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Protein

Putative ketoacyl reductase

Gene

actIII

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pathwayi: actinorhodin biosynthesis

This protein is involved in the pathway actinorhodin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway actinorhodin biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63NADP2 Publications1
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorPROSITE-ProRule annotation1
Binding sitei161NADP2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 39NADP2 PublicationsAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAntibiotic biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00173

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ketoacyl reductase (EC:1.3.1.-)
Gene namesi
Name:actIII
Ordered Locus Names:SCO5086
ORF Names:SCBAC28G1.12c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB01942 Formic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544471 – 261Putative ketoacyl reductaseAdd BLAST261

Proteomic databases

PRIDEiP16544

Interactioni

Subunit structurei

Homotetramer.2 Publications

Protein-protein interaction databases

STRINGi100226.SCO5086

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi17 – 28Combined sources12
Beta strandi32 – 38Combined sources7
Helixi40 – 52Combined sources13
Beta strandi57 – 61Combined sources5
Helixi67 – 80Combined sources14
Beta strandi85 – 89Combined sources5
Helixi99 – 101Combined sources3
Helixi104 – 114Combined sources11
Helixi116 – 126Combined sources11
Turni127 – 129Combined sources3
Helixi131 – 134Combined sources4
Beta strandi136 – 142Combined sources7
Helixi145 – 147Combined sources3
Helixi155 – 175Combined sources21
Turni176 – 178Combined sources3
Beta strandi179 – 187Combined sources9
Beta strandi189 – 192Combined sources4
Helixi193 – 206Combined sources14
Helixi210 – 220Combined sources11
Helixi229 – 240Combined sources12
Helixi242 – 244Combined sources3
Beta strandi251 – 255Combined sources5

3D structure databases

ProteinModelPortaliP16544
SMRiP16544
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16544

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DTD Bacteria
ENOG410XPTP LUCA
InParanoidiP16544
KOiK12420
OMAiALNQLTW
OrthoDBiPOG091H012M
PhylomeDBiP16544

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P16544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQDSEVAL VTGATSGIGL EIARRLGKEG LRVFVCARGE EGLRTTLKEL
60 70 80 90 100
REAGVEADGR TCDVRSVPEI EALVAAVVER YGPVDVLVNN AGRPGGGATA
110 120 130 140 150
ELADELWLDV VETNLTGVFR VTKQVLKAGG MLERGTGRIV NIASTGGKQG
160 170 180 190 200
VVHAAPYSAS KHGVVGFTKA LGLELARTGI TVNAVCPGFV ETPMAASVRE
210 220 230 240 250
HYSDIWEVST EEAFDRITAR VPIGRYVQPS EVAEMVAYLI GPGAAAVTAQ
260
ALNVCGGLGN Y
Length:261
Mass (Da):27,265
Last modified:August 1, 1990 - v1
Checksum:iB87C83F45A88B7A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19536 Genomic DNA Translation: AAA26688.1
AL939122 Genomic DNA Translation: CAC44199.1
PIRiJS0108 A28788
RefSeqiNP_629236.1, NC_003888.3
WP_003973892.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAC44199; CAC44199; CAC44199
GeneIDi1100527
KEGGisco:SCO5086
PATRICifig|100226.15.peg.5166

Similar proteinsi

Entry informationi

Entry nameiACT3_STRCO
AccessioniPrimary (citable) accession number: P16544
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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