UniProtKB - P16442 (BGAT_HUMAN)
Protein
Histo-blood group ABO system transferase
Gene
ABO
Organism
Homo sapiens (Human)
Status
Functioni
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Catalytic activityi
- an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine = an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H+ + UDP2 PublicationsEC:2.4.1.402 Publications
- an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose = an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H+ + UDP2 PublicationsEC:2.4.1.372 Publications
Cofactori
Mn2+1 PublicationNote: Binds 1 Mn2+ ion per subunit.1 Publication
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.CuratedView all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 126 | UDP-N-acetyl-galactosamineCombined sources5 Publications | 1 | |
Metal bindingi | 211 | ManganeseCombined sources4 Publications | 1 | |
Metal bindingi | 213 | ManganeseCombined sources4 Publications | 1 | |
Binding sitei | 233 | Glycoprotein fucosyl-galactosyl groupCombined sources1 Publication | 1 | |
Binding sitei | 245 | Glycoprotein fucosyl-galactosyl groupCombined sources3 Publications | 1 | |
Active sitei | 303 | NucleophileBy similarity | 1 | |
Binding sitei | 303 | Glycoprotein fucosyl-galactosyl groupCombined sources3 Publications | 1 | |
Binding sitei | 326 | Glycoprotein fucosyl-galactosyl groupCombined sources2 Publications | 1 |
GO - Molecular functioni
- antigen binding Source: CAFA
- fucosylgalactoside 3-alpha-galactosyltransferase activity Source: UniProtKB-EC
- glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC
- manganese ion binding Source: CAFA
- nucleotide binding Source: CAFA
- transferase activity, transferring glycosyl groups Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- lipid glycosylation Source: GO_Central
- protein glycosylation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Blood group antigen, Glycosyltransferase, Transferase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS10887-MONOMER |
BRENDAi | 2.4.1.37, 2681 2.4.1.40, 2681 |
PathwayCommonsi | P16442 |
Reactomei | R-HSA-9033807, ABO blood group biosynthesis |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT6, Glycosyltransferase Family 6 |
Names & Taxonomyi
Protein namesi | Recommended name: Histo-blood group ABO system transferaseAlternative name(s): Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.402 Publications) Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.372 Publications) Histo-blood group A transferase Short name: A transferase Histo-blood group B transferase Short name: B transferase NAGAT Cleaved into the following chain: |
Gene namesi | Name:ABO |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:79, ABO |
MIMi | 110300, gene |
neXtProti | NX_P16442 |
Subcellular locationi
Extracellular region or secreted
Golgi apparatus
Note: Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi cisterna membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- vesicle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 53 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 354 | LumenalSequence analysisAdd BLAST | 301 |
Keywords - Cellular componenti
Golgi apparatus, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 214 | M → T or V: Alters substrate specificity so that both UDP-N-acetyl-D-galactosamine and UDP-galactose are utilized. 1 Publication | 1 | |
Mutagenesisi | 234 | P → S: Alters substrate specificity of group B transferase. | 1 | |
Mutagenesisi | 303 | E → A: Decreases specific activity of group B transferase almost to zero. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 28 |
MIMi | 616093, phenotype |
PharmGKBi | PA24415 |
Miscellaneous databases
Pharosi | P16442, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2321639 |
DrugBanki | DB04141, 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol DB03772, 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,5-Diol DB07357, 4-AMINO-2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL DB07378, 4-AMINO-2-OCTYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL DB04681, BETA-METHYLLACTOSIDE DB04680, GALACTOSE GREASE DB03501, Galactose-uridine-5'-diphosphate DB04678, H TYPE II TRISACCHARIDE DB04679, Human blood group H type 1 trisaccharide DB07341, octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranoside DB07633, octyl 3-deoxy-2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-xylo-hexopyranoside DB03435, Uridine-5'-Diphosphate DB02196, Uridine-Diphosphate-N-Acetylgalactosamine |
Genetic variation databases
BioMutai | ABO |
DMDMi | 114949 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000012268 | 1 – 354 | Histo-blood group ABO system transferaseAdd BLAST | 354 | |
ChainiPRO_0000012269 | 54 – 354 | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble formAdd BLAST | 301 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The soluble form derives from the membrane form by proteolytic processing.
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P16442 |
MassIVEi | P16442 |
PeptideAtlasi | P16442 |
PRIDEi | P16442 |
ProteomicsDBi | 53361 |
PTM databases
GlyGeni | P16442, 1 site |
iPTMneti | P16442 |
PhosphoSitePlusi | P16442 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 106546, 3 interactors |
STRINGi | 9606.ENSP00000483018 |
Chemistry databases
BindingDBi | P16442 |
Miscellaneous databases
RNActi | P16442, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P16442 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16442 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 123 | UDP-N-acetyl-galactosamine bindingCombined sources5 Publications | 3 | |
Regioni | 211 – 213 | UDP-N-acetyl-galactosamine bindingCombined sources5 Publications | 3 |
Domaini
The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
Sequence similaritiesi
Belongs to the glycosyltransferase 6 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQAJ, Eukaryota |
InParanoidi | P16442 |
OrthoDBi | 1204439at2759 |
PhylomeDBi | P16442 |
Family and domain databases
DisProti | DP00339 |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR005076, Glyco_trans_6 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR10462, PTHR10462, 1 hit |
Pfami | View protein in Pfam PF03414, Glyco_transf_6, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P16442-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEVLRTLAG KPKCHALRPM ILFLIMLVLV LFGYGVLSPR SLMPGSLERG
60 70 80 90 100
FCMAVREPDH LQRVSLPRMV YPQPKVLTPC RKDVLVVTPW LAPIVWEGTF
110 120 130 140 150
NIDILNEQFR LQNTTIGLTV FAIKKYVAFL KLFLETAEKH FMVGHRVHYY
160 170 180 190 200
VFTDQPAAVP RVTLGTGRQL SVLEVRAYKR WQDVSMRRME MISDFCERRF
210 220 230 240 250
LSEVDYLVCV DVDMEFRDHV GVEILTPLFG TLHPGFYGSS REAFTYERRP
260 270 280 290 300
QSQAYIPKDE GDFYYLGGFF GGSVQEVQRL TRACHQAMMV DQANGIEAVW
310 320 330 340 350
HDESHLNKYL LRHKPTKVLS PEYLWDQQLL GWPAVLRKLR FTAVPKNHQA
VRNP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X009 | A0A087X009_HUMAN | Histo-blood group ABO system transf... | ABO | 373 | Annotation score: | ||
A0A087X0C2 | A0A087X0C2_HUMAN | Histo-blood group ABO system transf... | ABO | 353 | Annotation score: |
Polymorphismi
Genetic variations in ABO define the ABO blood group system [MIMi:616093]. The ABO blood group system is the most important blood group system in blood transfusion. The sequence shown here is that of the A transferase. The B form differs by a few residues substitution. Residues 266 and 268 are important for specificity. The reference genome assembly (GRCh38/hg38) describes a non-functional O-type ABO allele. The O-type ABO allele results in a guanine deletion (NM_020469.2: c.286delG). This deletion induces a frameshift and creates a premature stop codon resulting in a truncated (117 amino acids) protein deprived of any glycosyltransferase activity (PubMed:2333095).13 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019147 | 35 | G → R1 PublicationCorresponds to variant dbSNP:rs8176696Ensembl. | 1 | |
Natural variantiVAR_019148 | 36 | V → F1 PublicationCorresponds to variant dbSNP:rs688976EnsemblClinVar. | 1 | |
Natural variantiVAR_019149 | 63 | R → H1 PublicationCorresponds to variant dbSNP:rs549446Ensembl. | 1 | |
Natural variantiVAR_019150 | 74 | P → S2 PublicationsCorresponds to variant dbSNP:rs512770EnsemblClinVar. | 1 | |
Natural variantiVAR_003408 | 80 – 81 | CR → W. | 2 | |
Natural variantiVAR_003409 | 156 | P → L in allele A2. 5 PublicationsCorresponds to variant dbSNP:rs1053878EnsemblClinVar. | 1 | |
Natural variantiVAR_019151 | 161 | R → H1 PublicationCorresponds to variant dbSNP:rs8176738Ensembl. | 1 | |
Natural variantiVAR_036738 | 163 | T → M in allele Aw08. 1 PublicationCorresponds to variant dbSNP:rs55756402Ensembl. | 1 | |
Natural variantiVAR_003410 | 176 | R → G in allele Aw08 and allele Bw08. 7 PublicationsCorresponds to variant dbSNP:rs7853989Ensembl. | 1 | |
Natural variantiVAR_036739 | 198 | R → W in allele Aw07. 1 Publication | 1 | |
Natural variantiVAR_019152 | 199 | R → C1 PublicationCorresponds to variant dbSNP:rs8176739Ensembl. | 1 | |
Natural variantiVAR_036740 | 214 | M → R in allele Bel01; loss of manganese binding and reduced catalytic activity. 2 Publications | 1 | |
Natural variantiVAR_019153 | 216 | F → I2 PublicationsCorresponds to variant dbSNP:rs8176740EnsemblClinVar. | 1 | |
Natural variantiVAR_036741 | 223 | E → D in allele B106. 1 Publication | 1 | |
Natural variantiVAR_055227 | 230 | G → R in group B transferase; lower-level protein expression and intracellular cytoplasmic mislocation. 1 Publication | 1 | |
Natural variantiVAR_072628 | 234 | P → A in allele B(A). 1 Publication | 1 | |
Natural variantiVAR_003411 | 235 | G → S in allele Bw08. 8 PublicationsCorresponds to variant dbSNP:rs8176743Ensembl. | 1 | |
Natural variantiVAR_033540 | 257 | P → L. Corresponds to variant dbSNP:rs8176745Ensembl. | 1 | |
Natural variantiVAR_003412 | 266 | L → M in allele Bw08. 8 PublicationsCorresponds to variant dbSNP:rs8176746Ensembl. | 1 | |
Natural variantiVAR_003413 | 268 | G → A in allele Bw08. 7 PublicationsCorresponds to variant dbSNP:rs8176747EnsemblClinVar. | 1 | |
Natural variantiVAR_033541 | 268 | G → R in allele Aw08. 1 PublicationCorresponds to variant dbSNP:rs41302905Ensembl. | 1 | |
Natural variantiVAR_019154 | 277 | V → M2 PublicationsCorresponds to variant dbSNP:rs8176748Ensembl. | 1 | |
Natural variantiVAR_036742 | 288 | M → R1 Publication | 1 | |
Natural variantiVAR_036743 | 291 | D → N in allele B104. 1 Publication | 1 | |
Natural variantiVAR_036744 | 346 | K → M in allele Bw08. 2 Publications | 1 | |
Natural variantiVAR_036745 | 352 | R → G in allele A107. 1 Publication | 1 | |
Natural variantiVAR_003414 | 352 | R → W in allele A106 and allele B3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05175 mRNA Translation: AAA36792.1 X84746 , X84747, X84748, X84749, X84750, X84751, X84752 Genomic DNA Translation: CAA59233.1 AF134412 mRNA Translation: AAD26572.1 AF134413 mRNA Translation: AAD26573.1 AF134414 mRNA Translation: AAD26574.1 AH007586 Genomic DNA Translation: AAD26575.1 AH007587 Genomic DNA Translation: AAD26576.1 AH007592 Genomic DNA Translation: AAD26581.1 AJ920329 Genomic DNA Translation: CAI79116.1 AM423110 Genomic DNA Translation: CAM28424.1 AM492698 Genomic DNA Translation: CAM34526.1 AM492699 Genomic DNA Translation: CAM34527.1 AY268591 Genomic DNA Translation: AAP03430.1 BC069595 mRNA Translation: AAH69595.1 BC111575 mRNA Translation: AAI11576.1 AJ536135 Genomic DNA Translation: CAD60222.1 AJ536136 Genomic DNA Translation: CAD60223.1 D82842 Genomic DNA Translation: BAA11591.2 D82843 Genomic DNA Translation: BAA11592.2 AF016622 Genomic DNA Translation: AAB86462.1 AF448199 Genomic DNA Translation: AAQ04662.1 AF448200 Genomic DNA Translation: AAQ04663.1 AJ276689 Genomic DNA Translation: CAB81779.1 |
PIRi | PC1165 |
RefSeqi | NP_065202.2, NM_020469.2 |
Genome annotation databases
GeneIDi | 28 |
KEGGi | hsa:28 |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Functional Glycomics Gateway - GTase Histo-blood group ABO system transferase |
Functional Glycomics Gateway - GTase Histo-blood group ABO system transferase |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05175 mRNA Translation: AAA36792.1 X84746 , X84747, X84748, X84749, X84750, X84751, X84752 Genomic DNA Translation: CAA59233.1 AF134412 mRNA Translation: AAD26572.1 AF134413 mRNA Translation: AAD26573.1 AF134414 mRNA Translation: AAD26574.1 AH007586 Genomic DNA Translation: AAD26575.1 AH007587 Genomic DNA Translation: AAD26576.1 AH007592 Genomic DNA Translation: AAD26581.1 AJ920329 Genomic DNA Translation: CAI79116.1 AM423110 Genomic DNA Translation: CAM28424.1 AM492698 Genomic DNA Translation: CAM34526.1 AM492699 Genomic DNA Translation: CAM34527.1 AY268591 Genomic DNA Translation: AAP03430.1 BC069595 mRNA Translation: AAH69595.1 BC111575 mRNA Translation: AAI11576.1 AJ536135 Genomic DNA Translation: CAD60222.1 AJ536136 Genomic DNA Translation: CAD60223.1 D82842 Genomic DNA Translation: BAA11591.2 D82843 Genomic DNA Translation: BAA11592.2 AF016622 Genomic DNA Translation: AAB86462.1 AF448199 Genomic DNA Translation: AAQ04662.1 AF448200 Genomic DNA Translation: AAQ04663.1 AJ276689 Genomic DNA Translation: CAB81779.1 |
PIRi | PC1165 |
RefSeqi | NP_065202.2, NM_020469.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LZ0 | X-ray | 1.80 | A | 64-354 | [»] | |
1LZ7 | X-ray | 1.65 | A | 64-354 | [»] | |
1LZI | X-ray | 1.35 | A | 64-354 | [»] | |
1LZJ | X-ray | 1.32 | A | 64-354 | [»] | |
1R7T | X-ray | 2.09 | A | 64-345 | [»] | |
1R7U | X-ray | 1.61 | A | 64-345 | [»] | |
1R7V | X-ray | 2.09 | A | 64-345 | [»] | |
1R7X | X-ray | 1.97 | A | 64-345 | [»] | |
1R7Y | X-ray | 1.75 | A | 64-345 | [»] | |
1R80 | X-ray | 1.65 | A | 64-345 | [»] | |
1R81 | X-ray | 1.75 | A | 64-345 | [»] | |
1R82 | X-ray | 1.55 | A | 64-345 | [»] | |
1WSZ | X-ray | 1.59 | A | 64-354 | [»] | |
1WT0 | X-ray | 1.80 | A | 64-354 | [»] | |
1WT1 | X-ray | 1.55 | A | 64-354 | [»] | |
1WT2 | X-ray | 1.90 | A | 64-354 | [»] | |
1WT3 | X-ray | 1.80 | A | 64-354 | [»] | |
1XZ6 | X-ray | 1.55 | A | 64-354 | [»] | |
1ZHJ | X-ray | 1.59 | A | 64-354 | [»] | |
1ZI1 | X-ray | 1.57 | A | 64-354 | [»] | |
1ZI3 | X-ray | 1.69 | A | 64-354 | [»] | |
1ZI4 | X-ray | 1.85 | A | 64-354 | [»] | |
1ZI5 | X-ray | 1.55 | A | 64-354 | [»] | |
1ZIZ | X-ray | 1.49 | A | 64-354 | [»] | |
1ZJ0 | X-ray | 1.67 | A | 64-354 | [»] | |
1ZJ1 | X-ray | 1.65 | A | 64-354 | [»] | |
1ZJ2 | X-ray | 1.69 | A | 64-354 | [»] | |
1ZJ3 | X-ray | 1.69 | A | 64-354 | [»] | |
1ZJO | X-ray | 1.64 | A | 64-354 | [»] | |
1ZJP | X-ray | 1.59 | A | 64-354 | [»] | |
2A8U | X-ray | 1.69 | A | 64-354 | [»] | |
2A8W | X-ray | 1.59 | A | 64-354 | [»] | |
2I7B | X-ray | 1.99 | A | 64-354 | [»] | |
2O1F | X-ray | 1.99 | A | 64-354 | [»] | |
2O1G | X-ray | 1.71 | A | 64-354 | [»] | |
2O1H | X-ray | 1.67 | A | 64-354 | [»] | |
2PGV | X-ray | 1.79 | A | 64-354 | [»] | |
2PGY | X-ray | 2.39 | A | 64-354 | [»] | |
2RIT | X-ray | 1.43 | A | 64-354 | [»] | |
2RIX | X-ray | 1.75 | A | 64-354 | [»] | |
2RIY | X-ray | 1.55 | A | 64-354 | [»] | |
2RIZ | X-ray | 1.45 | A | 64-354 | [»] | |
2RJ0 | X-ray | 1.52 | A | 64-354 | [»] | |
2RJ1 | X-ray | 1.55 | A | 64-354 | [»] | |
2RJ4 | X-ray | 1.47 | A | 64-354 | [»] | |
2RJ5 | X-ray | 1.45 | A | 64-354 | [»] | |
2RJ6 | X-ray | 1.41 | A | 64-354 | [»] | |
2RJ7 | X-ray | 1.70 | A | 64-354 | [»] | |
2RJ8 | X-ray | 1.69 | A | 64-354 | [»] | |
2RJ9 | X-ray | 1.69 | A | 64-354 | [»] | |
2Y7A | X-ray | 2.06 | A/B/C/D | 64-354 | [»] | |
3I0C | X-ray | 1.55 | A | 69-354 | [»] | |
3I0D | X-ray | 1.90 | A | 69-354 | [»] | |
3I0E | X-ray | 1.81 | A | 69-354 | [»] | |
3I0F | X-ray | 1.56 | A | 69-354 | [»] | |
3I0G | X-ray | 1.40 | A | 69-354 | [»] | |
3I0H | X-ray | 2.00 | A | 69-354 | [»] | |
3I0I | X-ray | 1.90 | X | 69-354 | [»] | |
3I0J | X-ray | 1.48 | A | 69-354 | [»] | |
3I0K | X-ray | 2.20 | A | 69-354 | [»] | |
3I0L | X-ray | 1.60 | A | 69-354 | [»] | |
3IOH | X-ray | 1.25 | A | 64-354 | [»] | |
3IOI | X-ray | 1.45 | A | 64-354 | [»] | |
3IOJ | X-ray | 1.65 | A/B | 64-354 | [»] | |
3SX3 | X-ray | 1.45 | A | 64-354 | [»] | |
3SX5 | X-ray | 1.43 | A | 64-354 | [»] | |
3SX7 | X-ray | 1.42 | A | 64-354 | [»] | |
3SX8 | X-ray | 1.47 | A | 64-354 | [»] | |
3SXA | X-ray | 1.50 | A | 64-354 | [»] | |
3SXB | X-ray | 1.49 | A | 64-354 | [»] | |
3SXC | X-ray | 1.90 | A | 64-354 | [»] | |
3SXD | X-ray | 1.55 | A | 64-354 | [»] | |
3SXE | X-ray | 1.49 | A | 64-354 | [»] | |
3SXG | X-ray | 1.86 | A | 64-354 | [»] | |
3U0X | X-ray | 1.85 | A/B | 64-354 | [»] | |
3U0Y | X-ray | 1.60 | A/B | 64-354 | [»] | |
3V0L | X-ray | 1.75 | A | 64-354 | [»] | |
3V0M | X-ray | 1.68 | A/B | 64-354 | [»] | |
3V0N | X-ray | 1.75 | A/B | 64-354 | [»] | |
3V0O | X-ray | 1.65 | A/B | 64-354 | [»] | |
3V0P | X-ray | 1.90 | A/B | 64-354 | [»] | |
3V0Q | X-ray | 1.80 | A/B | 64-354 | [»] | |
3ZGF | X-ray | 1.70 | A/B | 64-354 | [»] | |
3ZGG | X-ray | 1.90 | A | 64-354 | [»] | |
4C2S | X-ray | 2.48 | A/B | 64-354 | [»] | |
4FQW | X-ray | 2.02 | A | 64-354 | [»] | |
4FRA | X-ray | 1.43 | A | 64-354 | [»] | |
4FRB | X-ray | 1.54 | A | 64-354 | [»] | |
4FRD | X-ray | 1.55 | A | 64-354 | [»] | |
4FRE | X-ray | 1.85 | A | 64-354 | [»] | |
4FRH | X-ray | 1.80 | A | 64-354 | [»] | |
4FRL | X-ray | 1.90 | A | 64-354 | [»] | |
4FRM | X-ray | 1.90 | A | 64-354 | [»] | |
4FRO | X-ray | 1.75 | A | 64-354 | [»] | |
4FRP | X-ray | 2.00 | A | 64-354 | [»] | |
4FRQ | X-ray | 2.35 | A | 64-354 | [»] | |
4GBP | X-ray | 2.15 | A | 64-354 | [»] | |
4KC1 | X-ray | 1.50 | A | 64-346 | [»] | |
4KC2 | X-ray | 1.70 | A | 64-346 | [»] | |
4KC4 | X-ray | 1.60 | A | 64-346 | [»] | |
4KXO | X-ray | 2.00 | A | 64-354 | [»] | |
4Y62 | X-ray | 1.60 | A | 1-354 | [»] | |
4Y63 | X-ray | 1.30 | A | 1-354 | [»] | |
4Y64 | X-ray | 1.60 | A | 1-354 | [»] | |
5BXC | X-ray | 1.40 | A | 64-354 | [»] | |
5C1G | X-ray | 1.46 | A | 64-354 | [»] | |
5C1H | X-ray | 1.55 | A | 64-354 | [»] | |
5C1L | X-ray | 1.40 | A | 64-354 | [»] | |
5C36 | X-ray | 1.55 | A | 64-354 | [»] | |
5C38 | X-ray | 1.45 | A | 64-354 | [»] | |
5C3A | X-ray | 1.33 | A | 64-354 | [»] | |
5C3B | X-ray | 1.40 | A | 64-354 | [»] | |
5C3D | X-ray | 1.39 | A | 64-354 | [»] | |
5C47 | X-ray | 1.39 | A | 64-354 | [»] | |
5C48 | X-ray | 1.46 | A | 64-354 | [»] | |
5C49 | X-ray | 1.49 | A | 64-354 | [»] | |
5C4B | X-ray | 1.54 | A | 64-354 | [»] | |
5C4C | X-ray | 1.43 | A | 64-354 | [»] | |
5C4D | X-ray | 1.40 | A | 64-354 | [»] | |
5C4E | X-ray | 1.55 | A | 64-354 | [»] | |
5C4F | X-ray | 1.41 | A | 64-354 | [»] | |
5C8R | X-ray | 1.45 | A | 64-354 | [»] | |
5CMF | X-ray | 1.95 | X | 64-345 | [»] | |
5CMG | X-ray | 1.83 | X | 64-354 | [»] | |
5CMH | X-ray | 1.61 | A | 64-354 | [»] | |
5CMI | X-ray | 1.85 | A | 64-354 | [»] | |
5CMJ | X-ray | 1.73 | A | 64-354 | [»] | |
5CQL | X-ray | 1.69 | X | 64-354 | [»] | |
5CQM | X-ray | 1.65 | X | 64-354 | [»] | |
5CQN | X-ray | 1.61 | X | 64-354 | [»] | |
5CQO | X-ray | 1.69 | A | 64-354 | [»] | |
5CQP | X-ray | 1.83 | A | 64-354 | [»] | |
5M79 | X-ray | 1.30 | A | 64-354 | [»] | |
5M7A | X-ray | 1.30 | A | 64-354 | [»] | |
5M7B | X-ray | 1.50 | A | 64-354 | [»] | |
5M7C | X-ray | 1.60 | A/B | 64-354 | [»] | |
5M7D | X-ray | 1.20 | A | 64-354 | [»] | |
5TJK | X-ray | 1.45 | A | 64-354 | [»] | |
5TJL | X-ray | 1.89 | A | 64-354 | [»] | |
5TJN | X-ray | 1.47 | A | 64-354 | [»] | |
5TJO | X-ray | 1.57 | A | 64-354 | [»] | |
6BJI | X-ray | 1.54 | A | 64-354 | [»] | |
6BJJ | X-ray | 1.45 | A | 64-354 | [»] | |
6BJK | X-ray | 2.12 | A | 64-354 | [»] | |
6BJL | X-ray | 1.69 | A | 64-345 | [»] | |
6BJM | X-ray | 1.45 | A | 64-345 | [»] | |
6GWY | X-ray | 1.40 | A | 64-354 | [»] | |
6GWZ | X-ray | 1.65 | A | 64-354 | [»] | |
6GX0 | X-ray | 1.25 | A | 64-354 | [»] | |
6GX1 | X-ray | 1.60 | A | 64-354 | [»] | |
6GX2 | X-ray | 1.07 | A | 64-354 | [»] | |
SMRi | P16442 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106546, 3 interactors |
STRINGi | 9606.ENSP00000483018 |
Chemistry databases
BindingDBi | P16442 |
ChEMBLi | CHEMBL2321639 |
DrugBanki | DB04141, 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol DB03772, 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,5-Diol DB07357, 4-AMINO-2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL DB07378, 4-AMINO-2-OCTYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL DB04681, BETA-METHYLLACTOSIDE DB04680, GALACTOSE GREASE DB03501, Galactose-uridine-5'-diphosphate DB04678, H TYPE II TRISACCHARIDE DB04679, Human blood group H type 1 trisaccharide DB07341, octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranoside DB07633, octyl 3-deoxy-2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-xylo-hexopyranoside DB03435, Uridine-5'-Diphosphate DB02196, Uridine-Diphosphate-N-Acetylgalactosamine |
Protein family/group databases
CAZyi | GT6, Glycosyltransferase Family 6 |
PTM databases
GlyGeni | P16442, 1 site |
iPTMneti | P16442 |
PhosphoSitePlusi | P16442 |
Genetic variation databases
BioMutai | ABO |
DMDMi | 114949 |
Proteomic databases
jPOSTi | P16442 |
MassIVEi | P16442 |
PeptideAtlasi | P16442 |
PRIDEi | P16442 |
ProteomicsDBi | 53361 |
Protocols and materials databases
DNASUi | 28 |
Genome annotation databases
GeneIDi | 28 |
KEGGi | hsa:28 |
Organism-specific databases
CTDi | 28 |
DisGeNETi | 28 |
GeneCardsi | ABO |
HGNCi | HGNC:79, ABO |
MIMi | 110300, gene 616093, phenotype |
neXtProti | NX_P16442 |
PharmGKBi | PA24415 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQAJ, Eukaryota |
InParanoidi | P16442 |
OrthoDBi | 1204439at2759 |
PhylomeDBi | P16442 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
BioCyci | MetaCyc:HS10887-MONOMER |
BRENDAi | 2.4.1.37, 2681 2.4.1.40, 2681 |
PathwayCommonsi | P16442 |
Reactomei | R-HSA-9033807, ABO blood group biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 28, 1 hit in 96 CRISPR screens |
ChiTaRSi | ABO, human |
EvolutionaryTracei | P16442 |
GeneWikii | ABO_(gene) |
GenomeRNAii | 28 |
Pharosi | P16442, Tbio |
PROi | PR:P16442 |
RNActi | P16442, protein |
SOURCEi | Search... |
Family and domain databases
DisProti | DP00339 |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR005076, Glyco_trans_6 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR10462, PTHR10462, 1 hit |
Pfami | View protein in Pfam PF03414, Glyco_transf_6, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BGAT_HUMAN | |
Accessioni | P16442Primary (citable) accession number: P16442 Secondary accession number(s): B0JDB9 Q9UQ69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 216 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants - Blood group antigen proteins
Nomenclature of blood group antigens and list of entries