UniProtKB - P16435 (NCPR_HUMAN)
Protein
NADPH--cytochrome P450 reductase
Gene
POR
Organism
Homo sapiens (Human)
Status
Functioni
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.UniRule annotation
Caution
An alternative upstream Met is found in primates and translation may initiate from the upstream Met which would give rise to a 680-residue protein. However, the upstream codon has a weak Kozak signal while the codon used for translation of the shorter 677-residue sequence has a strong Kozak signal and is widely conserved. In addition, protein sequencing indicates that this is the preferred start codon in vivo.Curated
Catalytic activityi
- EC:1.6.2.4UniRule annotation
Cofactori
Protein has several cofactor binding sites:- FADUniRule annotation1 PublicationNote: Binds 1 FAD per monomer.UniRule annotation1 Publication
- FMNUniRule annotation1 PublicationNote: Binds 1 FMN per monomer.UniRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 208 | FMNUniRule annotation2 Publications | 1 | |
Binding sitei | 298 | NADPUniRule annotation1 Publication | 1 | |
Binding sitei | 424 | FADUniRule annotation2 Publications | 1 | |
Binding sitei | 478 | FADUniRule annotation2 Publications | 1 | |
Binding sitei | 535 | NADPUniRule annotation1 Publication | 1 | |
Binding sitei | 638 | NADPUniRule annotation1 Publication | 1 | |
Binding sitei | 676 | FADUniRule annotation2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 86 – 91 | FMNUniRule annotation2 Publications | 6 | |
Nucleotide bindingi | 138 – 141 | FMNUniRule annotation2 Publications | 4 | |
Nucleotide bindingi | 173 – 182 | FMNUniRule annotation2 Publications | 10 | |
Nucleotide bindingi | 454 – 457 | FADUniRule annotation2 Publications | 4 | |
Nucleotide bindingi | 472 – 474 | FADUniRule annotation2 Publications | 3 | |
Nucleotide bindingi | 488 – 491 | FADUniRule annotation2 Publications | 4 | |
Nucleotide bindingi | 596 – 597 | NADPUniRule annotation1 Publication | 2 | |
Nucleotide bindingi | 602 – 606 | NADPUniRule annotation1 Publication | 5 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: GO_Central
- FMN binding Source: GO_Central
- NADP binding Source: UniProtKB-UniRule
- NADPH-hemoprotein reductase activity Source: UniProtKB
- oxidoreductase activity Source: GO_Central
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: GO_Central
GO - Biological processi
- cellular organofluorine metabolic process Source: BHF-UCL
- electron transport chain Source: UniProtKB
- positive regulation of monooxygenase activity Source: BHF-UCL
- response to hormone Source: GO_Central
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, FMN, NADP |
Enzyme and pathway databases
BRENDAi | 1.6.2.4, 2681 |
PathwayCommonsi | P16435 |
Reactomei | R-HSA-211897, Cytochrome P450 - arranged by substrate type |
SABIO-RKi | P16435 |
SIGNORi | P16435 |
Names & Taxonomyi
Protein namesi | Recommended name: NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)Short name: CPRUniRule annotation Short name: P450RUniRule annotation |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9208, POR |
MIMi | 124015, gene |
neXtProti | NX_P16435 |
VEuPathDBi | HostDB:ENSG00000127948.13 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation; Single-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
Cytosol
- cytosol Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 21 | LumenalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 22 – 42 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 43 – 677 | CytoplasmicUniRule annotationAdd BLAST | 635 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021155 | 284 | A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications | 1 | |
Natural variantiVAR_021156 | 454 | R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications | 1 | |
Natural variantiVAR_021157 | 489 | V → E in ABS1; significant reduction of activity. 1 Publication | 1 | |
Natural variantiVAR_021159 | 575 | Y → C in ABS1. 1 Publication | 1 | |
Natural variantiVAR_021161 | 609 – 617 | LKQDREHLW → R in ABS1. | 9 |
Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021154 | 178 | Y → D in DISPORD; complete loss of activity. 1 Publication | 1 | |
Natural variantiVAR_021155 | 284 | A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications | 1 | |
Natural variantiVAR_021156 | 454 | R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications | 1 | |
Natural variantiVAR_021158 | 566 | C → Y in DISPORD; significant reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs72552772Ensembl. | 1 | |
Natural variantiVAR_021160 | 605 | V → F in DISPORD; significant reduction of activity. 1 Publication | 1 |
Keywords - Diseasei
Congenital adrenal hyperplasia, Craniosynostosis, Disease variantOrganism-specific databases
DisGeNETi | 5447 |
GeneReviewsi | POR |
MalaCardsi | POR |
MIMi | 201750, phenotype 613571, phenotype |
Orphaneti | 95699, Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency |
PharmGKBi | PA33532 |
Miscellaneous databases
Pharosi | P16435, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2169731 |
DrugBanki | DB06263, Amrubicin DB00865, Benzphetamine DB00694, Daunorubicin DB00997, Doxorubicin DB01466, Ethylmorphine DB03147, Flavin adenine dinucleotide DB03247, Flavin mononucleotide DB09332, Kappadione DB00166, Lipoic acid DB00305, Mitomycin DB03461, Nicotinamide adenine dinucleotide phosphate DB00665, Nilutamide DB00698, Nitrofurantoin |
Genetic variation databases
BioMutai | POR |
DMDMi | 2851393 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000167596 | 2 – 677 | NADPH--cytochrome P450 reductaseAdd BLAST | 676 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycine1 Publication | 1 | |
Modified residuei | 63 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P16435 |
jPOSTi | P16435 |
MassIVEi | P16435 |
MaxQBi | P16435 |
PaxDbi | P16435 |
PeptideAtlasi | P16435 |
PRIDEi | P16435 |
ProteomicsDBi | 53360 |
PTM databases
GlyConnecti | 1535, 1 N-Linked glycan (1 site) |
GlyGeni | P16435, 1 site |
iPTMneti | P16435 |
PhosphoSitePlusi | P16435 |
SwissPalmi | P16435 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127948, Expressed in right adrenal gland and 219 other tissues |
ExpressionAtlasi | P16435, baseline and differential |
Genevisiblei | P16435, HS |
Organism-specific databases
HPAi | ENSG00000127948, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Hide detailsP16435
With | #Exp. | IntAct |
---|---|---|
PGRMC1 [O00264] | 5 | EBI-726554,EBI-1045534 |
CYP2C2 [P00181] from Oryctolagus cuniculus. | 4 | EBI-726554,EBI-4320576 |
Protein-protein interaction databases
BioGRIDi | 111443, 140 interactors |
DIPi | DIP-29682N |
IntActi | P16435, 22 interactors |
MINTi | P16435 |
STRINGi | 9606.ENSP00000419970 |
Chemistry databases
BindingDBi | P16435 |
Miscellaneous databases
RNActi | P16435, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P16435 |
SMRi | P16435 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16435 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 224 | Flavodoxin-likeUniRule annotationAdd BLAST | 145 | |
Domaini | 279 – 521 | FAD-binding FR-typeUniRule annotationAdd BLAST | 243 |
Sequence similaritiesi
Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1158, Eukaryota |
HOGENOMi | CLU_001570_17_3_1 |
InParanoidi | P16435 |
OrthoDBi | 318396at2759 |
PhylomeDBi | P16435 |
TreeFami | TF105719 |
Family and domain databases
Gene3Di | 1.20.990.10, 2 hits 3.40.50.360, 1 hit 3.40.50.80, 1 hit |
HAMAPi | MF_03212, NCPR, 1 hit |
InterProi | View protein in InterPro IPR003097, CysJ-like_FAD-binding IPR017927, FAD-bd_FR_type IPR001094, Flavdoxin-like IPR008254, Flavodoxin/NO_synth IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039, Flavoprotein-like_sf IPR039261, FNR_nucleotide-bd IPR023173, NADPH_Cyt_P450_Rdtase_alpha IPR001433, OxRdtase_FAD/NAD-bd IPR023208, P450R IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667, FAD_binding_1, 1 hit PF00258, Flavodoxin_1, 1 hit PF00175, NAD_binding_1, 1 hit |
PIRSFi | PIRSF000208, P450R, 1 hit |
PRINTSi | PR00369, FLAVODOXIN PR00371, FPNCR |
SUPFAMi | SSF52218, SSF52218, 1 hit SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit PS50902, FLAVODOXIN_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P16435-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDSHVDTSS TVSEAVAEEV SLFSMTDMIL FSLIVGLLTY WFLFRKKKEE
60 70 80 90 100
VPEFTKIQTL TSSVRESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK
110 120 130 140 150
DAHRYGMRGM SADPEEYDLA DLSSLPEIDN ALVVFCMATY GEGDPTDNAQ
160 170 180 190 200
DFYDWLQETD VDLSGVKFAV FGLGNKTYEH FNAMGKYVDK RLEQLGAQRI
210 220 230 240 250
FELGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES SIRQYELVVH
260 270 280 290 300
TDIDAAKVYM GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL
310 320 330 340 350
MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGKILGA DLDVVMSLNN
360 370 380 390 400
LDEESNKKHP FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE
410 420 430 440 450
LLRKMASSSG EGKELYLSWV VEARRHILAI LQDCPSLRPP IDHLCELLPR
460 470 480 490 500
LQARYYSIAS SSKVHPNSVH ICAVVVEYET KAGRINKGVA TNWLRAKEPA
510 520 530 540 550
GENGGRALVP MFVRKSQFRL PFKATTPVIM VGPGTGVAPF IGFIQERAWL
560 570 580 590 600
RQQGKEVGET LLYYGCRRSD EDYLYREELA QFHRDGALTQ LNVAFSREQS
610 620 630 640 650
HKVYVQHLLK QDREHLWKLI EGGAHIYVCG DARNMARDVQ NTFYDIVAEL
660 670
GAMEHAQAVD YIKKLMTKGR YSLDVWS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y4R2 | H0Y4R2_HUMAN | NADPH--hemoprotein reductase | POR | 725 | Annotation score: | ||
E7EWU0 | E7EWU0_HUMAN | NADPH--cytochrome P450 reductase | POR | 101 | Annotation score: | ||
E7EMD0 | E7EMD0_HUMAN | NADPH--cytochrome P450 reductase | POR | 418 | Annotation score: | ||
C9JU80 | C9JU80_HUMAN | NADPH--cytochrome P450 reductase | POR | 108 | Annotation score: | ||
C9JQ78 | C9JQ78_HUMAN | NADPH--cytochrome P450 reductase | POR | 39 | Annotation score: | ||
C9JDE2 | C9JDE2_HUMAN | NADPH--cytochrome P450 reductase | POR | 54 | Annotation score: |
Sequence cautioni
The sequence AAH34277 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 405 | M → L in BAB18572 (Ref. 3) Curated | 1 | |
Sequence conflicti | 518 | F → L in AAB21814 (PubMed:1550342).Curated | 1 | |
Sequence conflicti | 518 | F → L in BAB18572 (Ref. 3) Curated | 1 | |
Sequence conflicti | 537 – 538 | VA → WH in AAB21814 (PubMed:1550342).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021154 | 178 | Y → D in DISPORD; complete loss of activity. 1 Publication | 1 | |
Natural variantiVAR_047885 | 225 | P → L2 PublicationsCorresponds to variant dbSNP:rs782427303Ensembl. | 1 | |
Natural variantiVAR_047886 | 252 | D → N1 Publication | 1 | |
Natural variantiVAR_021155 | 284 | A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications | 1 | |
Natural variantiVAR_021156 | 454 | R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications | 1 | |
Natural variantiVAR_021157 | 489 | V → E in ABS1; significant reduction of activity. 1 Publication | 1 | |
Natural variantiVAR_004617 | 500 | A → V4 PublicationsCorresponds to variant dbSNP:rs1057868Ensembl. | 1 | |
Natural variantiVAR_004618 | 551 | R → Q. | 1 | |
Natural variantiVAR_021158 | 566 | C → Y in DISPORD; significant reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs72552772Ensembl. | 1 | |
Natural variantiVAR_021159 | 575 | Y → C in ABS1. 1 Publication | 1 | |
Natural variantiVAR_021160 | 605 | V → F in DISPORD; significant reduction of activity. 1 Publication | 1 | |
Natural variantiVAR_021161 | 609 – 617 | LKQDREHLW → R in ABS1. | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S90469 mRNA Translation: AAB21814.1 AF258341 mRNA Translation: AAG09798.1 AB051763 mRNA Translation: BAB18572.1 DQ640499 Genomic DNA Translation: ABF70199.1 AC005067 Genomic DNA Translation: AAD45961.1 AC006330 Genomic DNA No translation available. BC034277 mRNA Translation: AAH34277.1 Different initiation. |
PIRi | A33421, A60557 |
RefSeqi | NP_000932.3, NM_000941.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S90469 mRNA Translation: AAB21814.1 AF258341 mRNA Translation: AAG09798.1 AB051763 mRNA Translation: BAB18572.1 DQ640499 Genomic DNA Translation: ABF70199.1 AC005067 Genomic DNA Translation: AAD45961.1 AC006330 Genomic DNA No translation available. BC034277 mRNA Translation: AAH34277.1 Different initiation. |
PIRi | A33421, A60557 |
RefSeqi | NP_000932.3, NM_000941.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B1C | X-ray | 1.93 | A | 61-241 | [»] | |
3FJO | X-ray | 2.50 | A | 232-677 | [»] | |
3QE2 | X-ray | 1.75 | A/B | 64-677 | [»] | |
3QFC | X-ray | 1.80 | A/B | 64-677 | [»] | |
3QFR | X-ray | 2.40 | A/B | 64-677 | [»] | |
3QFS | X-ray | 1.40 | A | 241-677 | [»] | |
3QFT | X-ray | 1.40 | A | 241-677 | [»] | |
5EMN | X-ray | 2.20 | A/B | 64-677 | [»] | |
5FA6 | X-ray | 2.30 | A/B | 64-677 | [»] | |
BMRBi | P16435 | |||||
SMRi | P16435 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111443, 140 interactors |
DIPi | DIP-29682N |
IntActi | P16435, 22 interactors |
MINTi | P16435 |
STRINGi | 9606.ENSP00000419970 |
Chemistry databases
BindingDBi | P16435 |
ChEMBLi | CHEMBL2169731 |
DrugBanki | DB06263, Amrubicin DB00865, Benzphetamine DB00694, Daunorubicin DB00997, Doxorubicin DB01466, Ethylmorphine DB03147, Flavin adenine dinucleotide DB03247, Flavin mononucleotide DB09332, Kappadione DB00166, Lipoic acid DB00305, Mitomycin DB03461, Nicotinamide adenine dinucleotide phosphate DB00665, Nilutamide DB00698, Nitrofurantoin |
PTM databases
GlyConnecti | 1535, 1 N-Linked glycan (1 site) |
GlyGeni | P16435, 1 site |
iPTMneti | P16435 |
PhosphoSitePlusi | P16435 |
SwissPalmi | P16435 |
Genetic variation databases
BioMutai | POR |
DMDMi | 2851393 |
Proteomic databases
EPDi | P16435 |
jPOSTi | P16435 |
MassIVEi | P16435 |
MaxQBi | P16435 |
PaxDbi | P16435 |
PeptideAtlasi | P16435 |
PRIDEi | P16435 |
ProteomicsDBi | 53360 |
Protocols and materials databases
Antibodypediai | 2433, 434 antibodies |
DNASUi | 5447 |
Genome annotation databases
Organism-specific databases
CTDi | 5447 |
DisGeNETi | 5447 |
GeneCardsi | POR |
GeneReviewsi | POR |
HGNCi | HGNC:9208, POR |
HPAi | ENSG00000127948, Tissue enhanced (liver) |
MalaCardsi | POR |
MIMi | 124015, gene 201750, phenotype 613571, phenotype |
neXtProti | NX_P16435 |
Orphaneti | 95699, Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency |
PharmGKBi | PA33532 |
VEuPathDBi | HostDB:ENSG00000127948.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1158, Eukaryota |
HOGENOMi | CLU_001570_17_3_1 |
InParanoidi | P16435 |
OrthoDBi | 318396at2759 |
PhylomeDBi | P16435 |
TreeFami | TF105719 |
Enzyme and pathway databases
BRENDAi | 1.6.2.4, 2681 |
PathwayCommonsi | P16435 |
Reactomei | R-HSA-211897, Cytochrome P450 - arranged by substrate type |
SABIO-RKi | P16435 |
SIGNORi | P16435 |
Miscellaneous databases
BioGRID-ORCSi | 5447, 12 hits in 997 CRISPR screens |
ChiTaRSi | POR, human |
EvolutionaryTracei | P16435 |
GeneWikii | Cytochrome_P450_reductase |
GenomeRNAii | 5447 |
Pharosi | P16435, Tbio |
PROi | PR:P16435 |
RNActi | P16435, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127948, Expressed in right adrenal gland and 219 other tissues |
ExpressionAtlasi | P16435, baseline and differential |
Genevisiblei | P16435, HS |
Family and domain databases
Gene3Di | 1.20.990.10, 2 hits 3.40.50.360, 1 hit 3.40.50.80, 1 hit |
HAMAPi | MF_03212, NCPR, 1 hit |
InterProi | View protein in InterPro IPR003097, CysJ-like_FAD-binding IPR017927, FAD-bd_FR_type IPR001094, Flavdoxin-like IPR008254, Flavodoxin/NO_synth IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039, Flavoprotein-like_sf IPR039261, FNR_nucleotide-bd IPR023173, NADPH_Cyt_P450_Rdtase_alpha IPR001433, OxRdtase_FAD/NAD-bd IPR023208, P450R IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667, FAD_binding_1, 1 hit PF00258, Flavodoxin_1, 1 hit PF00175, NAD_binding_1, 1 hit |
PIRSFi | PIRSF000208, P450R, 1 hit |
PRINTSi | PR00369, FLAVODOXIN PR00371, FPNCR |
SUPFAMi | SSF52218, SSF52218, 1 hit SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit PS50902, FLAVODOXIN_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCPR_HUMAN | |
Accessioni | P16435Primary (citable) accession number: P16435 Secondary accession number(s): Q16455 Q9UDT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 229 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families