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Entry version 194 (07 Apr 2021)
Sequence version 2 (25 Apr 2018)
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Protein

UDP-glucuronosyltransferase 2B7

Gene

UGT2B7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15472229, PubMed:15470161, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:17442341). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:2159463, PubMed:15472229, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:26220143, PubMed:17442341). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).11 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values.2 Publications
  1. KM=10 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
  2. KM=33 µM for the formation of 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2)1 Publication
  3. KM=33 µM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3)1 Publication
  4. KM=22 µM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3)1 Publication
  5. KM=10 µM for 4-hydroxy-17beta-estradiol (when assaying glucuronidation at position 4)1 Publication
  6. KM=62 µM for 4-hydroxy-estrone (when assaying glucuronidation at position 4)1 Publication
  7. KM=3.4 µM for 16alpha-hydroxyestrone (when assaying glucuronidation at position 16)1 Publication
  8. KM=5.96 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
  9. KM=1.7 µM for epitestosterone (when assaying glucuronidation at position 17)1 Publication
  10. KM=1.3 µM for all-trans-retinoate1 Publication
  11. KM=221 µM for all-trans-4-hydroxyretinoate1 Publication
  12. KM=200 µM for mycophenolate (when assaying glucuronidation at position 6')1 Publication
  13. KM=162.3 µM for losartan1 Publication
  14. KM=4.2 µM for calcitriol (when assaying glucuronidation at position 25)1 Publication
  1. Vmax=42 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  2. Vmax=14 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate)1 Publication
  3. Vmax=372 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  4. Vmax=48 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  5. Vmax=523 pmol/min/mg enzyme for the formation of 4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronate)1 Publication
  6. Vmax=872 pmol/min/mg enzyme for the formation of 4-hydroxy-estrone 4-O-(beta-D-glucuronate)1 Publication
  7. Vmax=190 pmol/min/mg enzyme for the formation of 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate)1 Publication
  8. Vmax=590 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  9. Vmax=631 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  10. Vmax=32.6 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  11. Vmax=4.5 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  12. Vmax=1198 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 16-O-(beta-D-glucuronate)1 Publication
  13. Vmax=2717 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 16-O-(beta-D-glucuronate)1 Publication
  14. Vmax=35.2 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate)1 Publication
  15. Vmax=1537 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate)1 Publication
  16. Vmax=337 pmol/min/mg enzyme for the formation of epitestosterone 17-O-(beta-D-glucuronate)1 Publication
  17. Vmax=523 pmol/min/mg enzyme for the formation of all-trans-retinoate 1-O-(beta-D-glucuronate)1 Publication
  18. Vmax=1709 pmol/min/mg enzyme for the formation of 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate1 Publication
  19. Vmax=220 pmol/min/mg enzyme for the formation of mycophenolic acid O-acyl-glucuronide1 Publication
  20. Vmax=16.1 pmol/min/mg enzyme for the formation of losartan-N2-beta-D-glucuronide1 Publication
  21. Vmax=1.4 pmol/min/mg enzyme for the formation of calcitriol 25-O-(beta-D-glucuronate)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei398UDP-glucuronic acidCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi373 – 379UDP-glucuronic acidCurated7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10272-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.4.1.17, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P16662

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156588, Glucuronidation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P16662

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P16662

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT1, Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001695

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B71 Publication (EC:2.4.1.177 Publications)
Short name:
UDPGT 2B7
Short name:
UGT2B7
Alternative name(s):
3,4-catechol estrogen-specific UDPGT
UDP-glucuronosyltransferase 2B9
Short name:
UDPGT 2B9
UDPGTh-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT2B7Imported
Synonyms:UGTB2B9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12554, UGT2B7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600068, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P16662

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000171234.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei493 – 509HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15S → A: Reduced androsterone, hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi35H → A: Reduced androsterone, hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi151D → A: Reduced androsterone and tetrachlorocatechol glucuronosyltransferase activities; abolished hyodeoxycholic acid glucuronosyltransferase activity. 1 Publication1
Mutagenesisi151D → N: Abolished androsterone glucuronosyltransferase activity; reduced hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi373T → V: Reduced androsterone, hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi374H → A or E: Abolished androsterone glucuronosyltransferase activity; reduced hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi378N → A: Abolished androsterone glucuronosyltransferase activity; reduced hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi379G → D: Abolished androsterone glucuronosyltransferase activity; reduced hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi379G → S: Abolished androsterone glucuronosyltransferase activity; no change in hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi398D → A or N: Reduced androsterone, hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1
Mutagenesisi399Q → A: Abolished androsterone, hyodeoxycholic acid and tetrachlorocatechol glucuronosyltransferase activities. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7364

Open Targets

More...
OpenTargetsi
ENSG00000171234

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA361

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P16662, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4370

Drug and drug target database

More...
DrugBanki
DB13783, Acemetacin
DB06403, Ambrisentan
DB01217, Anastrozole
DB00714, Apomorphine
DB11638, Artenimol
DB09274, Artesunate
DB11936, Bempedoic acid
DB00564, Carbamazepine
DB01136, Carvedilol
DB06119, Cenobamate
DB06777, Chenodeoxycholic acid
DB00318, Codeine
DB14635, Curcumin sulfate
DB06695, Dabigatran etexilate
DB06292, Dapagliflozin
DB09213, Dexibuprofen
DB00514, Dextromethorphan
DB00586, Diclofenac
DB05928, Dovitinib
DB09038, Empagliflozin
DB13874, Enasidenib
DB00445, Epirubicin
DB11827, Ertugliflozin
DB00783, Estradiol
DB00977, Ethinylestradiol
DB00749, Etodolac
DB00973, Ezetimibe
DB01544, Flunitrazepam
DB00712, Flurbiprofen
DB01095, Fluvastatin
DB00983, Formoterol
DB11796, Fostemsavir
DB01241, Gemfibrozil
DB00327, Hydromorphone
DB01050, Ibuprofen
DB00328, Indomethacin
DB01026, Ketoconazole
DB00465, Ketorolac
DB00598, Labetalol
DB00555, Lamotrigine
DB01006, Letrozole
DB00678, Losartan
DB00227, Lovastatin
DB09212, Loxoprofen
DB01252, Mitiglinide
DB00295, Morphine
DB00688, Mycophenolate mofetil
DB01024, Mycophenolic acid
DB06230, Nalmefene
DB00788, Naproxen
DB11837, Osilodrostat
DB00842, Oxazepam
DB01174, Phenobarbital
DB08860, Pitavastatin
DB00794, Primidone
DB00503, Ritonavir
DB06207, Silodosin
DB00641, Simvastatin
DB00870, Suprofen
DB00675, Tamoxifen
DB06204, Tapentadol
DB00197, Troglitazone
DB13609, Umifenovir
DB06235, Vadimezan
DB00313, Valproic acid
DB06737, Zaltoprofen
DB00495, Zidovudine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UGT2B7

Domain mapping of disease mutations (DMDM)

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DMDMi
136727

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23By similarityAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003603124 – 529UDP-glucuronosyltransferase 2B7Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16662

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P16662

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16662

PeptideAtlas

More...
PeptideAtlasi
P16662

PRoteomics IDEntifications database

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PRIDEi
P16662

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53391

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P16662, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P16662

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P16662

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000171234, Expressed in intestine and 74 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16662, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171234, Group enriched (kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113211, 2 interactors

Protein interaction database and analysis system

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IntActi
P16662, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000304811

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P16662, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1529
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16662

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16662

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1192, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_012949_3_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16662

Identification of Orthologs from Complete Genome Data

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OMAi
QEIMSTF

Database of Orthologous Groups

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OrthoDBi
508327at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P16662

TreeFam database of animal gene trees

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TreeFami
TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00201, UDPGT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00375, UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P16662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVKWTSVIL LIQLSFCFSS GNCGKVLVWA AEYSHWMNIK TILDELIQRG
60 70 80 90 100
HEVTVLASSA SILFDPNNSS ALKIEIYPTS LTKTELENFI MQQIKRWSDL
110 120 130 140 150
PKDTFWLYFS QVQEIMSIFG DITRKFCKDV VSNKKFMKKV QESRFDVIFA
160 170 180 190 200
DAIFPCSELL AELFNIPFVY SLSFSPGYTF EKHSGGFIFP PSYVPVVMSE
210 220 230 240 250
LTDQMTFMER VKNMIYVLYF DFWFEIFDMK KWDQFYSEVL GRPTTLSETM
260 270 280 290 300
GKADVWLIRN SWNFQFPYPL LPNVDFVGGL HCKPAKPLPK EMEDFVQSSG
310 320 330 340 350
ENGVVVFSLG SMVSNMTEER ANVIASALAQ IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFADQP
410 420 430 440 450
DNIAHMKARG AAVRVDFNTM SSTDLLNALK RVINDPSYKE NVMKLSRIQH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVIGFLLVC
510 520
VATVIFIVTK CCLFCFWKFA RKAKKGKND
Length:529
Mass (Da):60,721
Last modified:April 25, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94B8B31CE929C836
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH08D6RH08_HUMAN
UDP-glucuronosyltransferase
UGT2B7
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBP8E9PBP8_HUMAN
UDP-glucuronosyltransferase 2B7
UGT2B7
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X084A0A087X084_HUMAN
UDP-glucuronosyltransferase 2B7
UGT2B7
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

2 alleles have been identified: UGT2B7*1 (His-268) and UGT2B7*2 (Tyr-268). The sequence shown is that of allele UGT2B7*2.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05732771A → S. Corresponds to variant dbSNP:rs12233719EnsemblClinVar.1
Natural variantiVAR_012342268Y → H in allele UGT2B7*1. 2 PublicationsCorresponds to variant dbSNP:rs7439366EnsemblClinVar.1
Natural variantiVAR_057328378N → S. Corresponds to variant dbSNP:rs35590824Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05428 mRNA Translation: AAA36793.1
AK313190 mRNA Translation: BAG36007.1
AK223142 mRNA Translation: BAD96862.1
AC111000 Genomic DNA Translation: AAY41045.1
BC030974 mRNA Translation: AAH30974.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3526.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A35366

NCBI Reference Sequences

More...
RefSeqi
NP_001065.2, NM_001074.3
NP_001317648.1, NM_001330719.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305231; ENSP00000304811; ENSG00000171234

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7364

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7364

UCSC genome browser

More...
UCSCi
uc003heg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05428 mRNA Translation: AAA36793.1
AK313190 mRNA Translation: BAG36007.1
AK223142 mRNA Translation: BAD96862.1
AC111000 Genomic DNA Translation: AAY41045.1
BC030974 mRNA Translation: AAH30974.1
CCDSiCCDS3526.1
PIRiA35366
RefSeqiNP_001065.2, NM_001074.3
NP_001317648.1, NM_001330719.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O6LX-ray1.80A/B285-451[»]
SMRiP16662
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113211, 2 interactors
IntActiP16662, 1 interactor
STRINGi9606.ENSP00000304811

Chemistry databases

ChEMBLiCHEMBL4370
DrugBankiDB13783, Acemetacin
DB06403, Ambrisentan
DB01217, Anastrozole
DB00714, Apomorphine
DB11638, Artenimol
DB09274, Artesunate
DB11936, Bempedoic acid
DB00564, Carbamazepine
DB01136, Carvedilol
DB06119, Cenobamate
DB06777, Chenodeoxycholic acid
DB00318, Codeine
DB14635, Curcumin sulfate
DB06695, Dabigatran etexilate
DB06292, Dapagliflozin
DB09213, Dexibuprofen
DB00514, Dextromethorphan
DB00586, Diclofenac
DB05928, Dovitinib
DB09038, Empagliflozin
DB13874, Enasidenib
DB00445, Epirubicin
DB11827, Ertugliflozin
DB00783, Estradiol
DB00977, Ethinylestradiol
DB00749, Etodolac
DB00973, Ezetimibe
DB01544, Flunitrazepam
DB00712, Flurbiprofen
DB01095, Fluvastatin
DB00983, Formoterol
DB11796, Fostemsavir
DB01241, Gemfibrozil
DB00327, Hydromorphone
DB01050, Ibuprofen
DB00328, Indomethacin
DB01026, Ketoconazole
DB00465, Ketorolac
DB00598, Labetalol
DB00555, Lamotrigine
DB01006, Letrozole
DB00678, Losartan
DB00227, Lovastatin
DB09212, Loxoprofen
DB01252, Mitiglinide
DB00295, Morphine
DB00688, Mycophenolate mofetil
DB01024, Mycophenolic acid
DB06230, Nalmefene
DB00788, Naproxen
DB11837, Osilodrostat
DB00842, Oxazepam
DB01174, Phenobarbital
DB08860, Pitavastatin
DB00794, Primidone
DB00503, Ritonavir
DB06207, Silodosin
DB00641, Simvastatin
DB00870, Suprofen
DB00675, Tamoxifen
DB06204, Tapentadol
DB00197, Troglitazone
DB13609, Umifenovir
DB06235, Vadimezan
DB00313, Valproic acid
DB06737, Zaltoprofen
DB00495, Zidovudine
SwissLipidsiSLP:000001695

Protein family/group databases

CAZyiGT1, Glycosyltransferase Family 1

PTM databases

GlyGeniP16662, 3 sites
iPTMnetiP16662
PhosphoSitePlusiP16662

Genetic variation databases

BioMutaiUGT2B7
DMDMi136727

Proteomic databases

jPOSTiP16662
MassIVEiP16662
PaxDbiP16662
PeptideAtlasiP16662
PRIDEiP16662
ProteomicsDBi53391

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44203, 174 antibodies

The DNASU plasmid repository

More...
DNASUi
7364

Genome annotation databases

EnsembliENST00000305231; ENSP00000304811; ENSG00000171234
GeneIDi7364
KEGGihsa:7364
UCSCiuc003heg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7364
DisGeNETi7364

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UGT2B7
HGNCiHGNC:12554, UGT2B7
HPAiENSG00000171234, Group enriched (kidney, liver)
MIMi600068, gene
neXtProtiNX_P16662
OpenTargetsiENSG00000171234
PharmGKBiPA361
VEuPathDBiHostDB:ENSG00000171234.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1192, Eukaryota
GeneTreeiENSGT00940000158332
HOGENOMiCLU_012949_3_2_1
InParanoidiP16662
OMAiQEIMSTF
OrthoDBi508327at2759
PhylomeDBiP16662
TreeFamiTF315472

Enzyme and pathway databases

BioCyciMetaCyc:HS10272-MONOMER
BRENDAi2.4.1.17, 2681
PathwayCommonsiP16662
ReactomeiR-HSA-156588, Glucuronidation
SABIO-RKiP16662
SIGNORiP16662

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7364, 6 hits in 915 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UGT2B7, human
EvolutionaryTraceiP16662

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
UGT2B7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7364
PharosiP16662, Tchem

Protein Ontology

More...
PROi
PR:P16662
RNActiP16662, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171234, Expressed in intestine and 74 other tissues
ExpressionAtlasiP16662, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201, UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375, UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD2B7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16662
Secondary accession number(s): B2R810, Q6GTW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 25, 2018
Last modified: April 7, 2021
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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