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Entry version 193 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H1.2

Gene

HIST1H1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H1.2
Alternative name(s):
Histone H1c
Histone H1d
Histone H1s-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIST1H1C
Synonyms:H1F2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000187837.3

Human Gene Nomenclature Database

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HGNCi
HGNC:4716 HIST1H1C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142710 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16403

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi187K → R: Abolishes methylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3006

Open Targets

More...
OpenTargetsi
ENSG00000187837

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29094

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HIST1H1C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
417101

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources3 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001959062 – 213Histone H1.2Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine; partialCombined sources2 Publications1
Modified residuei2PhosphoserineCombined sources1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei23N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei26N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei27N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei34N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei34N6-crotonyllysine; alternate1 Publication1
Modified residuei34N6-methyllysine; alternate1 Publication1
Modified residuei46N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei52N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei52N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei54CitrullineBy similarity1
Modified residuei63N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei64N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei64N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei64N6-crotonyllysine; alternate1 Publication1
Modified residuei75N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei81N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei85N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei85N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei85N6-crotonyllysine; alternate1 Publication1
Modified residuei90N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei90N6-(beta-hydroxybutyryl)lysine; alternateBy similarity1
Modified residuei90N6-crotonyllysine; alternate1 Publication1
Modified residuei97N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei97N6-crotonyllysine; alternate1 Publication1
Modified residuei97N6-succinyllysine; alternateBy similarity1
Modified residuei104Phosphoserine; by PKCBy similarity1
Modified residuei106N6-(beta-hydroxybutyryl)lysineBy similarity1
Modified residuei110N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei117N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei121N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei129N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei136N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei146PhosphothreonineCombined sources1
Modified residuei148N6-(2-hydroxyisobutyryl)lysine1 Publication1
Modified residuei159N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei159N6-crotonyllysine; alternate1 Publication1
Modified residuei168N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication1
Modified residuei168N6-crotonyllysine; alternate1 Publication1
Modified residuei187N6-methyllysine; by EHMT1 and EHMT21 Publication1
Modified residuei188ADP-ribosylserine1 Publication1
Modified residuei213N6-(2-hydroxyisobutyryl)lysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication
Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity
ADP-ribosylated on Ser-188 in response to DNA damage.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination, Hydroxylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P16403

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P16403

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P16403

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16403

PeptideAtlas

More...
PeptideAtlasi
P16403

PRoteomics IDEntifications database

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PRIDEi
P16403

ProteomicsDB human proteome resource

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ProteomicsDBi
53353

Consortium for Top Down Proteomics

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TopDownProteomicsi
P16403

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16403

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16403

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P16403

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187837 Expressed in 205 organ(s), highest expression level in stomach

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16403 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB011507

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109261, 128 interactors

Database of interacting proteins

More...
DIPi
DIP-36359N

Protein interaction database and analysis system

More...
IntActi
P16403, 182 interactors

Molecular INTeraction database

More...
MINTi
P16403

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339566

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16403

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16403

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 109H15PROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is required for high-affinity binding to chromatin.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4012 Eukaryota
ENOG4112541 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000163082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251627

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG009035

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16403

KEGG Orthology (KO)

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KOi
K11275

Identification of Orthologs from Complete Genome Data

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OMAi
SWIDMIK

Database of Orthologous Groups

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OrthoDBi
1565299at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P16403

TreeFam database of animal gene trees

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TreeFami
TF313664

Family and domain databases

Conserved Domains Database

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CDDi
cd00073 H15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00538 Linker_histone, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00624 HISTONEH5

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00526 H15, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51504 H15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P16403-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA
60 70 80 90 100
SKERSGVSLA ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG
110 120 130 140 150
ASGSFKLNKK AASGEAKPKV KKAGGTKPKK PVGAAKKPKK AAGGATPKKS
160 170 180 190 200
AKKTPKKAKK PAAATVTKKV AKSPKKAKVA KPKKAAKSAA KAVKPKAAKP
210
KVVKPKKAAP KKK
Length:213
Mass (Da):21,365
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA66EA1901D8D56B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00361818A → V. Corresponds to variant dbSNP:rs2230653Ensembl.1
Natural variantiVAR_049304113S → A. Corresponds to variant dbSNP:rs34810376Ensembl.1
Natural variantiVAR_049305124G → A. Corresponds to variant dbSNP:rs12111009Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57129 Genomic DNA Translation: CAA40408.1
AF531300 Genomic DNA Translation: AAN06700.1
AK290947 mRNA Translation: BAF83636.1
AB451259 mRNA Translation: BAG70073.1
AB451385 mRNA Translation: BAG70199.1
U91328 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55515.1
BC002649 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4577.1

Protein sequence database of the Protein Information Resource

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PIRi
S26364 HSHU11

NCBI Reference Sequences

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RefSeqi
NP_005310.1, NM_005319.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.7644

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343677; ENSP00000339566; ENSG00000187837

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3006

UCSC genome browser

More...
UCSCi
uc003nfw.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57129 Genomic DNA Translation: CAA40408.1
AF531300 Genomic DNA Translation: AAN06700.1
AK290947 mRNA Translation: BAF83636.1
AB451259 mRNA Translation: BAG70073.1
AB451385 mRNA Translation: BAG70199.1
U91328 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55515.1
BC002649 mRNA No translation available.
CCDSiCCDS4577.1
PIRiS26364 HSHU11
RefSeqiNP_005310.1, NM_005319.3
UniGeneiHs.7644

3D structure databases

ProteinModelPortaliP16403
SMRiP16403
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109261, 128 interactors
DIPiDIP-36359N
IntActiP16403, 182 interactors
MINTiP16403
STRINGi9606.ENSP00000339566

PTM databases

iPTMnetiP16403
PhosphoSitePlusiP16403
SwissPalmiP16403

Polymorphism and mutation databases

BioMutaiHIST1H1C
DMDMi417101

Proteomic databases

EPDiP16403
jPOSTiP16403
MaxQBiP16403
PaxDbiP16403
PeptideAtlasiP16403
PRIDEiP16403
ProteomicsDBi53353
TopDownProteomicsiP16403

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3006
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343677; ENSP00000339566; ENSG00000187837
GeneIDi3006
KEGGihsa:3006
UCSCiuc003nfw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3006
DisGeNETi3006
EuPathDBiHostDB:ENSG00000187837.3

GeneCards: human genes, protein and diseases

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GeneCardsi
HIST1H1C
HGNCiHGNC:4716 HIST1H1C
HPAiCAB011507
MIMi142710 gene
neXtProtiNX_P16403
OpenTargetsiENSG00000187837
PharmGKBiPA29094

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00940000163082
HOGENOMiHOG000251627
HOVERGENiHBG009035
InParanoidiP16403
KOiK11275
OMAiSWIDMIK
OrthoDBi1565299at2759
PhylomeDBiP16403
TreeFamiTF313664

Enzyme and pathway databases

ReactomeiR-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HIST1H1C human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HIST1H1C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3006

Protein Ontology

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PROi
PR:P16403

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187837 Expressed in 205 organ(s), highest expression level in stomach
GenevisibleiP16403 HS

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16403
Secondary accession number(s): A8K4I2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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