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UniProtKB - P16435 (NCPR_HUMAN)

Entry version 218 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

NADPH--cytochrome P450 reductase

Gene

POR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei208FMNUniRule annotation2 Publications1
Binding sitei298NADPUniRule annotation1 Publication1
Binding sitei424FADUniRule annotation2 Publications1
Binding sitei478FADUniRule annotation2 Publications1
Binding sitei535NADPUniRule annotation1 Publication1
Binding sitei638NADPUniRule annotation1 Publication1
Binding sitei676FADUniRule annotation2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi86 – 91FMNUniRule annotation2 Publications6
Nucleotide bindingi138 – 141FMNUniRule annotation2 Publications4
Nucleotide bindingi173 – 182FMNUniRule annotation2 Publications10
Nucleotide bindingi454 – 457FADUniRule annotation2 Publications4
Nucleotide bindingi472 – 474FADUniRule annotation2 Publications3
Nucleotide bindingi488 – 491FADUniRule annotation2 Publications4
Nucleotide bindingi596 – 597NADPUniRule annotation1 Publication2
Nucleotide bindingi602 – 606NADPUniRule annotation1 Publication5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05140-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.6.2.4 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211897 Cytochrome P450 - arranged by substrate type

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P16435

SIGNOR Signaling Network Open Resource

More...SIGNORi		P16435

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)
Short name:
CPRUniRule annotation
Short name:
P450RUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PORUniRule annotation
Synonyms:CYPOR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9208 POR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		124015 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16435

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 21LumenalUniRule annotationAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Topological domaini43 – 677CytoplasmicUniRule annotationAdd BLAST635

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021155284A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications1
Natural variantiVAR_021156454R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications1
Natural variantiVAR_021157489V → E in ABS1; significant reduction of activity. 1 Publication1
Natural variantiVAR_021159575Y → C in ABS1. 1 Publication1
Natural variantiVAR_021161609 – 617LKQDREHLW → R in ABS1. 9
Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021154178Y → D in DISPORD; complete loss of activity. 1 Publication1
Natural variantiVAR_021155284A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications1
Natural variantiVAR_021156454R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications1
Natural variantiVAR_021158566C → Y in DISPORD; significant reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs72552772Ensembl.1
Natural variantiVAR_021160605V → F in DISPORD; significant reduction of activity. 1 Publication1

Keywords - Diseasei

Congenital adrenal hyperplasia, Craniosynostosis, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		5447

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		POR

MalaCards human disease database

More...MalaCardsi		POR
MIMi201750 phenotype
613571 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		95699 Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33532

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2169731

Drug and drug target database

More...DrugBanki		DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB06263 Amrubicin
DB00865 Benzphetamine
DB00694 Daunorubicin
DB00997 Doxorubicin
DB01466 Ethylmorphine
DB03147 Flavin adenine dinucleotide
DB03247 Flavin mononucleotide
DB09332 Kappadione
DB00166 Lipoic Acid
DB00305 Mitomycin
DB00665 Nilutamide
DB00698 Nitrofurantoin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POR

Domain mapping of disease mutations (DMDM)

More...DMDMi		2851393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001675962 – 677NADPH--cytochrome P450 reductaseAdd BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei63PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P16435

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16435

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16435

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16435

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16435

PeptideAtlas

More...PeptideAtlasi		P16435

PRoteomics IDEntifications database

More...PRIDEi		P16435

ProteomicsDB human proteome resource

More...ProteomicsDBi		53360

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1535

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16435

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16435

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P16435

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127948 Expressed in 207 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16435 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16435 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB004372
HPA010136

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111443, 40 interactors

Database of interacting proteins

More...DIPi		DIP-29682N

Protein interaction database and analysis system

More...IntActi		P16435, 14 interactors

Molecular INTeraction database

More...MINTi		P16435

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419970

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16435

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16435

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 224Flavodoxin-likeUniRule annotationAdd BLAST145
Domaini279 – 521FAD-binding FR-typeUniRule annotationAdd BLAST243

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1158 Eukaryota
COG0369 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000282027

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16435

KEGG Orthology (KO)

More...KOi		K00327

Database of Orthologous Groups

More...OrthoDBi		318396at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16435

TreeFam database of animal gene trees

More...TreeFami		TF105719

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.990.10, 2 hits
3.40.50.360, 1 hit
3.40.50.80, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_03212 NCPR, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000208 P450R, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00369 FLAVODOXIN
PR00371 FPNCR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P16435-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDSHVDTSS TVSEAVAEEV SLFSMTDMIL FSLIVGLLTY WFLFRKKKEE 
        60         70         80         90        100
VPEFTKIQTL TSSVRESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK 
       110        120        130        140        150
DAHRYGMRGM SADPEEYDLA DLSSLPEIDN ALVVFCMATY GEGDPTDNAQ 
       160        170        180        190        200
DFYDWLQETD VDLSGVKFAV FGLGNKTYEH FNAMGKYVDK RLEQLGAQRI 
       210        220        230        240        250
FELGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES SIRQYELVVH 
       260        270        280        290        300
TDIDAAKVYM GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL 
       310        320        330        340        350
MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGKILGA DLDVVMSLNN 
       360        370        380        390        400
LDEESNKKHP FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE 
       410        420        430        440        450
LLRKMASSSG EGKELYLSWV VEARRHILAI LQDCPSLRPP IDHLCELLPR 
       460        470        480        490        500
LQARYYSIAS SSKVHPNSVH ICAVVVEYET KAGRINKGVA TNWLRAKEPA 
       510        520        530        540        550
GENGGRALVP MFVRKSQFRL PFKATTPVIM VGPGTGVAPF IGFIQERAWL 
       560        570        580        590        600
RQQGKEVGET LLYYGCRRSD EDYLYREELA QFHRDGALTQ LNVAFSREQS 
       610        620        630        640        650
HKVYVQHLLK QDREHLWKLI EGGAHIYVCG DARNMARDVQ NTFYDIVAEL 
       660        670 
GAMEHAQAVD YIKKLMTKGR YSLDVWS
Length:677
Mass (Da):76,690
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F7D4B9CDFDF5A74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4R2H0Y4R2_HUMAN
NADPH--cytochrome P450 reductase
POR
725Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWU0E7EWU0_HUMAN
NADPH--cytochrome P450 reductase
POR
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU80C9JU80_HUMAN
NADPH--cytochrome P450 reductase
POR
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMD0E7EMD0_HUMAN
NADPH--cytochrome P450 reductase
POR
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDE2C9JDE2_HUMAN
NADPH--cytochrome P450 reductase
POR
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ78C9JQ78_HUMAN
NADPH--cytochrome P450 reductase
POR
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34277 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti405M → L in BAB18572 (Ref. 3) Curated1
Sequence conflicti518F → L in AAB21814 (PubMed:1550342).Curated1
Sequence conflicti518F → L in BAB18572 (Ref. 3) Curated1
Sequence conflicti537 – 538VA → WH in AAB21814 (PubMed:1550342).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021154178Y → D in DISPORD; complete loss of activity. 1 Publication1
Natural variantiVAR_047885225P → L2 PublicationsCorresponds to variant dbSNP:rs782427303Ensembl.1
Natural variantiVAR_047886252D → N1 Publication1
Natural variantiVAR_021155284A → P in ABS1 and DISPORD; significant reduction of activity. 2 Publications1
Natural variantiVAR_021156454R → H in ABS1 and DISPORD; significant reduction of activity. 5 Publications1
Natural variantiVAR_021157489V → E in ABS1; significant reduction of activity. 1 Publication1
Natural variantiVAR_004617500A → V4 PublicationsCorresponds to variant dbSNP:rs1057868Ensembl.1
Natural variantiVAR_004618551R → Q. 1
Natural variantiVAR_021158566C → Y in DISPORD; significant reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs72552772Ensembl.1
Natural variantiVAR_021159575Y → C in ABS1. 1 Publication1
Natural variantiVAR_021160605V → F in DISPORD; significant reduction of activity. 1 Publication1
Natural variantiVAR_021161609 – 617LKQDREHLW → R in ABS1. 9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S90469 mRNA Translation: AAB21814.1
AF258341 mRNA Translation: AAG09798.1
AB051763 mRNA Translation: BAB18572.1
DQ640499 Genomic DNA Translation: ABF70199.1
AC005067 Genomic DNA Translation: AAD45961.1
AC006330 Genomic DNA No translation available.
BC034277 mRNA Translation: AAH34277.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		A33421 A60557

NCBI Reference Sequences

More...RefSeqi		NP_000932.3, NM_000941.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000394893; ENSP00000378355; ENSG00000127948
ENST00000412064; ENSP00000404731; ENSG00000127948
ENST00000412521; ENSP00000409238; ENSG00000127948
ENST00000414186; ENSP00000399327; ENSG00000127948
ENST00000418341; ENSP00000389719; ENSG00000127948
ENST00000432753; ENSP00000389409; ENSG00000127948
ENST00000439963; ENSP00000390540; ENSG00000127948
ENST00000449920; ENSP00000399556; ENSG00000127948
ENST00000453773; ENSP00000395813; ENSG00000127948
ENST00000454934; ENSP00000414263; ENSG00000127948
ENST00000461988; ENSP00000419970; ENSG00000127948

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5447

UCSC genome browser

More...UCSCi		uc003udy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S90469 mRNA Translation: AAB21814.1
AF258341 mRNA Translation: AAG09798.1
AB051763 mRNA Translation: BAB18572.1
DQ640499 Genomic DNA Translation: ABF70199.1
AC005067 Genomic DNA Translation: AAD45961.1
AC006330 Genomic DNA No translation available.
BC034277 mRNA Translation: AAH34277.1 Different initiation.
PIRiA33421 A60557
RefSeqiNP_000932.3, NM_000941.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B1CX-ray1.93A61-241[»]
3FJOX-ray2.50A232-677[»]
3QE2X-ray1.75A/B64-677[»]
3QFCX-ray1.80A/B64-677[»]
3QFRX-ray2.40A/B64-677[»]
3QFSX-ray1.40A241-677[»]
3QFTX-ray1.40A241-677[»]
5EMNX-ray2.20A/B64-677[»]
5FA6X-ray2.30A/B64-677[»]
SMRiP16435
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111443, 40 interactors
DIPiDIP-29682N
IntActiP16435, 14 interactors
MINTiP16435
STRINGi9606.ENSP00000419970

Chemistry databases

ChEMBLiCHEMBL2169731
DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB06263 Amrubicin
DB00865 Benzphetamine
DB00694 Daunorubicin
DB00997 Doxorubicin
DB01466 Ethylmorphine
DB03147 Flavin adenine dinucleotide
DB03247 Flavin mononucleotide
DB09332 Kappadione
DB00166 Lipoic Acid
DB00305 Mitomycin
DB00665 Nilutamide
DB00698 Nitrofurantoin

PTM databases

GlyConnecti1535
iPTMnetiP16435
PhosphoSitePlusiP16435
SwissPalmiP16435

Polymorphism and mutation databases

BioMutaiPOR
DMDMi2851393

Proteomic databases

EPDiP16435
jPOSTiP16435
MassIVEiP16435
MaxQBiP16435
PaxDbiP16435
PeptideAtlasiP16435
PRIDEiP16435
ProteomicsDBi53360

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5447
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394893; ENSP00000378355; ENSG00000127948
ENST00000412064; ENSP00000404731; ENSG00000127948
ENST00000412521; ENSP00000409238; ENSG00000127948
ENST00000414186; ENSP00000399327; ENSG00000127948
ENST00000418341; ENSP00000389719; ENSG00000127948
ENST00000432753; ENSP00000389409; ENSG00000127948
ENST00000439963; ENSP00000390540; ENSG00000127948
ENST00000449920; ENSP00000399556; ENSG00000127948
ENST00000453773; ENSP00000395813; ENSG00000127948
ENST00000454934; ENSP00000414263; ENSG00000127948
ENST00000461988; ENSP00000419970; ENSG00000127948
GeneIDi5447
KEGGihsa:5447
UCSCiuc003udy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5447
DisGeNETi5447

GeneCards: human genes, protein and diseases

More...GeneCardsi		POR
GeneReviewsiPOR
HGNCiHGNC:9208 POR
HPAiCAB004372
HPA010136
MalaCardsiPOR
MIMi124015 gene
201750 phenotype
613571 phenotype
neXtProtiNX_P16435
Orphaneti95699 Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
PharmGKBiPA33532

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1158 Eukaryota
COG0369 LUCA
HOGENOMiHOG000282027
InParanoidiP16435
KOiK00327
OrthoDBi318396at2759
PhylomeDBiP16435
TreeFamiTF105719

Enzyme and pathway databases

BioCyciMetaCyc:HS05140-MONOMER
BRENDAi1.6.2.4 2681
ReactomeiR-HSA-211897 Cytochrome P450 - arranged by substrate type
SABIO-RKiP16435
SIGNORiP16435

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POR human
EvolutionaryTraceiP16435

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cytochrome_P450_reductase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5447

Pharos

More...Pharosi		P16435

Protein Ontology

More...PROi		PR:P16435

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127948 Expressed in 207 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiP16435 baseline and differential
GenevisibleiP16435 HS

Family and domain databases

Gene3Di1.20.990.10, 2 hits
3.40.50.360, 1 hit
3.40.50.80, 1 hit
HAMAPiMF_03212 NCPR, 1 hit
InterProiView protein in InterPro
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000208 P450R, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16435
Secondary accession number(s): Q16455
, Q197M5, Q8N181, Q9H3M8, Q9UDT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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