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Protein

E-selectin

Gene

SELE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi101CalciumCombined sources1 Publication1
Metal bindingi103CalciumCombined sources2 Publications1
Metal bindingi109CalciumCombined sources2 Publications1
Metal bindingi126CalciumCombined sources2 Publications1
Metal bindingi127CalciumCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • oligosaccharide binding Source: BHF-UCL
  • phospholipase binding Source: BHF-UCL
  • sialic acid binding Source: BHF-UCL
  • transmembrane signaling receptor activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall

SIGNOR Signaling Network Open Resource

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SIGNORi
P16581

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P16581

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SELE
Synonyms:ELAM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000007908.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10718 SELE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131210 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16581

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 556ExtracellularSequence analysisAdd BLAST535
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei557 – 578HelicalSequence analysisAdd BLAST22
Topological domaini579 – 610CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi109E → D: Decreased adhesion to cells expressing SELPLG. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6401

MalaCards human disease database

More...
MalaCardsi
SELE

Open Targets

More...
OpenTargetsi
ENSG00000007908

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35640

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3890

Drug and drug target database

More...
DrugBanki
DB01136 Carvedilol
DB03721 N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SELE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126180

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001749222 – 610E-selectinAdd BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineCombined sources1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 138Combined sources2 Publications
Disulfide bondi111 ↔ 130Combined sources2 Publications
Disulfide bondi143 ↔ 154Combined sources2 Publications
Glycosylationi145N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi148 ↔ 163Combined sources2 Publications
Glycosylationi160N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi165 ↔ 174Combined sources2 Publications
Glycosylationi179N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi180 ↔ 224Combined sources1 Publication
Disulfide bondi193 ↔ 206Combined sources1 Publication
Glycosylationi199N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi203N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi210 ↔ 237Combined sources1 Publication
Disulfide bondi242 ↔ 286Combined sources1 Publication
Disulfide bondi255 ↔ 268Combined sources1 Publication
Glycosylationi265N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi272 ↔ 299Combined sources1 Publication
Disulfide bondi304 ↔ 349By similarity
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 362By similarity
Disulfide bondi367 ↔ 412By similarity
Disulfide bondi398 ↔ 425By similarity
Disulfide bondi430 ↔ 475By similarity
Disulfide bondi461 ↔ 488By similarity
Disulfide bondi493 ↔ 534By similarity
Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi520 ↔ 547By similarity
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16581

PeptideAtlas

More...
PeptideAtlasi
P16581

PRoteomics IDEntifications database

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PRIDEi
P16581

ProteomicsDB human proteome resource

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ProteomicsDBi
53381

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P16581

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P16581

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000007908 Expressed in 150 organ(s), highest expression level in vena cava

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16581 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16581 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002143

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112301, 16 interactors

Database of interacting proteins

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DIPi
DIP-58639N

Protein interaction database and analysis system

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IntActi
P16581, 5 interactors

Molecular INTeraction database

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MINTi
P16581

STRING: functional protein association networks

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STRINGi
9606.ENSP00000331736

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P16581

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1610
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16581

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16581

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16581

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 139C-type lectinPROSITE-ProRule annotationAdd BLAST118
Domaini140 – 175EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini178 – 239Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini240 – 301Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini303 – 364Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini366 – 427Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini429 – 490Sushi 5PROSITE-ProRule annotationAdd BLAST62
Domaini491 – 549Sushi 6PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 109Carbohydrate bindingCombined sources1 Publication9
Regioni113 – 118Carbohydrate bindingCombined sources1 Publication6
Regioni126 – 128Carbohydrate bindingCombined sources1 Publication3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236254

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052375

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16581

KEGG Orthology (KO)

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KOi
K06494

Identification of Orthologs from Complete Genome Data

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OMAi
AQGQWTQ

Database of Orthologous Groups

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OrthoDBi
EOG091G04KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16581

TreeFam database of animal gene trees

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TreeFami
TF326910

Family and domain databases

Conserved Domains Database

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CDDi
cd00033 CCP, 6 hits
cd03592 CLECT_selectins_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00343 SELECTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 6 hits
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P16581-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI
60 70 80 90 100
QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG
160 170 180 190 200
HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF
210 220 230 240 250
SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN
260 270 280 290 300
GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
310 320 330 340 350
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT
360 370 380 390 400
TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ
410 420 430 440 450
GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE
460 470 480 490 500
FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG
510 520 530 540 550
KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP
560 570 580 590 600
TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
610
GSYQKPSYIL
Length:610
Mass (Da):66,655
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D43E3C0D1229229
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TI72Q5TI72_HUMAN
E-selectin
SELE
484Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TI75Q5TI75_HUMAN
E-selectin
SELE
485Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TI74Q5TI74_HUMAN
E-selectin
SELE
547Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TI73Q5TI73_HUMAN
E-selectin
SELE
547Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYI4V9GYI4_HUMAN
E-selectin
SELE
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01430021A → S1 PublicationCorresponds to variant dbSNP:rs3917407Ensembl.1
Natural variantiVAR_01430131M → I1 PublicationCorresponds to variant dbSNP:rs3917408Ensembl.1
Natural variantiVAR_011790130C → W. Corresponds to variant dbSNP:rs5360Ensembl.1
Natural variantiVAR_004191149S → R Polymorphism associated with coronary artery disease; no effect on ligand-specificity; may increase levels of rolling and adhesion of neutrophils and peripheral blood mononuclear cells to the endothelium; may induce constitutive stimulation of the MAPK signaling pathway, in the absence of leukocyte adhesion. 7 PublicationsCorresponds to variant dbSNP:rs5361Ensembl.1
Natural variantiVAR_014302257Q → P1 PublicationCorresponds to variant dbSNP:rs3917422Ensembl.1
Natural variantiVAR_011791295E → K1 PublicationCorresponds to variant dbSNP:rs5364Ensembl.1
Natural variantiVAR_011792421E → Q1 PublicationCorresponds to variant dbSNP:rs5366Ensembl.1
Natural variantiVAR_011793468H → Y2 PublicationsCorresponds to variant dbSNP:rs5368EnsemblClinVar.1
Natural variantiVAR_074189545P → L1 Publication1
Natural variantiVAR_014303550P → S1 PublicationCorresponds to variant dbSNP:rs3917429Ensembl.1
Natural variantiVAR_011794575L → F4 PublicationsCorresponds to variant dbSNP:rs5355Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M30640 mRNA Translation: AAA52377.1
M61893
, M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA Translation: AAA52375.1
M24736 mRNA Translation: AAA52376.1
AF540378 Genomic DNA Translation: AAN01237.1
AL021940 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90860.1
BC131551 mRNA Translation: AAI31552.1
BC142677 mRNA Translation: AAI42678.1
BC142711 mRNA Translation: AAI42712.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1283.1

Protein sequence database of the Protein Information Resource

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PIRi
A38615 A35046

NCBI Reference Sequences

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RefSeqi
NP_000441.2, NM_000450.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.82848

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000333360; ENSP00000331736; ENSG00000007908

Database of genes from NCBI RefSeq genomes

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GeneIDi
6401

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6401

UCSC genome browser

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UCSCi
uc001ggm.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

E-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30640 mRNA Translation: AAA52377.1
M61893
, M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA Translation: AAA52375.1
M24736 mRNA Translation: AAA52376.1
AF540378 Genomic DNA Translation: AAN01237.1
AL021940 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90860.1
BC131551 mRNA Translation: AAI31552.1
BC142677 mRNA Translation: AAI42678.1
BC142711 mRNA Translation: AAI42712.1
CCDSiCCDS1283.1
PIRiA38615 A35046
RefSeqiNP_000441.2, NM_000450.2
UniGeneiHs.82848

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ESLX-ray2.00A22-183[»]
1G1TX-ray1.50A22-178[»]
1KJAmodel-A22-141[»]
4C16X-ray1.93A/B22-301[»]
4CSYX-ray2.41A/B22-301[»]
ProteinModelPortaliP16581
SMRiP16581
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112301, 16 interactors
DIPiDIP-58639N
IntActiP16581, 5 interactors
MINTiP16581
STRINGi9606.ENSP00000331736

Chemistry databases

BindingDBiP16581
ChEMBLiCHEMBL3890
DrugBankiDB01136 Carvedilol
DB03721 N-acetyl-alpha-neuraminic acid

Protein family/group databases

UniLectiniP16581

PTM databases

iPTMnetiP16581
PhosphoSitePlusiP16581

Polymorphism and mutation databases

BioMutaiSELE
DMDMi126180

Proteomic databases

PaxDbiP16581
PeptideAtlasiP16581
PRIDEiP16581
ProteomicsDBi53381

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333360; ENSP00000331736; ENSG00000007908
GeneIDi6401
KEGGihsa:6401
UCSCiuc001ggm.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6401
DisGeNETi6401
EuPathDBiHostDB:ENSG00000007908.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SELE
HGNCiHGNC:10718 SELE
HPAiCAB002143
MalaCardsiSELE
MIMi131210 gene
neXtProtiNX_P16581
OpenTargetsiENSG00000007908
PharmGKBiPA35640

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000160168
HOGENOMiHOG000236254
HOVERGENiHBG052375
InParanoidiP16581
KOiK06494
OMAiAQGQWTQ
OrthoDBiEOG091G04KC
PhylomeDBiP16581
TreeFamiTF326910

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
SIGNORiP16581

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SELE human
EvolutionaryTraceiP16581

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
E-selectin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6401

Protein Ontology

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PROi
PR:P16581

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000007908 Expressed in 150 organ(s), highest expression level in vena cava
ExpressionAtlasiP16581 baseline and differential
GenevisibleiP16581 HS

Family and domain databases

CDDicd00033 CCP, 6 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 6 hits
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 6 hits
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 6 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYAM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16581
Secondary accession number(s): A2RRD6, P16111
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: December 5, 2018
This is version 214 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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