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Protein

Potassium voltage-gated channel subfamily A member 3

Gene

Kcna3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 3
Alternative name(s):
MK3
Voltage-gated potassium channel subunit Kv1.3
Gene namesi
Name:Kcna3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96660 Kcna3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 187CytoplasmicSequence analysisAdd BLAST187
Transmembranei188 – 206Helical; Name=Segment S1Sequence analysisAdd BLAST19
Topological domaini207 – 247ExtracellularSequence analysisAdd BLAST41
Transmembranei248 – 269Helical; Name=Segment S2Sequence analysisAdd BLAST22
Topological domaini270 – 280CytoplasmicSequence analysisAdd BLAST11
Transmembranei281 – 301Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini302 – 315ExtracellularSequence analysisAdd BLAST14
Transmembranei316 – 334Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST19
Topological domaini335 – 350CytoplasmicSequence analysisAdd BLAST16
Transmembranei351 – 370Helical; Name=Segment S5Sequence analysisAdd BLAST20
Topological domaini371 – 411ExtracellularSequence analysisAdd BLAST41
Transmembranei412 – 434Helical; Name=Segment S6Sequence analysisAdd BLAST23
Topological domaini435 – 528CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4818
GuidetoPHARMACOLOGYi540

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539781 – 528Potassium voltage-gated channel subfamily A member 3Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi270S-palmitoyl cysteineSequence analysis1
Modified residuei473Phosphoserine; by PKASequence analysis1

Post-translational modificationi

N-glycosylation promotes the cell surface expression.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP16390
PaxDbiP16390
PeptideAtlasiP16390
PRIDEiP16390

PTM databases

iPTMnetiP16390
PhosphoSitePlusiP16390

Expressioni

Gene expression databases

BgeeiENSMUSG00000047959 Expressed in 72 organ(s), highest expression level in thymus
GenevisibleiP16390 MM

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200878, 1 interactor
IntActiP16390, 1 interactor
STRINGi10090.ENSMUSP00000050680

Chemistry databases

BindingDBiP16390

Structurei

3D structure databases

ProteinModelPortaliP16390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi397 – 402Selectivity filterBy similarity6
Motifi526 – 528PDZ-bindingBy similarity3

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiP16390
KOiK04876
OMAiCQFPETL
OrthoDBiEOG091G10NU
PhylomeDBiP16390
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004050 K_chnl_volt-dep_Kv1.3
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01510 KV13CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

P16390-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVVPGDHLL EPEAAGGGGG DPPQGGCGSG GGGGGCDRYE PLPPALPAAG
60 70 80 90 100
EQDCCGERVV INISGLRFET QLKTLCQFPE TLLGDPKRRM RYFDPLRNEY
110 120 130 140 150
FFDRNRPSFD AILYYYQSGG RIRRPVNVPI DIFSEEIRFY QLGEEAMEKF
160 170 180 190 200
REDEGFLREE ERPLPRRDFQ RQVWLLFEYP ESSGPARGIA IVSVLVILIS
210 220 230 240 250
IVIFCLETLP EFRDEKDYPA SPSQDVFEAA NNSTSGAPSG ASSFSDPFFV
260 270 280 290 300
VETLCIIWFS FELLVRFFAC PSKATFSRNI MNLIDIVAII PYFITLGTEL
310 320 330 340 350
AERQGNGQQA MSLAILRVIR LVRVFRIFKL SRHSKGLQIL GQTLKASMRE
360 370 380 390 400
LGLLIFFLFI GVILFSSAVY FAEADDPSSG FNSIPDAFWW AVVTMTTVGY
410 420 430 440 450
GDMHPVTIGG KIVGSLCAIA GVLTIALPVP VIVSNFNYFY HRETEGEEQA
460 470 480 490 500
QYMHVGSCQH LSSSAEELRK ARSNSTLSKS EYMVIEEGGM NHSAFPQTPF
510 520
KTGNSTATCT TNNNPNSCVN IKKIFTDV
Length:528
Mass (Da):58,564
Last modified:November 25, 2008 - v3
Checksum:i12AC94FB13A523E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369V → A in AAA39716 (PubMed:2305265).Curated1
Sequence conflicti492H → Q in AAA39716 (PubMed:2305265).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30441 Genomic DNA Translation: AAA39716.1
CH466607 Genomic DNA Translation: EDL01888.1
BC132349 mRNA Translation: AAI32350.1
BC137667 mRNA Translation: AAI37668.1
CCDSiCCDS17730.1
PIRiC40090 I84205
S09044
RefSeqiNP_032444.2, NM_008418.2
UniGeneiMm.30640

Genome annotation databases

EnsembliENSMUST00000052718; ENSMUSP00000050680; ENSMUSG00000047959
GeneIDi16491
KEGGimmu:16491
UCSCiuc008qwp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30441 Genomic DNA Translation: AAA39716.1
CH466607 Genomic DNA Translation: EDL01888.1
BC132349 mRNA Translation: AAI32350.1
BC137667 mRNA Translation: AAI37668.1
CCDSiCCDS17730.1
PIRiC40090 I84205
S09044
RefSeqiNP_032444.2, NM_008418.2
UniGeneiMm.30640

3D structure databases

ProteinModelPortaliP16390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200878, 1 interactor
IntActiP16390, 1 interactor
STRINGi10090.ENSMUSP00000050680

Chemistry databases

BindingDBiP16390
ChEMBLiCHEMBL4818
GuidetoPHARMACOLOGYi540

PTM databases

iPTMnetiP16390
PhosphoSitePlusiP16390

Proteomic databases

MaxQBiP16390
PaxDbiP16390
PeptideAtlasiP16390
PRIDEiP16390

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052718; ENSMUSP00000050680; ENSMUSG00000047959
GeneIDi16491
KEGGimmu:16491
UCSCiuc008qwp.2 mouse

Organism-specific databases

CTDi3738
MGIiMGI:96660 Kcna3

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiP16390
KOiK04876
OMAiCQFPETL
OrthoDBiEOG091G10NU
PhylomeDBiP16390
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

PROiPR:P16390
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047959 Expressed in 72 organ(s), highest expression level in thymus
GenevisibleiP16390 MM

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR004050 K_chnl_volt-dep_Kv1.3
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01510 KV13CHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNA3_MOUSE
AccessioniPrimary (citable) accession number: P16390
Secondary accession number(s): A3KMM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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