UniProtKB - P16611 (IBP3_PIG)
Insulin-like growth factor-binding protein 3
IGFBP3
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis (By similarity).
By similarityGO - Molecular functioni
- fibronectin binding Source: GO_Central
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
- protein tyrosine phosphatase activator activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of myoblast differentiation Source: UniProtKB
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- response to insulin Source: AgBase
Keywordsi
Molecular function | Growth factor binding |
Biological process | Apoptosis |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 3Short name: IBP-3 Short name: IGF-binding protein 3 Short name: IGFBP-3 |
Gene namesi | Name:IGFBP3 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: AgBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | 1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000045904 | 28 – 293 | Insulin-like growth factor-binding protein 3Add BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 150 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 215 ↔ 242 | PROSITE-ProRule annotation | ||
Disulfide bondi | 253 ↔ 264 | PROSITE-ProRule annotation | ||
Disulfide bondi | 266 ↔ 287 | PROSITE-ProRule annotation |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P16611 |
PRIDEi | P16611 |
Interactioni
Subunit structurei
Interacts with XLKD1. Binds IGF2 more than IGF1.
Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS).
Interacts with TMEM219 (By similarity).
By similarityGO - Molecular functioni
- fibronectin binding Source: GO_Central
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000017719 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 119 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 212 – 287 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 132 – 166 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 178 – 213 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 192 – 208 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QWC0, Eukaryota |
InParanoidi | P16611 |
OMAi | ALEQCKP |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012211, IGFBP-3 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF3, PTHR11551:SF3, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01979, IGFBPFAMILY3 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MQRARPALWA AALIALALLR GPPAARAGSG AAGTGPVVRC EPCDARALAQ
60 70 80 90 100
CAPPPAAPPC AELVREPGCG CCLTCALREG QACGVYTERC GAGLRCQPPP
110 120 130 140 150
GEPRPLQALL DGRGICANAS AAGRLRAYLL PAPPAPGNGS ESEEDRSVDS
160 170 180 190 200
MENQALPSTH RVPDSKLHSV HTKMDVIKKG HAKDSQRYKV DYESQSTDTQ
210 220 230 240 250
NFSSESKRET EYGPCRREME DTLNHLKFLN MLSPRGIHIP NCDKKGFYKK
260 270 280 290
KQCRPSKGRK RGFCWCVDKY GQPLPGFDVK GKGDVHCYSM ESK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | P → S in AAF23229 (PubMed:12553871).Curated | 1 | |
Sequence conflicti | 32 | A → V (PubMed:12553871).Curated | 1 | |
Sequence conflicti | 32 | A → V (PubMed:1688850).Curated | 1 | |
Sequence conflicti | 170 | V → I in AAF23229 (PubMed:12553871).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF085482 mRNA Translation: AAF23229.1 AY464121 Genomic DNA Translation: AAR87008.1 J05228 mRNA Translation: AAA31054.1 AY422045 Genomic DNA Translation: AAQ97624.1 |
PIRi | A35037 JH0516 |
RefSeqi | NP_001005156.1, NM_001005156.1 |
Genome annotation databases
GeneIDi | 448812 |
KEGGi | ssc:448812 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF085482 mRNA Translation: AAF23229.1 AY464121 Genomic DNA Translation: AAR87008.1 J05228 mRNA Translation: AAA31054.1 AY422045 Genomic DNA Translation: AAQ97624.1 |
PIRi | A35037 JH0516 |
RefSeqi | NP_001005156.1, NM_001005156.1 |
3D structure databases
SMRi | P16611 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000017719 |
Protein family/group databases
MEROPSi | I31.952 |
Proteomic databases
PaxDbi | P16611 |
PRIDEi | P16611 |
Genome annotation databases
GeneIDi | 448812 |
KEGGi | ssc:448812 |
Organism-specific databases
CTDi | 3486 |
Phylogenomic databases
eggNOGi | ENOG502QWC0, Eukaryota |
InParanoidi | P16611 |
OMAi | ALEQCKP |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012211, IGFBP-3 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF3, PTHR11551:SF3, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01979, IGFBPFAMILY3 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP3_PIG | |
Accessioni | P16611Primary (citable) accession number: P16611 Secondary accession number(s): Q6S6K2, Q9TTI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | February 7, 2006 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |