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Protein

NADPH--cytochrome P450 reductase

Gene

POR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei208FMNUniRule annotation2 Publications1
Binding sitei298NADPUniRule annotation1 Publication1
Binding sitei424FADUniRule annotation2 Publications1
Binding sitei478FADUniRule annotation2 Publications1
Binding sitei535NADPUniRule annotation1 Publication1
Binding sitei638NADPUniRule annotation1 Publication1
Binding sitei676FADUniRule annotation2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi86 – 91FMNUniRule annotation2 Publications6
Nucleotide bindingi138 – 141FMNUniRule annotation2 Publications4
Nucleotide bindingi173 – 182FMNUniRule annotation2 Publications10
Nucleotide bindingi454 – 457FADUniRule annotation2 Publications4
Nucleotide bindingi472 – 474FADUniRule annotation2 Publications3
Nucleotide bindingi488 – 491FADUniRule annotation2 Publications4
Nucleotide bindingi596 – 597NADPUniRule annotation1 Publication2
Nucleotide bindingi602 – 606NADPUniRule annotation1 Publication5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05140-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.6.2.4 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211897 Cytochrome P450 - arranged by substrate type

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P16435

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P16435

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)
Short name:
CPRUniRule annotation
Short name:
P450RUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PORUniRule annotation
Synonyms:CYPOR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127948.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9208 POR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
124015 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16435

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 21LumenalUniRule annotationAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Topological domaini43 – 677CytoplasmicUniRule annotationAdd BLAST635

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures.
See also OMIM:201750
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021157489V → E in ABS1; significant reduction of activity. 1 Publication1
Natural variantiVAR_021159575Y → C in ABS1. 1 Publication1
Natural variantiVAR_021161609 – 617LKQDREHLW → R in ABS1. 9
Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
See also OMIM:613571
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021154178Y → D in DISPORD; complete loss of activity. 1 Publication1
Natural variantiVAR_021158566C → Y in DISPORD; significant reduction of activity. 2 Publications1
Natural variantiVAR_021160605V → F in DISPORD; significant reduction of activity. 1 Publication1

Keywords - Diseasei

Congenital adrenal hyperplasia, Craniosynostosis, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5447

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
POR

MalaCards human disease database

More...
MalaCardsi
POR
MIMi201750 phenotype
613571 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
95699 Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33532

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2169731

Drug and drug target database

More...
DrugBanki
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB00865 Benzphetamine
DB00694 Daunorubicin
DB00997 Doxorubicin
DB01466 Ethylmorphine
DB03147 Flavin adenine dinucleotide
DB00166 Lipoic Acid
DB00305 Mitomycin
DB00665 Nilutamide
DB00698 Nitrofurantoin
DB03247 Riboflavin Monophosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2851393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001675962 – 677NADPH--cytochrome P450 reductaseAdd BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei63PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P16435

MaxQB - The MaxQuant DataBase

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MaxQBi
P16435

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16435

PeptideAtlas

More...
PeptideAtlasi
P16435

PRoteomics IDEntifications database

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PRIDEi
P16435

ProteomicsDB human proteome resource

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ProteomicsDBi
53360

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1535

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16435

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16435

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P16435

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000127948 Expressed in 207 organ(s), highest expression level in right adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_POR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P16435 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16435 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004372
HPA010136

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111443, 38 interactors

Database of interacting proteins

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DIPi
DIP-29682N

Protein interaction database and analysis system

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IntActi
P16435, 11 interactors

Molecular INTeraction database

More...
MINTi
P16435

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419970

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16435

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16435

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16435

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 224Flavodoxin-likeUniRule annotationAdd BLAST145
Domaini279 – 521FAD-binding FR-typeUniRule annotationAdd BLAST243

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1158 Eukaryota
COG0369 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000282027

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000432

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16435

KEGG Orthology (KO)

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KOi
K00327

Database for complete collections of gene phylogenies

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PhylomeDBi
P16435

TreeFam database of animal gene trees

More...
TreeFami
TF105719

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.990.10, 2 hits
3.40.50.360, 1 hit
3.40.50.80, 1 hit

HAMAP database of protein families

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HAMAPi
MF_03212 NCPR, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000208 P450R, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00369 FLAVODOXIN
PR00371 FPNCR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P16435-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDSHVDTSS TVSEAVAEEV SLFSMTDMIL FSLIVGLLTY WFLFRKKKEE
60 70 80 90 100
VPEFTKIQTL TSSVRESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK
110 120 130 140 150
DAHRYGMRGM SADPEEYDLA DLSSLPEIDN ALVVFCMATY GEGDPTDNAQ
160 170 180 190 200
DFYDWLQETD VDLSGVKFAV FGLGNKTYEH FNAMGKYVDK RLEQLGAQRI
210 220 230 240 250
FELGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES SIRQYELVVH
260 270 280 290 300
TDIDAAKVYM GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL
310 320 330 340 350
MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGKILGA DLDVVMSLNN
360 370 380 390 400
LDEESNKKHP FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE
410 420 430 440 450
LLRKMASSSG EGKELYLSWV VEARRHILAI LQDCPSLRPP IDHLCELLPR
460 470 480 490 500
LQARYYSIAS SSKVHPNSVH ICAVVVEYET KAGRINKGVA TNWLRAKEPA
510 520 530 540 550
GENGGRALVP MFVRKSQFRL PFKATTPVIM VGPGTGVAPF IGFIQERAWL
560 570 580 590 600
RQQGKEVGET LLYYGCRRSD EDYLYREELA QFHRDGALTQ LNVAFSREQS
610 620 630 640 650
HKVYVQHLLK QDREHLWKLI EGGAHIYVCG DARNMARDVQ NTFYDIVAEL
660 670
GAMEHAQAVD YIKKLMTKGR YSLDVWS
Length:677
Mass (Da):76,690
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F7D4B9CDFDF5A74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4R2H0Y4R2_HUMAN
NADPH--cytochrome P450 reductase
POR
725Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWU0E7EWU0_HUMAN
NADPH--cytochrome P450 reductase
POR
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU80C9JU80_HUMAN
NADPH--cytochrome P450 reductase
POR
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMD0E7EMD0_HUMAN
NADPH--cytochrome P450 reductase
POR
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ78C9JQ78_HUMAN
NADPH--cytochrome P450 reductase
POR
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDE2C9JDE2_HUMAN
NADPH--cytochrome P450 reductase
POR
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34277 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti405M → L in BAB18572 (Ref. 3) Curated1
Sequence conflicti518F → L in AAB21814 (PubMed:1550342).Curated1
Sequence conflicti518F → L in BAB18572 (Ref. 3) Curated1
Sequence conflicti537 – 538VA → WH in AAB21814 (PubMed:1550342).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021154178Y → D in DISPORD; complete loss of activity. 1 Publication1
Natural variantiVAR_047885225P → L2 Publications1
Natural variantiVAR_047886252D → N1 Publication1
Natural variantiVAR_021155284A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications1
Natural variantiVAR_021156454R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications1
Natural variantiVAR_021157489V → E in ABS1; significant reduction of activity. 1 Publication1
Natural variantiVAR_004617500A → V4 PublicationsCorresponds to variant dbSNP:rs1057868Ensembl.1
Natural variantiVAR_004618551R → Q. 1
Natural variantiVAR_021158566C → Y in DISPORD; significant reduction of activity. 2 Publications1
Natural variantiVAR_021159575Y → C in ABS1. 1 Publication1
Natural variantiVAR_021160605V → F in DISPORD; significant reduction of activity. 1 Publication1
Natural variantiVAR_021161609 – 617LKQDREHLW → R in ABS1. 9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S90469 mRNA Translation: AAB21814.1
AF258341 mRNA Translation: AAG09798.1
AB051763 mRNA Translation: BAB18572.1
DQ640499 Genomic DNA Translation: ABF70199.1
AC005067 Genomic DNA Translation: AAD45961.1
AC006330 Genomic DNA No translation available.
BC034277 mRNA Translation: AAH34277.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
A33421 A60557

NCBI Reference Sequences

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RefSeqi
NP_000932.3, NM_000941.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.354056

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394893; ENSP00000378355; ENSG00000127948
ENST00000412064; ENSP00000404731; ENSG00000127948
ENST00000412521; ENSP00000409238; ENSG00000127948
ENST00000414186; ENSP00000399327; ENSG00000127948
ENST00000418341; ENSP00000389719; ENSG00000127948
ENST00000432753; ENSP00000389409; ENSG00000127948
ENST00000439963; ENSP00000390540; ENSG00000127948
ENST00000449920; ENSP00000399556; ENSG00000127948
ENST00000453773; ENSP00000395813; ENSG00000127948
ENST00000454934; ENSP00000414263; ENSG00000127948
ENST00000461988; ENSP00000419970; ENSG00000127948

Database of genes from NCBI RefSeq genomes

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GeneIDi
5447

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5447

UCSC genome browser

More...
UCSCi
uc003udy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S90469 mRNA Translation: AAB21814.1
AF258341 mRNA Translation: AAG09798.1
AB051763 mRNA Translation: BAB18572.1
DQ640499 Genomic DNA Translation: ABF70199.1
AC005067 Genomic DNA Translation: AAD45961.1
AC006330 Genomic DNA No translation available.
BC034277 mRNA Translation: AAH34277.1 Different initiation.
PIRiA33421 A60557
RefSeqiNP_000932.3, NM_000941.2
UniGeneiHs.354056

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B1CX-ray1.93A61-241[»]
3FJOX-ray2.50A232-677[»]
3QE2X-ray1.75A/B64-677[»]
3QFCX-ray1.80A/B64-677[»]
3QFRX-ray2.40A/B64-677[»]
3QFSX-ray1.40A241-677[»]
3QFTX-ray1.40A241-677[»]
5EMNX-ray2.20A/B64-677[»]
5FA6X-ray2.30A/B64-677[»]
ProteinModelPortaliP16435
SMRiP16435
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111443, 38 interactors
DIPiDIP-29682N
IntActiP16435, 11 interactors
MINTiP16435
STRINGi9606.ENSP00000419970

Chemistry databases

ChEMBLiCHEMBL2169731
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB00865 Benzphetamine
DB00694 Daunorubicin
DB00997 Doxorubicin
DB01466 Ethylmorphine
DB03147 Flavin adenine dinucleotide
DB00166 Lipoic Acid
DB00305 Mitomycin
DB00665 Nilutamide
DB00698 Nitrofurantoin
DB03247 Riboflavin Monophosphate

PTM databases

GlyConnecti1535
iPTMnetiP16435
PhosphoSitePlusiP16435
SwissPalmiP16435

Polymorphism and mutation databases

BioMutaiPOR
DMDMi2851393

Proteomic databases

EPDiP16435
MaxQBiP16435
PaxDbiP16435
PeptideAtlasiP16435
PRIDEiP16435
ProteomicsDBi53360

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5447
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394893; ENSP00000378355; ENSG00000127948
ENST00000412064; ENSP00000404731; ENSG00000127948
ENST00000412521; ENSP00000409238; ENSG00000127948
ENST00000414186; ENSP00000399327; ENSG00000127948
ENST00000418341; ENSP00000389719; ENSG00000127948
ENST00000432753; ENSP00000389409; ENSG00000127948
ENST00000439963; ENSP00000390540; ENSG00000127948
ENST00000449920; ENSP00000399556; ENSG00000127948
ENST00000453773; ENSP00000395813; ENSG00000127948
ENST00000454934; ENSP00000414263; ENSG00000127948
ENST00000461988; ENSP00000419970; ENSG00000127948
GeneIDi5447
KEGGihsa:5447
UCSCiuc003udy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5447
DisGeNETi5447
EuPathDBiHostDB:ENSG00000127948.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POR
GeneReviewsiPOR
HGNCiHGNC:9208 POR
HPAiCAB004372
HPA010136
MalaCardsiPOR
MIMi124015 gene
201750 phenotype
613571 phenotype
neXtProtiNX_P16435
Orphaneti95699 Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
PharmGKBiPA33532

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1158 Eukaryota
COG0369 LUCA
HOGENOMiHOG000282027
HOVERGENiHBG000432
InParanoidiP16435
KOiK00327
PhylomeDBiP16435
TreeFamiTF105719

Enzyme and pathway databases

BioCyciMetaCyc:HS05140-MONOMER
BRENDAi1.6.2.4 2681
ReactomeiR-HSA-211897 Cytochrome P450 - arranged by substrate type
SABIO-RKiP16435
SIGNORiP16435

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POR human
EvolutionaryTraceiP16435

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cytochrome_P450_reductase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5447

Protein Ontology

More...
PROi
PR:P16435

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127948 Expressed in 207 organ(s), highest expression level in right adrenal gland
CleanExiHS_POR
ExpressionAtlasiP16435 baseline and differential
GenevisibleiP16435 HS

Family and domain databases

Gene3Di1.20.990.10, 2 hits
3.40.50.360, 1 hit
3.40.50.80, 1 hit
HAMAPiMF_03212 NCPR, 1 hit
InterProiView protein in InterPro
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000208 P450R, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16435
Secondary accession number(s): Q16455
, Q197M5, Q8N181, Q9H3M8, Q9UDT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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