FER

Functionⁱ

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

10 Publications

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10028
2 Publications
Manual assertion based on experiment inⁱ
- Ref.11
  "Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells."
  Kogata N., Masuda M., Kamioka Y., Yamagishi A., Endo A., Okada M., Mochizuki N.
  Mol. Biol. Cell 14:3553-3564(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION IN PHOSPHORYLATION OF PECAM1; PTPN11 AND GAB1, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, MUTAGENESIS OF ARG-483, INTERACTION WITH PECAM1.
- Ref.20
  "The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration."
  Itoh T., Hasegawa J., Tsujita K., Kanaho Y., Takenawa T.
  Sci. Signal. 2:RA52-RA52(2009) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION IN REGULATION OF ACTIN CYTOSKELETON AND CELL MIGRATION, CATALYTIC ACTIVITY, DOMAIN, LIPID-BINDING, ACTIVITY REGULATION.
EC:
2.7.10.2
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10028
2 Publications
Manual assertion based on experiment inⁱ
- Ref.11
  "Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells."
  Kogata N., Masuda M., Kamioka Y., Yamagishi A., Endo A., Okada M., Mochizuki N.
  Mol. Biol. Cell 14:3553-3564(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION IN PHOSPHORYLATION OF PECAM1; PTPN11 AND GAB1, SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, MUTAGENESIS OF ARG-483, INTERACTION WITH PECAM1.
- Ref.20
  "The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration."
  Itoh T., Hasegawa J., Tsujita K., Kanaho Y., Takenawa T.
  Sci. Signal. 2:RA52-RA52(2009) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION IN REGULATION OF ACTIN CYTOSKELETON AND CELL MIGRATION, CATALYTIC ACTIVITY, DOMAIN, LIPID-BINDING, ACTIVITY REGULATION.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-tyrosyl-[protein]
L-tyrosine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-tyrosyl-[protein]
L-tyrosine-phosphate residue
zoom

Activity regulationⁱ

Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	591	ATPPROSITE-ProRule annotation		1
Active siteⁱ	684	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	569 – 577	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2, 2681
PathwayCommonsⁱ	P16591
Reactomeⁱ	R-HSA-1433557, Signaling by SCF-KIT
SignaLinkⁱ	P16591
SIGNORⁱ	P16591

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinase Fer (EC:2.7.10.2) Alternative name(s): Feline encephalitis virus-related kinase FER Fujinami poultry sarcoma/Feline sarcoma-related protein Fer Proto-oncogene c-Fer Tyrosine kinase 3 p94-Fer
Gene namesⁱ	Name:FER Synonyms:TYK3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3655, FER
MIMⁱ	176942, gene
neXtProtⁱ	NX_P16591
VEuPathDBⁱ	HostDB:ENSG00000151422

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	483	R → Q: Abolishes kinase activity. Abolishes location at microtubules. 1 Publication		1
Mutagenesisⁱ	591	K → R: Abolishes kinase activity. 1 Publication		1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2241
Open Targets More...OpenTargetsⁱ	ENSG00000151422
PharmGKBⁱ	PA28095

Miscellaneous databases

Pharosⁱ	P16591, Tclin

Pharosⁱ

P16591, Tclin

Chemistry databases

ChEMBLⁱ	CHEMBL3982
Drug and drug target database More...DrugBankⁱ	DB12010, Fostamatinib
DrugCentral More...DrugCentralⁱ	P16591
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2022

Genetic variation databases

BioMutaⁱ	FER
DMDMⁱ	97536202

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000088084	1 – 822	Tyrosine-protein kinase FerAdd BLAST		822

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	402	PhosphotyrosineCombined sources	1
Modified residueⁱ	434	PhosphoserineCombined sources	1
Modified residueⁱ	615	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	714	Phosphotyrosine; by autocatalysisBy similarity	1

Post-translational modificationⁱ

Autophosphorylated.2 Publications

Polyubiquitinated; this leads to proteasomal degradation.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P16591
jPOSTⁱ	P16591
MassIVEⁱ	P16591
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16591
PaxDbⁱ	P16591
PeptideAtlas More...PeptideAtlasⁱ	P16591
PRIDEⁱ	P16591
ProteomicsDBⁱ	53382 [P16591-1] 53383 [P16591-2] 53384 [P16591-3]

PTM databases

iPTMnetⁱ	P16591
PhosphoSitePlusⁱ	P16591

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000151422, Expressed in corpus callosum and 228 other tissues
ExpressionAtlasⁱ	P16591, baseline and differential
Genevisibleⁱ	P16591, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000151422, Low tissue specificity

HPAⁱ

ENSG00000151422, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Homotrimer.

Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1.

Interacts with PPP1CA and regulates its phosphorylation at 'Thr-320' (By similarity).

Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3.

Interacts (via SH2 domain) with CTTN.

Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation.

Component of a complex that contains at least FER, CTTN and PTK2/FAK1.

By similarity8 Publications

Binary interactionsⁱ

Hide details

P16591

With	#Exp.	IntAct
CDC37 [Q16543]	2	EBI-1380661,EBI-295634
Bcat [O42486] from Gallus gallus.	2	EBI-1380661,EBI-972394

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	108532, 24 interactors
CORUMⁱ	P16591
IntActⁱ	P16591, 20 interactors
Molecular INTeraction database More...MINTⁱ	P16591
STRINGⁱ	9606.ENSP00000281092

Chemistry databases

BindingDBⁱ

P16591

Miscellaneous databases

RNActⁱ	P16591, protein

RNActⁱ

P16591, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	455 – 457	Combined sources	3
Beta strandⁱ	461 – 464	Combined sources	4
Helixⁱ	467 – 473	Combined sources	7
Beta strandⁱ	479 – 484	Combined sources	6
Beta strandⁱ	486 – 488	Combined sources	3
Beta strandⁱ	492 – 498	Combined sources	7
Beta strandⁱ	501 – 510	Combined sources	10
Beta strandⁱ	513 – 518	Combined sources	6
Beta strandⁱ	521 – 523	Combined sources	3
Helixⁱ	524 – 534	Combined sources	11
Turnⁱ	540 – 542	Combined sources	3

Show more details

3D structure databases

BMRBⁱ	P16591
SMRⁱ	P16591
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P16591

EvolutionaryTraceⁱ

P16591

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 259	F-BARPROSITE-ProRule annotationAdd BLAST	259
Domainⁱ	460 – 550	SH2PROSITE-ProRule annotationAdd BLAST	91
Domainⁱ	563 – 816	Protein kinasePROSITE-ProRule annotationAdd BLAST	254

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 300	Important for interaction with membranes containing phosphoinositidesAdd BLAST		300

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	123 – 185	Sequence analysisAdd BLAST		63
Coiled coilⁱ	301 – 390	Sequence analysisAdd BLAST		90

Domainⁱ

The coiled coil domains mediate homooligomerization and are required for location at microtubules.

The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil, SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG0194, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154997
HOGENOMⁱ	CLU_005265_0_0_1
InParanoidⁱ	P16591
OMAⁱ	CGARTQQ
Database of Orthologous Groups More...OrthoDBⁱ	556386at2759
PhylomeDBⁱ	P16591
TreeFamⁱ	TF315363

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07686, F-BAR_Fer, 1 hit cd10361, SH2_Fps_family, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer IPR037452, Fer_F-BAR IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom
PANTHERⁱ	PTHR24418:SF227, PTHR24418:SF227, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit
PIRSFⁱ	PIRSF000632, TyrPK_fps, 1 hit
PRINTSⁱ	PR00401, SH2DOMAIN PR00109, TYRKINASE
SMARTⁱ	View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit
SUPFAMⁱ	SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P16591-1) [UniParc]FASTA Add to basket

Also known as: p94

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC 
        60         70         80         90        100
NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL 
       110        120        130        140        150
TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA 
       160        170        180        190        200
KEKYKEALAK GKETEKAKER YDKATMKLHM LHNQYVLALK GAQLHQNQYY 
       210        220        230        240        250
DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI VNVHKEIQMS 
       260        270        280        290        300
VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL 
       310        320        330        340        350
TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI 
       360        370        380        390        400
VLLLSQKQAL EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV 
       410        420        430        440        450
NYEEDARSVT SMERKERLSK FESIRHSIAG IIRSPKSALG SSALSDMISI 
       460        470        480        490        500
SEKPLAEQDW YHGAIPRIEA QELLKKQGDF LVRESHGKPG EYVLSVYSDG 
       510        520        530        540        550
QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK KSGVVLLNPI 
       560        570        580        590        600
PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE 
       610        620        630        640        650
LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR 
       660        670        680        690        700
RKKDELKLKQ LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI 
       710        720        730        740        750
SDFGMSRQED GGVYSSSGLK QIPIKWTAPE ALNYGRYSSE SDVWSFGILL 
       760        770        780        790        800
WETFSLGVCP YPGMTNQQAR EQVERGYRMS APQHCPEDIS KIMMKCWDYK 
       810        820 
PENRPKFSEL QKELTIIKRK LT

Length:822

Mass (Da):94,638

Last modified:May 16, 2006 - v2

Checksum:ⁱBD42DF6C03419C76

GO

Isoform 2 (identifier: P16591-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-175: Missing.

« Hide

        10         20         30         40         50
MKLHMLHNQY VLALKGAQLH QNQYYDITLP LLLDSLQKMQ EEMIKALKGI 
        60         70         80         90        100
FDEYSQITSL VTEEIVNVHK EIQMSVEQID PSTEYNNFID VHRTTAAKEQ 
       110        120        130        140        150
EIEFDTSLLE ENENLQANEI MWNNLTAESL QVMLKTLAEE LMQTQQMLLN 
       160        170        180        190        200
KEEAVLELEK RIEESSETCE KKSDIVLLLS QKQALEELKQ SVQQLRCTEA 
       210        220        230        240        250
KFSAQKELLE QKVQENDGKE PPPVVNYEED ARSVTSMERK ERLSKFESIR 
       260        270        280        290        300
HSIAGIIRSP KSALGSSALS DMISISEKPL AEQDWYHGAI PRIEAQELLK 
       310        320        330        340        350
KQGDFLVRES HGKPGEYVLS VYSDGQRRHF IIQYVDNMYR FEGTGFSNIP 
       360        370        380        390        400
QLIDHHYTTK QVITKKSGVV LLNPIPKDKK WILSHEDVIL GELLGKGNFG 
       410        420        430        440        450
EVYKGTLKDK TSVAVKTCKE DLPQELKIKF LQEAKILKQY DHPNIVKLIG 
       460        470        480        490        500
VCTQRQPVYI IMELVSGGDF LTFLRRKKDE LKLKQLVKFS LDAAAGMLYL 
       510        520        530        540        550
ESKNCIHRDL AARNCLVGEN NVLKISDFGM SRQEDGGVYS SSGLKQIPIK 
       560        570        580        590        600
WTAPEALNYG RYSSESDVWS FGILLWETFS LGVCPYPGMT NQQAREQVER 
       610        620        630        640 
GYRMSAPQHC PEDISKIMMK CWDYKPENRP KFSELQKELT IIKRKLT

Show »

Length:647

Mass (Da):74,266

Checksum:ⁱF05F6497716D7D36

GO

Isoform 3 (identifier: P16591-3) [UniParc]FASTA Add to basket

Also known as: FerT, p47

The sequence of this isoform differs from the canonical sequence as follows:
1-369: Missing.
370-412: LRCTEAKFSA...EEDARSVTSM → MEQKMKCPHC...PSTSEVHRDQ

« Hide

        10         20         30         40         50
MEQKMKCPHC KDQLESGFGS QSCKTCALMF SSEPSTSEVH RDQERKERLS 
        60         70         80         90        100
KFESIRHSIA GIIRSPKSAL GSSALSDMIS ISEKPLAEQD WYHGAIPRIE 
       110        120        130        140        150
AQELLKKQGD FLVRESHGKP GEYVLSVYSD GQRRHFIIQY VDNMYRFEGT 
       160        170        180        190        200
GFSNIPQLID HHYTTKQVIT KKSGVVLLNP IPKDKKWILS HEDVILGELL 
       210        220        230        240        250
GKGNFGEVYK GTLKDKTSVA VKTCKEDLPQ ELKIKFLQEA KILKQYDHPN 
       260        270        280        290        300
IVKLIGVCTQ RQPVYIIMEL VSGGDFLTFL RRKKDELKLK QLVKFSLDAA 
       310        320        330        340        350
AGMLYLESKN CIHRDLAARN CLVGENNVLK ISDFGMSRQE DGGVYSSSGL 
       360        370        380        390        400
KQIPIKWTAP EALNYGRYSS ESDVWSFGIL LWETFSLGVC PYPGMTNQQA 
       410        420        430        440        450
REQVERGYRM SAPQHCPEDI SKIMMKCWDY KPENRPKFSE LQKELTIIKR 

KLT

Note: Produced by alternative promoter usage.Curated

Show »

Length:453

Mass (Da):51,643

Checksum:ⁱE9B8AD1A2DD0A7DC

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

W0S4B9	W0S4B9_HUMAN	Tyrosine-protein kinase Tyrosine-protein kinase, EC 2.7.10.2	FER Pe1Fe10	411	Annotation score:
A0A0D9SEV4	A0A0D9SEV4_HUMAN	Tyrosine-protein kinase Fer Tyrosine-protein kinase Fer	FER	163	Annotation score:
D6RAF9	D6RAF9_HUMAN	Tyrosine-protein kinase Fer Tyrosine-protein kinase Fer	FER	84	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	219	I → L in BAG61714 (PubMed:14702039).Curated	1
Sequence conflictⁱ	234	S → N in BAG61714 (PubMed:14702039).Curated	1
Sequence conflictⁱ	426	H → Q in BAG61714 (PubMed:14702039).Curated	1
Sequence conflictⁱ	447	M → L in AEY69041 (PubMed:22223638).Curated	1
Sequence conflictⁱ	485	S → G in AEY69041 (PubMed:22223638).Curated	1
Sequence conflictⁱ	492	Y → H in AEY69041 (PubMed:22223638).Curated	1
Sequence conflictⁱ	505	F → L in BAG61714 (PubMed:14702039).Curated	1
Sequence conflictⁱ	558	L → F in AEY69041 (PubMed:22223638).Curated	1
Sequence conflictⁱ	730	E → G in BAG61714 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041691	128	V → F1 PublicationCorresponds to variant dbSNP:rs35150210Ensembl.	1
Natural variantⁱVAR_041692	404	E → Q in an ovarian Endometrioid carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041693	412	M → V1 PublicationCorresponds to variant dbSNP:rs33940843Ensembl.	1
Natural variantⁱVAR_006282	439	L → V3 PublicationsCorresponds to variant dbSNP:rs2229086Ensembl.	1
Natural variantⁱVAR_041694	443	A → P1 PublicationCorresponds to variant dbSNP:rs34259824Ensembl.	1
Natural variantⁱVAR_041695	460	W → C in a lung small cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_051695	507	I → T. Corresponds to variant dbSNP:rs34204308Ensembl.	1
Natural variantⁱVAR_041696	813	E → Q1 PublicationCorresponds to variant dbSNP:rs56097357Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043846	1 – 369	Missing in isoform 3. 1 PublicationAdd BLAST	369
Alternative sequenceⁱVSP_041765	1 – 175	Missing in isoform 2. 1 PublicationAdd BLAST	175
Alternative sequenceⁱVSP_043847	370 – 412	LRCTE…SVTSM → MEQKMKCPHCKDQLESGFGS QSCKTCALMFSSEPSTSEVH RDQ in isoform 3. 1 PublicationAdd BLAST	43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03358 mRNA Translation: AAA61190.1 JQ412173 mRNA Translation: AEY69041.1 AK299855 mRNA Translation: BAG61714.1 AK315234 mRNA Translation: BAG37661.1 AC034207 Genomic DNA No translation available. AC008871 Genomic DNA No translation available. AC109481 Genomic DNA No translation available. AC008955 Genomic DNA No translation available. AC010228 Genomic DNA No translation available. AC011421 Genomic DNA No translation available. AC116428 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49055.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4098.1 [P16591-1] CCDS78044.1 [P16591-3]
PIRⁱ	A31943, TVHUFE
NCBI Reference Sequences More...RefSeqⁱ	NP_001294957.1, NM_001308028.1 [P16591-2] NP_001294960.1, NM_001308031.1 [P16591-3] NP_001294967.1, NM_001308038.1 NP_005237.2, NM_005246.3 [P16591-1] XP_011541573.1, XM_011543271.2 [P16591-1] XP_016864719.1, XM_017009230.1 [P16591-1] XP_016864720.1, XM_017009231.1 [P16591-1]

Genome annotation databases

Ensemblⁱ	ENST00000281092; ENSP00000281092; ENSG00000151422 ENST00000618353; ENSP00000484767; ENSG00000151422 [P16591-3]
GeneIDⁱ	2241
KEGGⁱ	hsa:2241
MANE-Selectⁱ	ENST00000281092.9; ENSP00000281092.4; NM_005246.4; NP_005237.2
UCSC genome browser More...UCSCⁱ	uc031skp.2, human [P16591-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16591	Tyrosine-protein kinase		HUMAN		822	UniRef100_P16591
Tyrosine-protein kinase		PANTR		822
Tyrosine-protein kinase		GORGO		822
Tyrosine-protein kinase		PANTR		822
Tyrosine-protein kinase		HUMAN		647
+6

Protein	Similar proteins		Species	Score	Length	Source
P16591	Tyrosine-protein kinase Fer		CANLF		823	UniRef90_P16591
Tyrosine-protein kinase		HUMAN		822
Tyrosine-protein kinase		PANTR		822
Tyrosine-protein kinase		GORGO		822
Tyrosine-protein kinase		ROUAE		833
+172
P16591-3	Tyrosine-protein kinase		AILME		457	UniRef90_P16591-3
FER tyrosine kinase		PANLE		457
Tyrosine-protein kinase		PANPR		457
Tyrosine-protein kinase		ACIJB		457
Tyrosine-protein kinase		LYNCA		457
+52

Protein	Similar proteins		Species	Score	Length	Source
P16591	Tyrosine-protein kinase Fer		MOUSE		823	UniRef50_P70451
Tyrosine-protein kinase Fer		RAT		823
Tyrosine-protein kinase Fer		CANLF		823
Tyrosine-protein kinase		MUSCR		823
Fer (fms/fps related) protein kinase		MUSSI		765
+934
P16591-3	Isoform 4 of Tyrosine-protein kinase Fer		MOUSE		453	UniRef50_P70451-4
Fer (fms/fps related) protein kinase		MUSSI		453
Tyrosine-protein kinase		PERMB		453
Tyrosine-protein kinase		MESAU		453
Tyrosine-protein kinase		RAT		453
+117

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03358 mRNA Translation: AAA61190.1 JQ412173 mRNA Translation: AEY69041.1 AK299855 mRNA Translation: BAG61714.1 AK315234 mRNA Translation: BAG37661.1 AC034207 Genomic DNA No translation available. AC008871 Genomic DNA No translation available. AC109481 Genomic DNA No translation available. AC008955 Genomic DNA No translation available. AC010228 Genomic DNA No translation available. AC011421 Genomic DNA No translation available. AC116428 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49055.1
CCDSⁱ	CCDS4098.1 [P16591-1] CCDS78044.1 [P16591-3]
PIRⁱ	A31943, TVHUFE
RefSeqⁱ	NP_001294957.1, NM_001308028.1 [P16591-2] NP_001294960.1, NM_001308031.1 [P16591-3] NP_001294967.1, NM_001308038.1 NP_005237.2, NM_005246.3 [P16591-1] XP_011541573.1, XM_011543271.2 [P16591-1] XP_016864719.1, XM_017009230.1 [P16591-1] XP_016864720.1, XM_017009231.1 [P16591-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KK6	NMR	-	A	453-557	[»]
	6KC4	X-ray	1.37	A/C/E/G/I/K	453-552	[»]
BMRBⁱ	P16591
SMRⁱ	P16591
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108532, 24 interactors
CORUMⁱ	P16591
IntActⁱ	P16591, 20 interactors
MINTⁱ	P16591
STRINGⁱ	9606.ENSP00000281092

Chemistry databases

BindingDBⁱ	P16591
ChEMBLⁱ	CHEMBL3982
DrugBankⁱ	DB12010, Fostamatinib
DrugCentralⁱ	P16591
GuidetoPHARMACOLOGYⁱ	2022

PTM databases

iPTMnetⁱ	P16591
PhosphoSitePlusⁱ	P16591

Genetic variation databases

BioMutaⁱ	FER
DMDMⁱ	97536202

Proteomic databases

EPDⁱ	P16591
jPOSTⁱ	P16591
MassIVEⁱ	P16591
MaxQBⁱ	P16591
PaxDbⁱ	P16591
PeptideAtlasⁱ	P16591
PRIDEⁱ	P16591
ProteomicsDBⁱ	53382 [P16591-1] 53383 [P16591-2] 53384 [P16591-3]

Protocols and materials databases

Antibodypediaⁱ	2083, 590 antibodies from 40 providers
The DNASU plasmid repository More...DNASUⁱ	2241

Genome annotation databases

Ensemblⁱ	ENST00000281092; ENSP00000281092; ENSG00000151422 ENST00000618353; ENSP00000484767; ENSG00000151422 [P16591-3]
GeneIDⁱ	2241
KEGGⁱ	hsa:2241
MANE-Selectⁱ	ENST00000281092.9; ENSP00000281092.4; NM_005246.4; NP_005237.2
UCSCⁱ	uc031skp.2, human [P16591-1]

Organism-specific databases

CTDⁱ	2241
DisGeNETⁱ	2241
GeneCardsⁱ	FER
HGNCⁱ	HGNC:3655, FER
HPAⁱ	ENSG00000151422, Low tissue specificity
MIMⁱ	176942, gene
neXtProtⁱ	NX_P16591
OpenTargetsⁱ	ENSG00000151422
PharmGKBⁱ	PA28095
VEuPathDBⁱ	HostDB:ENSG00000151422
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0194, Eukaryota
GeneTreeⁱ	ENSGT00940000154997
HOGENOMⁱ	CLU_005265_0_0_1
InParanoidⁱ	P16591
OMAⁱ	CGARTQQ
OrthoDBⁱ	556386at2759
PhylomeDBⁱ	P16591
TreeFamⁱ	TF315363

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2, 2681
PathwayCommonsⁱ	P16591
Reactomeⁱ	R-HSA-1433557, Signaling by SCF-KIT
SignaLinkⁱ	P16591
SIGNORⁱ	P16591

Miscellaneous databases

BioGRID-ORCSⁱ	2241, 13 hits in 1081 CRISPR screens
ChiTaRSⁱ	FER, human
EvolutionaryTraceⁱ	P16591
GeneWikiⁱ	FER_(gene)
GenomeRNAiⁱ	2241
Pharosⁱ	P16591, Tclin
Protein Ontology More...PROⁱ	PR:P16591
RNActⁱ	P16591, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151422, Expressed in corpus callosum and 228 other tissues
ExpressionAtlasⁱ	P16591, baseline and differential
Genevisibleⁱ	P16591, HS

Family and domain databases

CDDⁱ	cd07686, F-BAR_Fer, 1 hit cd10361, SH2_Fps_family, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer IPR037452, Fer_F-BAR IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom
PANTHERⁱ	PTHR24418:SF227, PTHR24418:SF227, 1 hit
Pfamⁱ	View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit
PIRSFⁱ	PIRSF000632, TyrPK_fps, 1 hit
PRINTSⁱ	PR00401, SH2DOMAIN PR00109, TYRKINASE
SMARTⁱ	View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit
SUPFAMⁱ	SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FER_HUMAN
Accessionⁱ	P16591Primary (citable) accession number: P16591 Secondary accession number(s): B2RCR4, B4DSQ2, H2FLB8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	May 16, 2006
	Last modified:	February 23, 2022
	This is version 220 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P16591 (FER_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Tyrosine-protein kinase Fer

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoplasm and Cytosol

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P16591

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Your basket is currently empty. ⁱ

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ