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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.By similarity

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.By similarity

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.

Cofactori

dipyrromethaneNote: Binds 1 dipyrromethane group covalently.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Porphobilinogen deaminase (hemC)
  3. Uroporphyrinogen-III synthase (hemD)
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU28150-MONOMER
UniPathwayiUPA00251; UER00319

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminase (EC:2.5.1.61)
Short name:
PBG
Alternative name(s):
Hydroxymethylbilane synthase
Short name:
HMBS
Pre-uroporphyrinogen synthase
Gene namesi
Name:hemC
Ordered Locus Names:BSU28150
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001429101 – 313Porphobilinogen deaminaseAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242S-(dipyrrolylmethanemethyl)cysteineBy similarity1

Proteomic databases

PaxDbiP16616
PRIDEiP16616

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015381

Structurei

3D structure databases

ProteinModelPortaliP16616
SMRiP16616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.Curated

Phylogenomic databases

eggNOGiENOG4105D6W Bacteria
COG0181 LUCA
HOGENOMiHOG000228587
InParanoidiP16616
KOiK01749
OMAiCQVPIGV
PhylomeDBiP16616

Family and domain databases

Gene3Di3.30.160.40, 1 hit
HAMAPiMF_00260 Porphobil_deam, 1 hit
InterProiView protein in InterPro
IPR000860 HemC
IPR022419 Porphobilin_deaminase_cofac_BS
IPR022417 Porphobilin_deaminase_N
IPR022418 Porphobilinogen_deaminase_C
IPR036803 Porphobilinogen_deaminase_C_sf
PANTHERiPTHR11557 PTHR11557, 1 hit
PfamiView protein in Pfam
PF01379 Porphobil_deam, 1 hit
PF03900 Porphobil_deamC, 1 hit
PIRSFiPIRSF001438 4pyrrol_synth_OHMeBilane_synth, 1 hit
PRINTSiPR00151 PORPHBDMNASE
SUPFAMiSSF54782 SSF54782, 1 hit
TIGRFAMsiTIGR00212 hemC, 1 hit
PROSITEiView protein in PROSITE
PS00533 PORPHOBILINOGEN_DEAM, 1 hit

Sequencei

Sequence statusi: Complete.

P16616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRTIKVGSR RSKLAMTQTK WVIQKLKEIN PSFAFEIKEI VTKGDRIVDV
60 70 80 90 100
TLSKVGGKGL FVKEIEQALL NEEIDMAVHS MKDMPAVLPE GLVIGCIPER
110 120 130 140 150
EDPRDALISK NRVKLSEMKK GAVIGTSSLR RSAQLLIERP DLTIKWIRGN
160 170 180 190 200
IDTRLQKLET EDYDAIILAA AGLSRMGWKQ DVVTEFLEPE RCLPAVGQGA
210 220 230 240 250
LAIECRESDE ELLALFSQFT DEYTKRTVLA ERAFLNAMEG GCQVPIAGYS
260 270 280 290 300
VLNGQDEIEM TGLVASPDGK IIFKETVTGN DPEEVGKRCA ALMADKGAKD
310
LIDRVKRELD EDGK
Length:314
Mass (Da):34,838
Last modified:May 26, 2009 - v3
Checksum:iA4F13170243E874D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57676 Genomic DNA Translation: AAA22512.1
AL009126 Genomic DNA Translation: CAB14775.1
PIRiC35252 IBBS
RefSeqiNP_390693.1, NC_000964.3
WP_010886587.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14775; CAB14775; BSU28150
GeneIDi937488
KEGGibsu:BSU28150
PATRICifig|224308.43.peg.2942

Similar proteinsi

Entry informationi

Entry nameiHEM3_BACSU
AccessioniPrimary (citable) accession number: P16616
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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