CTLA4

Functionⁱ

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.2 Publications

Miscellaneous

The therapeutic antibody Ipilimumab competes for the binding site of the endogenous ligands CD80/B7-1, CD86/B7-2 and ICOSLG.

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
B cell receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17875758
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17875758
immune response
Source: ProtInc
Traceable author statementⁱ
- 3220103
negative regulation of B cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17875758
negative regulation of regulatory T cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18641304
positive regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17875758
regulation of regulatory T cell differentiation Source: Reactome
T cell costimulation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389513 CTLA4 inhibitory signaling R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
SIGNORⁱ	P16410

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytotoxic T-lymphocyte protein 4 Alternative name(s): Cytotoxic T-lymphocyte-associated antigen 4 Short name: CTLA-4 CD_antigen: CD152
Gene namesⁱ	Name:CTLA4 Synonyms:CD152
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163599.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2505 CTLA4
MIMⁱ	123890 gene
neXtProtⁱ	NX_P16410

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	36 – 161	Extracellular1 PublicationAdd BLAST	126
Transmembraneⁱ	162 – 182	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	183 – 223	CytoplasmicSequence analysisAdd BLAST	41

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Systemic lupus erythematosus (SLE)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Diabetes mellitus, insulin-dependent, 12 (IDDM12)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Celiac disease 3 (CELIAC3)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.

Autoimmune lymphoproliferative syndrome 5 (ALPS5)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_072681	70	R → W in ALPS5. 1 PublicationCorresponds to variant dbSNP:rs606231422EnsemblClinVar.		1

Pharmaceutical useⁱ

Engineered fusion proteins consisting of the extracellular domain of CTLA4 and the IgG Fc region (Ctla4-Ig), inhibit T-cell-dependent antibody responses, and are used as immunosuppressive agents. They are soluble, have an enhanced affinity for B7 ligands and act as a competitive inhibitor of CD28.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	45	V → D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	47	L → D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	49	S → A: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	70	R → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	130	K → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	132	E → A or R: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	139	Y → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1
Mutagenesisⁱ	143	I → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication	1

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation, Systemic lupus erythematosus

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1493
MalaCards human disease database More...MalaCardsⁱ	CTLA4
MIMⁱ	109100 phenotype 152700 phenotype 601388 phenotype 609755 phenotype 610424 phenotype 616100 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163599
Orphanetⁱ	391490 Adult-onset myasthenia gravis 436159 Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency 2584 Classic mycosis fungoides 900 Granulomatosis with polyangiitis 536 NON RARE IN EUROPE: Systemic lupus erythematosus 3162 Sezary syndrome
PharmGKBⁱ	PA27006

Chemistry databases

ChEMBLⁱ	CHEMBL2364164
Drug and drug target database More...DrugBankⁱ	DB06186 Ipilimumab
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2743

Polymorphism and mutation databases

BioMutaⁱ	CTLA4
DMDMⁱ	27735177

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 35	Sequence analysisAdd BLAST		35
ChainⁱPRO_0000014734	36 – 223	Cytotoxic T-lymphocyte protein 4Add BLAST		188

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	58 ↔ 129	Combined sources6 Publications
Disulfide bondⁱ	85 ↔ 103	Combined sources6 Publications
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	145	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	157	InterchainCombined sources2 Publications
Modified residueⁱ	201	Phosphotyrosine; by TXK and JAK23 Publications	1

Post-translational modificationⁱ

N-glycosylation is important for dimerization.3 Publications

Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.3 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P16410
PeptideAtlas More...PeptideAtlasⁱ	P16410
PRIDEⁱ	P16410
ProteomicsDBⁱ	53354 53355 [P16410-2] 53356 [P16410-3] 53357 [P16410-4]

PTM databases

iPTMnetⁱ	P16410
PhosphoSitePlusⁱ	P16410

Expressionⁱ

Tissue specificityⁱ

Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000163599 Expressed in 110 organ(s), highest expression level in lymph node
CleanExⁱ	HS_CTLA4
ExpressionAtlasⁱ	P16410 baseline and differential
Genevisibleⁱ	P16410 HS

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked (PubMed:11279501, PubMed:11279502, Ref. 23, PubMed:21156796, PubMed:28484017). Binds to CD80/B7-1 and CD86/B7.2 (PubMed:11279501, PubMed:11279502, PubMed:28484017). Interacts with ICOSLG (PubMed:28484017).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CD80	P33681	7	EBI-1030991,EBI-1031024
CD86	P42081	3	EBI-1030991,EBI-1030956
PIK3R1	P27986	3	EBI-1030991,EBI-79464

Protein-protein interaction databases

BioGridⁱ	107875, 109 interactors
Database of interacting proteins More...DIPⁱ	DIP-35607N
ELMⁱ	P16410
IntActⁱ	P16410, 15 interactors
Molecular INTeraction database More...MINTⁱ	P16410
STRINGⁱ	9606.ENSP00000303939

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	39 – 41	Combined sources	3
Beta strandⁱ	44 – 47	Combined sources	4
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	54 – 60	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	68 – 77	Combined sources	10
Beta strandⁱ	80 – 90	Combined sources	11
Beta strandⁱ	102 – 108	Combined sources	7
Beta strandⁱ	111 – 116	Combined sources	6
Helixⁱ	121 – 123	Combined sources	3
Beta strandⁱ	125 – 138	Combined sources	14
Beta strandⁱ	140 – 143	Combined sources	4
Beta strandⁱ	147 – 150	Combined sources	4
Beta strandⁱ	156 – 158	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P16410
SMRⁱ	P16410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P16410

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 140	Ig-like V-typeAdd BLAST		102

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	46 – 50	Homodimerization1 Publication	5
Regionⁱ	134 – 139	Important for interaction with CD80 and CD861 Publication	6
Regionⁱ	150 – 155	Homodimerization2 Publications	6

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJ05 Eukaryota ENOG410YUQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063873
HOGENOMⁱ	HOG000112047
HOVERGENⁱ	HBG057978
InParanoidⁱ	P16410
KEGG Orthology (KO) More...KOⁱ	K06538
OMAⁱ	FSKGMHV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IGY
PhylomeDBⁱ	P16410
TreeFamⁱ	TF335679

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR008096 CTLA4 IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
PANTHERⁱ	PTHR11494:SF8 PTHR11494:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
PRINTSⁱ	PR01720 CTLANTIGEN4
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P16410-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS 
        60         70         80         90        100
RGIASFVCEY ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD 
       110        120        130        140        150
SICTGTSSGN QVNLTIQGLR AMDTGLYICK VELMYPPPYY LGIGNGTQIY 
       160        170        180        190        200
VIDPEPCPDS DFLLWILAAV SSGLFFYSFL LTAVSLSKML KKRSPLTTGV 
       210        220 
YVKMPPTEPE CEKQFQPYFI PIN

Length:223

Mass (Da):24,656

Last modified:January 10, 2003 - v3

Checksum:ⁱ6F9466FB2E139A5A

GO

Isoform 2 (identifier: P16410-2) [UniParc]FASTA Add to basket

Also known as: ss-CTLA-4

The sequence of this isoform differs from the canonical sequence as follows:
38-204: Missing.

« Hide

        10         20         30         40         50
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAPPT EPECEKQFQP 

YFIPIN

Show »

Length:56

Mass (Da):6,560

Checksum:ⁱ096CBF7AD57AE9B9

GO

Isoform 3 (identifier: P16410-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
38-204: Missing.
205-223: PPTEPECEKQFQPYFIPIN → KEKKPSYNRGLCENAPNRARM

« Hide

        10         20         30         40         50
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAKEK KPSYNRGLCE 

NAPNRARM

Show »

Length:58

Mass (Da):6,745

Checksum:ⁱ5F70948EEDC80A94

GO

Isoform 4 (identifier: P16410-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: C → S
     59-204: Missing.
     205-223: PPTEPECEKQFQPYFIPIN → KEKKPSYNRGLCENAPNRARM

« Hide

        10         20         30         40         50
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS 
        60         70 
RGIASFVSKE KKPSYNRGLC ENAPNRARM

Show »

Length:79

Mass (Da):8,855

Checksum:ⁱ60CBF1BC1DA59D8A

GO

Isoform 5 (identifier: P16410-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
153-174: DPEPCPDSDFLLWILAAVSSGL → AKEKKPSYNRGLCENAPNRARM
175-223: Missing.

« Hide

        10         20         30         40         50
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS 
        60         70         80         90        100
RGIASFVCEY ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD 
       110        120        130        140        150
SICTGTSSGN QVNLTIQGLR AMDTGLYICK VELMYPPPYY LGIGNGTQIY 
       160        170 
VIAKEKKPSY NRGLCENAPN RARM

Show »

Length:174

Mass (Da):19,145

Checksum:ⁱ0881BFA757AC3FDB

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0C4DH58	A0A0C4DH58_HUMAN		Cytotoxic T-lymphocyte protein 4 Cytotoxic T-lymphocyte protein 4	CTLA4	137	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	37	A → V in ABG85285 (PubMed:18595775).Curated		1
Sequence conflictⁱ	147	T → A in AAA52773 (PubMed:3220103).Curated		1

Polymorphismⁱ

Genetic variations in CTLA4 are associated with susceptibility to several autoimmune disorders (PubMed:18595775, PubMed:12724780, PubMed:10189842, PubMed:10924276, PubMed:15138458, PubMed:15657618, PubMed:15688186, PubMed:25329329, PubMed:25213377). They influence responsiveness to hepatitis B virus (HBV) infection [MIMⁱ:610424] (PubMed:15452244).10 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_013577	17	T → A Increased risk for Graves disease, insulin-dependent diabetes mellitus, thyroid-associated orbitopathy, systemic lupus erythematosus and susceptibility to HBV infection. 7 PublicationsCorresponds to variant dbSNP:rs231775EnsemblClinVar.		1
Natural variantⁱVAR_072681	70	R → W in ALPS5. 1 PublicationCorresponds to variant dbSNP:rs606231422EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_041284	38 – 204	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST	167
Alternative sequenceⁱVSP_041285	58	C → S in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_041286	59 – 204	Missing in isoform 4. 1 PublicationAdd BLAST	146
Alternative sequenceⁱVSP_047238	153 – 174	DPEPC…VSSGL → AKEKKPSYNRGLCENAPNRA RM in isoform 5. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_047239	175 – 223	Missing in isoform 5. 1 PublicationAdd BLAST	49
Alternative sequenceⁱVSP_041287	205 – 223	PPTEP…FIPIN → KEKKPSYNRGLCENAPNRAR M in isoform 3 and isoform 4. 1 PublicationAdd BLAST	19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L15006 mRNA Translation: AAB59385.1 M74363 Genomic DNA Translation: AAA52127.1 AF411058 Genomic DNA Translation: AAL40932.1 AY792514 mRNA Translation: AAV66331.1 AY999702 mRNA Translation: AAY00166.1 DQ785106 mRNA Translation: ABG85285.1 AF414120 mRNA Translation: AAL07473.1 DQ357942 Genomic DNA Translation: ABC67470.1 AC010138 Genomic DNA Translation: AAX93176.1 BC074842 mRNA Translation: AAH74842.1 BC074893 mRNA Translation: AAH74893.1 AH002733 Genomic DNA Translation: AAA52773.1 U90273 mRNA Translation: AAD00698.1 AF142144 Genomic DNA Translation: AAF02499.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2362.1 [P16410-1] CCDS42803.1 [P16410-5]
PIRⁱ	S08614
NCBI Reference Sequences More...RefSeqⁱ	NP_001032720.1, NM_001037631.2 [P16410-5] NP_005205.2, NM_005214.4 [P16410-1]
UniGeneⁱ	Hs.247824

Genome annotation databases

Ensemblⁱ	ENST00000295854; ENSP00000295854; ENSG00000163599 [P16410-5] ENST00000302823; ENSP00000303939; ENSG00000163599 [P16410-1] ENST00000472206; ENSP00000417779; ENSG00000163599 [P16410-4]
GeneIDⁱ	1493
KEGGⁱ	hsa:1493
UCSC genome browser More...UCSCⁱ	uc002vak.3 human [P16410-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16410	CTLA4 isoform 1		PANTR		223	UniRef100_P16410
Uncharacterized protein		PANPA		223
Cytotoxic T-lymphocyte associated protein 4		GORGO		223
Cytotoxic T-lymphocyte-associated protein 4 (Fragment)		HUMAN		24
Cytotoxic T-lymphocyte antigen 4 (Fragment)		HUMAN		22
+7
P16410-4	CTLA4 isoform 3		PONAB		79	UniRef100_A0A2J8WUM4
CTLA4 isoform 3		PANTR		79
P16410-5	Cytotoxic T-lymphocyte protein 4		HUMAN		137	UniRef100_A0A0C4DH58
CTLA4 isoform 2		PANTR		174
Uncharacterized protein		PANPA		174
Cytotoxic T-lymphocyte associated protein 4		GORGO		174
CTLA4 isoform 5		PANTR		137

Protein	Similar proteins		Species	Score	Length	Source
P16410	CTLA4 isoform 1		PANTR		223	UniRef90_P16410
Uncharacterized protein		PANPA		223
Cytotoxic T-lymphocyte associated protein 4		GORGO		223
Cytotoxic T-lymphocyte-associated protein 4 (Fragment)		HUMAN		24
CD152 protein		PAPAN		223
+34
P16410-4	Uncharacterized protein		MACMU		79	UniRef90_F7CHH4
CTLA4 isoform 3		PONAB		79
CTLA4 isoform 3		PANTR		79
P16410-5	Uncharacterized protein		NOMLE		174	UniRef90_A0A2I3FRI8
Cytotoxic T-lymphocyte associated protein 4		SAIBB		174
Uncharacterized protein		CALJA		174
Uncharacterized protein		COLAP		174
Uncharacterized protein		Cebus capucinus imitator		174
+16

Protein	Similar proteins		Species	Score	Length	Source
P16410	Cytotoxic T-lymphocyte protein 4		RABIT		223	UniRef50_P16410
Cytotoxic T-lymphocyte protein 4	)	MOUSE		223
CTLA4 isoform 1		PANTR		223
Uncharacterized protein		PANPA		223
Cytotoxic T-lymphocyte associated protein 4		GORGO		223
+93
P16410-4	Uncharacterized protein		MACMU		79	UniRef50_F7CHH4
CTLA4 isoform 3		PONAB		79
CTLA4 isoform 3		PANTR		79
P16410-5	Cytotoxic T-lymphocyte-associated protein 4		RAT		174	UniRef50_G3V7D2
Cytotoxic T-lymphocyte protein 4		MOUSE		174
cytotoxic T-lymphocyte protein 4 isoform X2		Florida manatee		173
cytotoxic T-lymphocyte protein 4 isoform X2		MESAU		174
cytotoxic T-lymphocyte protein 4 isoform X2		URSMA		174
+91

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CLTA-4 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L15006 mRNA Translation: AAB59385.1 M74363 Genomic DNA Translation: AAA52127.1 AF411058 Genomic DNA Translation: AAL40932.1 AY792514 mRNA Translation: AAV66331.1 AY999702 mRNA Translation: AAY00166.1 DQ785106 mRNA Translation: ABG85285.1 AF414120 mRNA Translation: AAL07473.1 DQ357942 Genomic DNA Translation: ABC67470.1 AC010138 Genomic DNA Translation: AAX93176.1 BC074842 mRNA Translation: AAH74842.1 BC074893 mRNA Translation: AAH74893.1 AH002733 Genomic DNA Translation: AAA52773.1 U90273 mRNA Translation: AAD00698.1 AF142144 Genomic DNA Translation: AAF02499.1
CCDSⁱ	CCDS2362.1 [P16410-1] CCDS42803.1 [P16410-5]
PIRⁱ	S08614
RefSeqⁱ	NP_001032720.1, NM_001037631.2 [P16410-5] NP_005205.2, NM_005214.4 [P16410-1]
UniGeneⁱ	Hs.247824

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AH1	NMR	-	A	37-161	[»]
	1H6E	X-ray	3.60	P	197-207	[»]
	1I85	X-ray	3.20	C/D	36-161	[»]
	1I8L	X-ray	3.00	C/D	36-161	[»]
	2X44	X-ray	2.60	D	36-161	[»]
	3BX7	X-ray	2.10	C	38-161	[»]
	3OSK	X-ray	1.80	A/B	36-161	[»]
	5GGV	X-ray	2.00	Y	36-161	[»]
	5TRU	X-ray	3.00	C/c	37-154	[»]
	5XJ3	X-ray	3.20	C/F/I/L	36-161	[»]
ProteinModelPortalⁱ	P16410
SMRⁱ	P16410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107875, 109 interactors
DIPⁱ	DIP-35607N
ELMⁱ	P16410
IntActⁱ	P16410, 15 interactors
MINTⁱ	P16410
STRINGⁱ	9606.ENSP00000303939

Chemistry databases

ChEMBLⁱ	CHEMBL2364164
DrugBankⁱ	DB06186 Ipilimumab
GuidetoPHARMACOLOGYⁱ	2743

PTM databases

iPTMnetⁱ	P16410
PhosphoSitePlusⁱ	P16410

Polymorphism and mutation databases

BioMutaⁱ	CTLA4
DMDMⁱ	27735177

Proteomic databases

PaxDbⁱ	P16410
PeptideAtlasⁱ	P16410
PRIDEⁱ	P16410
ProteomicsDBⁱ	53354 53355 [P16410-2] 53356 [P16410-3] 53357 [P16410-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000295854; ENSP00000295854; ENSG00000163599 [P16410-5] ENST00000302823; ENSP00000303939; ENSG00000163599 [P16410-1] ENST00000472206; ENSP00000417779; ENSG00000163599 [P16410-4]
GeneIDⁱ	1493
KEGGⁱ	hsa:1493
UCSCⁱ	uc002vak.3 human [P16410-1]

Organism-specific databases

CTDⁱ	1493
DisGeNETⁱ	1493
EuPathDBⁱ	HostDB:ENSG00000163599.14
GeneCardsⁱ	CTLA4
HGNCⁱ	HGNC:2505 CTLA4
MalaCardsⁱ	CTLA4
MIMⁱ	109100 phenotype 123890 gene 152700 phenotype 601388 phenotype 609755 phenotype 610424 phenotype 616100 phenotype
neXtProtⁱ	NX_P16410
OpenTargetsⁱ	ENSG00000163599
Orphanetⁱ	391490 Adult-onset myasthenia gravis 436159 Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency 2584 Classic mycosis fungoides 900 Granulomatosis with polyangiitis 536 NON RARE IN EUROPE: Systemic lupus erythematosus 3162 Sezary syndrome
PharmGKBⁱ	PA27006
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ05 Eukaryota ENOG410YUQR LUCA
GeneTreeⁱ	ENSGT00530000063873
HOGENOMⁱ	HOG000112047
HOVERGENⁱ	HBG057978
InParanoidⁱ	P16410
KOⁱ	K06538
OMAⁱ	FSKGMHV
OrthoDBⁱ	EOG091G0IGY
PhylomeDBⁱ	P16410
TreeFamⁱ	TF335679

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389513 CTLA4 inhibitory signaling R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
SIGNORⁱ	P16410

Miscellaneous databases

EvolutionaryTraceⁱ	P16410
GeneWikiⁱ	CTLA-4
GenomeRNAiⁱ	1493
Protein Ontology More...PROⁱ	PR:P16410
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163599 Expressed in 110 organ(s), highest expression level in lymph node
CleanExⁱ	HS_CTLA4
ExpressionAtlasⁱ	P16410 baseline and differential
Genevisibleⁱ	P16410 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR008096 CTLA4 IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
PANTHERⁱ	PTHR11494:SF8 PTHR11494:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
PRINTSⁱ	PR01720 CTLANTIGEN4
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CTLA4_HUMAN
Accessionⁱ	P16410Primary (citable) accession number: P16410 Secondary accession number(s): A0N1S0 Q9UKN9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 10, 2003
	Last modified:	November 7, 2018
	This is version 204 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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Cytotoxic T-lymphocyte protein 4

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