UniProtKB - P16649 (TUP1_YEAST)

BLAST

>sp|P16649|TUP1_YEAST General transcriptional corepressor TUP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TUP1 PE=1 SV=2
MTASVSNTQNKLNELLDAIRQEFLQVSQEANTYRLQNQKDYDFKMNQQLAEMQQIRNTVY
ELELTHRKMKDAYEEEIKHLKLGLEQRDHQIASLTVQQQRQQQQQQQVQQHLQQQQQQLA
AASASVPVAQQPPATTSATATPAANTTTGSPSAFPVQASRPNLVGSQLPTTTLPVVSSNA
QQQLPQQQLQQQQLQQQQPPPQVSVAPLSNTAINGSPTSKETTTLPSVKAPESTLKETEP
ENNNTSKINDTGSATTATTTTATETEIKPKEEDATPASLHQDHYLVPYNQRANHSKPIPP
FLLDLDSQSVPDALKKQTNDYYILYNPALPREIDVELHKSLDHTSVVCCVKFSNDGEYLA
TGCNKTTQVYRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTMTTTTTTTITTTA
MTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLIRIWDIENRKIVMI
LQGHEQDIYSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGK
YIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSV
KLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKK
SGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWKYKKIAPN

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History
Entry version 200 (07 Nov 2018)
Sequence version 2 (01 May 1991)
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Protein

General transcriptional corepressor TUP1

Gene

TUP1

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.7 Publications

Miscellaneous

Present with 5840 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functionⁱ

histone binding
Source: SGD
Inferred from direct assayⁱ
- 8675011
histone deacetylase binding
Source: SGD
Inferred from direct assayⁱ
- 14525981
mediator complex binding
Source: SGD
Inferred from direct assayⁱ
- 11226276
phosphatidylinositol-3,5-bisphosphate binding
Source: SGD
Inferred from direct assayⁱ
- 21536737
transcription corepressor activity
Source: SGD
Inferred from direct assayⁱ
- 9741624

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
Source: SGD
Inferred from mutant phenotypeⁱ
- 9461460
histone exchange
Source: SGD
Inferred from mutant phenotypeⁱ
- 17387147
negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
Source: SGD
Inferred from mutant phenotypeⁱ
- 18708352
negative regulation of mating-type specific transcription from RNA polymerase II promoter
Source: SGD
Inferred from mutant phenotypeⁱ
- 1312982
negative regulation of transcription by RNA polymerase II
Source: SGD
Inferred from mutant phenotypeⁱ
nucleosome positioning
Source: SGD
Inferred from direct assayⁱ
- 15116071
positive regulation of transcription by RNA polymerase II
Source: SGD
Inferred from mutant phenotypeⁱ
- 26546823
regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
Source: SGD
Inferred from mutant phenotypeⁱ
- 9280286
regulation of invasive growth in response to glucose limitation
Source: SGD
Inferred from mutant phenotypeⁱ
- 18202364
regulation of response to DNA damage stimulus
Source: SGD
Inferred from mutant phenotypeⁱ
- 9741624

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29380-MONOMER
Reactomeⁱ	R-SCE-111458 Formation of apoptosome R-SCE-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: General transcriptional corepressor TUP1 Alternative name(s): Flocculation suppressor protein Glucose repression regulatory protein TUP1 Repressor AER2
Gene namesⁱ	Name:TUP1 Synonyms:AAR1, AER2, AMM1, CYC9, FLK1, SFL2, UMR7 Ordered Locus Names:YCR084C ORF Names:YCR84C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome III

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000000680 TUP1

SGDⁱ

S000000680 TUP1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051312	1 – 713	General transcriptional corepressor TUP1Add BLAST		713

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	439	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16649
PaxDbⁱ	P16649
PRIDEⁱ	P16649

PTM databases

iPTMnetⁱ	P16649

iPTMnetⁱ

P16649

Interactionⁱ

Subunit structureⁱ

Associates with CYC8/SSN6 to form the CYC8-TUP1 (or TUP1-SSN6) corepressor complex that is composed of 4 copies of TUP1 and one copy of CYC8. Interacts with histone H3, histone H4, MATALPHA2, RFX1, SKO1, PGD1, HDA1, HDA2, HOS1, HOS2 AND RPD3.9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CYC8	P14922	6	EBI-19654,EBI-18215
PGD1	P40356	3	EBI-19654,EBI-13268
RFX1	P48743	2	EBI-19654,EBI-15036
RPD3	P32561	2	EBI-19654,EBI-15864

GO - Molecular functionⁱ

histone binding
Source: SGD
Inferred from direct assayⁱ
- 8675011
histone deacetylase binding
Source: SGD
Inferred from direct assayⁱ
- 14525981

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	31057, 108 interactors
ComplexPortalⁱ	CPX-1663 CYP8-TUP1 corepressor complex
Database of interacting proteins More...DIPⁱ	DIP-512N
IntActⁱ	P16649, 27 interactors
Molecular INTeraction database More...MINTⁱ	P16649
STRINGⁱ	4932.YCR084C

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	19 – 26	Combined sources	8
Helixⁱ	27 – 84	Combined sources	58
Beta strandⁱ	290 – 292	Combined sources	3
Helixⁱ	300 – 303	Combined sources	4
Beta strandⁱ	307 – 310	Combined sources	4
Beta strandⁱ	314 – 317	Combined sources	4
Beta strandⁱ	322 – 325	Combined sources	4
Beta strandⁱ	333 – 339	Combined sources	7
Beta strandⁱ	415 – 417	Combined sources	3
Beta strandⁱ	424 – 427	Combined sources	4
Beta strandⁱ	431 – 437	Combined sources	7
Beta strandⁱ	442 – 446	Combined sources	5
Beta strandⁱ	457 – 461	Combined sources	5
Beta strandⁱ	489 – 493	Combined sources	5
Beta strandⁱ	497 – 504	Combined sources	8
Beta strandⁱ	509 – 513	Combined sources	5
Turnⁱ	514 – 517	Combined sources	4
Beta strandⁱ	518 – 523	Combined sources	6
Beta strandⁱ	529 – 534	Combined sources	6
Beta strandⁱ	539 – 546	Combined sources	8
Beta strandⁱ	549 – 555	Combined sources	7
Turnⁱ	556 – 559	Combined sources	4
Beta strandⁱ	560 – 566	Combined sources	7
Beta strandⁱ	579 – 584	Combined sources	6
Beta strandⁱ	590 – 595	Combined sources	6
Beta strandⁱ	600 – 604	Combined sources	5
Beta strandⁱ	609 – 612	Combined sources	4
Beta strandⁱ	633 – 638	Combined sources	6
Beta strandⁱ	642 – 649	Combined sources	8
Beta strandⁱ	652 – 657	Combined sources	6
Beta strandⁱ	664 – 669	Combined sources	6
Beta strandⁱ	675 – 680	Combined sources	6
Beta strandⁱ	691 – 697	Combined sources	7
Beta strandⁱ	700 – 709	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P16649
SMRⁱ	P16649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P16649

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	342 – 371	WD 1Add BLAST	30
Repeatⁱ	441 – 471	WD 2Add BLAST	31
Repeatⁱ	483 – 513	WD 3Add BLAST	31
Repeatⁱ	524 – 555	WD 4Add BLAST	32
Repeatⁱ	574 – 604	WD 5Add BLAST	31
Repeatⁱ	628 – 658	WD 6Add BLAST	31
Repeatⁱ	670 – 706	WD 7Add BLAST	37

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	97 – 118	Gln-richAdd BLAST	22
Compositional biasⁱ	181 – 198	Poly-GlnAdd BLAST	18
Compositional biasⁱ	399 – 409	Thr-richAdd BLAST	11

Sequence similaritiesⁱ

Belongs to the WD repeat TUP1 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150996
HOGENOMⁱ	HOG000200558
InParanoidⁱ	P16649
KEGG Orthology (KO) More...KOⁱ	K06666
OMAⁱ	EKVYAME
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C21A7

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR013890 Tscrpt_rep_Tup1_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08581 Tup_N, 1 hit PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010558 Transcrip_repressor_Tup1_N, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 4 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P16649-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTASVSNTQN KLNELLDAIR QEFLQVSQEA NTYRLQNQKD YDFKMNQQLA 
        60         70         80         90        100
EMQQIRNTVY ELELTHRKMK DAYEEEIKHL KLGLEQRDHQ IASLTVQQQR 
       110        120        130        140        150
QQQQQQQVQQ HLQQQQQQLA AASASVPVAQ QPPATTSATA TPAANTTTGS 
       160        170        180        190        200
PSAFPVQASR PNLVGSQLPT TTLPVVSSNA QQQLPQQQLQ QQQLQQQQPP 
       210        220        230        240        250
PQVSVAPLSN TAINGSPTSK ETTTLPSVKA PESTLKETEP ENNNTSKIND 
       260        270        280        290        300
TGSATTATTT TATETEIKPK EEDATPASLH QDHYLVPYNQ RANHSKPIPP 
       310        320        330        340        350
FLLDLDSQSV PDALKKQTND YYILYNPALP REIDVELHKS LDHTSVVCCV 
       360        370        380        390        400
KFSNDGEYLA TGCNKTTQVY RVSDGSLVAR LSDDSAANNH RNSITENNTT 
       410        420        430        440        450
TSTDNNTMTT TTTTTITTTA MTSAAELAKD VENLNTSSSP SSDLYIRSVC 
       460        470        480        490        500
FSPDGKFLAT GAEDRLIRIW DIENRKIVMI LQGHEQDIYS LDYFPSGDKL 
       510        520        530        540        550
VSGSGDRTVR IWDLRTGQCS LTLSIEDGVT TVAVSPGDGK YIAAGSLDRA 
       560        570        580        590        600
VRVWDSETGF LVERLDSENE SGTGHKDSVY SVVFTRDGQS VVSGSLDRSV 
       610        620        630        640        650
KLWNLQNANN KSDSKTPNSG TCEVTYIGHK DFVLSVATTQ NDEYILSGSK 
       660        670        680        690        700
DRGVLFWDKK SGNPLLMLQG HRNSVISVAV ANGSPLGPEY NVFATGSGDC 
       710 
KARIWKYKKI APN

Length:713

Mass (Da):78,308

Last modified:May 1, 1991 - v2

Checksum:ⁱ444104AAD63CB944

Sequence cautionⁱ

The sequence CAA34411 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	75	E → A in AAA35182 (PubMed:2247069).Curated	1
Sequence conflictⁱ	100	R → Q in AAA35182 (PubMed:2247069).Curated	1
Sequence conflictⁱ	685	P → S in AAA35182 (PubMed:2247069).Curated	1
Sequence conflictⁱ	685	P → S in AAA34413 (PubMed:1900249).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M31733 Genomic DNA Translation: AAA35182.1 M35861 Genomic DNA Translation: AAA34413.1 X16365 Genomic DNA Translation: CAA34411.1 Different initiation. X59720 Genomic DNA Translation: CAA42259.1 BK006937 Genomic DNA Translation: DAA07554.1
PIRⁱ	JN0133
NCBI Reference Sequences More...RefSeqⁱ	NP_010007.1, NM_001178790.1

Genome annotation databases

EnsemblFungiⁱ	CAA42259; CAA42259; CAA42259 YCR084C; YCR084C; YCR084C
GeneIDⁱ	850445
KEGGⁱ	sce:YCR084C

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16649	Tup1p		YEASA		725	UniRef90_P16649
Tup1p		YEASO		725
Tup1p		YEASC		718
TUP1-like protein		SACEU		714
Tup1p		YEASB		713
+13

Protein	Similar proteins		Species	Score	Length	Source
P16649	Tup1p		YEASO		725	UniRef50_P16649
Tup1p		YEASA		725
Tup1p		YEASC		718
TUP1-like protein		SACEU		714
TUP1-like protein		SACK1		713
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M31733 Genomic DNA Translation: AAA35182.1 M35861 Genomic DNA Translation: AAA34413.1 X16365 Genomic DNA Translation: CAA34411.1 Different initiation. X59720 Genomic DNA Translation: CAA42259.1 BK006937 Genomic DNA Translation: DAA07554.1
PIRⁱ	JN0133
RefSeqⁱ	NP_010007.1, NM_001178790.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ERJ	X-ray	2.30	A/B/C	282-388	[»]
				A/B/C	432-713	[»]
	3VP8	X-ray	1.91	A/B/C/D	1-92	[»]
	3VP9	X-ray	1.80	A/B	1-92	[»]
ProteinModelPortalⁱ	P16649
SMRⁱ	P16649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	31057, 108 interactors
ComplexPortalⁱ	CPX-1663 CYP8-TUP1 corepressor complex
DIPⁱ	DIP-512N
IntActⁱ	P16649, 27 interactors
MINTⁱ	P16649
STRINGⁱ	4932.YCR084C

PTM databases

iPTMnetⁱ	P16649

iPTMnetⁱ

P16649

Proteomic databases

MaxQBⁱ	P16649
PaxDbⁱ	P16649
PRIDEⁱ	P16649

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	CAA42259; CAA42259; CAA42259 YCR084C; YCR084C; YCR084C
GeneIDⁱ	850445
KEGGⁱ	sce:YCR084C

Organism-specific databases

SGDⁱ	S000000680 TUP1

Phylogenomic databases

GeneTreeⁱ	ENSGT00930000150996
HOGENOMⁱ	HOG000200558
InParanoidⁱ	P16649
KOⁱ	K06666
OMAⁱ	EKVYAME
OrthoDBⁱ	EOG092C21A7

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29380-MONOMER
Reactomeⁱ	R-SCE-111458 Formation of apoptosome R-SCE-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceⁱ	P16649
Protein Ontology More...PROⁱ	PR:P16649

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR013890 Tscrpt_rep_Tup1_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF08581 Tup_N, 1 hit PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD010558 Transcrip_repressor_Tup1_N, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 4 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TUP1_YEAST
Accessionⁱ	P16649Primary (citable) accession number: P16649 Secondary accession number(s): D6VR85, P17995, P18323
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	May 1, 1991
	Last modified:	November 7, 2018
	This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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UniProtKB - P16649 (TUP1_YEAST)

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General transcriptional corepressor TUP1

TUP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ