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Entry version 200 (12 Aug 2020)
Sequence version 1 (01 Aug 1990)
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Protein

Methylated-DNA--protein-cysteine methyltransferase

Gene

MGMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Miscellaneous

This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 1 zinc ion.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5Zinc1
Metal bindingi24Zinc1
Metal bindingi29Zinc1
Metal bindingi85Zinc1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei95DNA; via amide nitrogen2 Publications1
Binding sitei114DNA2 Publications1
Binding sitei115DNA; via amide nitrogen2 Publications1
Binding sitei123DNA2 Publications1
Binding sitei128DNA2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei145Nucleophile; methyl group acceptor1
Binding sitei151DNA; via amide nitrogen2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.63, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P16455

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5657655, MGMT-mediated DNA damage reversal

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P16455

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylated-DNA--protein-cysteine methyltransferase (EC:2.1.1.63)
Alternative name(s):
6-O-methylguanine-DNA methyltransferase
Short name:
MGMT
O-6-methylguanine-DNA-alkyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170430.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7059, MGMT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
156569, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16455

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi114Y → A: Decreases activity towards methylated DNA over 1000-fold. Slightly reduced reactivity with O6-benzylguanine. 1 Publication1
Mutagenesisi114Y → E: Loss of DNA repair activity. Slightly reduced reactivity with O6-benzylguanine. 1 Publication1
Mutagenesisi128R → A or D: Decreases activity towards methylated DNA over 1000-fold. No effect on reactivity with O6-benzylguanine. 2 Publications1
Mutagenesisi128R → G: Loss of DNA repair activity. 2 Publications1
Mutagenesisi128R → K or L: Slightly reduced DNA repair activity. 2 Publications1
Mutagenesisi138P → K: Decreased reactivity with O6-benzylguanine. 1 Publication1
Mutagenesisi140P → A: Decreased reactivity with O6-benzylguanine. 1 Publication1
Mutagenesisi145C → A: Loss of DNA repair activity. 2 Publications1
Mutagenesisi156G → A: Decreased reactivity with O6-benzylguanine. 1 Publication1
Mutagenesisi158Y → A: Reduced DNA repair activity. Decreased reactivity with O6-benzylguanine. 1 Publication1
Mutagenesisi158Y → F: Slightly reduced DNA repair activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4255

MalaCards human disease database

More...
MalaCardsi
MGMT

Open Targets

More...
OpenTargetsi
ENSG00000170430

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
618, Familial melanoma
251579, Giant cell glioblastoma
251576, Gliosarcoma

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P16455, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2864

Drug and drug target database

More...
DrugBanki
DB00151, Cysteine
DB11831, Dinitrochlorobenzene
DB04531, S-Benzylcysteine
DB02216, S-Methylcysteine
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MGMT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127069

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001393591 – 207Methylated-DNA--protein-cysteine methyltransferaseAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P16455

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16455

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P16455

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P16455

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16455

PeptideAtlas

More...
PeptideAtlasi
P16455

PRoteomics IDEntifications database

More...
PRIDEi
P16455

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53365

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1505, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P16455, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16455

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16455

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170430, Expressed in right lobe of liver and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P16455, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16455, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170430, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110411, 79 interactors

Protein interaction database and analysis system

More...
IntActi
P16455, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302111

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P16455

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P16455, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16455

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16455

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MGMT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4062, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_52_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16455

KEGG Orthology (KO)

More...
KOi
K00567

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16455

TreeFam database of animal gene trees

More...
TreeFami
TF314064

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06445, ATase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001497, MethylDNA_cys_MeTrfase_AS
IPR014048, MethylDNA_cys_MeTrfase_DNA-bd
IPR036217, MethylDNA_cys_MeTrfase_DNAb
IPR008332, MethylG_MeTrfase_N
IPR036631, MGMT_N_sf
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01035, DNA_binding_1, 1 hit
PF02870, Methyltransf_1N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46767, SSF46767, 1 hit
SSF53155, SSF53155, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00589, ogt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00374, MGMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P16455-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA
60 70 80 90 100
AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW
110 120 130 140 150
KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC
160 170 180 190 200
SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG

SPPAGRN
Length:207
Mass (Da):21,646
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76BBF19DFC4512D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DEE8B4DEE8_HUMAN
6-O-methylguanine-DNA methyltransfe...
MGMT
238Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127A → T in AAA52317 (PubMed:2188979).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01475030E → K. Corresponds to variant dbSNP:rs2020893EnsemblClinVar.1
Natural variantiVAR_05612953L → F. Corresponds to variant dbSNP:rs12917Ensembl.1
Natural variantiVAR_02911258P → S. Corresponds to variant dbSNP:rs2308322Ensembl.1
Natural variantiVAR_02035465W → C. Corresponds to variant dbSNP:rs2282164Ensembl.1
Natural variantiVAR_01475184L → F. Corresponds to variant dbSNP:rs12917Ensembl.1
Natural variantiVAR_056130112I → V. Corresponds to variant dbSNP:rs2308321Ensembl.1
Natural variantiVAR_014752143I → V. Corresponds to variant dbSNP:rs2308321Ensembl.1
Natural variantiVAR_014753160G → R. Corresponds to variant dbSNP:rs2308318Ensembl.1
Natural variantiVAR_014754166E → D. Corresponds to variant dbSNP:rs2308320Ensembl.1
Natural variantiVAR_014755178K → R. Corresponds to variant dbSNP:rs2308327Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54228 mRNA Translation: CAA38137.1
M29971 mRNA Translation: AAA59596.1
M31767 mRNA Translation: AAA52317.1
M60761 mRNA Translation: AAA59594.1
BT006714 mRNA Translation: AAP35360.1
AL157832 Genomic DNA No translation available.
AL355531 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49166.1
BC000824 mRNA Translation: AAH00824.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7660.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A34889, XUHUMC

NCBI Reference Sequences

More...
RefSeqi
NP_002403.2, NM_002412.4
XP_005252739.1, XM_005252682.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000651593; ENSP00000498729; ENSG00000170430

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4255

UCSC genome browser

More...
UCSCi
uc001lkh.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54228 mRNA Translation: CAA38137.1
M29971 mRNA Translation: AAA59596.1
M31767 mRNA Translation: AAA52317.1
M60761 mRNA Translation: AAA59594.1
BT006714 mRNA Translation: AAP35360.1
AL157832 Genomic DNA No translation available.
AL355531 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49166.1
BC000824 mRNA Translation: AAH00824.1
CCDSiCCDS7660.2
PIRiA34889, XUHUMC
RefSeqiNP_002403.2, NM_002412.4
XP_005252739.1, XM_005252682.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EH6X-ray2.00A1-207[»]
1EH7X-ray2.00A1-207[»]
1EH8X-ray2.50A1-207[»]
1QNTX-ray1.90A1-176[»]
1T38X-ray3.20A1-176[»]
1T39X-ray3.30A/B1-176[»]
1YFHX-ray3.01A/B/C1-179[»]
SMRiP16455
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110411, 79 interactors
IntActiP16455, 1 interactor
STRINGi9606.ENSP00000302111

Chemistry databases

BindingDBiP16455
ChEMBLiCHEMBL2864
DrugBankiDB00151, Cysteine
DB11831, Dinitrochlorobenzene
DB04531, S-Benzylcysteine
DB02216, S-Methylcysteine
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

PTM databases

GlyConnecti1505, 3 N-Linked glycans (1 site)
GlyGeniP16455, 1 site
iPTMnetiP16455
PhosphoSitePlusiP16455

Polymorphism and mutation databases

BioMutaiMGMT
DMDMi127069

Proteomic databases

EPDiP16455
jPOSTiP16455
MassIVEiP16455
MaxQBiP16455
PaxDbiP16455
PeptideAtlasiP16455
PRIDEiP16455
ProteomicsDBi53365

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32507, 826 antibodies

Genome annotation databases

EnsembliENST00000651593; ENSP00000498729; ENSG00000170430
GeneIDi4255
KEGGihsa:4255
UCSCiuc001lkh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4255
DisGeNETi4255
EuPathDBiHostDB:ENSG00000170430.9

GeneCards: human genes, protein and diseases

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GeneCardsi
MGMT
HGNCiHGNC:7059, MGMT
HPAiENSG00000170430, Low tissue specificity
MalaCardsiMGMT
MIMi156569, gene
neXtProtiNX_P16455
OpenTargetsiENSG00000170430
Orphaneti618, Familial melanoma
251579, Giant cell glioblastoma
251576, Gliosarcoma

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4062, Eukaryota
GeneTreeiENSGT00390000015799
HOGENOMiCLU_000445_52_2_1
InParanoidiP16455
KOiK00567
PhylomeDBiP16455
TreeFamiTF314064

Enzyme and pathway databases

BRENDAi2.1.1.63, 2681
PathwayCommonsiP16455
ReactomeiR-HSA-5657655, MGMT-mediated DNA damage reversal
SIGNORiP16455

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4255, 3 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MGMT, human
EvolutionaryTraceiP16455

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
O-6-methylguanine-DNA_methyltransferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4255
PharosiP16455, Tchem

Protein Ontology

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PROi
PR:P16455
RNActiP16455, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170430, Expressed in right lobe of liver and 220 other tissues
ExpressionAtlasiP16455, baseline and differential
GenevisibleiP16455, HS

Family and domain databases

CDDicd06445, ATase, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001497, MethylDNA_cys_MeTrfase_AS
IPR014048, MethylDNA_cys_MeTrfase_DNA-bd
IPR036217, MethylDNA_cys_MeTrfase_DNAb
IPR008332, MethylG_MeTrfase_N
IPR036631, MGMT_N_sf
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01035, DNA_binding_1, 1 hit
PF02870, Methyltransf_1N, 1 hit
SUPFAMiSSF46767, SSF46767, 1 hit
SSF53155, SSF53155, 1 hit
TIGRFAMsiTIGR00589, ogt, 1 hit
PROSITEiView protein in PROSITE
PS00374, MGMT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGMT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16455
Secondary accession number(s): Q5VY78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 12, 2020
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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