UniProtKB - P16410 (CTLA4_HUMAN)
Protein
Cytotoxic T-lymphocyte protein 4
Gene
CTLA4
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.2 Publications
Miscellaneous
The therapeutic antibody Ipilimumab competes for the binding site of the endogenous ligands CD80/B7-1, CD86/B7-2 and ICOSLG.
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- B cell receptor signaling pathway Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- immune response Source: ProtInc
- immune system process Source: GO_Central
- negative regulation of B cell proliferation Source: UniProtKB
- negative regulation of immune response Source: Ensembl
- negative regulation of regulatory T cell differentiation Source: BHF-UCL
- negative regulation of T cell proliferation Source: Ensembl
- positive regulation of apoptotic process Source: UniProtKB
- regulation of regulatory T cell differentiation Source: Reactome
- T cell costimulation Source: Reactome
- T cell receptor signaling pathway Source: GO_Central
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P16410 |
Reactomei | R-HSA-389513, CTLA4 inhibitory signaling R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
SIGNORi | P16410 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytotoxic T-lymphocyte protein 4Alternative name(s): Cytotoxic T-lymphocyte-associated antigen 4 Short name: CTLA-4 CD_antigen: CD152 |
Gene namesi | Name:CTLA4 Synonyms:CD152 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163599.14 |
HGNCi | HGNC:2505, CTLA4 |
MIMi | 123890, gene |
neXtProti | NX_P16410 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications
Note: Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
Golgi apparatus
- Golgi apparatus Source: BHF-UCL
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- clathrin-coated endocytic vesicle Source: BHF-UCL
- perinuclear region of cytoplasm Source: BHF-UCL
- protein complex involved in cell adhesion Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 36 – 161 | Extracellular1 PublicationAdd BLAST | 126 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 183 – 223 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Systemic lupus erythematosus (SLE)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Related information in OMIMGenetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.1 Publication
Diabetes mellitus, insulin-dependent, 12 (IDDM12)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIMCeliac disease 3 (CELIAC3)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.
Related information in OMIMAutoimmune lymphoproliferative syndrome 5 (ALPS5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072681 | 70 | R → W in ALPS5. 1 PublicationCorresponds to variant dbSNP:rs606231422EnsemblClinVar. | 1 |
Pharmaceutical usei
Engineered fusion proteins consisting of the extracellular domain of CTLA4 and the IgG Fc region (Ctla4-Ig), inhibit T-cell-dependent antibody responses, and are used as immunosuppressive agents. They are soluble, have an enhanced affinity for B7 ligands and act as a competitive inhibitor of CD28.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 45 | V → D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 47 | L → D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 49 | S → A: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 70 | R → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 130 | K → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 132 | E → A or R: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 139 | Y → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 | |
Mutagenesisi | 143 | I → A or D: Strongly reduced interaction with CD80, CD86 and ICOSLG. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease mutation, Systemic lupus erythematosusOrganism-specific databases
DisGeNETi | 1493 |
MalaCardsi | CTLA4 |
MIMi | 109100, phenotype 152700, phenotype 601388, phenotype 609755, phenotype 610424, phenotype 616100, phenotype |
OpenTargetsi | ENSG00000163599 |
Orphaneti | 391490, Adult-onset myasthenia gravis 436159, Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency 2584, Classic mycosis fungoides 900, Granulomatosis with polyangiitis 3162, Sezary syndrome 536, Systemic lupus erythematosus |
PharmGKBi | PA27006 |
Miscellaneous databases
Pharosi | P16410, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364164 |
DrugBanki | DB06186, Ipilimumab |
DrugCentrali | P16410 |
GuidetoPHARMACOLOGYi | 2743 |
Polymorphism and mutation databases
BioMutai | CTLA4 |
DMDMi | 27735177 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Sequence analysisAdd BLAST | 35 | |
ChainiPRO_0000014734 | 36 – 223 | Cytotoxic T-lymphocyte protein 4Add BLAST | 188 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 58 ↔ 129 | Combined sources6 Publications | ||
Disulfide bondi | 85 ↔ 103 | Combined sources6 Publications | ||
Glycosylationi | 113 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 157 | InterchainCombined sources2 Publications | ||
Modified residuei | 201 | Phosphotyrosine; by TXK and JAK23 Publications | 1 |
Post-translational modificationi
N-glycosylation is important for dimerization.3 Publications
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.3 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P16410 |
PeptideAtlasi | P16410 |
PRIDEi | P16410 |
ProteomicsDBi | 50980 53354 [P16410-1] 53355 [P16410-2] 53356 [P16410-3] 53357 [P16410-4] |
PTM databases
GlyGeni | P16410, 2 sites |
iPTMneti | P16410 |
PhosphoSitePlusi | P16410 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.3 Publications
Gene expression databases
Bgeei | ENSG00000163599, Expressed in lymph node and 129 other tissues |
Genevisiblei | P16410, HS |
Organism-specific databases
HPAi | ENSG00000163599, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP16410
Protein-protein interaction databases
BioGRIDi | 107875, 112 interactors |
DIPi | DIP-35607N |
ELMi | P16410 |
IntActi | P16410, 15 interactors |
MINTi | P16410 |
STRINGi | 9606.ENSP00000303939 |
Miscellaneous databases
RNActi | P16410, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P16410 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16410 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 140 | Ig-like V-typeAdd BLAST | 102 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 46 – 50 | Homodimerization1 Publication | 5 | |
Regioni | 134 – 139 | Important for interaction with CD80 and CD861 Publication | 6 | |
Regioni | 150 – 155 | Homodimerization2 Publications | 6 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZVK, Eukaryota |
GeneTreei | ENSGT00530000063873 |
HOGENOMi | CLU_085095_0_0_1 |
InParanoidi | P16410 |
OMAi | YVKMPSE |
OrthoDBi | 1222373at2759 |
PhylomeDBi | P16410 |
TreeFami | TF335679 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008096, CTLA4 IPR040216, CTLA4/CD28 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR11494, PTHR11494, 1 hit PTHR11494:SF8, PTHR11494:SF8, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
PRINTSi | PR01720, CTLANTIGEN4 |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P16410-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS
60 70 80 90 100
RGIASFVCEY ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD
110 120 130 140 150
SICTGTSSGN QVNLTIQGLR AMDTGLYICK VELMYPPPYY LGIGNGTQIY
160 170 180 190 200
VIDPEPCPDS DFLLWILAAV SSGLFFYSFL LTAVSLSKML KKRSPLTTGV
210 220
YVKMPPTEPE CEKQFQPYFI PIN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | A → V in ABG85285 (PubMed:18595775).Curated | 1 | |
Sequence conflicti | 147 | T → A in AAA52773 (PubMed:3220103).Curated | 1 |
Polymorphismi
Genetic variations in CTLA4 are associated with susceptibility to several autoimmune disorders (PubMed:18595775, PubMed:12724780, PubMed:10189842, PubMed:10924276, PubMed:15138458, PubMed:15657618, PubMed:15688186, PubMed:25329329, PubMed:25213377). They influence responsiveness to hepatitis B virus (HBV) infection [MIMi:610424] (PubMed:15452244).10 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013577 | 17 | T → A Increased risk for Graves disease, insulin-dependent diabetes mellitus, thyroid-associated orbitopathy, systemic lupus erythematosus and susceptibility to HBV infection. 7 PublicationsCorresponds to variant dbSNP:rs231775EnsemblClinVar. | 1 | |
Natural variantiVAR_072681 | 70 | R → W in ALPS5. 1 PublicationCorresponds to variant dbSNP:rs606231422EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041284 | 38 – 204 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 167 | |
Alternative sequenceiVSP_041285 | 58 | C → S in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_041286 | 59 – 204 | Missing in isoform 4. 1 PublicationAdd BLAST | 146 | |
Alternative sequenceiVSP_047238 | 153 – 174 | DPEPC…VSSGL → AKEKKPSYNRGLCENAPNRA RM in isoform 5. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_047239 | 175 – 223 | Missing in isoform 5. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_041287 | 205 – 223 | PPTEP…FIPIN → KEKKPSYNRGLCENAPNRAR M in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15006 mRNA Translation: AAB59385.1 M74363 Genomic DNA Translation: AAA52127.1 AF411058 Genomic DNA Translation: AAL40932.1 AY792514 mRNA Translation: AAV66331.1 AY999702 mRNA Translation: AAY00166.1 DQ785106 mRNA Translation: ABG85285.1 AF414120 mRNA Translation: AAL07473.1 DQ357942 Genomic DNA Translation: ABC67470.1 AC010138 Genomic DNA Translation: AAX93176.1 BC074842 mRNA Translation: AAH74842.1 BC074893 mRNA Translation: AAH74893.1 AH002733 Genomic DNA Translation: AAA52773.1 U90273 mRNA Translation: AAD00698.1 AF142144 Genomic DNA Translation: AAF02499.1 |
CCDSi | CCDS2362.1 [P16410-1] CCDS42803.1 [P16410-5] |
PIRi | S08614 |
RefSeqi | NP_001032720.1, NM_001037631.2 [P16410-5] NP_005205.2, NM_005214.4 [P16410-1] |
Genome annotation databases
Ensembli | ENST00000295854; ENSP00000295854; ENSG00000163599 [P16410-5] ENST00000472206; ENSP00000417779; ENSG00000163599 [P16410-4] ENST00000487393; ENSP00000497319; ENSG00000163599 [P16410-3] ENST00000648405; ENSP00000497102; ENSG00000163599 [P16410-1] |
GeneIDi | 1493 |
KEGGi | hsa:1493 |
UCSCi | uc002vak.3, human [P16410-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CLTA-4 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15006 mRNA Translation: AAB59385.1 M74363 Genomic DNA Translation: AAA52127.1 AF411058 Genomic DNA Translation: AAL40932.1 AY792514 mRNA Translation: AAV66331.1 AY999702 mRNA Translation: AAY00166.1 DQ785106 mRNA Translation: ABG85285.1 AF414120 mRNA Translation: AAL07473.1 DQ357942 Genomic DNA Translation: ABC67470.1 AC010138 Genomic DNA Translation: AAX93176.1 BC074842 mRNA Translation: AAH74842.1 BC074893 mRNA Translation: AAH74893.1 AH002733 Genomic DNA Translation: AAA52773.1 U90273 mRNA Translation: AAD00698.1 AF142144 Genomic DNA Translation: AAF02499.1 |
CCDSi | CCDS2362.1 [P16410-1] CCDS42803.1 [P16410-5] |
PIRi | S08614 |
RefSeqi | NP_001032720.1, NM_001037631.2 [P16410-5] NP_005205.2, NM_005214.4 [P16410-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AH1 | NMR | - | A | 37-161 | [»] | |
1H6E | X-ray | 3.60 | P | 197-207 | [»] | |
1I85 | X-ray | 3.20 | C/D | 36-161 | [»] | |
1I8L | X-ray | 3.00 | C/D | 36-161 | [»] | |
2X44 | X-ray | 2.60 | D | 36-161 | [»] | |
3BX7 | X-ray | 2.10 | C | 38-161 | [»] | |
3OSK | X-ray | 1.80 | A/B | 36-161 | [»] | |
5GGV | X-ray | 2.00 | Y | 36-161 | [»] | |
5TRU | X-ray | 3.00 | C/c | 37-154 | [»] | |
5XJ3 | X-ray | 3.20 | C/F/I/L | 36-161 | [»] | |
6RP8 | X-ray | 2.60 | C/c | 37-154 | [»] | |
6RPJ | X-ray | 3.25 | A/C/E/G | 37-156 | [»] | |
6RQM | X-ray | 3.00 | A | 37-161 | [»] | |
SMRi | P16410 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107875, 112 interactors |
DIPi | DIP-35607N |
ELMi | P16410 |
IntActi | P16410, 15 interactors |
MINTi | P16410 |
STRINGi | 9606.ENSP00000303939 |
Chemistry databases
ChEMBLi | CHEMBL2364164 |
DrugBanki | DB06186, Ipilimumab |
DrugCentrali | P16410 |
GuidetoPHARMACOLOGYi | 2743 |
PTM databases
GlyGeni | P16410, 2 sites |
iPTMneti | P16410 |
PhosphoSitePlusi | P16410 |
Polymorphism and mutation databases
BioMutai | CTLA4 |
DMDMi | 27735177 |
Proteomic databases
PaxDbi | P16410 |
PeptideAtlasi | P16410 |
PRIDEi | P16410 |
ProteomicsDBi | 50980 53354 [P16410-1] 53355 [P16410-2] 53356 [P16410-3] 53357 [P16410-4] |
Protocols and materials databases
ABCDi | P16410, 160 sequenced antibodies |
Antibodypediai | 19961, 1565 antibodies |
Genome annotation databases
Ensembli | ENST00000295854; ENSP00000295854; ENSG00000163599 [P16410-5] ENST00000472206; ENSP00000417779; ENSG00000163599 [P16410-4] ENST00000487393; ENSP00000497319; ENSG00000163599 [P16410-3] ENST00000648405; ENSP00000497102; ENSG00000163599 [P16410-1] |
GeneIDi | 1493 |
KEGGi | hsa:1493 |
UCSCi | uc002vak.3, human [P16410-1] |
Organism-specific databases
CTDi | 1493 |
DisGeNETi | 1493 |
EuPathDBi | HostDB:ENSG00000163599.14 |
GeneCardsi | CTLA4 |
HGNCi | HGNC:2505, CTLA4 |
HPAi | ENSG00000163599, Tissue enhanced (blood, lymphoid tissue) |
MalaCardsi | CTLA4 |
MIMi | 109100, phenotype 123890, gene 152700, phenotype 601388, phenotype 609755, phenotype 610424, phenotype 616100, phenotype |
neXtProti | NX_P16410 |
OpenTargetsi | ENSG00000163599 |
Orphaneti | 391490, Adult-onset myasthenia gravis 436159, Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency 2584, Classic mycosis fungoides 900, Granulomatosis with polyangiitis 3162, Sezary syndrome 536, Systemic lupus erythematosus |
PharmGKBi | PA27006 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZVK, Eukaryota |
GeneTreei | ENSGT00530000063873 |
HOGENOMi | CLU_085095_0_0_1 |
InParanoidi | P16410 |
OMAi | YVKMPSE |
OrthoDBi | 1222373at2759 |
PhylomeDBi | P16410 |
TreeFami | TF335679 |
Enzyme and pathway databases
PathwayCommonsi | P16410 |
Reactomei | R-HSA-389513, CTLA4 inhibitory signaling R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) |
SIGNORi | P16410 |
Miscellaneous databases
BioGRID-ORCSi | 1493, 2 hits in 844 CRISPR screens |
EvolutionaryTracei | P16410 |
GeneWikii | CTLA-4 |
GenomeRNAii | 1493 |
Pharosi | P16410, Tclin |
PROi | PR:P16410 |
RNActi | P16410, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163599, Expressed in lymph node and 129 other tissues |
Genevisiblei | P16410, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008096, CTLA4 IPR040216, CTLA4/CD28 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR11494, PTHR11494, 1 hit PTHR11494:SF8, PTHR11494:SF8, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
PRINTSi | PR01720, CTLANTIGEN4 |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTLA4_HUMAN | |
Accessioni | P16410Primary (citable) accession number: P16410 Secondary accession number(s): A0N1S0 Q9UKN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 10, 2003 | |
Last modified: | December 2, 2020 | |
This is version 220 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Pharmaceutical, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries