UniProtKB - P16443 (DBP_RAT)
D site-binding protein
Dbp
Functioni
This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- circadian rhythm Source: InterPro
- liver development Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: D site-binding proteinAlternative name(s): Albumin D box-binding protein Albumin D-element-binding protein D site albumin promoter-binding protein 1 |
Gene namesi | Name:Dbp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2491, Dbp |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076509 | 1 – 325 | D site-binding proteinAdd BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P16443 |
PRIDEi | P16443 |
PTM databases
iPTMneti | P16443 |
PhosphoSitePlusi | P16443 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000021027, Expressed in brain and 22 other tissues |
ExpressionAtlasi | P16443, baseline and differential |
Genevisiblei | P16443, RN |
Interactioni
Subunit structurei
Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028547 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 255 – 318 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 98 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 124 – 203 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 230 – 255 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 257 – 279 | Basic motifPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 283 – 297 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 127 – 151 | Pro residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 152 – 167 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000162136 |
HOGENOMi | CLU_051922_0_0_1 |
InParanoidi | P16443 |
OMAi | PKEPASX |
OrthoDBi | 1023460at2759 |
PhylomeDBi | P16443 |
TreeFami | TF315869 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR029830, DBP IPR040223, PAR_bZIP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF7, PTHR11988:SF7, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK
60 70 80 90 100
EKERKATLPS APVPGPVLET AGPADAPTGA VSGGGSPRGR SGPVAGPSLF
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP
160 170 180 190 200
SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JTI1 | A0A0G2JTI1_RAT | D site-binding protein | Dbp | 378 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03179 mRNA Translation: AAA41083.1 BC087668 mRNA Translation: AAH87668.1 |
PIRi | A34894 |
RefSeqi | NP_036675.1, NM_012543.3 |
Genome annotation databases
Ensembli | ENSRNOT00000028546; ENSRNOP00000028547; ENSRNOG00000021027 |
GeneIDi | 24309 |
KEGGi | rno:24309 |
UCSCi | RGD:2491, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03179 mRNA Translation: AAA41083.1 BC087668 mRNA Translation: AAH87668.1 |
PIRi | A34894 |
RefSeqi | NP_036675.1, NM_012543.3 |
3D structure databases
AlphaFoldDBi | P16443 |
SMRi | P16443 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028547 |
PTM databases
iPTMneti | P16443 |
PhosphoSitePlusi | P16443 |
Proteomic databases
PaxDbi | P16443 |
PRIDEi | P16443 |
Genome annotation databases
Ensembli | ENSRNOT00000028546; ENSRNOP00000028547; ENSRNOG00000021027 |
GeneIDi | 24309 |
KEGGi | rno:24309 |
UCSCi | RGD:2491, rat |
Organism-specific databases
CTDi | 1628 |
RGDi | 2491, Dbp |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000162136 |
HOGENOMi | CLU_051922_0_0_1 |
InParanoidi | P16443 |
OMAi | PKEPASX |
OrthoDBi | 1023460at2759 |
PhylomeDBi | P16443 |
TreeFami | TF315869 |
Miscellaneous databases
PROi | PR:P16443 |
Gene expression databases
Bgeei | ENSRNOG00000021027, Expressed in brain and 22 other tissues |
ExpressionAtlasi | P16443, baseline and differential |
Genevisiblei | P16443, RN |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR029830, DBP IPR040223, PAR_bZIP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF7, PTHR11988:SF7, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DBP_RAT | |
Accessioni | P16443Primary (citable) accession number: P16443 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families