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UniProtKB - P16659 (SYP_ECOLI)

Entry version 189 (23 Feb 2022)
Sequence version 4 (29 Aug 2003)
Previous versions | rss
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Protein

Proline--tRNA ligase

Gene

proS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). Misacylated Cys-tRNA(Pro) is not edited by ProRS, but instead may be edited in trans by YbaK.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.25 mM for proline3 Publications
  2. KM=140 mM for alanine3 Publications
  3. KM=0.17 mM for cysteine3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • prolyl-tRNA aminoacylation Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PROS-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.1.1.15, 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P16659

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline--tRNA ligase (EC:6.1.1.15)
Alternative name(s):
Global RNA synthesis factor
Prolyl-tRNA synthetase
Short name:
ProRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:proS
Synonyms:drpA
Ordered Locus Names:b0194, JW0190
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi257T → A: Reduces the posttransfer editing activity 5-fold, with little change in both the aminoacylation and the pretransfer editing activities. 1 Publication1
Mutagenesisi279K → A: Severely affects the posttransfer editing activity, with little change in both the aminoacylation and the pretransfer editing activities. 1 Publication1
Mutagenesisi350D → A: Abolishes the pretransfer editing activity and reduces the aminoacylation activity 20-fold and the posttransfer editing activity 5-fold. 1 Publication1
Mutagenesisi369H → A: Reduces both the aminoacylation and the pretransfer editing activities 2.5-fold, and the posttransfer editing activity 5-fold. Loss of specificity in deacylation. 1 Publication1
Mutagenesisi378D → A: Little change in both the aminoacylation and the editing activities. 1 Publication1
Mutagenesisi386D → A: Reduces the posttransfer editing activity approximately 2-fold, with little change in both the aminoacylation and the pretransfer editing activities. 1 Publication1
Mutagenesisi394D → A: Reduces the posttransfer editing activity approximately 2-fold, with little change in both the aminoacylation and the pretransfer editing activities. 1 Publication1
Mutagenesisi443C → G: 150-fold decrease in posttransfer editing activity against alanine, without change neither in pretransfer editing nor in aminoacylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001393291 – 572Proline--tRNA ligaseAdd BLAST572

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16659

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16659

PRoteomics IDEntifications database

More...PRIDEi		P16659

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P16659

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P16659

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261629, 32 interactors

Database of interacting proteins

More...DIPi		DIP-10573N

Protein interaction database and analysis system

More...IntActi		P16659, 20 interactors

STRING: functional protein association networks

More...STRINGi		511145.b0194

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16659

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0442, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016739_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16659

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16659

Family and domain databases

Conserved Domains Database

More...CDDi		cd00861, ProRS_anticodon_short, 1 hit
cd00779, ProRS_core_prok, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.930.10, 2 hits
3.40.50.800, 1 hit
3.90.960.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01569, Pro_tRNA_synth_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002314, aa-tRNA-synt_IIb
IPR006195, aa-tRNA-synth_II
IPR045864, aa-tRNA-synth_II/BPL/LPL
IPR004154, Anticodon-bd
IPR036621, Anticodon-bd_dom_sf
IPR002316, Pro-tRNA-ligase_IIa
IPR004500, Pro-tRNA-synth_IIa_bac-type
IPR023717, Pro-tRNA-Synthase_IIa_type1
IPR044140, ProRS_anticodon_short
IPR033730, ProRS_core_prok
IPR036754, YbaK/aa-tRNA-synt-asso_dom_sf
IPR007214, YbaK/aa-tRNA-synth-assoc-dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03129, HGTP_anticodon, 1 hit
PF00587, tRNA-synt_2b, 1 hit
PF04073, tRNA_edit, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001535, ProRS_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01046, TRNASYNTHPRO

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55681, SSF55681, 1 hit
SSF55826, SSF55826, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00409, proS_fam_II, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50862, AA_TRNA_LIGASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P16659-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTSQYLLST LKETPADAEV ISHQLMLRAG MIRKLASGLY TWLPTGVRVL 
        60         70         80         90        100
KKVENIVREE MNNAGAIEVS MPVVQPADLW QESGRWEQYG PELLRFVDRG 
       110        120        130        140        150
ERPFVLGPTH EEVITDLIRN ELSSYKQLPL NFYQIQTKFR DEVRPRFGVM 
       160        170        180        190        200
RSREFLMKDA YSFHTSQESL QETYDAMYAA YSKIFSRMGL DFRAVQADTG 
       210        220        230        240        250
SIGGSASHEF QVLAQSGEDD VVFSDTSDYA ANIELAEAIA PKEPRAAATQ 
       260        270        280        290        300
EMTLVDTPNA KTIAELVEQF NLPIEKTVKT LLVKAVEGSS FPQVALLVRG 
       310        320        330        340        350
DHELNEVKAE KLPQVASPLT FATEEEIRAV VKAGPGSLGP VNMPIPVVID 
       360        370        380        390        400
RTVAAMSDFA AGANIDGKHY FGINWDRDVA TPEVADIRNV VAGDPSPDGQ 
       410        420        430        440        450
GRLLIKRGIE VGHIFQLGTK YSEALKASVQ GEDGRNQILT MGCYGIGVTR 
       460        470        480        490        500
VVAAAIEQNY DERGIVWPDA IAPFQVAILP MNMHKSFRVQ ELAEKLYSEL 
       510        520        530        540        550
RAQGIEVLLD DRKERPGVMF ADMELIGIPH TIVLGDRNLD NDDIEYKYRR 
       560        570 
NGEKQLIKTG DIVEYLVKQI KG
Length:572
Mass (Da):63,693
Last modified:August 29, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i312D29390E91C486
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26 – 27ML → IV (PubMed:2203971).Curated2
Sequence conflicti127 – 128QL → HV in AAA23710 (PubMed:1688424).Curated2
Sequence conflicti205 – 216SASHE…VLAQS → RPLTNSRCWRR in AAA23710 (PubMed:1688424).CuratedAdd BLAST12
Sequence conflicti205S → Q (PubMed:2203971).Curated1
Sequence conflicti516 – 517PG → RA (PubMed:1688424).Curated2
Sequence conflicti518 – 572Missing (PubMed:1688424).CuratedAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X55518 Genomic DNA Translation: CAA39134.1
M97858 Genomic DNA Translation: AAA24420.1
M32357 Genomic DNA Translation: AAA23710.1
U70214 Genomic DNA Translation: AAB08622.1
U00096 Genomic DNA Translation: AAC73305.1
AP009048 Genomic DNA Translation: BAA77870.2
D15061 Genomic DNA Translation: BAA03654.1

Protein sequence database of the Protein Information Resource

More...PIRi		B64744, YPEC

NCBI Reference Sequences

More...RefSeqi		NP_414736.1, NC_000913.3
WP_001260717.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73305; AAC73305; b0194
BAA77870; BAA77870; BAA77870

Database of genes from NCBI RefSeq genomes

More...GeneIDi		949116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0190
eco:b0194

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2084

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55518 Genomic DNA Translation: CAA39134.1
M97858 Genomic DNA Translation: AAA24420.1
M32357 Genomic DNA Translation: AAA23710.1
U70214 Genomic DNA Translation: AAB08622.1
U00096 Genomic DNA Translation: AAC73305.1
AP009048 Genomic DNA Translation: BAA77870.2
D15061 Genomic DNA Translation: BAA03654.1
PIRiB64744, YPEC
RefSeqiNP_414736.1, NC_000913.3
WP_001260717.1, NZ_LN832404.1

3D structure databases

SMRiP16659
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261629, 32 interactors
DIPiDIP-10573N
IntActiP16659, 20 interactors
STRINGi511145.b0194

PTM databases

CarbonylDBiP16659

2D gel databases

SWISS-2DPAGEiP16659

Proteomic databases

jPOSTiP16659
PaxDbiP16659
PRIDEiP16659

Genome annotation databases

EnsemblBacteriaiAAC73305; AAC73305; b0194
BAA77870; BAA77870; BAA77870
GeneIDi949116
KEGGiecj:JW0190
eco:b0194
PATRICifig|1411691.4.peg.2084

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0763

Phylogenomic databases

eggNOGiCOG0442, Bacteria
HOGENOMiCLU_016739_0_0_6
InParanoidiP16659
PhylomeDBiP16659

Enzyme and pathway databases

BioCyciEcoCyc:PROS-MONOMER
BRENDAi6.1.1.15, 2026
SABIO-RKiP16659

Miscellaneous databases

Protein Ontology

More...PROi		PR:P16659

Family and domain databases

CDDicd00861, ProRS_anticodon_short, 1 hit
cd00779, ProRS_core_prok, 1 hit
Gene3Di3.30.930.10, 2 hits
3.40.50.800, 1 hit
3.90.960.10, 1 hit
HAMAPiMF_01569, Pro_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR002314, aa-tRNA-synt_IIb
IPR006195, aa-tRNA-synth_II
IPR045864, aa-tRNA-synth_II/BPL/LPL
IPR004154, Anticodon-bd
IPR036621, Anticodon-bd_dom_sf
IPR002316, Pro-tRNA-ligase_IIa
IPR004500, Pro-tRNA-synth_IIa_bac-type
IPR023717, Pro-tRNA-Synthase_IIa_type1
IPR044140, ProRS_anticodon_short
IPR033730, ProRS_core_prok
IPR036754, YbaK/aa-tRNA-synt-asso_dom_sf
IPR007214, YbaK/aa-tRNA-synth-assoc-dom
PfamiView protein in Pfam
PF03129, HGTP_anticodon, 1 hit
PF00587, tRNA-synt_2b, 1 hit
PF04073, tRNA_edit, 1 hit
PIRSFiPIRSF001535, ProRS_1, 1 hit
PRINTSiPR01046, TRNASYNTHPRO
SUPFAMiSSF55681, SSF55681, 1 hit
SSF55826, SSF55826, 1 hit
TIGRFAMsiTIGR00409, proS_fam_II, 1 hit
PROSITEiView protein in PROSITE
PS50862, AA_TRNA_LIGASE_II, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16659
Secondary accession number(s): P78272, Q59430
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 29, 2003
Last modified: February 23, 2022
This is version 189 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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