Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P16471 (PRLR_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Prolactin receptor

Gene

PRLR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi211Zinc1
Metal bindingi212Zinc1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ornithine decarboxylase activator activity Source: UniProtKB
  • peptide hormone binding Source: BHF-UCL
  • prolactin receptor activity Source: ProtInc
  • protein homodimerization activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • activation of Janus kinase activity Source: UniProtKB
  • activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
  • cell surface receptor signaling pathway Source: UniProtKB
  • embryo implantation Source: ProtInc
  • JAK-STAT cascade involved in growth hormone signaling pathway Source: Reactome
  • lactation Source: ProtInc
  • negative regulation of apoptotic process Source: UniProtKB
  • steroid biosynthetic process Source: UniProtKB
  • T cell activation Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP16471
SIGNORiP16471

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin receptor
Short name:
PRL-R
Gene namesi
Name:PRLR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113494.16
HGNCiHGNC:9446 PRLR
MIMi176761 gene
neXtProtiNX_P16471

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 234ExtracellularSequence analysisAdd BLAST210
Transmembranei235 – 258HelicalSequence analysisAdd BLAST24
Topological domaini259 – 622CytoplasmicSequence analysisAdd BLAST364

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Multiple fibroadenomas of the breast (MFAB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
See also OMIM:615554
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070894170I → L in MFAB; confers constitutive activity. 1 PublicationCorresponds to variant dbSNP:rs72478580EnsemblClinVar.1
Hyperprolactinemia (HPRL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.
See also OMIM:615555
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070895212H → R in HPRL; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398122522EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5618
MalaCardsiPRLR
MIMi615554 phenotype
615555 phenotype
OpenTargetsiENSG00000113494
Orphaneti397685 Familial hyperprolactinemia
50920 Multiple fibroadenoma of the breast
PharmGKBiPA33791

Chemistry databases

ChEMBLiCHEMBL5588
DrugBankiDB01185 Fluoxymesterone
DB00052 Somatropin recombinant

Polymorphism and mutation databases

BioMutaiPRLR
DMDMi130321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001097725 – 622Prolactin receptorAdd BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 461 Publication
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 861 Publication
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP16471
PeptideAtlasiP16471
PRIDEiP16471
ProteomicsDBi53366
53367 [P16471-2]
53368 [P16471-3]
53369 [P16471-4]
53370 [P16471-5]
53371 [P16471-6]
53372 [P16471-7]
53373 [P16471-8]

PTM databases

iPTMnetiP16471
PhosphoSitePlusiP16471

Expressioni

Tissue specificityi

Expressed in breast, placenta, kidney, liver and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000113494
CleanExiHS_PRLR
ExpressionAtlasiP16471 baseline and differential
GenevisibleiP16471 HS

Interactioni

Subunit structurei

Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111603, 13 interactors
CORUMiP16471
DIPiDIP-288N
ELMiP16471
IntActiP16471, 6 interactors
MINTiP16471
STRINGi9606.ENSP00000371432

Chemistry databases

BindingDBiP16471

Structurei

Secondary structure

1622
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 42Combined sources11
Beta strandi44 – 49Combined sources6
Beta strandi52 – 54Combined sources3
Beta strandi58 – 66Combined sources9
Turni67 – 69Combined sources3
Beta strandi85 – 88Combined sources4
Helixi90 – 92Combined sources3
Beta strandi95 – 97Combined sources3
Beta strandi99 – 107Combined sources9
Beta strandi110 – 113Combined sources4
Beta strandi117 – 119Combined sources3
Helixi121 – 123Combined sources3
Beta strandi131 – 138Combined sources8
Beta strandi141 – 143Combined sources3
Beta strandi146 – 152Combined sources7
Beta strandi155 – 157Combined sources3
Beta strandi162 – 164Combined sources3
Beta strandi166 – 173Combined sources8
Beta strandi181 – 186Combined sources6
Beta strandi189 – 193Combined sources5
Beta strandi201 – 213Combined sources13
Beta strandi222 – 225Combined sources4
Helixi230 – 232Combined sources3
Helixi234 – 254Combined sources21
Turni255 – 257Combined sources3
Beta strandi258 – 262Combined sources5

3D structure databases

DisProtiDP01106
ProteinModelPortaliP16471
SMRiP16471
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16471

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 128Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini129 – 229Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 219WSXWS motif5
Motifi267 – 275Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUSW Eukaryota
ENOG410XRJS LUCA
GeneTreeiENSGT00530000063112
HOGENOMiHOG000059569
HOVERGENiHBG007314
InParanoidiP16471
KOiK05081
OMAiEDQQLMP
OrthoDBiEOG091G07CK
PhylomeDBiP16471
TreeFamiTF330851

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
IPR033230 PRLR
PANTHERiPTHR23036:SF86 PTHR23036:SF86, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequences (9)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P16471-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP 
        60         70         80         90        100
GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI 
       110        120        130        140        150
MMVNATNQMG SSFSDELYVD VTYIVQPDPP LELAVEVKQP EDRKPYLWIK 
       160        170        180        190        200
WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW EIHFAGQQTE FKILSLHPGQ 
       210        220        230        240        250
KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS VAVLSAVICL 
       260        270        280        290        300
IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD 
       310        320        330        340        350
FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG 
       360        370        380        390        400
RGSCDSPSLL SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME 
       410        420        430        440        450
GKIPYFHAGG SKCSTWPLPQ PSQHNPRSSY HNITDVCELA VGPAGAPATL 
       460        470        480        490        500
LNEAGKDALK SSQTIKSREE GKATQQREVE SFHSETDQDT PWLLPQEKTP 
       510        520        530        540        550
FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP ENNKEYAKVS 
       560        570        580        590        600
GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS 
       610        620 
KCRLQLGGLD YLDPACFTHS FH
Length:622
Mass (Da):69,506
Last modified:August 1, 1990 - v1
Checksum:iDB7FD0328608C787
GO
Isoform 2 (identifier: P16471-2) [UniParc]FASTAAdd to basket
Also known as: Delta-S1

The sequence of this isoform differs from the canonical sequence as follows:
     24-124: Missing.

Show »
Length:521
Mass (Da):57,953
Checksum:i1CF312424037E85B
GO
Isoform 3 (identifier: P16471-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: DF → AW
     231-622: Missing.

Note: Soluble isoform that appears specific for the BT-474 breast cancer cell line.
Show »
Length:230
Mass (Da):26,545
Checksum:i5288BCF71248D291
GO
Isoform 4 (identifier: P16471-4) [UniParc]FASTAAdd to basket
Also known as: SF1a, Short form 1a

The sequence of this isoform differs from the canonical sequence as follows:
     338-376: MKPTYLDPDT...PQANPSTFYD → DPLMLGASHY...FTKATLTTVQ
     377-622: Missing.

Note: Includes exon 11. Does not transduce prolactin signaling.
Show »
Length:376
Mass (Da):42,639
Checksum:i112DC2555FBC4601
GO
Isoform 5 (identifier: P16471-5) [UniParc]FASTAAdd to basket
Also known as: Intermediate

The sequence of this isoform differs from the canonical sequence as follows:
     337-349: GMKPTYLDPDTDS → EREQRQAQEARDS
     350-622: Missing.

Note: Produced by deletion of part of exon 10 and frameshift.
Show »
Length:349
Mass (Da):39,806
Checksum:i932F200E850CDD27
GO
Isoform 6 (identifier: P16471-6) [UniParc]FASTAAdd to basket
Also known as: SF1b, Short form 1b

The sequence of this isoform differs from the canonical sequence as follows:
     286-288: KGK → VTP
     289-622: Missing.

Note: Does not transduce prolactin signaling.
Show »
Length:288
Mass (Da):32,760
Checksum:iB45203EC045EB417
GO
Isoform 7 (identifier: P16471-7) [UniParc]FASTAAdd to basket
Also known as: Delta 7/11

The sequence of this isoform differs from the canonical sequence as follows:
     229-268: DFTMNDTTVW...KGYSMVTCIF → GDPLMLGASH...FTKATLTTVQ
     269-622: Missing.

Note: Splices from exon 7 to exon 11.
Show »
Length:268
Mass (Da):30,705
Checksum:iFBB498AB649A078C
GO
Isoform 8 (identifier: P16471-8) [UniParc]FASTAAdd to basket
Also known as: Delta 4-SF1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     286-288: KGK → VTP
     289-622: Missing.

Note: SF1b with deletion of exon 4. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:217
Mass (Da):24,773
Checksum:iE59A9BB9016C3397
GO
Isoform 9 (identifier: P16471-9) [UniParc]FASTAAdd to basket
Also known as: SF1c, Short form 1c

The sequence of this isoform differs from the canonical sequence as follows:
     286-309: KGKSEELLSALGCQDFPPTSDYED → DRLCTPGRCCVSTGLTDLDYSCST
     310-622: Missing.

Show »
Length:309
Mass (Da):35,011
Checksum:i1FC88E4E2F4E9DEB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049172100I → V. Corresponds to variant dbSNP:rs2228482Ensembl.1
Natural variantiVAR_070894170I → L in MFAB; confers constitutive activity. 1 PublicationCorresponds to variant dbSNP:rs72478580EnsemblClinVar.1
Natural variantiVAR_070895212H → R in HPRL; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398122522EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0265311 – 71Missing in isoform 8. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_00172024 – 124Missing in isoform 2. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_026532229 – 268DFTMN…VTCIF → GDPLMLGASHYKNLKSYRPR KISSQGRLAVFTKATLTTVQ in isoform 7. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_012620229 – 230DF → AW in isoform 3. 1 Publication2
Alternative sequenceiVSP_012621231 – 622Missing in isoform 3. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_026533269 – 622Missing in isoform 7. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_047882286 – 309KGKSE…SDYED → DRLCTPGRCCVSTGLTDLDY SCST in isoform 9. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_026534286 – 288KGK → VTP in isoform 6 and isoform 8. 2 Publications3
Alternative sequenceiVSP_026535289 – 622Missing in isoform 6 and isoform 8. 2 PublicationsAdd BLAST334
Alternative sequenceiVSP_047883310 – 622Missing in isoform 9. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_026536337 – 349GMKPT…PDTDS → EREQRQAQEARDS in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_026537338 – 376MKPTY…STFYD → DPLMLGASHYKNLKSYRPRK ISSQGRLAVFTKATLTTVQ in isoform 4. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_026538350 – 622Missing in isoform 5. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_026539377 – 622Missing in isoform 4. 2 PublicationsAdd BLAST246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31661 mRNA Translation: AAA60174.1
AF166329 mRNA Translation: AAD49855.1
AF091870
, AF091863, AF091864, AF091865, AF091866, AF091867, AF091868, AF091869 Genomic DNA Translation: AAD32032.1
AF349939 mRNA Translation: AAK32703.1
AF416618 mRNA Translation: AAL23914.1
AF416619 mRNA Translation: AAL23915.1
AF492470 mRNA Translation: AAM18048.1
AF493069 mRNA Translation: AAM11661.1
GU133399 mRNA Translation: ACZ04321.1
AK313270 mRNA Translation: BAG36079.1
AC010368 Genomic DNA No translation available.
AC091851 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55919.1
BC059392 mRNA Translation: AAH59392.1
S78505 mRNA Translation: AAB34470.1
CCDSiCCDS3909.1 [P16471-1]
CCDS56358.1 [P16471-2]
CCDS56359.1 [P16471-7]
CCDS56360.1 [P16471-6]
CCDS56361.1 [P16471-4]
CCDS56362.1 [P16471-5]
PIRiA40144
A59405
B59405
RefSeqiNP_000940.1, NM_000949.6 [P16471-1]
NP_001191243.1, NM_001204314.2 [P16471-2]
NP_001191244.1, NM_001204315.1 [P16471-5]
NP_001191245.1, NM_001204316.1 [P16471-4]
NP_001191246.1, NM_001204317.1 [P16471-6]
NP_001191247.1, NM_001204318.1 [P16471-7]
XP_006714547.1, XM_006714484.2 [P16471-1]
XP_011512370.1, XM_011514068.2 [P16471-1]
XP_011512371.1, XM_011514069.2 [P16471-1]
XP_016865135.1, XM_017009646.1 [P16471-9]
UniGeneiHs.368587
Hs.602914

Genome annotation databases

EnsembliENST00000231423; ENSP00000231423; ENSG00000113494 [P16471-4]
ENST00000310101; ENSP00000309008; ENSG00000113494 [P16471-5]
ENST00000348262; ENSP00000311613; ENSG00000113494 [P16471-7]
ENST00000509140; ENSP00000425300; ENSG00000113494 [P16471-6]
ENST00000511486; ENSP00000422556; ENSG00000113494 [P16471-2]
ENST00000513753; ENSP00000424841; ENSG00000113494 [P16471-6]
ENST00000514088; ENSP00000422935; ENSG00000113494 [P16471-7]
ENST00000542609; ENSP00000441813; ENSG00000113494 [P16471-4]
ENST00000618457; ENSP00000482954; ENSG00000113494 [P16471-1]
ENST00000619676; ENSP00000484768; ENSG00000113494 [P16471-5]
ENST00000620785; ENSP00000482689; ENSG00000113494 [P16471-2]
GeneIDi5618
KEGGihsa:5618
UCSCiuc003jjg.3 human [P16471-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRLR_HUMAN
AccessioniPrimary (citable) accession number: P16471
Secondary accession number(s): B2R882
, D1MDP1, Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87, Q9UHJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 18, 2018
This is version 204 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health