UniProtKB - P16613 (PACA_SHEEP)
Protein
Pituitary adenylate cyclase-activating polypeptide
Gene
ADCYAP1
Organism
Ovis aries (Sheep)
Status
Functioni
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).By similarity
GO - Molecular functioni
- neuropeptide hormone activity Source: UniProtKB
- peptide hormone receptor binding Source: UniProtKB
- pituitary adenylate cyclase activating polypeptide activity Source: BHF-UCL
- pituitary adenylate cyclase-activating polypeptide receptor binding Source: InterPro
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- cAMP-mediated signaling Source: UniProtKB
- insulin secretion Source: UniProtKB
- neuron projection development Source: UniProtKB
- neuropeptide signaling pathway Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of growth hormone secretion Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of protein kinase activity Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
- regulation of protein localization Source: BHF-UCL
Keywordsi
Molecular function | Hormone |
Biological process | Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Pituitary adenylate cyclase-activating polypeptideShort name: PACAP Cleaved into the following 3 chains: Alternative name(s): PRP-48 |
Gene namesi | Name:ADCYAP1 |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000011506 | 25 – 80 | Add BLAST | 56 | |
PeptideiPRO_0000011507 | 82 – 129 | PACAP-related peptideAdd BLAST | 48 | |
PeptideiPRO_0000011508 | 132 – 169 | Pituitary adenylate cyclase-activating polypeptide 38Add BLAST | 38 | |
PeptideiPRO_0000011509 | 132 – 158 | Pituitary adenylate cyclase-activating polypeptide 27Add BLAST | 27 | |
PropeptideiPRO_0000011510 | 173 – 176 | 4 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 158 | Leucine amide1 Publication | 1 | |
Modified residuei | 169 | Lysine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesInteractioni
Subunit structurei
Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
By similarityGO - Molecular functioni
- neuropeptide hormone activity Source: UniProtKB
- peptide hormone receptor binding Source: UniProtKB
- pituitary adenylate cyclase activating polypeptide activity Source: BHF-UCL
- pituitary adenylate cyclase-activating polypeptide receptor binding Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 150 – 158 | Important for receptor bindingBy similarity | 9 |
Sequence similaritiesi
Belongs to the glucagon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
OMAi | KPCSDRF |
OrthoDBi | 1415722at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000532, Glucagon_GIP_secretin_VIP IPR039080, PACAP |
PANTHERi | PTHR11213:SF1, PTHR11213:SF1, 1 hit |
Pfami | View protein in Pfam PF00123, Hormone_2, 2 hits |
PRINTSi | PR00275, GLUCAGON |
SMARTi | View protein in SMART SM00070, GLUCA, 2 hits |
PROSITEi | View protein in PROSITE PS00260, GLUCAGON, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P16613-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMCSGARLA LLVYGILMHS SVYGSPAASG LRFPGIRPEN EAYDEDGNPQ
60 70 80 90 100
QDFYDSEPPG VGSPASALRD AYALYYPAEE RDVAHGILDK AYRKVLDQLS
110 120 130 140 150
ARRYLQTLMA KGLGGTPGGG ADDDSEPLSK RHSDGIFTDS YSRYRKQMAV
160 170
KKYLAAVLGK RYKQRVKNKG RRIPYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32216 mRNA Translation: AAA31575.1 S83511 mRNA Translation: AAB21469.1 |
PIRi | A34044 |
RefSeqi | NP_001009776.1, NM_001009776.1 |
Genome annotation databases
Ensembli | ENSOART00020014250; ENSOARP00020011753; ENSOARG00020009231 |
GeneIDi | 443337 |
KEGGi | oas:443337 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32216 mRNA Translation: AAA31575.1 S83511 mRNA Translation: AAB21469.1 |
PIRi | A34044 |
RefSeqi | NP_001009776.1, NM_001009776.1 |
3D structure databases
BMRBi | P16613 |
SMRi | P16613 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENSOART00020014250; ENSOARP00020011753; ENSOARG00020009231 |
GeneIDi | 443337 |
KEGGi | oas:443337 |
Organism-specific databases
CTDi | 116 |
Phylogenomic databases
OMAi | KPCSDRF |
OrthoDBi | 1415722at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000532, Glucagon_GIP_secretin_VIP IPR039080, PACAP |
PANTHERi | PTHR11213:SF1, PTHR11213:SF1, 1 hit |
Pfami | View protein in Pfam PF00123, Hormone_2, 2 hits |
PRINTSi | PR00275, GLUCAGON |
SMARTi | View protein in SMART SM00070, GLUCA, 2 hits |
PROSITEi | View protein in PROSITE PS00260, GLUCAGON, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PACA_SHEEP | |
Accessioni | P16613Primary (citable) accession number: P16613 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families