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UniProtKB - P16471 (PRLR_HUMAN)

Entry version 226 (02 Jun 2021)
Sequence version 1 (01 Aug 1990)
Previous versions | rss
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Protein

Prolactin receptor

Gene

PRLR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi211Zinc1
Metal bindingi212Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16471

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1170546, Prolactin receptor signaling
R-HSA-982772, Growth hormone receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P16471

SIGNOR Signaling Network Open Resource

More...SIGNORi		P16471

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolactin receptor
Short name:
PRL-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRLR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9446, PRLR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176761, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16471

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000113494.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 234ExtracellularSequence analysisAdd BLAST210
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei235 – 258HelicalSequence analysisAdd BLAST24
Topological domaini259 – 622CytoplasmicSequence analysisAdd BLAST364

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Multiple fibroadenomas of the breast (MFAB)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070894170I → L in MFAB; confers constitutive activity. 1 PublicationCorresponds to variant dbSNP:rs72478580EnsemblClinVar.1
Hyperprolactinemia (HPRL)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070895212H → R in HPRL; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398122522EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		5618

MalaCards human disease database

More...MalaCardsi		PRLR
MIMi615554, phenotype
615555, phenotype

Open Targets

More...OpenTargetsi		ENSG00000113494

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		397685, Familial hyperprolactinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33791

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16471, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5588

Drug and drug target database

More...DrugBanki		DB00052, Somatotropin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRLR

Domain mapping of disease mutations (DMDM)

More...DMDMi		130321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Add BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001097725 – 622Prolactin receptorAdd BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 461 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 861 Publication
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16471

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16471

PeptideAtlas

More...PeptideAtlasi		P16471

PRoteomics IDEntifications database

More...PRIDEi		P16471

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		12725
53366 [P16471-1]
53367 [P16471-2]
53368 [P16471-3]
53369 [P16471-4]
53370 [P16471-5]
53371 [P16471-6]
53372 [P16471-7]
53373 [P16471-8]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16471, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16471

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16471

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in breast, placenta, kidney, liver and pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113494, Expressed in placenta and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16471, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16471, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113494, Tissue enhanced (brain, placenta, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer upon hormone binding.

Interacts with SMARCA1.

Interacts with GH1.

Interacts with CSH.

Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111603, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P16471

Database of interacting proteins

More...DIPi		DIP-288N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P16471

Protein interaction database and analysis system

More...IntActi		P16471, 8 interactors

Molecular INTeraction database

More...MINTi		P16471

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000482954

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P16471

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16471, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1622
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P16471

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16471

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16471

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 128Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini129 – 229Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni326 – 378DisorderedSequence analysisAdd BLAST53
Regioni461 – 505DisorderedSequence analysisAdd BLAST45
Regioni520 – 545DisorderedSequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi215 – 219WSXWS motif5
Motifi267 – 275Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi462 – 485Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R22A, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017892_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16471

Identification of Orthologs from Complete Genome Data

More...OMAi		SCWWKPG

Database of Orthologous Groups

More...OrthoDBi		346239at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16471

TreeFam database of animal gene trees

More...TreeFami		TF330851

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 2 hits

Database of protein disorder

More...DisProti		DP01106

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR015152, Growth/epo_recpt_lig-bind
IPR013783, Ig-like_fold
IPR003528, Long_hematopoietin_rcpt_CS
IPR033230, PRLR

The PANTHER Classification System

More...PANTHERi		PTHR23036:SF86, PTHR23036:SF86, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09067, EpoR_lig-bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 2 hits
PS01352, HEMATOPO_REC_L_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16471-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP 
        60         70         80         90        100
GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI 
       110        120        130        140        150
MMVNATNQMG SSFSDELYVD VTYIVQPDPP LELAVEVKQP EDRKPYLWIK 
       160        170        180        190        200
WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW EIHFAGQQTE FKILSLHPGQ 
       210        220        230        240        250
KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS VAVLSAVICL 
       260        270        280        290        300
IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 
       310        320        330        340        350
FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG 
       360        370        380        390        400
RGSCDSPSLL SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME 
       410        420        430        440        450
GKIPYFHAGG SKCSTWPLPQ PSQHNPRSSY HNITDVCELA VGPAGAPATL 
       460        470        480        490        500
LNEAGKDALK SSQTIKSREE GKATQQREVE SFHSETDQDT PWLLPQEKTP 
       510        520        530        540        550
FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP ENNKEYAKVS 
       560        570        580        590        600
GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS 
       610        620 
KCRLQLGGLD YLDPACFTHS FH
Length:622
Mass (Da):69,506
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB7FD0328608C787
GO
Isoform 2 (identifier: P16471-2) [UniParc]FASTAAdd to basket
Also known as: Delta-S1

The sequence of this isoform differs from the canonical sequence as follows:
     24-124: Missing.

Show »
Length:521
Mass (Da):57,953
Checksum:i1CF312424037E85B
GO
Isoform 3 (identifier: P16471-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: DF → AW
     231-622: Missing.

Note: Soluble isoform that appears specific for the BT-474 breast cancer cell line.Curated
Show »
Length:230
Mass (Da):26,545
Checksum:i5288BCF71248D291
GO
Isoform 4 (identifier: P16471-4) [UniParc]FASTAAdd to basket
Also known as: SF1a, Short form 1a

The sequence of this isoform differs from the canonical sequence as follows:
     338-376: MKPTYLDPDT...PQANPSTFYD → DPLMLGASHY...FTKATLTTVQ
     377-622: Missing.

Note: Includes exon 11. Does not transduce prolactin signaling.Curated
Show »
Length:376
Mass (Da):42,639
Checksum:i112DC2555FBC4601
GO
Isoform 5 (identifier: P16471-5) [UniParc]FASTAAdd to basket
Also known as: Intermediate

The sequence of this isoform differs from the canonical sequence as follows:
     337-349: GMKPTYLDPDTDS → EREQRQAQEARDS
     350-622: Missing.

Note: Produced by deletion of part of exon 10 and frameshift.Curated
Show »
Length:349
Mass (Da):39,806
Checksum:i932F200E850CDD27
GO
Isoform 6 (identifier: P16471-6) [UniParc]FASTAAdd to basket
Also known as: SF1b, Short form 1b

The sequence of this isoform differs from the canonical sequence as follows:
     286-288: KGK → VTP
     289-622: Missing.

Note: Does not transduce prolactin signaling.Curated
Show »
Length:288
Mass (Da):32,760
Checksum:iB45203EC045EB417
GO
Isoform 7 (identifier: P16471-7) [UniParc]FASTAAdd to basket
Also known as: Delta 7/11

The sequence of this isoform differs from the canonical sequence as follows:
     229-268: DFTMNDTTVW...KGYSMVTCIF → GDPLMLGASH...FTKATLTTVQ
     269-622: Missing.

Note: Splices from exon 7 to exon 11.Curated
Show »
Length:268
Mass (Da):30,705
Checksum:iFBB498AB649A078C
GO
Isoform 8 (identifier: P16471-8) [UniParc]FASTAAdd to basket
Also known as: Delta 4-SF1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     286-288: KGK → VTP
     289-622: Missing.

Note: SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:217
Mass (Da):24,773
Checksum:iE59A9BB9016C3397
GO
Isoform 9 (identifier: P16471-9) [UniParc]FASTAAdd to basket
Also known as: SF1c, Short form 1c

The sequence of this isoform differs from the canonical sequence as follows:
     286-309: KGKSEELLSALGCQDFPPTSDYED → DRLCTPGRCCVSTGLTDLDYSCST
     310-622: Missing.

Show »
Length:309
Mass (Da):35,011
Checksum:i1FC88E4E2F4E9DEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9P5D6R9P5_HUMAN
Prolactin receptor
PRLR
120Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC67D6RC67_HUMAN
Prolactin receptor
PRLR
102Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD41D6RD41_HUMAN
Prolactin receptor
PRLR
111Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9V7D6R9V7_HUMAN
Prolactin receptor
PRLR
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAN9D6RAN9_HUMAN
Prolactin receptor
PRLR
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJC8D6RJC8_HUMAN
Prolactin receptor
PRLR
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9E1D6R9E1_HUMAN
Prolactin receptor
PRLR
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049172100I → V. Corresponds to variant dbSNP:rs2228482Ensembl.1
Natural variantiVAR_070894170I → L in MFAB; confers constitutive activity. 1 PublicationCorresponds to variant dbSNP:rs72478580EnsemblClinVar.1
Natural variantiVAR_070895212H → R in HPRL; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398122522EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0265311 – 71Missing in isoform 8. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_00172024 – 124Missing in isoform 2. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_026532229 – 268DFTMN…VTCIF → GDPLMLGASHYKNLKSYRPR KISSQGRLAVFTKATLTTVQ in isoform 7. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_012620229 – 230DF → AW in isoform 3. 1 Publication2
Alternative sequenceiVSP_012621231 – 622Missing in isoform 3. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_026533269 – 622Missing in isoform 7. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_047882286 – 309KGKSE…SDYED → DRLCTPGRCCVSTGLTDLDY SCST in isoform 9. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_026534286 – 288KGK → VTP in isoform 6 and isoform 8. 2 Publications3
Alternative sequenceiVSP_026535289 – 622Missing in isoform 6 and isoform 8. 2 PublicationsAdd BLAST334
Alternative sequenceiVSP_047883310 – 622Missing in isoform 9. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_026536337 – 349GMKPT…PDTDS → EREQRQAQEARDS in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_026537338 – 376MKPTY…STFYD → DPLMLGASHYKNLKSYRPRK ISSQGRLAVFTKATLTTVQ in isoform 4. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_026538350 – 622Missing in isoform 5. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_026539377 – 622Missing in isoform 4. 2 PublicationsAdd BLAST246

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M31661 mRNA Translation: AAA60174.1
AF166329 mRNA Translation: AAD49855.1
AF091870 AF091869 Genomic DNA Translation: AAD32032.1
AF349939 mRNA Translation: AAK32703.1
AF416618 mRNA Translation: AAL23914.1
AF416619 mRNA Translation: AAL23915.1
AF492470 mRNA Translation: AAM18048.1
AF493069 mRNA Translation: AAM11661.1
GU133399 mRNA Translation: ACZ04321.1
AK313270 mRNA Translation: BAG36079.1
AC010368 Genomic DNA No translation available.
AC091851 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55919.1
BC059392 mRNA Translation: AAH59392.1
S78505 mRNA Translation: AAB34470.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3909.1 [P16471-1]
CCDS56358.1 [P16471-2]
CCDS56359.1 [P16471-7]
CCDS56360.1 [P16471-6]
CCDS56361.1 [P16471-4]
CCDS56362.1 [P16471-5]

Protein sequence database of the Protein Information Resource

More...PIRi		A40144
A59405
B59405

NCBI Reference Sequences

More...RefSeqi		NP_000940.1, NM_000949.6 [P16471-1]
NP_001191243.1, NM_001204314.2 [P16471-2]
NP_001191244.1, NM_001204315.1 [P16471-5]
NP_001191245.1, NM_001204316.1 [P16471-4]
NP_001191246.1, NM_001204317.1 [P16471-6]
NP_001191247.1, NM_001204318.1 [P16471-7]
XP_006714547.1, XM_006714484.2 [P16471-1]
XP_011512370.1, XM_011514068.2 [P16471-1]
XP_011512371.1, XM_011514069.2 [P16471-1]
XP_016865135.1, XM_017009646.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000231423; ENSP00000231423; ENSG00000113494 [P16471-4]
ENST00000310101; ENSP00000309008; ENSG00000113494 [P16471-5]
ENST00000348262; ENSP00000311613; ENSG00000113494 [P16471-7]
ENST00000509140; ENSP00000425300; ENSG00000113494 [P16471-6]
ENST00000511486; ENSP00000422556; ENSG00000113494 [P16471-2]
ENST00000513753; ENSP00000424841; ENSG00000113494 [P16471-6]
ENST00000514088; ENSP00000422935; ENSG00000113494 [P16471-7]
ENST00000542609; ENSP00000441813; ENSG00000113494 [P16471-4]
ENST00000618457; ENSP00000482954; ENSG00000113494 [P16471-1]
ENST00000619676; ENSP00000484768; ENSG00000113494 [P16471-5]
ENST00000620785; ENSP00000482689; ENSG00000113494 [P16471-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5618

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5618

UCSC genome browser

More...UCSCi		uc003jjg.3, human [P16471-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31661 mRNA Translation: AAA60174.1
AF166329 mRNA Translation: AAD49855.1
AF091870 AF091869 Genomic DNA Translation: AAD32032.1
AF349939 mRNA Translation: AAK32703.1
AF416618 mRNA Translation: AAL23914.1
AF416619 mRNA Translation: AAL23915.1
AF492470 mRNA Translation: AAM18048.1
AF493069 mRNA Translation: AAM11661.1
GU133399 mRNA Translation: ACZ04321.1
AK313270 mRNA Translation: BAG36079.1
AC010368 Genomic DNA No translation available.
AC091851 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55919.1
BC059392 mRNA Translation: AAH59392.1
S78505 mRNA Translation: AAB34470.1
CCDSiCCDS3909.1 [P16471-1]
CCDS56358.1 [P16471-2]
CCDS56359.1 [P16471-7]
CCDS56360.1 [P16471-6]
CCDS56361.1 [P16471-4]
CCDS56362.1 [P16471-5]
PIRiA40144
A59405
B59405
RefSeqiNP_000940.1, NM_000949.6 [P16471-1]
NP_001191243.1, NM_001204314.2 [P16471-2]
NP_001191244.1, NM_001204315.1 [P16471-5]
NP_001191245.1, NM_001204316.1 [P16471-4]
NP_001191246.1, NM_001204317.1 [P16471-6]
NP_001191247.1, NM_001204318.1 [P16471-7]
XP_006714547.1, XM_006714484.2 [P16471-1]
XP_011512370.1, XM_011514068.2 [P16471-1]
XP_011512371.1, XM_011514069.2 [P16471-1]
XP_016865135.1, XM_017009646.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BP3X-ray2.90B25-235[»]
2LFGNMR-A123-234[»]
2N7INMR-A230-264[»]
3D48X-ray2.50R25-234[»]
3MZGX-ray2.10B26-234[»]
3N06X-ray2.00B26-234[»]
3N0PX-ray2.10B26-234[»]
3NCBX-ray2.10B26-234[»]
3NCCX-ray2.50B26-234[»]
3NCEX-ray2.00B26-234[»]
3NCFX-ray2.80B26-234[»]
4I18X-ray3.24C/R25-235[»]
BMRBiP16471
SMRiP16471
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111603, 17 interactors
CORUMiP16471
DIPiDIP-288N
ELMiP16471
IntActiP16471, 8 interactors
MINTiP16471
STRINGi9606.ENSP00000482954

Chemistry databases

BindingDBiP16471
ChEMBLiCHEMBL5588
DrugBankiDB00052, Somatotropin

PTM databases

GlyGeniP16471, 3 sites
iPTMnetiP16471
PhosphoSitePlusiP16471

Genetic variation databases

BioMutaiPRLR
DMDMi130321

Proteomic databases

MassIVEiP16471
PaxDbiP16471
PeptideAtlasiP16471
PRIDEiP16471
ProteomicsDBi12725
53366 [P16471-1]
53367 [P16471-2]
53368 [P16471-3]
53369 [P16471-4]
53370 [P16471-5]
53371 [P16471-6]
53372 [P16471-7]
53373 [P16471-8]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P16471, 42 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10116, 927 antibodies

The DNASU plasmid repository

More...DNASUi		5618

Genome annotation databases

EnsembliENST00000231423; ENSP00000231423; ENSG00000113494 [P16471-4]
ENST00000310101; ENSP00000309008; ENSG00000113494 [P16471-5]
ENST00000348262; ENSP00000311613; ENSG00000113494 [P16471-7]
ENST00000509140; ENSP00000425300; ENSG00000113494 [P16471-6]
ENST00000511486; ENSP00000422556; ENSG00000113494 [P16471-2]
ENST00000513753; ENSP00000424841; ENSG00000113494 [P16471-6]
ENST00000514088; ENSP00000422935; ENSG00000113494 [P16471-7]
ENST00000542609; ENSP00000441813; ENSG00000113494 [P16471-4]
ENST00000618457; ENSP00000482954; ENSG00000113494 [P16471-1]
ENST00000619676; ENSP00000484768; ENSG00000113494 [P16471-5]
ENST00000620785; ENSP00000482689; ENSG00000113494 [P16471-2]
GeneIDi5618
KEGGihsa:5618
UCSCiuc003jjg.3, human [P16471-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5618
DisGeNETi5618

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRLR
HGNCiHGNC:9446, PRLR
HPAiENSG00000113494, Tissue enhanced (brain, placenta, seminal vesicle)
MalaCardsiPRLR
MIMi176761, gene
615554, phenotype
615555, phenotype
neXtProtiNX_P16471
OpenTargetsiENSG00000113494
Orphaneti397685, Familial hyperprolactinemia
PharmGKBiPA33791
VEuPathDBiHostDB:ENSG00000113494.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R22A, Eukaryota
GeneTreeiENSGT00940000154851
HOGENOMiCLU_017892_1_0_1
InParanoidiP16471
OMAiSCWWKPG
OrthoDBi346239at2759
PhylomeDBiP16471
TreeFamiTF330851

Enzyme and pathway databases

PathwayCommonsiP16471
ReactomeiR-HSA-1170546, Prolactin receptor signaling
R-HSA-982772, Growth hormone receptor signaling
SignaLinkiP16471
SIGNORiP16471

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5618, 4 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRLR, human
EvolutionaryTraceiP16471

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5618
PharosiP16471, Tbio

Protein Ontology

More...PROi		PR:P16471
RNActiP16471, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113494, Expressed in placenta and 165 other tissues
ExpressionAtlasiP16471, baseline and differential
GenevisibleiP16471, HS

Family and domain databases

CDDicd00063, FN3, 2 hits
DisProtiDP01106
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR015152, Growth/epo_recpt_lig-bind
IPR013783, Ig-like_fold
IPR003528, Long_hematopoietin_rcpt_CS
IPR033230, PRLR
PANTHERiPTHR23036:SF86, PTHR23036:SF86, 2 hits
PfamiView protein in Pfam
PF09067, EpoR_lig-bind, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SUPFAMiSSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS01352, HEMATOPO_REC_L_F1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRLR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16471
Secondary accession number(s): B2R882
, D1MDP1, Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87, Q9UHJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 2, 2021
This is version 226 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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