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Protein

Protein bicaudal D

Gene

BicD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk.3 Publications

GO - Molecular functioni

  • clathrin heavy chain binding Source: FlyBase
  • cytoskeletal adaptor activity Source: InterPro
  • dynein complex binding Source: FlyBase
  • Rab GTPase binding Source: FlyBase

GO - Biological processi

  • cellular macromolecule localization Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • germarium-derived oocyte fate determination Source: FlyBase
  • intracellular mRNA localization Source: FlyBase
  • mRNA transport Source: FlyBase
  • oocyte axis specification Source: FlyBase
  • oocyte microtubule cytoskeleton organization Source: FlyBase
  • oocyte microtubule cytoskeleton polarization Source: FlyBase
  • oocyte nucleus migration involved in oocyte dorsal/ventral axis specification Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of clathrin-dependent endocytosis Source: FlyBase
  • positive regulation of synaptic vesicle exocytosis Source: FlyBase
  • regulation of endocytosis Source: FlyBase
  • RNA transport Source: FlyBase
  • synaptic vesicle endocytosis Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-DME-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Protein bicaudal D
Gene namesi
Name:BicD
ORF Names:CG6605
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000183 BicD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mutant embryos show Nanos mislocalization and thus bicaudal development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002053611 – 782Protein bicaudal DAdd BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103Phosphoserine2 Publications1
Modified residuei285Phosphoserine1 Publication1
Modified residuei288Phosphoserine1 Publication1
Modified residuei305Phosphoserine1 Publication1
Modified residuei306Phosphothreonine1 Publication1
Modified residuei310Phosphoserine1 Publication1
Modified residuei528Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP16568
PRIDEiP16568

PTM databases

iPTMnetiP16568

Expressioni

Tissue specificityi

In ovaries, expressed in oocyte and nurse cells.1 Publication

Developmental stagei

Expressed maternally and zygotically. Expressed during oogenesis and throughout development.1 Publication

Gene expression databases

BgeeiFBgn0000183
ExpressionAtlasiP16568 baseline and differential
GenevisibleiP16568 DM

Interactioni

Subunit structurei

Interacts (via C-terminal domain) with Rab6.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ChcP297425EBI-112159,EBI-160368

GO - Molecular functioni

  • clathrin heavy chain binding Source: FlyBase
  • cytoskeletal adaptor activity Source: InterPro
  • Rab GTPase binding Source: FlyBase

Protein-protein interaction databases

BioGridi61047, 32 interactors
DIPiDIP-21297N
IntActiP16568, 22 interactors
MINTiP16568
STRINGi7227.FBpp0303259

Structurei

Secondary structure

1782
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi664 – 739Combined sources76

3D structure databases

ProteinModelPortaliP16568
SMRiP16568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni699 – 722Interaction with Rab6Add BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3 – 263Sequence analysisAdd BLAST261
Coiled coili319 – 477Sequence analysisAdd BLAST159
Coiled coili601 – 746Sequence analysisAdd BLAST146

Sequence similaritiesi

Belongs to the BicD family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0999 Eukaryota
ENOG410XR47 LUCA
GeneTreeiENSGT00390000004114
InParanoidiP16568
KOiK18739
OMAiVHMEKEL
OrthoDBiEOG091G01P4
PhylomeDBiP16568

Family and domain databases

InterProiView protein in InterPro
IPR018477 BICD
PANTHERiPTHR31233 PTHR31233, 1 hit
PfamiView protein in Pfam
PF09730 BicD, 1 hit

Sequencei

Sequence statusi: Complete.

P16568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSASNNGPS ADQSVQDLQM EVERLTRELD QVSSASAQSA QYGLSLLEEK
60 70 80 90 100
SALQQKCEEL ETLYDNTRHE LDITQEALTK FQTSQKVTNK TGIEQEDALL
110 120 130 140 150
NESAARETSL NLQIFDLENE LKQLRHELER VRNERDRMLQ ENSDFGRDKS
160 170 180 190 200
DSEADRLRLK SELKDLKFRE TRMLSEYSEL EEENISLQKQ VSSLRSSQVE
210 220 230 240 250
FEGAKHEIRR LTEEVELLNQ QVDELANLKK IAEKQMEEAL ETLQGEREAK
260 270 280 290 300
YALKKELDGH LNRESMYHIS NLAYSIRSNM EDNASNNSDG EEENLALKRL
310 320 330 340 350
EADLSTELKS PDGTKCDLFS EIHLNELKKL EKQLESMESE KTHLTANLRE
360 370 380 390 400
AQTSLDKSQN ELQNFMSRLA LLAAHVDALV QLKKQIDVKE QGKEGGQKKD
410 420 430 440 450
ELEQQLRALI SQYANWFTLS AKEIDGLKTD IAELQKGLNY TDATTTLRNE
460 470 480 490 500
VTNLKNKLLA TEQKSLDLQS DVQTLTHISQ NAGQSLGSAR STLVALSDDL
510 520 530 540 550
AQLYHLVCTV NGETPTRVLL DHKTDDMSFE NDSLTAIQSQ FKSDVFIAKP
560 570 580 590 600
QIVEDLQGLA DSVEIKKYVD TVSDQIKYLK TAVEHTIDMN KHKIRSEGGD
610 620 630 640 650
ALEKVNTEEM EELQEQIVKL KSLLSVKREQ IGTLRNVLKS NKQTAEVALT
660 670 680 690 700
NLKSKYENEK IIVSDTMSKL RNELRLLKED AATFSSLRAM FAARCEEYVT
710 720 730 740 750
QVDDLNRQLE AAEEEKKTLN QLLRLAVQQK LALTQRLEEM EMDREMRHVR
760 770 780
RPMPAQRGTS GKSSFSTRPS SRNPASSNAN PF
Length:782
Mass (Da):88,954
Last modified:December 1, 2000 - v2
Checksum:i5A71776171DF58E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296A → S in AAA28393 (PubMed:2590944).Curated1
Sequence conflicti318L → P in AAA28393 (PubMed:2590944).Curated1
Sequence conflicti477H → R in AAA28393 (PubMed:2590944).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31684 mRNA Translation: AAA28393.1
X51652 mRNA Translation: CAA35964.1
AE014134 Genomic DNA Translation: AAF53616.1
AY069452 mRNA Translation: AAL39597.1
PIRiA34219
RefSeqiNP_001260530.1, NM_001273601.1
NP_724056.1, NM_165220.3
UniGeneiDm.3232

Genome annotation databases

EnsemblMetazoaiFBtr0081002; FBpp0080555; FBgn0000183
FBtr0330225; FBpp0303258; FBgn0000183
GeneIDi35051
KEGGidme:Dmel_CG6605

Similar proteinsi

Entry informationi

Entry nameiBICD_DROME
AccessioniPrimary (citable) accession number: P16568
Secondary accession number(s): Q9VJD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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