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Protein

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL

Gene

phnL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.1 Publication

Catalytic activityi

ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • organic phosphonate catabolic process Source: EcoCyc

Keywordsi

Molecular functionTransferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PHNL-MONOMER
MetaCyc:PHNL-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL (EC:2.7.8.37)
Short name:
RPnTP synthase subunit PhnL
Gene namesi
Name:phnL
Ordered Locus Names:b4096, JW4057
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10721 phnL

Subcellular locationi

GO - Cellular componenti

  • alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000927451 – 226Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnLAdd BLAST226

Proteomic databases

PaxDbiP16679
PRIDEiP16679

Interactioni

Protein-protein interaction databases

BioGridi4262019, 4 interactors
ComplexPortaliCPX-1929 PhnGHIJKL complex
IntActiP16679, 4 interactors
STRINGi316385.ECDH10B_4287

Structurei

3D structure databases

ProteinModelPortaliP16679
SMRiP16679
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 226ABC transporterPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105HRV Bacteria
COG4778 LUCA
InParanoidiP16679
KOiK05780
OMAiMHLRDGI
PhylomeDBiP16679

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR012701 CP_lyase_PhnL
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02324 CP_lyasePhnL, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P16679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVQNVSKT FILHQQNGVR LPVLNRASLT VNAGECVVLH GHSGSGKSTL
60 70 80 90 100
LRSLYANYLP DEGQIQIKHG DEWVDLVTAP ARKVVEIRKT TVGWVSQFLR
110 120 130 140 150
VIPRISALEV VMQPLLDTGV PREACAAKAA RLLTRLNVPE RLWHLAPSTF
160 170 180 190 200
SGGEQQRVNI ARGFIVDYPI LLLDEPTASL DAKNSAAVVE LIREAKTRGA
210 220
AIVGIFHDEA VRNDVADRLH PMGASS
Length:226
Mass (Da):24,705
Last modified:August 1, 1990 - v1
Checksum:i195EC8BB5A2D21D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05260 Genomic DNA Translation: AAA24350.1
D90227 Genomic DNA Translation: BAA14272.1
U14003 Genomic DNA Translation: AAA96995.1
U00096 Genomic DNA Translation: AAC77057.1
AP009048 Genomic DNA Translation: BAE78099.1
PIRiD35719
RefSeqiNP_418520.1, NC_000913.3
WP_000611405.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77057; AAC77057; b4096
BAE78099; BAE78099; BAE78099
GeneIDi948612
KEGGiecj:JW4057
eco:b4096
PATRICifig|1411691.4.peg.2604

Similar proteinsi

Entry informationi

Entry nameiPHNL_ECOLI
AccessioniPrimary (citable) accession number: P16679
Secondary accession number(s): Q2M6K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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