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Protein

Platelet glycoprotein 4

Gene

CD36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).By similarity1 Publication7 Publications
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei463Critical for TLR4-TLR6 dimerization and signaling1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236974 ER-Phagosome pathway
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-1989781 PPARA activates gene expression
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SIGNORiP16671

Protein family/group databases

TCDBi9.B.39.1.4 the long chain fatty acid translocase (lcfat) family

Chemistry databases

SwissLipidsiSLP:000001098

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Fatty acid translocase
Short name:
FAT
Glycoprotein IIIb
Short name:
GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
Short name:
GPIV
Thrombospondin receptor
CD_antigen: CD36
Gene namesi
Name:CD36
Synonyms:GP3B, GP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000135218.17
HGNCiHGNC:1663 CD36
MIMi173510 gene
neXtProtiNX_P16671

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 7CytoplasmicSequence analysis6
Transmembranei8 – 29HelicalSequence analysisAdd BLAST22
Topological domaini30 – 439ExtracellularSequence analysisAdd BLAST410
Transmembranei440 – 461HelicalSequence analysisAdd BLAST22
Topological domaini462 – 472CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Platelet glycoprotein IV deficiency (PG4D)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk.1 Publication
Disease descriptionA disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
See also OMIM:608404
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01791390P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant dbSNP:rs75326924EnsemblClinVar.1
Natural variantiVAR_017917254F → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs142186404EnsemblClinVar.1
Natural variantiVAR_017919413I → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs121918035EnsemblClinVar.1
Coronary heart disease 7 (CHDS7)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
See also OMIM:610938

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi462 – 472SYCACRSKTIK → AAAAAAAAAAA: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. 1 PublicationAdd BLAST11
Mutagenesisi463Y → A: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. Loss of complex formation with TLR4 and TLR6. 1 Publication1
Mutagenesisi464C → S: No effect on cell surface location, nor on oxLDL-induced NF-kappa-B activation. 1 Publication1
Mutagenesisi469 – 472KTIK → ATIA: Abolishes ubiquitination induced by lipids. Enhances fatty acid uptake. 2 Publications4

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi948
MalaCardsiCD36
MIMi248310 phenotype
608404 phenotype
610938 phenotype
611162 phenotype
OpenTargetsiENSG00000135218
PharmGKBiPA26212

Chemistry databases

ChEMBLiCHEMBL1744526

Polymorphism and mutation databases

BioMutaiCD36
DMDMi115982

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001441512 – 472Platelet glycoprotein 4Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi3S-palmitoyl cysteine1 Publication1
Lipidationi7S-palmitoyl cysteine1 Publication1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi243 ↔ 311By similarity
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi313 ↔ 322By similarity
Glycosylationi321N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi417N-linked (GlcNAc...) asparagine2 Publications1
Lipidationi464S-palmitoyl cysteine1 Publication1
Lipidationi466S-palmitoyl cysteine1 Publication1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

Post-translational modificationi

N-glycosylated and O-glycosylated with a ratio of 2:1.4 Publications
Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

MaxQBiP16671
PaxDbiP16671
PeptideAtlasiP16671
PRIDEiP16671
ProteomicsDBi53392

PTM databases

GlyConnecti1611
iPTMnetiP16671
PhosphoSitePlusiP16671
SwissPalmiP16671

Expressioni

Gene expression databases

BgeeiENSG00000135218 Expressed in 198 organ(s), highest expression level in adipose tissue
ExpressionAtlasiP16671 baseline and differential
GenevisibleiP16671 HS

Organism-specific databases

HPAiCAB025866
HPA002018
HPA071026

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).By similarity3 Publications
(Microbial infection) Binds to Plasmodium falciparum EMP1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107386, 18 interactors
IntActiP16671, 13 interactors
STRINGi9606.ENSP00000308165

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP16671
SMRiP16671
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 120Required for interaction with thrombospondins, THBS1 and THBS21 PublicationAdd BLAST28
Regioni460 – 472Interaction with PTK2, PXN and LYN1 PublicationAdd BLAST13

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776 Eukaryota
ENOG410XS17 LUCA
GeneTreeiENSGT00530000062927
HOVERGENiHBG002754
InParanoidiP16671
KOiK06259
OMAiNVTQDPE
OrthoDBiEOG091G0CH9
PhylomeDBiP16671
TreeFamiTF317925

Family and domain databases

InterProiView protein in InterPro
IPR005428 CD36/SCARB1/SNMP1
IPR033076 CD36_chordates
IPR002159 CD36_fam
PANTHERiPTHR11923 PTHR11923, 1 hit
PTHR11923:SF12 PTHR11923:SF12, 1 hit
PfamiView protein in Pfam
PF01130 CD36, 1 hit
PRINTSiPR01610 CD36ANTIGEN
PR01609 CD36FAMILY

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA
60 70 80 90 100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK
110 120 130 140 150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ
160 170 180 190 200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL
210 220 230 240 250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD
260 270 280 290 300
AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
310 320 330 340 350
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS
360 370 380 390 400
PDVSEPIDGL NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ
410 420 430 440 450
VLKNLKRNYI VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS
460 470
VGVVMFVAFM ISYCACRSKT IK
Length:472
Mass (Da):53,053
Last modified:January 23, 2007 - v2
Checksum:i543E748259A094FA
GO
Isoform 2 (identifier: P16671-2) [UniParc]FASTAAdd to basket
Also known as: ex8-del

The sequence of this isoform differs from the canonical sequence as follows:
     274-288: SIYAVFESDVNLKGI → ETCVHFTSSFSVCKS
     289-472: Missing.

Show »
Length:288
Mass (Da):32,265
Checksum:iC82FFEF32AF7A690
GO
Isoform 3 (identifier: P16671-3) [UniParc]FASTAAdd to basket
Also known as: ex6-7-del

The sequence of this isoform differs from the canonical sequence as follows:
     234-272: Missing.

Show »
Length:433
Mass (Da):48,600
Checksum:i9D4A561C95F1ED4D
GO
Isoform 4 (identifier: P16671-4) [UniParc]FASTAAdd to basket
Also known as: ex4-del

The sequence of this isoform differs from the canonical sequence as follows:
     144-203: Missing.

Show »
Length:412
Mass (Da):46,090
Checksum:i33D8CA7991537066
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLT1E9PLT1_HUMAN
Platelet glycoprotein 4
CD36
396Annotation score:
E7EX47E7EX47_HUMAN
Platelet glycoprotein 4
CD36
203Annotation score:
E7EU05E7EU05_HUMAN
Platelet glycoprotein 4
CD36
463Annotation score:
E7EVU1E7EVU1_HUMAN
Platelet glycoprotein 4
CD36
99Annotation score:
E7ERZ9E7ERZ9_HUMAN
Platelet glycoprotein 4
CD36
143Annotation score:
E7EWI4E7EWI4_HUMAN
Platelet glycoprotein 4
CD36
148Annotation score:
H0YEE7H0YEE7_HUMAN
Platelet glycoprotein 4
CD36
66Annotation score:
E9PJX8E9PJX8_HUMAN
Platelet glycoprotein 4
CD36
65Annotation score:
E9PC45E9PC45_HUMAN
Platelet glycoprotein 4
CD36
93Annotation score:

Sequence cautioni

The sequence AAM14636 differs from that shown. Reason: Frameshift at position 53.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44L → R in AAD13993 (PubMed:7505064).Curated1
Sequence conflicti238Y → D in AAD13993 (PubMed:7505064).Curated1
Sequence conflicti374E → Q in AAA16068 (PubMed:7693552).Curated1
Sequence conflicti374E → Q AA sequence (PubMed:15242332).Curated1

Polymorphismi

Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIMi:611162].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01791390P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant dbSNP:rs75326924EnsemblClinVar.1
Natural variantiVAR_017914123E → K in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs183461468Ensembl.1
Natural variantiVAR_019049127S → L1 PublicationCorresponds to variant dbSNP:rs201765331Ensembl.1
Natural variantiVAR_013918154V → F1 PublicationCorresponds to variant dbSNP:rs5957Ensembl.1
Natural variantiVAR_017915174T → A in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs756525492Ensembl.1
Natural variantiVAR_017916232G → GN in individuals from a malaria endemic area in West Africa. 1 Publication1
Natural variantiVAR_017917254F → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs142186404EnsemblClinVar.1
Natural variantiVAR_017918271I → T in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs370072057Ensembl.1
Natural variantiVAR_071161386R → W1 PublicationCorresponds to variant dbSNP:rs148910227Ensembl.1
Natural variantiVAR_017919413I → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs121918035EnsemblClinVar.1
Natural variantiVAR_071162470T → I1 PublicationCorresponds to variant dbSNP:rs200771788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055976144 – 203Missing in isoform 4. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_055977234 – 272Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_055978274 – 288SIYAV…NLKGI → ETCVHFTSSFSVCKS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_055979289 – 472Missing in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA Translation: AAA35534.1
M98398 mRNA Translation: AAA58412.1
M98399 mRNA Translation: AAA58413.1
L06850 mRNA Translation: AAA16068.1
S67532 mRNA Translation: AAD13993.1
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA Translation: CAA83662.1
AY095373 Genomic DNA Translation: AAM14636.2 Frameshift.
HM217023 mRNA Translation: ADI80543.1
HM217024 mRNA Translation: ADI80544.1
HM217025 mRNA Translation: ADI80545.1
HM217026 mRNA Translation: ADI80546.1
AC004862 Genomic DNA No translation available.
AC073182 Genomic DNA No translation available.
AC073850 Genomic DNA No translation available.
AC092108 Genomic DNA No translation available.
AC124834 Genomic DNA No translation available.
BC008406 mRNA Translation: AAH08406.1
AF300626 Genomic DNA Translation: AAG60625.1
AF300627 Genomic DNA Translation: AAG60626.1
AF300628 Genomic DNA Translation: AAG60627.1
AF300633 Genomic DNA Translation: AAG60632.1
AF300634 Genomic DNA Translation: AAG60633.1
AF300635 Genomic DNA Translation: AAG60634.1
AF300639 Genomic DNA Translation: AAG60638.1
AF300640 Genomic DNA Translation: AAG60639.1
S67044 mRNA Translation: AAB28992.1
Z22924 Genomic DNA Translation: CAA80504.1
CCDSiCCDS34673.1 [P16671-1]
CCDS78249.1 [P16671-3]
CCDS78250.1 [P16671-4]
PIRiA54870
RefSeqiNP_000063.2, NM_000072.3 [P16671-1]
NP_001001547.1, NM_001001547.2 [P16671-1]
NP_001001548.1, NM_001001548.2 [P16671-1]
NP_001120915.1, NM_001127443.1 [P16671-1]
NP_001120916.1, NM_001127444.1 [P16671-1]
NP_001276837.1, NM_001289908.1 [P16671-3]
NP_001276838.1, NM_001289909.1 [P16671-4]
NP_001276840.1, NM_001289911.1
XP_005250770.1, XM_005250713.1 [P16671-1]
XP_005250771.1, XM_005250714.1 [P16671-1]
XP_005250772.1, XM_005250715.4 [P16671-1]
UniGeneiHs.120949

Genome annotation databases

EnsembliENST00000309881; ENSP00000308165; ENSG00000135218 [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218 [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218 [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218 [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218 [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218 [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218 [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218 [P16671-2]
GeneIDi948
KEGGihsa:948
UCSCiuc003uhc.4 human [P16671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CD36 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA Translation: AAA35534.1
M98398 mRNA Translation: AAA58412.1
M98399 mRNA Translation: AAA58413.1
L06850 mRNA Translation: AAA16068.1
S67532 mRNA Translation: AAD13993.1
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA Translation: CAA83662.1
AY095373 Genomic DNA Translation: AAM14636.2 Frameshift.
HM217023 mRNA Translation: ADI80543.1
HM217024 mRNA Translation: ADI80544.1
HM217025 mRNA Translation: ADI80545.1
HM217026 mRNA Translation: ADI80546.1
AC004862 Genomic DNA No translation available.
AC073182 Genomic DNA No translation available.
AC073850 Genomic DNA No translation available.
AC092108 Genomic DNA No translation available.
AC124834 Genomic DNA No translation available.
BC008406 mRNA Translation: AAH08406.1
AF300626 Genomic DNA Translation: AAG60625.1
AF300627 Genomic DNA Translation: AAG60626.1
AF300628 Genomic DNA Translation: AAG60627.1
AF300633 Genomic DNA Translation: AAG60632.1
AF300634 Genomic DNA Translation: AAG60633.1
AF300635 Genomic DNA Translation: AAG60634.1
AF300639 Genomic DNA Translation: AAG60638.1
AF300640 Genomic DNA Translation: AAG60639.1
S67044 mRNA Translation: AAB28992.1
Z22924 Genomic DNA Translation: CAA80504.1
CCDSiCCDS34673.1 [P16671-1]
CCDS78249.1 [P16671-3]
CCDS78250.1 [P16671-4]
PIRiA54870
RefSeqiNP_000063.2, NM_000072.3 [P16671-1]
NP_001001547.1, NM_001001547.2 [P16671-1]
NP_001001548.1, NM_001001548.2 [P16671-1]
NP_001120915.1, NM_001127443.1 [P16671-1]
NP_001120916.1, NM_001127444.1 [P16671-1]
NP_001276837.1, NM_001289908.1 [P16671-3]
NP_001276838.1, NM_001289909.1 [P16671-4]
NP_001276840.1, NM_001289911.1
XP_005250770.1, XM_005250713.1 [P16671-1]
XP_005250771.1, XM_005250714.1 [P16671-1]
XP_005250772.1, XM_005250715.4 [P16671-1]
UniGeneiHs.120949

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LGDX-ray2.07A1-472[»]
ProteinModelPortaliP16671
SMRiP16671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107386, 18 interactors
IntActiP16671, 13 interactors
STRINGi9606.ENSP00000308165

Chemistry databases

ChEMBLiCHEMBL1744526
SwissLipidsiSLP:000001098

Protein family/group databases

TCDBi9.B.39.1.4 the long chain fatty acid translocase (lcfat) family

PTM databases

GlyConnecti1611
iPTMnetiP16671
PhosphoSitePlusiP16671
SwissPalmiP16671

Polymorphism and mutation databases

BioMutaiCD36
DMDMi115982

Proteomic databases

MaxQBiP16671
PaxDbiP16671
PeptideAtlasiP16671
PRIDEiP16671
ProteomicsDBi53392

Protocols and materials databases

DNASUi948
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309881; ENSP00000308165; ENSG00000135218 [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218 [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218 [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218 [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218 [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218 [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218 [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218 [P16671-2]
GeneIDi948
KEGGihsa:948
UCSCiuc003uhc.4 human [P16671-1]

Organism-specific databases

CTDi948
DisGeNETi948
EuPathDBiHostDB:ENSG00000135218.17
GeneCardsiCD36
HGNCiHGNC:1663 CD36
HPAiCAB025866
HPA002018
HPA071026
MalaCardsiCD36
MIMi173510 gene
248310 phenotype
608404 phenotype
610938 phenotype
611162 phenotype
neXtProtiNX_P16671
OpenTargetsiENSG00000135218
PharmGKBiPA26212
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3776 Eukaryota
ENOG410XS17 LUCA
GeneTreeiENSGT00530000062927
HOVERGENiHBG002754
InParanoidiP16671
KOiK06259
OMAiNVTQDPE
OrthoDBiEOG091G0CH9
PhylomeDBiP16671
TreeFamiTF317925

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236974 ER-Phagosome pathway
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-1989781 PPARA activates gene expression
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SIGNORiP16671

Miscellaneous databases

ChiTaRSiCD36 human
GeneWikiiCD36
GenomeRNAii948
PROiPR:P16671
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135218 Expressed in 198 organ(s), highest expression level in adipose tissue
ExpressionAtlasiP16671 baseline and differential
GenevisibleiP16671 HS

Family and domain databases

InterProiView protein in InterPro
IPR005428 CD36/SCARB1/SNMP1
IPR033076 CD36_chordates
IPR002159 CD36_fam
PANTHERiPTHR11923 PTHR11923, 1 hit
PTHR11923:SF12 PTHR11923:SF12, 1 hit
PfamiView protein in Pfam
PF01130 CD36, 1 hit
PRINTSiPR01610 CD36ANTIGEN
PR01609 CD36FAMILY
ProtoNetiSearch...

Entry informationi

Entry nameiCD36_HUMAN
AccessioniPrimary (citable) accession number: P16671
Secondary accession number(s): D9IX66
, D9IX67, D9IX68, D9IX69, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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