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Protein

Histone H1.2

Gene

HIST1H1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity

GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • double-stranded DNA binding Source: GO_Central
  • nucleosomal DNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.2
Alternative name(s):
Histone H1c
Histone H1d
Histone H1s-1
Gene namesi
Name:HIST1H1C
Synonyms:H1F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000187837.3
HGNCiHGNC:4716 HIST1H1C
MIMi142710 gene
neXtProtiNX_P16403

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi187K → R: Abolishes methylation. 1 Publication1

Organism-specific databases

DisGeNETi3006
OpenTargetsiENSG00000187837
PharmGKBiPA29094

Polymorphism and mutation databases

BioMutaiHIST1H1C
DMDMi417101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources3 Publications
ChainiPRO_00001959062 – 213Histone H1.2Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine; partialCombined sources2 Publications1
Modified residuei2PhosphoserineCombined sources1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei23N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei26N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei27N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei34N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei34N6-crotonyllysine; alternate1 Publication1
Modified residuei34N6-methyllysine; alternate1 Publication1
Modified residuei46N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei52N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei52N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei54CitrullineBy similarity1
Modified residuei63N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei64N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei64N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei64N6-crotonyllysine; alternate1 Publication1
Modified residuei75N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei81N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei85N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei85N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei85N6-crotonyllysine; alternate1 Publication1
Modified residuei90N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei90N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei90N6-crotonyllysine; alternate1 Publication1
Modified residuei97N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei97N6-crotonyllysine; alternate1 Publication1
Modified residuei97N6-succinyllysine; alternateBy similarity1
Modified residuei104Phosphoserine; by PKCBy similarity1
Modified residuei106N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei110N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei117N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei121N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei129N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei136N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei146PhosphothreonineCombined sources1
Modified residuei148N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei159N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei159N6-crotonyllysine; alternate1 Publication1
Modified residuei168N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei168N6-crotonyllysine; alternate1 Publication1
Modified residuei187N6-methyllysine; by EHMT1 and EHMT21 Publication1
Modified residuei188ADP-ribosylserine1 Publication1
Modified residuei213N6-(2-hydroxyisobutyryl)lysine1 Publication1

Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity
ADP-ribosylated on Ser-188 in response to DNA damage.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination, Hydroxylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP16403
MaxQBiP16403
PaxDbiP16403
PeptideAtlasiP16403
PRIDEiP16403
ProteomicsDBi53353
TopDownProteomicsiP16403

PTM databases

iPTMnetiP16403
PhosphoSitePlusiP16403
SwissPalmiP16403

Expressioni

Gene expression databases

BgeeiENSG00000187837 Expressed in 205 organ(s), highest expression level in stomach
CleanExiHS_HIST1H1C
GenevisibleiP16403 HS

Organism-specific databases

HPAiCAB011507

Interactioni

Protein-protein interaction databases

BioGridi109261, 115 interactors
DIPiDIP-36359N
IntActiP16403, 30 interactors
MINTiP16403
STRINGi9606.ENSP00000339566

Structurei

3D structure databases

ProteinModelPortaliP16403
SMRiP16403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 109H15PROSITE-ProRule annotationAdd BLAST74

Domaini

The C-terminal domain is required for high-affinity binding to chromatin.By similarity

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00670000097781
HOGENOMiHOG000251627
HOVERGENiHBG009035
InParanoidiP16403
KOiK11275
OMAiSWIDMIK
OrthoDBiEOG091G0XGD
PhylomeDBiP16403
TreeFamiTF313664

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16403-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA
60 70 80 90 100
SKERSGVSLA ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG
110 120 130 140 150
ASGSFKLNKK AASGEAKPKV KKAGGTKPKK PVGAAKKPKK AAGGATPKKS
160 170 180 190 200
AKKTPKKAKK PAAATVTKKV AKSPKKAKVA KPKKAAKSAA KAVKPKAAKP
210
KVVKPKKAAP KKK
Length:213
Mass (Da):21,365
Last modified:January 23, 2007 - v2
Checksum:iAA66EA1901D8D56B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00361818A → V. Corresponds to variant dbSNP:rs2230653Ensembl.1
Natural variantiVAR_049304113S → A. Corresponds to variant dbSNP:rs34810376Ensembl.1
Natural variantiVAR_049305124G → A. Corresponds to variant dbSNP:rs12111009Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57129 Genomic DNA Translation: CAA40408.1
AF531300 Genomic DNA Translation: AAN06700.1
AK290947 mRNA Translation: BAF83636.1
AB451259 mRNA Translation: BAG70073.1
AB451385 mRNA Translation: BAG70199.1
U91328 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55515.1
BC002649 mRNA No translation available.
CCDSiCCDS4577.1
PIRiS26364 HSHU11
RefSeqiNP_005310.1, NM_005319.3
UniGeneiHs.7644

Genome annotation databases

EnsembliENST00000343677; ENSP00000339566; ENSG00000187837
GeneIDi3006
KEGGihsa:3006
UCSCiuc003nfw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57129 Genomic DNA Translation: CAA40408.1
AF531300 Genomic DNA Translation: AAN06700.1
AK290947 mRNA Translation: BAF83636.1
AB451259 mRNA Translation: BAG70073.1
AB451385 mRNA Translation: BAG70199.1
U91328 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55515.1
BC002649 mRNA No translation available.
CCDSiCCDS4577.1
PIRiS26364 HSHU11
RefSeqiNP_005310.1, NM_005319.3
UniGeneiHs.7644

3D structure databases

ProteinModelPortaliP16403
SMRiP16403
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109261, 115 interactors
DIPiDIP-36359N
IntActiP16403, 30 interactors
MINTiP16403
STRINGi9606.ENSP00000339566

PTM databases

iPTMnetiP16403
PhosphoSitePlusiP16403
SwissPalmiP16403

Polymorphism and mutation databases

BioMutaiHIST1H1C
DMDMi417101

Proteomic databases

EPDiP16403
MaxQBiP16403
PaxDbiP16403
PeptideAtlasiP16403
PRIDEiP16403
ProteomicsDBi53353
TopDownProteomicsiP16403

Protocols and materials databases

DNASUi3006
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343677; ENSP00000339566; ENSG00000187837
GeneIDi3006
KEGGihsa:3006
UCSCiuc003nfw.4 human

Organism-specific databases

CTDi3006
DisGeNETi3006
EuPathDBiHostDB:ENSG00000187837.3
GeneCardsiHIST1H1C
HGNCiHGNC:4716 HIST1H1C
HPAiCAB011507
MIMi142710 gene
neXtProtiNX_P16403
OpenTargetsiENSG00000187837
PharmGKBiPA29094
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00670000097781
HOGENOMiHOG000251627
HOVERGENiHBG009035
InParanoidiP16403
KOiK11275
OMAiSWIDMIK
OrthoDBiEOG091G0XGD
PhylomeDBiP16403
TreeFamiTF313664

Enzyme and pathway databases

ReactomeiR-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

ChiTaRSiHIST1H1C human
GeneWikiiHIST1H1C
GenomeRNAii3006
PROiPR:P16403
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187837 Expressed in 205 organ(s), highest expression level in stomach
CleanExiHS_HIST1H1C
GenevisibleiP16403 HS

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH12_HUMAN
AccessioniPrimary (citable) accession number: P16403
Secondary accession number(s): A8K4I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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