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Protein

Guanine nucleotide exchange factor subunit RGP1

Gene

RGP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment.2 Publications
Required for proper mitotic growth.

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central
  • Rab guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29734-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor subunit RGP1Curated
Alternative name(s):
Reduced growth phenotype protein 1Imported
Short name:
Rgp1p1 Publication
Gene namesi
Name:RGP11 PublicationImported
Ordered Locus Names:YDR137W
ORF Names:YD9302.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002544 RGP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973191 – 663Guanine nucleotide exchange factor subunit RGP1Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP16664
PaxDbiP16664
PRIDEiP16664

PTM databases

iPTMnetiP16664

Interactioni

Subunit structurei

Forms a complex with RIC1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RIC1P403954EBI-15080,EBI-15183

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32191, 522 interactors
ComplexPortaliCPX-3078 Ric1-Rgp1 guanyl-nucleotide exchange factor complex
DIPiDIP-6486N
IntActiP16664, 3 interactors
MINTiP16664
STRINGi4932.YDR137W

Structurei

3D structure databases

ProteinModelPortaliP16664
SMRiP16664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RGP1 family.Curated

Phylogenomic databases

HOGENOMiHOG000141765
InParanoidiP16664
KOiK20477
OMAiQFYEDKK
OrthoDBiEOG092C3FAS

Family and domain databases

InterProiView protein in InterPro
IPR014848 Rgp1
PANTHERiPTHR12507 PTHR12507, 1 hit
PfamiView protein in Pfam
PF08737 Rgp1, 1 hit

Sequencei

Sequence statusi: Complete.

P16664-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAHRIDTFL IRENIKLEII HESNSYFGGE HISIAFRFKH LGSQHELFNY
60 70 80 90 100
KEKLLTVDKA VEEKLEQQAK VQDDGEGTME NQTWSLKSLL GAFKRTGEPE
110 120 130 140 150
ESVDVDNMKM LNESKMLREK IQKQMYFHQP VTLISGYVQI SGVFQYDSEV
160 170 180 190 200
ISESKFKQDE VKMVGLDIVP GHTTNSVLAL EDGEHFKGKR NLTNYLNSDY
210 220 230 240 250
TNVTNGLLFS ESGSRGRTGT YNERTLMISN DTSIKTLPLL LIPQTLLFSE
260 270 280 290 300
ISLEPGEVRT FYFKSTKLPK DICPSYSSSK VASINYTLEV GADVLSDDNI
310 320 330 340 350
EKFSNRVPIT IAPYISSNAE QYTSRLDKPA IILKTGNIKE LKPRLFTRKV
360 370 380 390 400
STASAVSFGR RKSSIIDIDS PLEDNEFVKR VKKNFIELVE SNQNVSRDID
410 420 430 440 450
ELIDLQMGVQ FGKDEDSSDP EPNDSHFSNE MVTSAESSLR SDAVTKRRKS
460 470 480 490 500
YSVRDNISNL EQKMWNDCSL VKSDENSNLL PQLINLQNAY QINRNNETMA
510 520 530 540 550
KVSLSAPFYK TTDDINLVIE LDPITTPLLK VTSLTVSLES FEIINPKYKT
560 570 580 590 600
EGKGIGSKPK GNSVYEKHFI CFDECKSVSV KLLPPRSPTN QITGQFKTDV
610 620 630 640 650
FQHKWMIGLK FVIIAKTESI TLDQFYEDKK GILFHSKENL EGEEFTCYVP
660
IPILCTSEDF MGW
Length:663
Mass (Da):75,317
Last modified:November 1, 1997 - v2
Checksum:i4A3B311ED90ED14A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 56EKLLT → KAS in CAA36300 (PubMed:2179863).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52081 Genomic DNA Translation: CAA36300.1
Z48179 Genomic DNA Translation: CAA88219.1
BK006938 Genomic DNA Translation: DAA11980.1
PIRiS51865
RefSeqiNP_010421.1, NM_001180444.1

Genome annotation databases

EnsemblFungiiYDR137W; YDR137W; YDR137W
GeneIDi851714
KEGGisce:YDR137W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52081 Genomic DNA Translation: CAA36300.1
Z48179 Genomic DNA Translation: CAA88219.1
BK006938 Genomic DNA Translation: DAA11980.1
PIRiS51865
RefSeqiNP_010421.1, NM_001180444.1

3D structure databases

ProteinModelPortaliP16664
SMRiP16664
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32191, 522 interactors
ComplexPortaliCPX-3078 Ric1-Rgp1 guanyl-nucleotide exchange factor complex
DIPiDIP-6486N
IntActiP16664, 3 interactors
MINTiP16664
STRINGi4932.YDR137W

PTM databases

iPTMnetiP16664

Proteomic databases

MaxQBiP16664
PaxDbiP16664
PRIDEiP16664

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR137W; YDR137W; YDR137W
GeneIDi851714
KEGGisce:YDR137W

Organism-specific databases

SGDiS000002544 RGP1

Phylogenomic databases

HOGENOMiHOG000141765
InParanoidiP16664
KOiK20477
OMAiQFYEDKK
OrthoDBiEOG092C3FAS

Enzyme and pathway databases

BioCyciYEAST:G3O-29734-MONOMER

Miscellaneous databases

PROiPR:P16664

Family and domain databases

InterProiView protein in InterPro
IPR014848 Rgp1
PANTHERiPTHR12507 PTHR12507, 1 hit
PfamiView protein in Pfam
PF08737 Rgp1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGP1_YEAST
AccessioniPrimary (citable) accession number: P16664
Secondary accession number(s): D6VSC0, Q03915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health

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