Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P16415 (ZN823_HUMAN)

Entry version 170 (02 Dec 2020)
Sequence version 2 (12 Jun 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger protein 823

Gene

ZNF823

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri164 – 186C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 465C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri471 – 493C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri555 – 577C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri583 – 605C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16415

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 823
Alternative name(s):
Zinc finger protein ZFP-36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF823
Synonyms:ZFP36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000197933.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:30936, ZNF823

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16415

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55552

Open Targets

More...OpenTargetsi		ENSG00000197933

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162410690

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16415, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF823

Domain mapping of disease mutations (DMDM)

More...DMDMi		148887464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477781 – 610Zinc finger protein 823Add BLAST610

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P16415

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16415

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16415

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16415

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16415

PeptideAtlas

More...PeptideAtlasi		P16415

PRoteomics IDEntifications database

More...PRIDEi		P16415

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53358 [P16415-1]
6940

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16415

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16415

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197933, Expressed in calcaneal tendon and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16415, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16415, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197933, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120713, 1 interactor

Protein interaction database and analysis system

More...IntActi		P16415, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340683

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16415, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16415

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 97KRABPROSITE-ProRule annotationAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 465C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri471 – 493C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri555 – 577C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri583 – 605C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16415

Identification of Orthologs from Complete Genome Data

More...OMAi		FDCKECT

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16415

TreeFam database of animal gene trees

More...TreeFami		TF338854

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16415-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ 
        60         70         80         90        100
NIGDQCQNAK RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS 
       110        120        130        140        150
GECGEVVLGH SSLNCNIRVD TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS 
       160        170        180        190        200
FQTHERPPTG KKPFDCKECA KTFSSLGNLR RHMAAHHGDG PYKCKLCGKA 
       210        220        230        240        250
FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER IHTGEKAYEC 
       260        270        280        290        300
KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG 
       310        320        330        340        350
EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH 
       360        370        380        390        400
ETTHTGEKPY ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP 
       410        420        430        440        450
SLFQRHERTH TGEKPYQCKQ CGKAFSLAGS LRRHEATHTG VKPYKCQCGK 
       460        470        480        490        500
AFSDLSSFQN HETTHTGEKP YECKECGKAF SCFKYLSQHK RTHTVEKPYE 
       510        520        530        540        550
CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT CLLRHERIHT 
       560        570        580        590        600
GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR 
       610
HKRTHWKDTL
Length:610
Mass (Da):70,270
Last modified:June 12, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDE96CD36953772B
GO
Isoform 2 (identifier: P16415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Show »
Length:428
Mass (Da):49,594
Checksum:i6682B832965B1F77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JU45C9JU45_HUMAN
Zinc finger protein 823
ZNF823
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2N8C9J2N8_HUMAN
Zinc finger protein 823
ZNF823
469Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN93K7EN93_HUMAN
Zinc finger protein 823
ZNF823
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA36064 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052909566R → H. Corresponds to variant dbSNP:rs3745663Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559721 – 182Missing in isoform 2. 1 PublicationAdd BLAST182

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK303213 mRNA Translation: BAH13920.1
AC008543 Genomic DNA No translation available.
BC052597 mRNA Translation: AAH52597.1
BC063560 mRNA Translation: AAH63560.1
X51760 mRNA Translation: CAA36064.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45981.1 [P16415-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S08686

NCBI Reference Sequences

More...RefSeqi		NP_001073962.1, NM_001080493.3 [P16415-1]
NP_001284539.1, NM_001297610.1 [P16415-2]
NP_059977.1, NM_017507.1
XP_016882430.1, XM_017026941.1 [P16415-2]
XP_016882431.1, XM_017026942.1 [P16415-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341191; ENSP00000340683; ENSG00000197933 [P16415-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55552

UCSC genome browser

More...UCSCi		uc002msm.3, human [P16415-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303213 mRNA Translation: BAH13920.1
AC008543 Genomic DNA No translation available.
BC052597 mRNA Translation: AAH52597.1
BC063560 mRNA Translation: AAH63560.1
X51760 mRNA Translation: CAA36064.1 Different initiation.
CCDSiCCDS45981.1 [P16415-1]
PIRiS08686
RefSeqiNP_001073962.1, NM_001080493.3 [P16415-1]
NP_001284539.1, NM_001297610.1 [P16415-2]
NP_059977.1, NM_017507.1
XP_016882430.1, XM_017026941.1 [P16415-2]
XP_016882431.1, XM_017026942.1 [P16415-2]

3D structure databases

SMRiP16415
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120713, 1 interactor
IntActiP16415, 2 interactors
STRINGi9606.ENSP00000340683

PTM databases

iPTMnetiP16415
PhosphoSitePlusiP16415

Polymorphism and mutation databases

BioMutaiZNF823
DMDMi148887464

Proteomic databases

EPDiP16415
jPOSTiP16415
MassIVEiP16415
MaxQBiP16415
PaxDbiP16415
PeptideAtlasiP16415
PRIDEiP16415
ProteomicsDBi53358 [P16415-1]
6940

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6939, 60 antibodies

Genome annotation databases

EnsembliENST00000341191; ENSP00000340683; ENSG00000197933 [P16415-1]
GeneIDi55552
KEGGihsa:55552
UCSCiuc002msm.3, human [P16415-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55552
DisGeNETi55552
EuPathDBiHostDB:ENSG00000197933.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF823
HGNCiHGNC:30936, ZNF823
HPAiENSG00000197933, Low tissue specificity
neXtProtiNX_P16415
OpenTargetsiENSG00000197933
PharmGKBiPA162410690

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00950000182755
HOGENOMiCLU_002678_17_1_1
InParanoidiP16415
OMAiFDCKECT
OrthoDBi1318335at2759
PhylomeDBiP16415
TreeFamiTF338854

Enzyme and pathway databases

PathwayCommonsiP16415

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55552, 16 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF823, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55552
PharosiP16415, Tdark

Protein Ontology

More...PROi		PR:P16415
RNActiP16415, protein

Gene expression databases

BgeeiENSG00000197933, Expressed in calcaneal tendon and 203 other tissues
ExpressionAtlasiP16415, baseline and differential
GenevisibleiP16415, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 16 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN823_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16415
Secondary accession number(s): A0PJL4, B7Z8D4, Q6P4A9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 12, 2007
Last modified: December 2, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again