EPCAM

Functionⁱ

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.4 Publications

GO - Molecular functionⁱ

cadherin binding involved in cell-cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19136966

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

leukocyte migration Source: Reactome
negative regulation of cell-cell adhesion mediated by cadherin
Source: UniProtKB
Inferred from direct assayⁱ
- 9382878
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 15195135
positive regulation of stem cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19785009
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 15195135
- 15922867
signal transduction involved in regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19136966
stem cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19785009
ureteric bud development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Tumor antigen

Molecular function

Tumor antigen

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall
SIGNORⁱ	P16422

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Epithelial cell adhesion molecule Short name: Ep-CAM Alternative name(s): Adenocarcinoma-associated antigen Cell surface glycoprotein Trop-1 Epithelial cell surface antigen Epithelial glycoprotein Short name: EGP Epithelial glycoprotein 314 Short name: EGP314 Short name: hEGP314 KS 1/4 antigen KSA Major gastrointestinal tumor-associated protein GA733-2 Tumor-associated calcium signal transducer 1 CD_antigen: CD326
Gene namesⁱ	Name:EPCAM Synonyms:GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119888.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11529 EPCAM
MIMⁱ	185535 gene
neXtProtⁱ	NX_P16422

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 265	ExtracellularSequence analysisAdd BLAST	242
Transmembraneⁱ	266 – 288	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	289 – 314	CytoplasmicSequence analysisAdd BLAST	26

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diarrhea 5, with tufting enteropathy, congenital (DIAR5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.

Hereditary non-polyposis colorectal cancer 8 (HNPCC8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.

Disease descriptionAn autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	74	N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-111 and A-198. 1 Publication	1
Mutagenesisⁱ	111	N → A: Changed glycosylation pattern. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-198. 1 Publication	1
Mutagenesisⁱ	198	N → A: Decreased glycosyation, reduced protein stability and significant decrease in protein expression. Complete loss of glycosylation and substantial decrease in protein expression; when associated with A-74 and A-111. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Hereditary nonpolyposis colorectal cancer

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4072
GeneReviewsⁱ	EPCAM
MalaCards human disease database More...MalaCardsⁱ	EPCAM
MIMⁱ	613217 phenotype 613244 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000119888
Orphanetⁱ	92050 Congenital tufting enteropathy 144 Lynch syndrome
PharmGKBⁱ	PA35493

Chemistry databases

ChEMBLⁱ	CHEMBL3580493
Drug and drug target database More...DrugBankⁱ	DB05831 ING-1 DB05319 oportuzumab monatox

Polymorphism and mutation databases

BioMutaⁱ	EPCAM
DMDMⁱ	160266056

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000022467	24 – 314	Epithelial cell adhesion moleculeAdd BLAST		291

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	27 ↔ 46	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	29 ↔ 59	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	38 ↔ 48	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	66 ↔ 99	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	74	N-linked (GlcNAc...) asparagine; partial2 Publications	1
Disulfide bondⁱ	110 ↔ 116	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	111	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	118 ↔ 135	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagine2 Publications	1

Post-translational modificationⁱ

Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.3 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P16422
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16422
PaxDbⁱ	P16422
PeptideAtlas More...PeptideAtlasⁱ	P16422
PRIDEⁱ	P16422
ProteomicsDBⁱ	53359

PTM databases

GlyConnectⁱ	1217
iPTMnetⁱ	P16422
PhosphoSitePlusⁱ	P16422

Expressionⁱ

Tissue specificityⁱ

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000119888 Expressed in 196 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_EPCAM
ExpressionAtlasⁱ	P16422 baseline and differential
Genevisibleⁱ	P16422 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003809 CAB030012 CAB055098 HPA026761 HPA067463

HPAⁱ

CAB003809
CAB030012
CAB055098
HPA026761
HPA067463

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with phosphorylated CLDN7.2 Publications

GO - Molecular functionⁱ

cadherin binding involved in cell-cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110250, 5 interactors
IntActⁱ	P16422, 2 interactors
STRINGⁱ	9606.ENSP00000263735

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	35 – 40	Combined sources	6
Beta strandⁱ	46 – 50	Combined sources	5
Beta strandⁱ	56 – 58	Combined sources	3
Helixⁱ	65 – 72	Combined sources	8
Turnⁱ	73 – 75	Combined sources	3
Beta strandⁱ	107 – 111	Combined sources	5
Turnⁱ	112 – 114	Combined sources	3
Beta strandⁱ	115 – 120	Combined sources	6
Beta strandⁱ	130 – 132	Combined sources	3
Beta strandⁱ	141 – 150	Combined sources	10
Helixⁱ	159 – 173	Combined sources	15
Helixⁱ	178 – 180	Combined sources	3
Beta strandⁱ	181 – 187	Combined sources	7
Beta strandⁱ	190 – 196	Combined sources	7
Turnⁱ	199 – 201	Combined sources	3
Helixⁱ	209 – 220	Combined sources	12
Beta strandⁱ	226 – 228	Combined sources	3
Helixⁱ	244 – 246	Combined sources	3
Beta strandⁱ	248 – 255	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P16422
SMRⁱ	P16422
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	63 – 135	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		73

Sequence similaritiesⁱ

Belongs to the EPCAM family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFI6 Eukaryota ENOG4111M3B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018245
HOGENOMⁱ	HOG000074086
InParanoidⁱ	P16422
KEGG Orthology (KO) More...KOⁱ	K06737
PhylomeDBⁱ	P16422
TreeFamⁱ	TF332767

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00086 Thyroglobulin_1, 1 hit
SMARTⁱ	View protein in SMART SM00211 TY, 1 hit
SUPFAMⁱ	SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P16422-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS 
        60         70         80         90        100
VGAQNTVICS KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD 
       110        120        130        140        150
ESGLFKAKQC NGTSMCWCVN TAGVRRTDKD TEITCSERVR TYWIIIELKH 
       160        170        180        190        200
KAREKPYDSK SLRTALQKEI TTRYQLDPKF ITSILYENNV ITIDLVQNSS 
       210        220        230        240        250
QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL DLDPGQTLIY 
       260        270        280        290        300
YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 
       310 
EIKEMGEMHR ELNA

Length:314

Mass (Da):34,932

Last modified:November 13, 2007 - v2

Checksum:ⁱ023FCE418B2F1079

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B5MCA4	B5MCA4_HUMAN	Epithelial cell adhesion molecule Epithelial cell adhesion molecule	EPCAM	342	Annotation score:
C9JKY3	C9JKY3_HUMAN	Epithelial cell adhesion molecule Epithelial cell adhesion molecule	EPCAM	199	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	277	I → M in AAA36151 (PubMed:2463074).Curated	1
Sequence conflictⁱ	277	I → M in CAA32870 (PubMed:2463074).Curated	1
Sequence conflictⁱ	277	I → M in AAA59543 (PubMed:2469722).Curated	1
Sequence conflictⁱ	303	K → R in CAG47055 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063829	66	C → Y in DIAR5. 1 PublicationCorresponds to variant dbSNP:rs267606785EnsemblClinVar.		1
Natural variantⁱVAR_018329	115	M → T4 PublicationsCorresponds to variant dbSNP:rs1126497EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M32325 mRNA Translation: AAA36151.1 X14758 mRNA Translation: CAA32870.1 M26481 mRNA Translation: AAA59543.1 M32306 mRNA Translation: AAA35723.1 M33011 mRNA Translation: AAA35861.1 M93036 M93035 Genomic DNA Translation: AAB00775.1 CR542259 mRNA Translation: CAG47055.1 CR542283 mRNA Translation: CAG47078.1 AC079775 Genomic DNA Translation: AAY15095.1 CH471053 Genomic DNA Translation: EAX00218.1 BC014785 mRNA Translation: AAH14785.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1833.1
PIRⁱ	B48149
NCBI Reference Sequences More...RefSeqⁱ	NP_002345.2, NM_002354.2
UniGeneⁱ	Hs.542050

Genome annotation databases

Ensemblⁱ	ENST00000263735; ENSP00000263735; ENSG00000119888
GeneIDⁱ	4072
KEGGⁱ	hsa:4072
UCSC genome browser More...UCSCⁱ	uc002rvx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16422	Epithelial cell adhesion molecule		MACMU		314	UniRef90_P16422
EPCAM isoform 1		PONAB		387
Epithelial cell adhesion molecule		CALJA		315
Uncharacterized protein		CHLSB		314
Epithelial cell adhesion molecule		GORGO		314
+11

Protein	Similar proteins		Species	Score	Length	Source
P16422	Epithelial cell adhesion molecule		MACMU		314	UniRef50_P16422
Epithelial cell adhesion molecule		BOVIN		314
EPCAM isoform 1		PONAB		387
Epithelial cell adhesion molecule		CALJA		315
Uncharacterized protein		RHIRO		314
+43

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M32325 mRNA Translation: AAA36151.1 X14758 mRNA Translation: CAA32870.1 M26481 mRNA Translation: AAA59543.1 M32306 mRNA Translation: AAA35723.1 M33011 mRNA Translation: AAA35861.1 M93036 M93035 Genomic DNA Translation: AAB00775.1 CR542259 mRNA Translation: CAG47055.1 CR542283 mRNA Translation: CAG47078.1 AC079775 Genomic DNA Translation: AAY15095.1 CH471053 Genomic DNA Translation: EAX00218.1 BC014785 mRNA Translation: AAH14785.1
CCDSⁱ	CCDS1833.1
PIRⁱ	B48149
RefSeqⁱ	NP_002345.2, NM_002354.2
UniGeneⁱ	Hs.542050

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4MZV	X-ray	1.86	A	24-265	[»]
ProteinModelPortalⁱ	P16422
SMRⁱ	P16422
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110250, 5 interactors
IntActⁱ	P16422, 2 interactors
STRINGⁱ	9606.ENSP00000263735

Chemistry databases

ChEMBLⁱ	CHEMBL3580493
DrugBankⁱ	DB05831 ING-1 DB05319 oportuzumab monatox

PTM databases

GlyConnectⁱ	1217
iPTMnetⁱ	P16422
PhosphoSitePlusⁱ	P16422

Polymorphism and mutation databases

BioMutaⁱ	EPCAM
DMDMⁱ	160266056

Proteomic databases

EPDⁱ	P16422
MaxQBⁱ	P16422
PaxDbⁱ	P16422
PeptideAtlasⁱ	P16422
PRIDEⁱ	P16422
ProteomicsDBⁱ	53359

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4072
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263735; ENSP00000263735; ENSG00000119888
GeneIDⁱ	4072
KEGGⁱ	hsa:4072
UCSCⁱ	uc002rvx.4 human

Organism-specific databases

CTDⁱ	4072
DisGeNETⁱ	4072
EuPathDBⁱ	HostDB:ENSG00000119888.10
GeneCardsⁱ	EPCAM
GeneReviewsⁱ	EPCAM
H-InvDBⁱ	HIX0002040
HGNCⁱ	HGNC:11529 EPCAM
HPAⁱ	CAB003809 CAB030012 CAB055098 HPA026761 HPA067463
MalaCardsⁱ	EPCAM
MIMⁱ	185535 gene 613217 phenotype 613244 phenotype
neXtProtⁱ	NX_P16422
OpenTargetsⁱ	ENSG00000119888
Orphanetⁱ	92050 Congenital tufting enteropathy 144 Lynch syndrome
PharmGKBⁱ	PA35493
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFI6 Eukaryota ENOG4111M3B LUCA
GeneTreeⁱ	ENSGT00390000018245
HOGENOMⁱ	HOG000074086
InParanoidⁱ	P16422
KOⁱ	K06737
PhylomeDBⁱ	P16422
TreeFamⁱ	TF332767

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall
SIGNORⁱ	P16422

Miscellaneous databases

ChiTaRSⁱ	EPCAM human
GeneWikiⁱ	Epithelial_cell_adhesion_molecule
GenomeRNAiⁱ	4072
Protein Ontology More...PROⁱ	PR:P16422
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119888 Expressed in 196 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_EPCAM
ExpressionAtlasⁱ	P16422 baseline and differential
Genevisibleⁱ	P16422 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
Pfamⁱ	View protein in Pfam PF00086 Thyroglobulin_1, 1 hit
SMARTⁱ	View protein in SMART SM00211 TY, 1 hit
SUPFAMⁱ	SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPCAM_HUMAN
Accessionⁱ	P16422Primary (citable) accession number: P16422 Secondary accession number(s): P18180 , Q6FG26, Q6FG49, Q96C47, Q9UCD0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	November 13, 2007
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P16422 (EPCAM_HUMAN)

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Epithelial cell adhesion molecule

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

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Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ