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Entry version 205 (29 Sep 2021)
Sequence version 2 (01 Feb 1996)
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Protein

Potassium voltage-gated channel subfamily A member 2

Gene

KCNA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686).

Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134).

Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686).

In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559).

Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity).

KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity).

Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity).

Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity).

May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity).

May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity).

Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity).

Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity).

Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity).

By similarityCurated5 Publications

Miscellaneous

The delay or D-type current observed in hippocampus pyramidal neurons is probably mediated by potassium channels containing KCNA2 plus KCNA1 or other family members. It is activated at about -50 mV, i.e. below the action potential threshold, and is characterized by slow inactivation, extremely slow recovery from inactivation, sensitivity to dendrotoxin (DTX) and to 4-aminopyridine (4-AP).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by 4-aminopyridine (4-AP) and charybdotoxin (CTX), but not by tetraethylammonium (TEA) (PubMed:19912772). Inhibited by dendrotoxin (DTX) (By similarity). Inhibited by tityustoxin-K alpha (TsTX-Kalpha), a toxin that is highly specific for KCNA2 (By similarity). Inhibited by maurotoxin (By similarity). Inhibited by kappaM conotoxins kappaM-RIIIJ and kappaM-RIIIK; kappaM-RIIIJ has much higher affinity for channels containing KCNA2 than kappaM-RIIIK, with the exception of heterodimers formed by KCNA2 and KCNA7 where the opposite is true (PubMed:20220134).By similarity2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Homotetrameric channels activate rapidly, i.e within a few msec, but inactivation is very slow, with only a marginal decrease in conductance over several seconds. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system, post-translational modifications and the presence or absence of ancillary subunits. For the activation of homotetrameric channels expressed in xenopus oocytes, the threshold is at about -30 mV and the midpoint at about -5 mV.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei252Important for normal, slow channel gatingBy similarity1
Sitei381Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxinBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: UniProtKB
  • kinesin binding Source: Ensembl
  • outward rectifier potassium channel activity Source: Ensembl
  • potassium channel activity Source: ProtInc
  • voltage-gated potassium channel activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P16389

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296072, Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.1.2.10, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 2
Alternative name(s):
NGK1
Voltage-gated K(+) channel HuKIV1 Publication
Voltage-gated potassium channel HBK5
Voltage-gated potassium channel subunit Kv1.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6220, KCNA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176262, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P16389

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000177301

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 160CytoplasmicBy similarityAdd BLAST160
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei161 – 182Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini183 – 221ExtracellularBy similarityAdd BLAST39
Transmembranei222 – 243Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini244 – 254CytoplasmicBy similarityAdd BLAST11
Transmembranei255 – 275Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini276 – 289ExtracellularBy similarityAdd BLAST14
Transmembranei290 – 310Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini311 – 325CytoplasmicBy similarityAdd BLAST15
Transmembranei326 – 347Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini348 – 361ExtracellularBy similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei362 – 373Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei374 – 381By similarity8
Topological domaini382 – 388ExtracellularBy similarity7
Transmembranei389 – 417Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini418 – 499CytoplasmicBy similarityAdd BLAST82

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Developmental and epileptic encephalopathy 32 (DEE32)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073704263I → T in DEE32; dominant-negative mutation; loss of channel function. 1 PublicationCorresponds to variant dbSNP:rs786205231EnsemblClinVar.1
Natural variantiVAR_073705297R → Q in DEE32; causes a gain of function. 2 PublicationsCorresponds to variant dbSNP:rs786205232EnsemblClinVar.1
Natural variantiVAR_073706298L → F in DEE32; causes a gain of function. 1 PublicationCorresponds to variant dbSNP:rs876657390EnsemblClinVar.1
Natural variantiVAR_073707405P → L in DEE32; loss of channel function. 1 PublicationCorresponds to variant dbSNP:rs876657389Ensembl.1

Keywords - Diseasei

Disease variant, Epilepsy

Organism-specific databases

DisGeNET

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DisGeNETi
3737

MalaCards human disease database

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MalaCardsi
KCNA2
MIMi616366, phenotype

Open Targets

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OpenTargetsi
ENSG00000177301

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
442835, Non-specific early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA206

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P16389, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2086

Drug and drug target database

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DrugBanki
DB06637, Dalfampridine
DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

DrugCentral

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DrugCentrali
P16389

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
539

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KCNA2

Domain mapping of disease mutations (DMDM)

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DMDMi
1345813

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539721 – 499Potassium voltage-gated channel subfamily A member 2Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi244S-palmitoyl cysteineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei429PhosphotyrosineBy similarity1
Modified residuei434PhosphoserineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei449PhosphoserineBy similarity1
Modified residuei458PhosphotyrosineBy similarity1
Modified residuei468PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues; phosphorylation increases in response to ischemia (By similarity). Phosphorylated on tyrosine residues by activated PTK2B/PYK2 (By similarity). Phosphorylation on tyrosine residues suppresses ion channel activity (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation; this abolishes interaction with CTTN. This is probably due to endocytosis of the phosphorylated channel subunits (By similarity). Phosphorylated on serine residues in response to increased cAMP levels; phosphorylation is apparently not catalyzed by PKA (By similarity).By similarity
N-glycosylated, with complex, sialylated N-glycans.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P16389

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P16389

MaxQB - The MaxQuant DataBase

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MaxQBi
P16389

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16389

PeptideAtlas

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PeptideAtlasi
P16389

PRoteomics IDEntifications database

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PRIDEi
P16389

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53349 [P16389-1]
53350 [P16389-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P16389, 1 site

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P16389

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P16389

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex (PubMed:16473933). Detected in peroneal nerve in the juxtaparanodal regions of the node of Ranvier; expression is decreased in patients with diabetes mellitus that suffer from axonal neuropathy (PubMed:22649228). Detected in paranodal and juxtanodal zones in myelinated spinal cord (at protein level) (PubMed:11086297).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177301, Expressed in cerebellar vermis and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16389, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16389, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177301, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNA1, KCNA4, KCNA5, KCNA6 and KCNA7. Channel activity is regulated by interaction with the beta subunits, including KCNAB1 and KCNAB2.

Identified in a complex with KCNA1 and KCNAB2 (PubMed:11086297).

Identified in a complex with KCNA5 and KCNAB1 (By similarity).

Identified in a complex with KCNA4 and FYN (By similarity).

Interacts with the beta subunit KCNAB1 (PubMed:19713757).

Interacts with PTK2B (By similarity).

Interacts (via C-terminus) with CTTN (By similarity).

Interacts (via N-terminal cytoplasmic domain) with RHOA (GTP-bound form); this regulates channel activity by reducing location at the cell surface in response to CHRM1 activation (By similarity).

Interacts with DRD2 (By similarity).

Interacts with SIGMAR1; cocaine consumption leads to increased interaction (By similarity).

Interacts with ADAM22 (By similarity).

Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity).

Interacts with CNTNAP2 (PubMed:10624965).

By similarityCurated4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109940, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P16389

Protein interaction database and analysis system

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IntActi
P16389, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000433109

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P16389

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P16389, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16389

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 125Tetramerization domainBy similarityAdd BLAST125
Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni312 – 325S4-S5 linkerBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi374 – 379Selectivity filterBy similarity6
Motifi497 – 499PDZ-bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic N-terminus is important for tetramerization. Interactions between the different subunits modulate the gating characteristics (By similarity). Besides, the cytoplasmic N-terminal domain mediates interaction with RHOA and thus is required for RHOA-mediated endocytosis (By similarity).By similarity
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1545, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158688

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16389

Identification of Orthologs from Complete Genome Data

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OMAi
PIFRNDE

Database of Orthologous Groups

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OrthoDBi
695337at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P16389

TreeFam database of animal gene trees

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TreeFami
TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 1 hit
3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000210, BTB/POZ_dom
IPR005821, Ion_trans_dom
IPR003968, K_chnl_volt-dep_Kv
IPR003972, K_chnl_volt-dep_Kv1
IPR004049, K_chnl_volt-dep_Kv1.2
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR028325, VG_K_chnl
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11537, PTHR11537, 1 hit
PTHR11537:SF23, PTHR11537:SF23, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02214, BTB_2, 1 hit
PF00520, Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01509, KV12CHANNEL
PR01491, KVCHANNEL
PR01496, SHAKERCHANEL

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54695, SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16389-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVATGDPAD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT
60 70 80 90 100
LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR
110 120 130 140 150
PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW
160 170 180 190 200
LLFEYPESSG PARIIAIVSV MVILISIVSF CLETLPIFRD ENEDMHGSGV
210 220 230 240 250
TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR FFACPSKAGF
260 270 280 290 300
FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR
310 320 330 340 350
VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE
360 370 380 390 400
ADERESQFPS IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL
410 420 430 440 450
TIALPVPVIV SNFNYFYHRE TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA
460 470 480 490
STISKSDYME IQEGVNNSNE DFREENLKTA NCTLANTNYV NITKMLTDV
Length:499
Mass (Da):56,717
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B03F1B46A826C39
GO
Isoform 2 (identifier: P16389-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-499: VRVFRIFKLS...VNITKMLTDV → ERRPLQSQKS...PAVTTLHRMY

Show »
Length:356
Mass (Da):40,966
Checksum:i9917ABBFCCCF7411
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPN8A0A1W2PPN8_HUMAN
Potassium voltage-gated channel sub...
KCNA2
377Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPM7A0A1W2PPM7_HUMAN
Potassium voltage-gated channel sub...
KCNA2
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRY2A0A1W2PRY2_HUMAN
Potassium voltage-gated channel sub...
KCNA2
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PP65A0A1W2PP65_HUMAN
Potassium voltage-gated channel sub...
KCNA2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PR01A0A1W2PR01_HUMAN
Potassium voltage-gated channel sub...
KCNA2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230I → V in BAF82750 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073704263I → T in DEE32; dominant-negative mutation; loss of channel function. 1 PublicationCorresponds to variant dbSNP:rs786205231EnsemblClinVar.1
Natural variantiVAR_073705297R → Q in DEE32; causes a gain of function. 2 PublicationsCorresponds to variant dbSNP:rs786205232EnsemblClinVar.1
Natural variantiVAR_073706298L → F in DEE32; causes a gain of function. 1 PublicationCorresponds to variant dbSNP:rs876657390EnsemblClinVar.1
Natural variantiVAR_078206324S → T Probable disease-associated variant found in a patient with drug-resistant epilepsy. 1 Publication1
Natural variantiVAR_073707405P → L in DEE32; loss of channel function. 1 PublicationCorresponds to variant dbSNP:rs876657389Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043077299 – 499VRVFR…MLTDV → ERRPLQSQKSKRGRQHLNTS HDCTLGINLVAGMTVQWTRA SGPDDRQTPAVTTLHRMY in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L02752 mRNA Translation: AAA36141.1
AK290061 mRNA Translation: BAF82750.1
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56455.1
CH471122 Genomic DNA Translation: EAW56456.1
BC043564 mRNA Translation: AAH43564.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55625.1 [P16389-2]
CCDS827.1 [P16389-1]

Protein sequence database of the Protein Information Resource

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PIRi
I77466

NCBI Reference Sequences

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RefSeqi
NP_001191198.1, NM_001204269.1 [P16389-2]
NP_004965.1, NM_004974.3 [P16389-1]
XP_011539698.1, XM_011541396.2 [P16389-1]
XP_011539699.1, XM_011541397.2 [P16389-1]
XP_011539700.1, XM_011541398.2 [P16389-1]
XP_011539701.1, XM_011541399.2 [P16389-1]
XP_011539702.1, XM_011541400.2 [P16389-1]
XP_016856702.1, XM_017001213.1 [P16389-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316361; ENSP00000314520; ENSG00000177301 [P16389-1]
ENST00000369770; ENSP00000358785; ENSG00000177301 [P16389-2]
ENST00000485317; ENSP00000433109; ENSG00000177301 [P16389-1]
ENST00000633222; ENSP00000487785; ENSG00000177301 [P16389-1]
ENST00000638532; ENSP00000491613; ENSG00000177301 [P16389-1]
ENST00000638616; ENSP00000491977; ENSG00000177301 [P16389-1]
ENST00000675391; ENSP00000502642; ENSG00000177301 [P16389-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3737

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3737

UCSC genome browser

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UCSCi
uc009wfv.2, human [P16389-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02752 mRNA Translation: AAA36141.1
AK290061 mRNA Translation: BAF82750.1
AL365361 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56455.1
CH471122 Genomic DNA Translation: EAW56456.1
BC043564 mRNA Translation: AAH43564.1
CCDSiCCDS55625.1 [P16389-2]
CCDS827.1 [P16389-1]
PIRiI77466
RefSeqiNP_001191198.1, NM_001204269.1 [P16389-2]
NP_004965.1, NM_004974.3 [P16389-1]
XP_011539698.1, XM_011541396.2 [P16389-1]
XP_011539699.1, XM_011541397.2 [P16389-1]
XP_011539700.1, XM_011541398.2 [P16389-1]
XP_011539701.1, XM_011541399.2 [P16389-1]
XP_011539702.1, XM_011541400.2 [P16389-1]
XP_016856702.1, XM_017001213.1 [P16389-1]

3D structure databases

SMRiP16389
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109940, 19 interactors
CORUMiP16389
IntActiP16389, 3 interactors
STRINGi9606.ENSP00000433109

Chemistry databases

BindingDBiP16389
ChEMBLiCHEMBL2086
DrugBankiDB06637, Dalfampridine
DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine
DrugCentraliP16389
GuidetoPHARMACOLOGYi539

Protein family/group databases

TCDBi1.A.1.2.10, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniP16389, 1 site
iPTMnetiP16389
PhosphoSitePlusiP16389

Genetic variation databases

BioMutaiKCNA2
DMDMi1345813

Proteomic databases

jPOSTiP16389
MassIVEiP16389
MaxQBiP16389
PaxDbiP16389
PeptideAtlasiP16389
PRIDEiP16389
ProteomicsDBi53349 [P16389-1]
53350 [P16389-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P16389, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4539, 287 antibodies

The DNASU plasmid repository

More...
DNASUi
3737

Genome annotation databases

EnsembliENST00000316361; ENSP00000314520; ENSG00000177301 [P16389-1]
ENST00000369770; ENSP00000358785; ENSG00000177301 [P16389-2]
ENST00000485317; ENSP00000433109; ENSG00000177301 [P16389-1]
ENST00000633222; ENSP00000487785; ENSG00000177301 [P16389-1]
ENST00000638532; ENSP00000491613; ENSG00000177301 [P16389-1]
ENST00000638616; ENSP00000491977; ENSG00000177301 [P16389-1]
ENST00000675391; ENSP00000502642; ENSG00000177301 [P16389-1]
GeneIDi3737
KEGGihsa:3737
UCSCiuc009wfv.2, human [P16389-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3737
DisGeNETi3737

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNA2
HGNCiHGNC:6220, KCNA2
HPAiENSG00000177301, Tissue enriched (brain)
MalaCardsiKCNA2
MIMi176262, gene
616366, phenotype
neXtProtiNX_P16389
OpenTargetsiENSG00000177301
Orphaneti442835, Non-specific early-onset epileptic encephalopathy
PharmGKBiPA206
VEuPathDBiHostDB:ENSG00000177301

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1545, Eukaryota
GeneTreeiENSGT00940000158688
InParanoidiP16389
OMAiPIFRNDE
OrthoDBi695337at2759
PhylomeDBiP16389
TreeFamiTF313103

Enzyme and pathway databases

PathwayCommonsiP16389
ReactomeiR-HSA-1296072, Voltage gated Potassium channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3737, 11 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNA2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3737
PharosiP16389, Tclin

Protein Ontology

More...
PROi
PR:P16389
RNActiP16389, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177301, Expressed in cerebellar vermis and 148 other tissues
ExpressionAtlasiP16389, baseline and differential
GenevisibleiP16389, HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR005821, Ion_trans_dom
IPR003968, K_chnl_volt-dep_Kv
IPR003972, K_chnl_volt-dep_Kv1
IPR004049, K_chnl_volt-dep_Kv1.2
IPR011333, SKP1/BTB/POZ_sf
IPR003131, T1-type_BTB
IPR028325, VG_K_chnl
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR11537, PTHR11537, 1 hit
PTHR11537:SF23, PTHR11537:SF23, 1 hit
PfamiView protein in Pfam
PF02214, BTB_2, 1 hit
PF00520, Ion_trans, 1 hit
PRINTSiPR01509, KV12CHANNEL
PR01491, KVCHANNEL
PR01496, SHAKERCHANEL
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16389
Secondary accession number(s): A0A024R0D3, A8K1Z6, Q86XG6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: September 29, 2021
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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