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Entry version 164 (07 Oct 2020)
Sequence version 1 (01 Aug 1990)
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Protein

Formate hydrogenlyase subunit 5

Gene

hycE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Nickel

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
EcoCyc:HYCELARGE-MONOMER
MetaCyc:HYCELARGE-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
3.D.1.9.2, the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formate hydrogenlyase subunit 5
Short name:
FHL subunit 5
Alternative name(s):
Hydrogenase-3 component E
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hycE
Synonyms:hevE
Ordered Locus Names:b2721, JW2691
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000199851 – 537Formate hydrogenlyase subunit 5Add BLAST537
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000019986538 – 569Add BLAST32

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16431

PRoteomics IDEntifications database

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PRIDEi
P16431

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non-energy conserving pathway molecular hydrogen and carbodioxide from formate are released.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
4261447, 11 interactors
851718, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-317, Formate hydrogenlyase-H/Hydrogenase-3 complex

Database of interacting proteins

More...
DIPi
DIP-9975N

Protein interaction database and analysis system

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IntActi
P16431, 18 interactors

Molecular INTeraction database

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MINTi
P16431

STRING: functional protein association networks

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STRINGi
511145.b2721

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3261, Bacteria
COG3262, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015134_3_1_6

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16431

KEGG Orthology (KO)

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KOi
K15830

Database for complete collections of gene phylogenies

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PhylomeDBi
P16431

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.645.20, 1 hit
3.30.460.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001135, NADH_Q_OxRdtase_suD
IPR038290, NADH_Q_OxRdtase_suD_sf
IPR037232, NADH_quin_OxRdtase_su_C/D-like
IPR001268, NADH_UbQ_OxRdtase_30kDa_su
IPR014029, NADH_UbQ_OxRdtase_49kDa_CS
IPR001501, Ni-dep_hyd_lsu
IPR029014, NiFe-Hase_large

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00329, Complex1_30kDa, 1 hit
PF00346, Complex1_49kDa, 2 hits
PF00374, NiFeSe_Hases, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF143243, SSF143243, 1 hit
SSF56762, SSF56762, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00535, COMPLEX1_49K, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P16431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEKLGQHY LAALNEAFPG VVLDHAWQTK DQLTVTVKVN YLPEVVEFLY
60 70 80 90 100
YKQGGWLSVL FGNDERKLNG HYAVYYVLSM EKGTKCWITV RVEVDANKPE
110 120 130 140 150
YPSVTPRVPA AVWGEREVRD MYGLIPVGLP DERRLVLPDD WPDELYPLRK
160 170 180 190 200
DSMDYRQRPA PTTDAETYEF INELGDKKNN VVPIGPLHVT SDEPGHFRLF
210 220 230 240 250
VDGENIIDAD YRLFYVHRGM EKLAETRMGY NEVTFLSDRV CGICGFAHST
260 270 280 290 300
AYTTSVENAM GIQVPERAQM IRAILLEVER LHSHLLNLGL ACHFTGFDSG
310 320 330 340 350
FMQFFRVRET SMKMAEILTG ARKTYGLNLI GGIRRDLLKD DMIQTRQLAQ
360 370 380 390 400
QMRREVQELV DVLLSTPNME QRTVGIGRLD PEIARDFSNV GPMVRASGHA
410 420 430 440 450
RDTRADHPFV GYGLLPMEVH SEQGCDVISR LKVRINEVYT ALNMIDYGLD
460 470 480 490 500
NLPGGPLMVE GFTYIPHRFA LGFAEAPRGD DIHWSMTGDN QKLYRWRCRA
510 520 530 540 550
ATYANWPTLR YMLRGNTVSD APLIIGSLDP CYSCTDRMTV VDVRKKKSKV
560
VPYKELERYS IERKNSPLK
Length:569
Mass (Da):64,980
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38A2BCCB01B27463
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17506 Genomic DNA Translation: CAA35550.1
U29579 Genomic DNA Translation: AAA69231.1
U00096 Genomic DNA Translation: AAC75763.1
AP009048 Genomic DNA Translation: BAE76798.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S08623

NCBI Reference Sequences

More...
RefSeqi
NP_417201.1, NC_000913.3
WP_001288122.1, NZ_SSUR01000024.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75763; AAC75763; b2721
BAE76798; BAE76798; BAE76798

Database of genes from NCBI RefSeq genomes

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GeneIDi
947396

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2691
eco:b2721

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA Translation: CAA35550.1
U29579 Genomic DNA Translation: AAA69231.1
U00096 Genomic DNA Translation: AAC75763.1
AP009048 Genomic DNA Translation: BAE76798.1
PIRiS08623
RefSeqiNP_417201.1, NC_000913.3
WP_001288122.1, NZ_SSUR01000024.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261447, 11 interactors
851718, 2 interactors
ComplexPortaliCPX-317, Formate hydrogenlyase-H/Hydrogenase-3 complex
DIPiDIP-9975N
IntActiP16431, 18 interactors
MINTiP16431
STRINGi511145.b2721

Protein family/group databases

TCDBi3.D.1.9.2, the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Proteomic databases

PaxDbiP16431
PRIDEiP16431

Genome annotation databases

EnsemblBacteriaiAAC75763; AAC75763; b2721
BAE76798; BAE76798; BAE76798
GeneIDi947396
KEGGiecj:JW2691
eco:b2721
PATRICifig|1411691.4.peg.4020

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0473

Phylogenomic databases

eggNOGiCOG3261, Bacteria
COG3262, Bacteria
HOGENOMiCLU_015134_3_1_6
InParanoidiP16431
KOiK15830
PhylomeDBiP16431

Enzyme and pathway databases

BioCyciEcoCyc:HYCELARGE-MONOMER
MetaCyc:HYCELARGE-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P16431

Family and domain databases

Gene3Di1.10.645.20, 1 hit
3.30.460.80, 1 hit
InterProiView protein in InterPro
IPR001135, NADH_Q_OxRdtase_suD
IPR038290, NADH_Q_OxRdtase_suD_sf
IPR037232, NADH_quin_OxRdtase_su_C/D-like
IPR001268, NADH_UbQ_OxRdtase_30kDa_su
IPR014029, NADH_UbQ_OxRdtase_49kDa_CS
IPR001501, Ni-dep_hyd_lsu
IPR029014, NiFe-Hase_large
PfamiView protein in Pfam
PF00329, Complex1_30kDa, 1 hit
PF00346, Complex1_49kDa, 2 hits
PF00374, NiFeSe_Hases, 1 hit
SUPFAMiSSF143243, SSF143243, 1 hit
SSF56762, SSF56762, 1 hit
PROSITEiView protein in PROSITE
PS00535, COMPLEX1_49K, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYCE_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16431
Secondary accession number(s): Q2MAA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 7, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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