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Protein

E-selectin

Gene

SELE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101CalciumCombined sources1 Publication1
Metal bindingi103CalciumCombined sources2 Publications1
Metal bindingi109CalciumCombined sources2 Publications1
Metal bindingi126CalciumCombined sources2 Publications1
Metal bindingi127CalciumCombined sources2 Publications1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • oligosaccharide binding Source: BHF-UCL
  • phospholipase binding Source: BHF-UCL
  • sialic acid binding Source: BHF-UCL
  • transmembrane signaling receptor activity Source: BHF-UCL

GO - Biological processi

  • actin filament-based process Source: BHF-UCL
  • activation of phospholipase C activity Source: BHF-UCL
  • calcium-mediated signaling Source: BHF-UCL
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  • inflammatory response Source: ProtInc
  • leukocyte cell-cell adhesion Source: BHF-UCL
  • leukocyte migration Source: Reactome
  • leukocyte migration involved in inflammatory response Source: BHF-UCL
  • leukocyte tethering or rolling Source: BHF-UCL
  • positive regulation of receptor internalization Source: BHF-UCL
  • regulation of inflammatory response Source: BHF-UCL
  • response to interleukin-1 Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL
  • response to tumor necrosis factor Source: BHF-UCL

Keywordsi

Biological processCell adhesion
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
SIGNORiP16581

Protein family/group databases

UniLectiniP16581

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:SELE
Synonyms:ELAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000007908.15
HGNCiHGNC:10718 SELE
MIMi131210 gene
neXtProtiNX_P16581

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 556ExtracellularSequence analysisAdd BLAST535
Transmembranei557 – 578HelicalSequence analysisAdd BLAST22
Topological domaini579 – 610CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi109E → D: Decreased adhesion to cells expressing SELPLG. 1 Publication1

Organism-specific databases

DisGeNETi6401
MalaCardsiSELE
OpenTargetsiENSG00000007908
Orphaneti34145 Berger disease
PharmGKBiPA35640

Chemistry databases

ChEMBLiCHEMBL3890
DrugBankiDB01136 Carvedilol
DB03721 N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMutaiSELE
DMDMi126180

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001749222 – 610E-selectinAdd BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi40 ↔ 138Combined sources2 Publications
Disulfide bondi111 ↔ 130Combined sources2 Publications
Disulfide bondi143 ↔ 154Combined sources2 Publications
Glycosylationi145N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi148 ↔ 163Combined sources2 Publications
Glycosylationi160N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi165 ↔ 174Combined sources2 Publications
Glycosylationi179N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi180 ↔ 224Combined sources1 Publication
Disulfide bondi193 ↔ 206Combined sources1 Publication
Glycosylationi199N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi203N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi210 ↔ 237Combined sources1 Publication
Disulfide bondi242 ↔ 286Combined sources1 Publication
Disulfide bondi255 ↔ 268Combined sources1 Publication
Glycosylationi265N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi272 ↔ 299Combined sources1 Publication
Disulfide bondi304 ↔ 349By similarity
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 362By similarity
Disulfide bondi367 ↔ 412By similarity
Disulfide bondi398 ↔ 425By similarity
Disulfide bondi430 ↔ 475By similarity
Disulfide bondi461 ↔ 488By similarity
Disulfide bondi493 ↔ 534By similarity
Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi520 ↔ 547By similarity
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16581
PeptideAtlasiP16581
PRIDEiP16581
ProteomicsDBi53381

PTM databases

iPTMnetiP16581
PhosphoSitePlusiP16581

Expressioni

Gene expression databases

BgeeiENSG00000007908
ExpressionAtlasiP16581 baseline and differential
GenevisibleiP16581 HS

Organism-specific databases

HPAiCAB002143

Interactioni

Subunit structurei

Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.2 Publications

GO - Molecular functioni

  • phospholipase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112301, 16 interactors
DIPiDIP-58639N
IntActiP16581, 5 interactors
MINTiP16581
STRINGi9606.ENSP00000331736

Chemistry databases

BindingDBiP16581

Structurei

Secondary structure

1610
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 26Combined sources4
Helixi33 – 43Combined sources11
Beta strandi44 – 47Combined sources4
Helixi53 – 62Combined sources10
Beta strandi70 – 77Combined sources8
Beta strandi80 – 83Combined sources4
Turni84 – 86Combined sources3
Turni92 – 94Combined sources3
Beta strandi111 – 114Combined sources4
Beta strandi119 – 121Combined sources3
Beta strandi125 – 128Combined sources4
Beta strandi134 – 140Combined sources7
Helixi147 – 150Combined sources4
Beta strandi151 – 157Combined sources7
Beta strandi160 – 165Combined sources6
Beta strandi169 – 171Combined sources3
Beta strandi189 – 194Combined sources6
Beta strandi196 – 198Combined sources3
Beta strandi205 – 210Combined sources6
Beta strandi214 – 217Combined sources4
Beta strandi222 – 224Combined sources3
Beta strandi230 – 232Combined sources3
Beta strandi237 – 239Combined sources3
Beta strandi251 – 254Combined sources4
Beta strandi267 – 272Combined sources6
Beta strandi277 – 280Combined sources4
Beta strandi282 – 286Combined sources5
Beta strandi292 – 294Combined sources3
Beta strandi298 – 300Combined sources3

3D structure databases

ProteinModelPortaliP16581
SMRiP16581
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16581

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 139C-type lectinPROSITE-ProRule annotationAdd BLAST118
Domaini140 – 175EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini178 – 239Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini240 – 301Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini303 – 364Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini366 – 427Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini429 – 490Sushi 5PROSITE-ProRule annotationAdd BLAST62
Domaini491 – 549Sushi 6PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni101 – 109Carbohydrate bindingCombined sources1 Publication9
Regioni113 – 118Carbohydrate bindingCombined sources1 Publication6
Regioni126 – 128Carbohydrate bindingCombined sources1 Publication3

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000236254
HOVERGENiHBG052375
InParanoidiP16581
KOiK06494
OMAiQGQWTQQ
OrthoDBiEOG091G04KC
PhylomeDBiP16581
TreeFamiTF326910

Family and domain databases

CDDicd00033 CCP, 6 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 6 hits
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 6 hits
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 6 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI
60 70 80 90 100
QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG
160 170 180 190 200
HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF
210 220 230 240 250
SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN
260 270 280 290 300
GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK
310 320 330 340 350
AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT
360 370 380 390 400
TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ
410 420 430 440 450
GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE
460 470 480 490 500
FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG
510 520 530 540 550
KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP
560 570 580 590 600
TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD
610
GSYQKPSYIL
Length:610
Mass (Da):66,655
Last modified:August 1, 1990 - v1
Checksum:i7D43E3C0D1229229
GO

Polymorphismi

A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01430021A → S1 PublicationCorresponds to variant dbSNP:rs3917407Ensembl.1
Natural variantiVAR_01430131M → I1 PublicationCorresponds to variant dbSNP:rs3917408Ensembl.1
Natural variantiVAR_011790130C → W. Corresponds to variant dbSNP:rs5360Ensembl.1
Natural variantiVAR_004191149S → R Polymorphism associated with coronary artery disease; no effect on ligand-specificity; may increase levels of rolling and adhesion of neutrophils and peripheral blood mononuclear cells to the endothelium; may induce constitutive stimulation of the MAPK signaling pathway, in the absence of leukocyte adhesion. 7 PublicationsCorresponds to variant dbSNP:rs5361Ensembl.1
Natural variantiVAR_014302257Q → P1 PublicationCorresponds to variant dbSNP:rs3917422Ensembl.1
Natural variantiVAR_011791295E → K1 PublicationCorresponds to variant dbSNP:rs5364Ensembl.1
Natural variantiVAR_011792421E → Q1 PublicationCorresponds to variant dbSNP:rs5366Ensembl.1
Natural variantiVAR_011793468H → Y2 PublicationsCorresponds to variant dbSNP:rs5368EnsemblClinVar.1
Natural variantiVAR_074189545P → L1 Publication1
Natural variantiVAR_014303550P → S1 PublicationCorresponds to variant dbSNP:rs3917429Ensembl.1
Natural variantiVAR_011794575L → F4 PublicationsCorresponds to variant dbSNP:rs5355Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30640 mRNA Translation: AAA52377.1
M61893
, M61895, M61887, M61888, M61890, M61891, M61892 Genomic DNA Translation: AAA52375.1
M24736 mRNA Translation: AAA52376.1
AF540378 Genomic DNA Translation: AAN01237.1
AL021940 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90860.1
BC131551 mRNA Translation: AAI31552.1
BC142677 mRNA Translation: AAI42678.1
BC142711 mRNA Translation: AAI42712.1
CCDSiCCDS1283.1
PIRiA38615 A35046
RefSeqiNP_000441.2, NM_000450.2
UniGeneiHs.82848

Genome annotation databases

EnsembliENST00000333360; ENSP00000331736; ENSG00000007908
GeneIDi6401
KEGGihsa:6401
UCSCiuc001ggm.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLYAM2_HUMAN
AccessioniPrimary (citable) accession number: P16581
Secondary accession number(s): A2RRD6, P16111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 18, 2018
This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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