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Entry version 169 (12 Aug 2020)
Sequence version 2 (23 Nov 2004)
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Protein

Muscarinic acetylcholine receptor DM1

Gene

mAChR-A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-390648, Muscarinic acetylcholine receptors
R-DME-390650, Histamine receptors
R-DME-416476, G alpha (q) signalling events
R-DME-418594, G alpha (i) signalling events
R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscarinic acetylcholine receptor DM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mAChR-A
Synonyms:AcrC, mAcR-60C
ORF Names:CG4356
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000037, mAChR-A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 100ExtracellularBy similarityAdd BLAST100
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei101 – 121Helical; Name=1By similarityAdd BLAST21
Topological domaini122 – 141CytoplasmicBy similarityAdd BLAST20
Transmembranei142 – 162Helical; Name=2By similarityAdd BLAST21
Topological domaini163 – 177ExtracellularBy similarityAdd BLAST15
Transmembranei178 – 198Helical; Name=3By similarityAdd BLAST21
Topological domaini199 – 220CytoplasmicBy similarityAdd BLAST22
Transmembranei221 – 241Helical; Name=4By similarityAdd BLAST21
Topological domaini242 – 266ExtracellularBy similarityAdd BLAST25
Transmembranei267 – 287Helical; Name=5By similarityAdd BLAST21
Topological domaini288 – 718CytoplasmicBy similarityAdd BLAST431
Transmembranei719 – 739Helical; Name=6By similarityAdd BLAST21
Topological domaini740 – 752ExtracellularBy similarityAdd BLAST13
Transmembranei753 – 773Helical; Name=7By similarityAdd BLAST21
Topological domaini774 – 805CytoplasmicBy similarityAdd BLAST32

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2366467

DrugCentral

More...
DrugCentrali
P16395

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690511 – 805Muscarinic acetylcholine receptor DM1Add BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16395

PRoteomics IDEntifications database

More...
PRIDEi
P16395

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Intense staining in the glomeruli of the antennal lobes, the region of the nervous system containing terminals of antennal olfactory sensory neurons and mechanosensory neurons. Also a discrete group of neurosecretory cells in the pars intercerebralis of the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000037, Expressed in brain and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16395, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072275

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16395

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 69Thr-richAdd BLAST46
Compositional biasi502 – 534Asn-richAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4220, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166540

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16395

KEGG Orthology (KO)

More...
KOi
K04131

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIFHKRI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16395

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000995, Musac_Ach_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237, GPCRRHODOPSN
PR00243, MUSCARINICR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: P16395-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPVMSLALA AHGPPSILEP LFKTVTTSTT TTTTTTTSTT TTTASPAGYS
60 70 80 90 100
PGYPGTTLLT ALFENLTSTA ASGLYDPYSG MYGNQTNGTI GFETKGPRYS
110 120 130 140 150
LASMVVMGFV AAILSTVTVA GNVMVMISFK IDKQLQTISN YFLFSLAIAD
160 170 180 190 200
FAIGAISMPL FAVTTILGYW PLGPIVCDTW LALDYLASNA SVLNLLIISF
210 220 230 240 250
DRYFSVTRPL TYRAKRTTNR AAVMIGAAWG ISLLLWPPWI YSWPYIEGKR
260 270 280 290 300
TVPKDECYIQ FIETNQYITF GTALAAFYFP VTIMCFLYWR IWRETKKRQK
310 320 330 340 350
DLPNLQAGKK DSSKRSNSSD ENTVVNHASG GLLAFAQVGG NDHDTWRRPR
360 370 380 390 400
SESSPDAESV YMTNMVIDSG YHGMHSRKSS IKSTNTIKKS YTCFGSIKEW
410 420 430 440 450
CIAWWHSGRE DSDDFAYEQE EPSDLGYATP VTIETPLQSS VSRCTSMNVM
460 470 480 490 500
RDNYSMGGSV SGVRPPSILL SDVSPTPLPR PPLASISQLQ EMSAVTASTT
510 520 530 540 550
ANVNTSGNGN GAINNNNNAS HNGNGAVNGN GAGNGSGIGL GTTGNATHRD
560 570 580 590 600
SRTLPVINRI NSRSVSQDSV YTILIRLPSD GASSNAANGG GGGPGAGAAA
610 620 630 640 650
SASLSMQGDC APSIKMIHED GPTTTAAAAP LASAAATRRP LPSRDSEFSL
660 670 680 690 700
PLGRRMSHAQ HDARLLNAKV IPKQLGKAGG GAAGGGVGGA HALMNARNAA
710 720 730 740 750
KKKKKSQEKR QESKAAKTLS AILLSFIITW TPYNILVLIK PLTTCSDCIP
760 770 780 790 800
TELWDFFYAL CYINSTINPM CYALCNATFR RTYVRILTCK WHTRNREGMV

RGVYN
Length:805
Mass (Da):86,623
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97A9229CAA5BBED8
GO
Isoform A (identifier: P16395-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-443: Missing.

Show »
Length:788
Mass (Da):84,792
Checksum:iAD8476D9F52AB522
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA85449 differs from that shown. Reason: Frameshift.Curated
The sequence ABF85716 differs from that shown. Contaminating sequence. E.coli genomic contaminant.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23K → R in AAA28676 (PubMed:2507354).Curated1
Sequence conflicti23K → R in AFJ23964 (PubMed:23604020).Curated1
Sequence conflicti23K → R in AFJ23965 (PubMed:23604020).Curated1
Sequence conflicti23K → R in AEQ62993 (Ref. 5) Curated1
Sequence conflicti90I → M in AFJ23965 (PubMed:23604020).Curated1
Sequence conflicti155A → T in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti199S → N in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti216R → G in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti227Missing in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti306Q → H in AFJ23965 (PubMed:23604020).Curated1
Sequence conflicti331G → P in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti355P → A in AAA28676 (PubMed:2507354).Curated1
Sequence conflicti355P → A in AFJ23964 (PubMed:23604020).Curated1
Sequence conflicti355P → A in AFJ23965 (PubMed:23604020).Curated1
Sequence conflicti355P → A in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti462G → A in AAA28676 (PubMed:2507354).Curated1
Sequence conflicti532A → T in AFJ23964 (PubMed:23604020).Curated1
Sequence conflicti532A → T in AFJ23965 (PubMed:23604020).Curated1
Sequence conflicti532A → T in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti687 – 688VG → C in AAA85449 (PubMed:2510174).Curated2
Sequence conflicti696 – 697AR → P in AAA85449 (PubMed:2510174).Curated2
Sequence conflicti737 – 739VLI → CLS in AAA85449 (PubMed:2510174).Curated3
Sequence conflicti771C → S in AAA85449 (PubMed:2510174).Curated1
Sequence conflicti797 – 805EGMVRGVYN → DFMYAASTIR in AAA85449 (PubMed:2510174).Curated9

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012002427 – 443Missing in isoform A. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23412 mRNA Translation: AAA28676.1
JQ922420 mRNA Translation: AFJ23964.1
JQ922421 mRNA Translation: AFJ23965.1
AE013599 Genomic DNA Translation: AAF47197.1
AE013599 Genomic DNA Translation: AAM68310.1
BT025816 mRNA Translation: ABF85716.1 Sequence problems.
BT132689 mRNA Translation: AEQ62993.1
M27495 mRNA Translation: AAA85449.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
S05661

NCBI Reference Sequences

More...
RefSeqi
NP_523844.2, NM_079120.3 [P16395-1]
NP_726440.1, NM_166668.2 [P16395-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072367; FBpp0072274; FBgn0000037 [P16395-2]
FBtr0072368; FBpp0072275; FBgn0000037 [P16395-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4356

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23412 mRNA Translation: AAA28676.1
JQ922420 mRNA Translation: AFJ23964.1
JQ922421 mRNA Translation: AFJ23965.1
AE013599 Genomic DNA Translation: AAF47197.1
AE013599 Genomic DNA Translation: AAM68310.1
BT025816 mRNA Translation: ABF85716.1 Sequence problems.
BT132689 mRNA Translation: AEQ62993.1
M27495 mRNA Translation: AAA85449.1 Frameshift.
PIRiS05661
RefSeqiNP_523844.2, NM_079120.3 [P16395-1]
NP_726440.1, NM_166668.2 [P16395-2]

3D structure databases

SMRiP16395
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0072275

Chemistry databases

ChEMBLiCHEMBL2366467
DrugCentraliP16395

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Proteomic databases

PaxDbiP16395
PRIDEiP16395

Genome annotation databases

EnsemblMetazoaiFBtr0072367; FBpp0072274; FBgn0000037 [P16395-2]
FBtr0072368; FBpp0072275; FBgn0000037 [P16395-1]
GeneIDi37892
KEGGidme:Dmel_CG4356

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37892
FlyBaseiFBgn0000037, mAChR-A

Phylogenomic databases

eggNOGiKOG4220, Eukaryota
GeneTreeiENSGT00940000166540
InParanoidiP16395
KOiK04131
OMAiVIFHKRI
PhylomeDBiP16395

Enzyme and pathway databases

ReactomeiR-DME-390648, Muscarinic acetylcholine receptors
R-DME-390650, Histamine receptors
R-DME-416476, G alpha (q) signalling events
R-DME-418594, G alpha (i) signalling events
R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37892, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37892

Protein Ontology

More...
PROi
PR:P16395

Gene expression databases

BgeeiFBgn0000037, Expressed in brain and 20 other tissues
GenevisibleiP16395, DM

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000995, Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00243, MUSCARINICR
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACM1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16395
Secondary accession number(s): G4LU59
, M9NHK8, M9NKN3, Q1ECB8, Q8MLP2, Q9W180
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 23, 2004
Last modified: August 12, 2020
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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