENVI HLRTLRRVNG VALCLIDHYF
160 170 180 190 200
ADLTLWPTLQ RFDSGSLHDF LREQTGIALR RSQTRISARR AQAKECQRLE
210 220 230 240
IPNMSPLLCV RTLNHRDGES SPAEYSVSLT RADMIEFTME H
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05260 Genomic DNA Translation: AAA24343.1 D90227 Genomic DNA Translation: BAA14266.1 U14003 Genomic DNA Translation: AAA97001.1 U00096 Genomic DNA Translation: AAC77063.1 AP009048 Genomic DNA Translation: BAE78105.1 |
PIRi | G35718 |
RefSeqi | NP_418526.1, NC_000913.3 WP_001295387.1, NZ_STEB01000014.1 |
Genome annotation databases
EnsemblBacteriai | AAC77063; AAC77063; b4102 BAE78105; BAE78105; BAE78105 |
GeneIDi | 58459677 948617 |
KEGGi | ecj:JW4063 eco:b4102 |
PATRICi | fig|1411691.4.peg.2598 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05260 Genomic DNA Translation: AAA24343.1 D90227 Genomic DNA Translation: BAA14266.1 U14003 Genomic DNA Translation: AAA97001.1 U00096 Genomic DNA Translation: AAC77063.1 AP009048 Genomic DNA Translation: BAE78105.1 |
PIRi | G35718 |
RefSeqi | NP_418526.1, NC_000913.3 WP_001295387.1, NZ_STEB01000014.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FA1 | X-ray | 1.70 | A/B | 85-241 | [»] | |
AlphaFoldDBi | P16684 | |||||
SMRi | P16684 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263093, 10 interactors |
IntActi | P16684, 2 interactors |
STRINGi | 511145.b4102 |
Proteomic databases
PaxDbi | P16684 |
PRIDEi | P16684 |
Genome annotation databases
EnsemblBacteriai | AAC77063; AAC77063; b4102 BAE78105; BAE78105; BAE78105 |
GeneIDi | 58459677 948617 |
KEGGi | ecj:JW4063 eco:b4102 |
PATRICi | fig|1411691.4.peg.2598 |
Organism-specific databases
EchoBASEi | EB0709 |
Phylogenomic databases
eggNOGi | COG2188, Bacteria |
HOGENOMi | CLU_063236_2_2_6 |
InParanoidi | P16684 |
OMAi | HRPDKFR |
PhylomeDBi | P16684 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10715-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P16684 |
PROi | PR:P16684 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.40.1410.10, 1 hit |
InterProi | View protein in InterPro IPR028978, Chorismate_lyase_/UTRA_dom_sf IPR012702, CP_lyase_PhnF IPR000524, Tscrpt_reg_HTH_GntR IPR011663, UTRA IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00392, GntR, 1 hit PF07702, UTRA, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00345, HTH_GNTR, 1 hit SM00866, UTRA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF64288, SSF64288, 1 hit |
TIGRFAMsi | TIGR02325, C_P_lyase_phnF, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PHNF_ECOLI | |
Accessioni | P16684Primary (citable) accession number: P16684 Secondary accession number(s): Q2M6K1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references