UniProtKB - P16682 (PHND_ECOLI)
Protein
Phosphonates-binding periplasmic protein
Gene
phnD
Organism
Escherichia coli (strain K12)
Status
Functioni
Phosphonate binding protein that is part of the phosphonate uptake system. Exhibits high affinity for 2-aminoethylphosphonate, and somewhat less affinity to ethylphosphonate, methylphosphonate, phosphonoacetate and phenylphosphonate.1 Publication
Miscellaneous
The sequence shown is that of strain K12.
GO - Biological processi
- organic phosphonate transport Source: UniProtKB-KW
- transmembrane transport Source: InterPro
Keywordsi
Biological process | Phosphonate transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:PHND-MONOMER MetaCyc:PHND-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.9.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphonates-binding periplasmic protein |
Gene namesi | Name:phnD Synonyms:psiD Ordered Locus Names:b4105, JW4066 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Periplasm Curated
GO - Cellular componenti
- ATP-binding cassette (ABC) transporter complex Source: InterPro
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000031836 | 27 – 338 | Phosphonates-binding periplasmic proteinAdd BLAST | 312 |
Proteomic databases
PaxDbi | P16682 |
PRIDEi | P16682 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).
CuratedProtein-protein interaction databases
BioGRIDi | 4263091, 145 interactors |
DIPi | DIP-10483N |
IntActi | P16682, 4 interactors |
STRINGi | 511145.b4105 |
Family & Domainsi
Sequence similaritiesi
Belongs to the phosphate/phosphite/phosphonate binding protein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG3221, Bacteria |
HOGENOMi | CLU_051472_2_0_6 |
InParanoidi | P16682 |
PhylomeDBi | P16682 |
Family and domain databases
InterProi | View protein in InterPro IPR005770, PhnD IPR017797, Phosphnate-bd |
PANTHERi | PTHR30043:SF5, PTHR30043:SF5, 1 hit |
TIGRFAMsi | TIGR01098, 3A0109s03R, 1 hit TIGR03431, PhnD, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P16682-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAKIIASLA FTSMFSLSTL LSPAHAEEQE KALNFGIIST ESQQNLKPQW
60 70 80 90 100
TPFLQDMEKK LGVKVNAFFA PDYAGIIQGM RFNKVDIAWY GNLSAMEAVD
110 120 130 140 150
RANGQVFAQT VAADGSPGYW SVLIVNKDSP INNLNDLLAK RKDLTFGNGD
160 170 180 190 200
PNSTSGFLVP GYYVFAKNNI SASDFKRTVN AGHETNALAV ANKQVDVATN
210 220 230 240 250
NTENLDKLKT SAPEKLKELK VIWKSPLIPG DPIVWRKNLS ETTKDKIYDF
260 270 280 290 300
FMNYGKTPEE KAVLERLGWA PFRASSDLQL VPIRQLALFK EMQGVKSNKG
310 320 330
LNEQDKLAKT TEIQAQLDDL DRLNNALSAM SSVSKAVQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 312 | E → A in strain: B. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05260 Genomic DNA Translation: AAA24340.1 D90227 Genomic DNA Translation: BAA14263.1 U14003 Genomic DNA Translation: AAA97004.1 U00096 Genomic DNA Translation: AAC77066.1 AP009048 Genomic DNA Translation: BAE78107.1 |
PIRi | S56333 |
RefSeqi | NP_418529.1, NC_000913.3 WP_000992002.1, NZ_SSZK01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC77066; AAC77066; b4105 BAE78107; BAE78107; BAE78107 |
GeneIDi | 48133053 948624 |
KEGGi | ecj:JW4066 eco:b4105 |
PATRICi | fig|1411691.4.peg.2595 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05260 Genomic DNA Translation: AAA24340.1 D90227 Genomic DNA Translation: BAA14263.1 U14003 Genomic DNA Translation: AAA97004.1 U00096 Genomic DNA Translation: AAC77066.1 AP009048 Genomic DNA Translation: BAE78107.1 |
PIRi | S56333 |
RefSeqi | NP_418529.1, NC_000913.3 WP_000992002.1, NZ_SSZK01000016.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263091, 145 interactors |
DIPi | DIP-10483N |
IntActi | P16682, 4 interactors |
STRINGi | 511145.b4105 |
Protein family/group databases
TCDBi | 3.A.1.9.1, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P16682 |
PRIDEi | P16682 |
Genome annotation databases
EnsemblBacteriai | AAC77066; AAC77066; b4105 BAE78107; BAE78107; BAE78107 |
GeneIDi | 48133053 948624 |
KEGGi | ecj:JW4066 eco:b4105 |
PATRICi | fig|1411691.4.peg.2595 |
Organism-specific databases
EchoBASEi | EB0708 |
Phylogenomic databases
eggNOGi | COG3221, Bacteria |
HOGENOMi | CLU_051472_2_0_6 |
InParanoidi | P16682 |
PhylomeDBi | P16682 |
Enzyme and pathway databases
BioCyci | EcoCyc:PHND-MONOMER MetaCyc:PHND-MONOMER |
Miscellaneous databases
PROi | PR:P16682 |
Family and domain databases
InterProi | View protein in InterPro IPR005770, PhnD IPR017797, Phosphnate-bd |
PANTHERi | PTHR30043:SF5, PTHR30043:SF5, 1 hit |
TIGRFAMsi | TIGR01098, 3A0109s03R, 1 hit TIGR03431, PhnD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHND_ECOLI | |
Accessioni | P16682Primary (citable) accession number: P16682 Secondary accession number(s): Q2M6J9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | November 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families