UniProtKB - P16591 (FER_HUMAN)
Tyrosine-protein kinase Fer
FER
Functioni
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
10 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation2 PublicationsEC:2.7.10.2PROSITE-ProRule annotation2 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 591 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 684 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 569 – 577 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- actin binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: Ensembl
- epidermal growth factor receptor binding Source: UniProtKB
- gamma-catenin binding Source: Ensembl
- lipid binding Source: UniProtKB
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
- protein kinase binding Source: Ensembl
- protein phosphatase 1 binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: GO_Central
- signaling receptor binding Source: GO_Central
- small GTPase binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- cell adhesion Source: GO_Central
- cell-cell adhesion mediated by cadherin Source: UniProtKB
- cell differentiation Source: GO_Central
- cell population proliferation Source: InterPro
- cellular response to insulin stimulus Source: UniProtKB
- cellular response to macrophage colony-stimulating factor stimulus Source: UniProtKB
- cellular response to reactive oxygen species Source: UniProtKB
- chemotaxis Source: GO_Central
- cytokine-mediated signaling pathway Source: UniProtKB
- diapedesis Source: UniProtKB
- extracellular matrix-cell signaling Source: UniProtKB
- Fc-epsilon receptor signaling pathway Source: UniProtKB
- innate immune response Source: GO_Central
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: UniProtKB
- interleukin-6-mediated signaling pathway Source: UniProtKB
- intracellular signal transduction Source: ProtInc
- Kit signaling pathway Source: UniProtKB
- microtubule cytoskeleton organization Source: UniProtKB
- negative regulation of mast cell activation involved in immune response Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- platelet-derived growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of actin filament polymerization Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: CACAO
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: ProtInc
- regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- regulation of fibroblast migration Source: Ensembl
- regulation of lamellipodium assembly Source: UniProtKB
- regulation of mast cell degranulation Source: GO_Central
- regulation of protein phosphorylation Source: UniProtKB
- response to lipopolysaccharide Source: UniProtKB
- response to platelet-derived growth factor Source: UniProtKB
- substrate adhesion-dependent cell spreading Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- tyrosine phosphorylation of STAT protein Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Lipid-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P16591 |
Reactomei | R-HSA-1433557, Signaling by SCF-KIT |
SignaLinki | P16591 |
SIGNORi | P16591 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase Fer (EC:2.7.10.2)Alternative name(s): Feline encephalitis virus-related kinase FER Fujinami poultry sarcoma/Feline sarcoma-related protein Fer Proto-oncogene c-Fer Tyrosine kinase 3 p94-Fer |
Gene namesi | Name:FER Synonyms:TYK3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3655, FER |
MIMi | 176942, gene |
neXtProti | NX_P16591 |
VEuPathDBi | HostDB:ENSG00000151422 |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
Cytoskeleton
Plasma membrane
Other locations
Note: Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- cell cortex Source: UniProtKB-SubCell
- cell junction Source: UniProtKB-SubCell
- cell projection Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 483 | R → Q: Abolishes kinase activity. Abolishes location at microtubules. 1 Publication | 1 | |
Mutagenesisi | 591 | K → R: Abolishes kinase activity. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2241 |
OpenTargetsi | ENSG00000151422 |
PharmGKBi | PA28095 |
Miscellaneous databases
Pharosi | P16591, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3982 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P16591 |
GuidetoPHARMACOLOGYi | 2022 |
Genetic variation databases
BioMutai | FER |
DMDMi | 97536202 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088084 | 1 – 822 | Tyrosine-protein kinase FerAdd BLAST | 822 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 402 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 434 | PhosphoserineCombined sources | 1 | |
Modified residuei | 615 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 714 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P16591 |
jPOSTi | P16591 |
MassIVEi | P16591 |
MaxQBi | P16591 |
PaxDbi | P16591 |
PeptideAtlasi | P16591 |
PRIDEi | P16591 |
ProteomicsDBi | 53382 [P16591-1] 53383 [P16591-2] 53384 [P16591-3] |
PTM databases
iPTMneti | P16591 |
PhosphoSitePlusi | P16591 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000151422, Expressed in corpus callosum and 228 other tissues |
ExpressionAtlasi | P16591, baseline and differential |
Genevisiblei | P16591, HS |
Organism-specific databases
HPAi | ENSG00000151422, Low tissue specificity |
Interactioni
Subunit structurei
Homotrimer.
Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1.
Interacts with PPP1CA and regulates its phosphorylation at 'Thr-320' (By similarity).
Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3.
Interacts (via SH2 domain) with CTTN.
Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation.
Component of a complex that contains at least FER, CTTN and PTK2/FAK1.
By similarity8 PublicationsBinary interactionsi
P16591
With | #Exp. | IntAct |
---|---|---|
CDC37 [Q16543] | 2 | EBI-1380661,EBI-295634 |
Bcat [O42486] from Gallus gallus. | 2 | EBI-1380661,EBI-972394 |
GO - Molecular functioni
- actin binding Source: Ensembl
- cadherin binding Source: Ensembl
- epidermal growth factor receptor binding Source: UniProtKB
- gamma-catenin binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein phosphatase 1 binding Source: Ensembl
- signaling receptor binding Source: GO_Central
- small GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108532, 24 interactors |
CORUMi | P16591 |
IntActi | P16591, 20 interactors |
MINTi | P16591 |
STRINGi | 9606.ENSP00000281092 |
Chemistry databases
BindingDBi | P16591 |
Miscellaneous databases
RNActi | P16591, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P16591 |
SMRi | P16591 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16591 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 259 | F-BARPROSITE-ProRule annotationAdd BLAST | 259 | |
Domaini | 460 – 550 | SH2PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 563 – 816 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 300 | Important for interaction with membranes containing phosphoinositidesAdd BLAST | 300 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 123 – 185 | Sequence analysisAdd BLAST | 63 | |
Coiled coili | 301 – 390 | Sequence analysisAdd BLAST | 90 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH2 domainPhylogenomic databases
eggNOGi | KOG0194, Eukaryota |
GeneTreei | ENSGT00940000154997 |
HOGENOMi | CLU_005265_0_0_1 |
InParanoidi | P16591 |
OMAi | CGARTQQ |
OrthoDBi | 556386at2759 |
PhylomeDBi | P16591 |
TreeFami | TF315363 |
Family and domain databases
CDDi | cd07686, F-BAR_Fer, 1 hit cd10361, SH2_Fps_family, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer IPR037452, Fer_F-BAR IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
PANTHERi | PTHR24418:SF227, PTHR24418:SF227, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PIRSFi | PIRSF000632, TyrPK_fps, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC
60 70 80 90 100
NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL
110 120 130 140 150
TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA
160 170 180 190 200
KEKYKEALAK GKETEKAKER YDKATMKLHM LHNQYVLALK GAQLHQNQYY
210 220 230 240 250
DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI VNVHKEIQMS
260 270 280 290 300
VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL
310 320 330 340 350
TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI
360 370 380 390 400
VLLLSQKQAL EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV
410 420 430 440 450
NYEEDARSVT SMERKERLSK FESIRHSIAG IIRSPKSALG SSALSDMISI
460 470 480 490 500
SEKPLAEQDW YHGAIPRIEA QELLKKQGDF LVRESHGKPG EYVLSVYSDG
510 520 530 540 550
QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK KSGVVLLNPI
560 570 580 590 600
PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE
610 620 630 640 650
LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR
660 670 680 690 700
RKKDELKLKQ LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI
710 720 730 740 750
SDFGMSRQED GGVYSSSGLK QIPIKWTAPE ALNYGRYSSE SDVWSFGILL
760 770 780 790 800
WETFSLGVCP YPGMTNQQAR EQVERGYRMS APQHCPEDIS KIMMKCWDYK
810 820
PENRPKFSEL QKELTIIKRK LT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketW0S4B9 | W0S4B9_HUMAN | Tyrosine-protein kinase | FER Pe1Fe10 | 411 | Annotation score: | ||
A0A0D9SEV4 | A0A0D9SEV4_HUMAN | Tyrosine-protein kinase Fer | FER | 163 | Annotation score: | ||
D6RAF9 | D6RAF9_HUMAN | Tyrosine-protein kinase Fer | FER | 84 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 219 | I → L in BAG61714 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 234 | S → N in BAG61714 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 426 | H → Q in BAG61714 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 447 | M → L in AEY69041 (PubMed:22223638).Curated | 1 | |
Sequence conflicti | 485 | S → G in AEY69041 (PubMed:22223638).Curated | 1 | |
Sequence conflicti | 492 | Y → H in AEY69041 (PubMed:22223638).Curated | 1 | |
Sequence conflicti | 505 | F → L in BAG61714 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 558 | L → F in AEY69041 (PubMed:22223638).Curated | 1 | |
Sequence conflicti | 730 | E → G in BAG61714 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041691 | 128 | V → F1 PublicationCorresponds to variant dbSNP:rs35150210Ensembl. | 1 | |
Natural variantiVAR_041692 | 404 | E → Q in an ovarian Endometrioid carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041693 | 412 | M → V1 PublicationCorresponds to variant dbSNP:rs33940843Ensembl. | 1 | |
Natural variantiVAR_006282 | 439 | L → V3 PublicationsCorresponds to variant dbSNP:rs2229086Ensembl. | 1 | |
Natural variantiVAR_041694 | 443 | A → P1 PublicationCorresponds to variant dbSNP:rs34259824Ensembl. | 1 | |
Natural variantiVAR_041695 | 460 | W → C in a lung small cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_051695 | 507 | I → T. Corresponds to variant dbSNP:rs34204308Ensembl. | 1 | |
Natural variantiVAR_041696 | 813 | E → Q1 PublicationCorresponds to variant dbSNP:rs56097357Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043846 | 1 – 369 | Missing in isoform 3. 1 PublicationAdd BLAST | 369 | |
Alternative sequenceiVSP_041765 | 1 – 175 | Missing in isoform 2. 1 PublicationAdd BLAST | 175 | |
Alternative sequenceiVSP_043847 | 370 – 412 | LRCTE…SVTSM → MEQKMKCPHCKDQLESGFGS QSCKTCALMFSSEPSTSEVH RDQ in isoform 3. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03358 mRNA Translation: AAA61190.1 JQ412173 mRNA Translation: AEY69041.1 AK299855 mRNA Translation: BAG61714.1 AK315234 mRNA Translation: BAG37661.1 AC034207 Genomic DNA No translation available. AC008871 Genomic DNA No translation available. AC109481 Genomic DNA No translation available. AC008955 Genomic DNA No translation available. AC010228 Genomic DNA No translation available. AC011421 Genomic DNA No translation available. AC116428 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49055.1 |
CCDSi | CCDS4098.1 [P16591-1] CCDS78044.1 [P16591-3] |
PIRi | A31943, TVHUFE |
RefSeqi | NP_001294957.1, NM_001308028.1 [P16591-2] NP_001294960.1, NM_001308031.1 [P16591-3] NP_001294967.1, NM_001308038.1 NP_005237.2, NM_005246.3 [P16591-1] XP_011541573.1, XM_011543271.2 [P16591-1] XP_016864719.1, XM_017009230.1 [P16591-1] XP_016864720.1, XM_017009231.1 [P16591-1] |
Genome annotation databases
Ensembli | ENST00000281092; ENSP00000281092; ENSG00000151422 ENST00000618353; ENSP00000484767; ENSG00000151422 [P16591-3] |
GeneIDi | 2241 |
KEGGi | hsa:2241 |
MANE-Selecti | ENST00000281092.9; ENSP00000281092.4; NM_005246.4; NP_005237.2 |
UCSCi | uc031skp.2, human [P16591-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03358 mRNA Translation: AAA61190.1 JQ412173 mRNA Translation: AEY69041.1 AK299855 mRNA Translation: BAG61714.1 AK315234 mRNA Translation: BAG37661.1 AC034207 Genomic DNA No translation available. AC008871 Genomic DNA No translation available. AC109481 Genomic DNA No translation available. AC008955 Genomic DNA No translation available. AC010228 Genomic DNA No translation available. AC011421 Genomic DNA No translation available. AC116428 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49055.1 |
CCDSi | CCDS4098.1 [P16591-1] CCDS78044.1 [P16591-3] |
PIRi | A31943, TVHUFE |
RefSeqi | NP_001294957.1, NM_001308028.1 [P16591-2] NP_001294960.1, NM_001308031.1 [P16591-3] NP_001294967.1, NM_001308038.1 NP_005237.2, NM_005246.3 [P16591-1] XP_011541573.1, XM_011543271.2 [P16591-1] XP_016864719.1, XM_017009230.1 [P16591-1] XP_016864720.1, XM_017009231.1 [P16591-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KK6 | NMR | - | A | 453-557 | [»] | |
6KC4 | X-ray | 1.37 | A/C/E/G/I/K | 453-552 | [»] | |
BMRBi | P16591 | |||||
SMRi | P16591 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108532, 24 interactors |
CORUMi | P16591 |
IntActi | P16591, 20 interactors |
MINTi | P16591 |
STRINGi | 9606.ENSP00000281092 |
Chemistry databases
BindingDBi | P16591 |
ChEMBLi | CHEMBL3982 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P16591 |
GuidetoPHARMACOLOGYi | 2022 |
PTM databases
iPTMneti | P16591 |
PhosphoSitePlusi | P16591 |
Genetic variation databases
BioMutai | FER |
DMDMi | 97536202 |
Proteomic databases
EPDi | P16591 |
jPOSTi | P16591 |
MassIVEi | P16591 |
MaxQBi | P16591 |
PaxDbi | P16591 |
PeptideAtlasi | P16591 |
PRIDEi | P16591 |
ProteomicsDBi | 53382 [P16591-1] 53383 [P16591-2] 53384 [P16591-3] |
Protocols and materials databases
Antibodypediai | 2083, 590 antibodies from 40 providers |
DNASUi | 2241 |
Genome annotation databases
Ensembli | ENST00000281092; ENSP00000281092; ENSG00000151422 ENST00000618353; ENSP00000484767; ENSG00000151422 [P16591-3] |
GeneIDi | 2241 |
KEGGi | hsa:2241 |
MANE-Selecti | ENST00000281092.9; ENSP00000281092.4; NM_005246.4; NP_005237.2 |
UCSCi | uc031skp.2, human [P16591-1] |
Organism-specific databases
CTDi | 2241 |
DisGeNETi | 2241 |
GeneCardsi | FER |
HGNCi | HGNC:3655, FER |
HPAi | ENSG00000151422, Low tissue specificity |
MIMi | 176942, gene |
neXtProti | NX_P16591 |
OpenTargetsi | ENSG00000151422 |
PharmGKBi | PA28095 |
VEuPathDBi | HostDB:ENSG00000151422 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0194, Eukaryota |
GeneTreei | ENSGT00940000154997 |
HOGENOMi | CLU_005265_0_0_1 |
InParanoidi | P16591 |
OMAi | CGARTQQ |
OrthoDBi | 556386at2759 |
PhylomeDBi | P16591 |
TreeFami | TF315363 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P16591 |
Reactomei | R-HSA-1433557, Signaling by SCF-KIT |
SignaLinki | P16591 |
SIGNORi | P16591 |
Miscellaneous databases
BioGRID-ORCSi | 2241, 13 hits in 1081 CRISPR screens |
ChiTaRSi | FER, human |
EvolutionaryTracei | P16591 |
GeneWikii | FER_(gene) |
GenomeRNAii | 2241 |
Pharosi | P16591, Tclin |
PROi | PR:P16591 |
RNActi | P16591, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151422, Expressed in corpus callosum and 228 other tissues |
ExpressionAtlasi | P16591, baseline and differential |
Genevisiblei | P16591, HS |
Family and domain databases
CDDi | cd07686, F-BAR_Fer, 1 hit cd10361, SH2_Fps_family, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer IPR037452, Fer_F-BAR IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
PANTHERi | PTHR24418:SF227, PTHR24418:SF227, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PIRSFi | PIRSF000632, TyrPK_fps, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FER_HUMAN | |
Accessioni | P16591Primary (citable) accession number: P16591 Secondary accession number(s): B2RCR4, B4DSQ2, H2FLB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | May 16, 2006 | |
Last modified: | February 23, 2022 | |
This is version 220 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families